15
FOR DISCLOSURE AND FOOTNOTE INFORMATION, REFER TO THE JMP FACTS AND DISCLOSURES SECTION INVESTMENT HIGHLIGHTS We are initiating coverage of NeoStem with a Market Outperform rating and $3 price target. NeoStem is a company with core expertise in the field of stem cells and cellular therapies that has recently undergone a transition to a focused therapeutic development company. Through the acquisitions of Progenitor Cell Therapies (PCT) and Amorcyte, NeoStem has strengthened its core expertise in the stem cell arena and added industry-leading manufacturing expertise as well as a Phase II-ready development candidate. We anticipate that, over the coming 12-18 months, we will gain increased clarity on value-driving clinical catalysts for AMR- 001 in addition to the potential for further product candidate acquisitions. That said, we believe that investors are currently getting a "free call" on the potential for AMR-001 as a result of our view that the present value for the company's leading immunotherapy manufacturing business (~$50MM) and its China pharma subsidiary (~$35MM) provide downside valuation protection. Therefore, we are establishing a place-marker price target of $3.00 based on a sum-of-the-parts analysis including AMR-001 (5x revenue of $730MM in 2019, discounted by 40% per year), manufacturing service revenue from PCT (3x revenue of $25MM in 2012, discounted at 15%), and sales from the company's Chinese pharmaceutical division Suzhou Erye (50% ownership of 1x revenue of $70MM in 2011). AMR-001 emphasizes transition to a therapeutics-focused company. NeoStem is driving the transformation to a high-value therapeutics company through the development of AMR-001. This is an autologous cellular therapy poised to enter Phase II development to prevent progressive cardiac tissue damage in patients following acute myocardial infarction (heart attack). This 150-patient trial is on track to begin enrollment in 1Q12 with results expected in 2H13. PCT provides core expertise in cellular therapies that can be leveraged both to grow current manufacturing revenues but also to advance NeoStem's pipeline candidates. NeoStem's January 2011 acquisition of Progenitor Cell Therapies (PCT) expanded the company's expertise in stem cell technologies and provided a service business nearing breakeven. PCT has played a key role in the advancement of emerging development-stage cellular therapy candidates (notably leading the manufacturing development of Dendreon's Provenge), and we believe that this industry- leading experience can be leveraged both to offset cash burn and, more importantly, to advance the development of NeoStem's own proprietary development programs. Biotechnology - Initiation of Coverage September 16, 2011 NeoStem, Inc. (1,3) Initiation - Transformative Acquisitions Position Emerging Cell Therapy Player MARKET OUTPERFORM NBS $0.65 Price $0.65 FY Dec 2010A 2011E 2012E Target Price $3.00 Revenue (M) 1Q $15.8 $19.6A -- 52-Wk Range $0.60 - $2.15 2Q $19.4 $18.5A -- Shares Out. (M) 97 3Q $16.5 $20.6 -- Market Cap. (M) $63 4Q $18.1 $21.6 -- Average Daily Vol. (000) 200 FY $69.8 $80.3 $12.0 Float (M) 62 2010A 2011E 2012E LT Debt (M) $7 EPS 1Q ($0.12) ($0.14)A -- Cash (M) $20 2Q ($0.11) ($0.13)A -- Enterprise Value (M) $114 3Q ($0.13) ($0.12) -- Cash/Share $0.21 4Q ($0.10) ($0.12) -- FY ($0.46) ($0.50) ($0.18) P/E NM NM NM Previous FY -- NE NE CY ($0.46) ($0.50) ($0.18) PE NA NA NA NC indicates no change to previous estimate. NE indicates no previous estimate. Source: Company reports and JMP Securities Jason N. Butler, PhD [email protected] (212) 906-3505

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NeoStem, Inc. (AMEX: NBS; Stock Twits: $NBS) is engaged in the development and manufacturing of cell-based therapies in the U.S. Its January 2011 acquisition of Progenitor Cell Therapy, LLC ("PCT") is central to the Company's strategic mission of capturing the paradigm shift to cell therapy. The acquisition of PCT gives NeoStem not only access to a world class contract manufacturing cell therapy company but provides a platform and expertise around the evaluation, development and regulatory requirements to develop autologous, allogeneic, immunomodulatory and vaccine-based therapeutics. NeoStem also holds the worldwide exclusive license to VSEL(TM) Technology, which uses very small embryonic-like stem cells, shown to have several physical characteristics that are generally found in embryonic stem cells, and is pursuing the licensing of other technologies for therapeutic use. Headquartered in San Francisco, JMP Securities was founded in January 2000 in response to the consolidation of established independent research boutiques by large commercial banks. Since the mid-1990s nearly 50 regional investment banks—including San Francisco’s Montgomery Securities, Hambrecht & Quist and Robertson Stephens—have been acquired by major financial institutions. Such industry consolidation has pressured a new breed of bulge-bracket investment banks to compete for large market-capitalization clients and has greatly reduced Wall Street’s focus on the middle market. JMP Securities was formed in the mold of its independent, research-driven predecessors as a growth-oriented, entrepreneurial firm dedicated to serving the needs of small and midsized companies and the institutions that invest in them.

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Page 1: Neostem Research Report by JMP Securites

FOR DISCLOSURE AND FOOTNOTE INFORMATION, REFER TO THE JMP FACTS AND DISCLOSURES SECTION

INVESTMENT HIGHLIGHTS

• We are initiating coverage of NeoStem with a Market Outperform rating and $3 price target. NeoStem is a company with core expertise in the field of stem cells and cellular therapies that has recently undergone a transition to a focused therapeutic development company. Through the acquisitions of Progenitor Cell Therapies (PCT) and Amorcyte, NeoStem has strengthened its core expertise in the stem cell arena and added industry-leading manufacturing expertise as well as a Phase II-ready development candidate. We anticipate that, over the coming 12-18 months, we will gain increased clarity on value-driving clinical catalysts for AMR-001 in addition to the potential for further product candidate acquisitions. That said, we believe that investors are currently getting a "free call" on the potential for AMR-001 as a result of our view that the present value for the company's leading immunotherapy manufacturing business (~$50MM) and its China pharma subsidiary (~$35MM) provide downside valuation protection. Therefore, we are establishing a place-marker price target of $3.00 based on a sum-of-the-parts analysis including AMR-001 (5x revenue of $730MM in 2019, discounted by 40% per year), manufacturing service revenue from PCT (3x revenue of $25MM in 2012, discounted at 15%), and sales from the company's Chinese pharmaceutical division Suzhou Erye (50% ownership of 1x revenue of $70MM in 2011).

• AMR-001 emphasizes transition to a therapeutics-focused company. NeoStem is driving the transformation to a high-value therapeutics company through the development of AMR-001. This is an autologous cellular therapy poised to enter Phase II development to prevent progressive cardiac tissue damage in patients following acute myocardial infarction (heart attack). This 150-patient trial is on track to begin enrollment in 1Q12 with results expected in 2H13.

• PCT provides core expertise in cellular therapies that can be leveraged both to grow current manufacturing revenues but also to advance NeoStem's pipeline candidates. NeoStem's January 2011 acquisition of Progenitor Cell Therapies (PCT) expanded the company's expertise in stem cell technologies and provided a service business nearing breakeven. PCT has played a key role in the advancement of emerging development-stage cellular therapy candidates (notably leading the manufacturing development of Dendreon's Provenge), and we believe that this industry-leading experience can be leveraged both to offset cash burn and, more importantly, to advance the development of NeoStem's own proprietary development programs.

Biotechnology - Initiation of Coverage September 16, 2011

NeoStem, Inc. (1,3) Initiation - Transformative Acquisitions Position Emerging Cell Therapy Player

MARKET OUTPERFORM NBS $0.65

Price $0.65 FY Dec 2010A 2011E 2012E Target Price $3.00 Revenue (M) 1Q $15.8 $19.6A -- 52-Wk Range $0.60 - $2.15 2Q $19.4 $18.5A -- Shares Out. (M) 97 3Q $16.5 $20.6 -- Market Cap. (M) $63 4Q $18.1 $21.6 --

Average Daily Vol. (000) 200 FY $69.8 $80.3 $12.0 Float (M) 62

2010A 2011E 2012E LT Debt (M) $7 EPS 1Q ($0.12) ($0.14)A -- Cash (M) $20 2Q ($0.11) ($0.13)A -- Enterprise Value (M) $114 3Q ($0.13) ($0.12) -- Cash/Share $0.21 4Q ($0.10) ($0.12) --

FY ($0.46) ($0.50) ($0.18) P/E NM NM NM Previous FY -- NE NE

CY ($0.46) ($0.50) ($0.18) PE NA NA NA

NC indicates no change to previous estimate. NE indicates no previous estimate.

Source: Company reports and JMP Securities

Jason N. Butler, PhD

[email protected]

(212) 906-3505

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2

COMPANY DESCRIPTION

NeoStem is a diversified stem cell technology company that is focusing its broad expertise and

resources on the development of high-value cellular therapies aimed at impacting outcomes of serious

diseases with an unmet medical need. The company expanded its core expertise in stem cell

technologies into manufacturing and therapeutics through acquisitions over the past 12 months. Its lead

therapeutic candidate is AMR-001, an autologous cell therapy being developed for the treatment of

patients following acute myocardial infarction to prevent progressive cardiac tissue damage. Results

from a 31-patient Phase I trial established preliminary evidence of safety and efficacy, and NeoStem is

preparing to initiate a Phase II trial in 1Q12, intended to inform the design of a Phase III registration

program. NeoStem has two further therapeutic platform technologies from which we expect to see

candidates emerge into clinical development over the next 12-24 months. The company also has a

profitable pharmaceutical subsidiary in China, of which it holds 51% ownership, the divestiture of which

is currently being explored.

FIGURE 1: NeoStem Historical Price Chart

0.6

0.8

1

1.2

1.4

1.6

1.8

22.2

Sep Oct Nov Dec Jan Feb Mar Apr May Jun Jul Aug0

4

Source: FactSet

VALUATION

We value NeoStem based on a sum-of-the-parts analysis including AMR-001, manufacturing service

revenue from the Progenitor Cell Therapy (PCT) subsidiary, and sales from the company's Chinese

pharmaceutical division, Suzhou Erye.

FIGURE 2: Absolute Valuation

Sales Revenue year Profit share Multiple Discount

rateCurrent value

Current value

per shareAMR-001 730 2019 90% 5 40% 312 $2.10

PCT CM revenue 25 2015 100% 3 15% 49 $0.33

Suzhou Erye 70 2011 51% 1 36 $0.24

Total 397 $2.67

Source: JMP Securities, LLC

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3

Our price target assumes an estimate for fully diluted shares outstanding of approximately 148 million

shares. This estimate is based on approximately 96 million shares outstanding following the July equity

offering, approximately 33 million warrants with an exercise price below our objective, and 19 million

stock options with an average exercise price of $1.79.

AMR-001

We value AMR-001 based our projections for sales in acute myocardial infarction patients at high risk of

experiencing further major adverse cardiac events (MACE). We conservatively only include sales

projections in the U.S. Our model assumes that AMR-001 will be approved in 2016 and will be launched

by a specialized sales force assembled by NeoStem. We project peak sales in the U.S. of

approximately $715MM in 2019, the third full year of commercialization, of which the company owes a

10% royalty to Amorcyte shareholders. We then derive our valuation by applying a 5x multiple to our

2019 sales projection, discounted by 40% per year to the end of 2012. In our view, this discount rate

reflects higher than average clinical and regulatory risk despite the positive Phase I results and clear

scientific rationale, which takes into consideration uncertainties in cellular therapies arena.

There are approximately 1.25 million people who suffer from an acute myocardial infarction in the U.S.

each year. Of these, approximately 40% are ST-segment elevated myocardial infarctions (STEMI), as

characterized by electrocardiogram. Patients with ST elevation are experiencing ongoing cardiac tissue

injury and require immediate treatment to remove any blockage and restore blood flow. It is estimated

that half of STEMI patients will have a low ejection fraction (< 50%) and 60% of these patients are at

high risk for adverse cardiac remodeling, which involved changes in size, shape, and function of the

heart after injury that results in increased stress to the organ and a high risk for further MACE. Based on

these assumptions, we view the target population for AMR-001 is at least 150,000 patients per year in

the U.S.

We model AMR-001 penetration into this patient population projecting that peak penetration of 9.5% will

be achieved in 2019. We assume a cost of therapy of $50,000, conservatively with no annual price

increases, and therefore derive a peak sales estimate of $730MM. We believe that at peak sales,

NeoStem can achieve gross margins of 80%. We note that NeoStem has issued patents covering AMR-

001's composition of matter that extend through 2028. In addition, given the manufacturing and

regulatory complexities in the cellular therapeutics field, we do not view generic competition as a

meaningful risk at this time.

FIGURE 3: AMR-001 Revenue Model

US AMR-001 market 2015 2016 2017 2018 2019 2020

Acute myocardial infarction (MI) incidence 1,255,000 1,261,275 1,267,581 1,273,919 1,280,289 1,286,690

ST-elevated MI incidence 502,000 504,510 507,033 509,568 512,116 514,676

STEM with low ejection fraction 251,000 252,255 253,516 254,784 256,058 257,338

Patients at increased risk of MACE 150,600 151,353 152,110 152,870 153,635 154,403

AMR-001 penetration 0.0% 0.5% 1.5% 5.0% 9.5% 9.5%

Treated patients 757 2,282 7,644 14,595 14,668

Cost of therapy ($, annual) 50,000 50,000 50,000 50,000 50,000

Sales ($MM) 38 114 382 730 733

Source: Company reports and JMP Securities, LLC

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PCT

In 2010, PCT generated services revenue of approximately $10MM, which is approaching breakeven

for this business. We project that sales can grow to $25MM in 2015 based on 1) an increasing number

of clients and 2) clients progressing product candidates through to later stages of development and

ultimately commercialization. We value revenue generated by PCT by applying a 3x multiple to our

2015 revenue estimate of $25MM, discounted by 15% per year to the end of 2012. We estimate that

$25MM would reflect manufacturing service for clinical product to treat between 1,000 and 1,500

patients.

Suzhou Erye

In 2010, NeoStem reported sales of approximately $70MM from Suzhou Erye and in 1H11 sales were

$34MM. We project sales for FY11 of $71MM, to which we apply a 1x multiple and attribute 51% to

NeoStem based on its ownership stake.

Relative Valuation

We corroborate our absolute valuation methodology with a relative, comparable company analysis for

which we evaluated other companies with core platform technologies that can be leveraged to develop

high value therapeutic candidates. We focused also on companies with hybrid business models that

generate cash flow or value appreciation through existing non-core partnerships. Companies in our

comparable universe have a median enterprise value of $231 million (range of $76-447MM). This

compares favorably to the current enterprise value of NeoStem of $64MM. Using this median value, we

derive a 12-month price target of approximately $3 per share.

FIGURE 4: Relative Valuation

Company Name Ticker Price Shares Market Cap Cash Debt Enterprise Value

Aastrom Biosciences Inc. ASTM $2.62 38.6 101 19 0 83

Isis Pharmaceuticals Inc. ISIS $7.17 99.7 715 395 143 462

Lexicon Pharmaceuticals Inc. LXRX $1.28 337.7 432 164 24 292Rockwell Medical Technologies Inc. RMTI $8.73 18.1 158 21 0 137

Sangamo BioSciences Inc. SGMO $5.93 52.5 311 91 0 220Median 311 239

Neostem NBS $2.61 96.6 252 13.4 0 239

Source: JMP Securities, LLC and FactSet

KEY UPCOMING CATALYSTS

1Q12 Initiate Phase II trial for AMR-001 in AMI patients

2012 Initiate Phase I trial(s) for Athelos T reg therapeutic candidate(s)

2012 Monetize 51% ownership in Suzhou Erye

KEY INVESTMENT POINTS

NeoStem is positioning to become a leading player in cellular medicine. NeoStem is a

biopharmaceutical company with a focus in the field of stem cell technologies, with core expertise in

collection, storage, and manufacturing of stem cells globally. The company's Progenitor Cell Therapy

(PCT) unit is a key player providing contract manufacture and development/regulatory consultancy to

stem cell therapeutics companies. NeoStem is now leveraging their core expertise to advance emerging

therapeutic programs. Through the recent acquisition of Amorcyte, NeoStem has gained rights to AMR-

001, a well characterized autologous cell therapy product candidate with an established mechanism of

action and defined threshold dose. The company completed an equity financing over the summer,

raising gross proceeds of $16.5MM, which we believe can further enable the transformation into a

focused therapeutics development company and progress AMR-001 into Phase II development. In our

view, execution on the AMR-001 development program and continued commitment to high-value

therapeutic assets will further establish NeoStem as a focused development-stage biotechnology

company and can provide multiple value-inflecting milestones over the next 12-18 months. In turn, we

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5

believe, investors will begin to more appropriately value the potential of the company's assets and

capabilities.

Cellular therapies - emerging investable opportunities. The therapeutic potential of stem cells has

long been recognized as a powerful approach to treating diseases, especially in the field of regenerative

medicine but beyond this in a wide array of diseases ranging from autoimmune to neurodegenerative

and cardiovascular. However, there have been multiple challenges faced and, in many examples not

overcome, including ethical, technical, regulatory, and commercial considerations. Just as biologic

therapies (e.g., monoclonal antibodies) are considerably more complex than small molecule

pharmaceuticals, cellular therapies are even more complex. However, just as the therapeutic potential

of biologics was realized, we believe cellular therapies are now entering a period of development when

successes can become more frequent.

PCT unit provides core, industry leading expertise as well as growing contract manufacturing

revenue. NeoStem acquired Progenitor Cell Therapies (PCT) in January 2011. Since its inception in

1997, PCT has become an industry-leading resource in the cellular therapy space, specifically for

clinical trial products. The company has established cGMP manufacturing capabilities on the East and

West coasts of the U.S. and participated in the advancement of a growing list of clinical candidates, in

terms of product and process development, regulatory advice, manufacturing, and logistics. Its most

notable client has been Dendreon, and PCT's expertise and experience was influential in the

development of its now-approved cellular therapy product Provenge. The company intends to continue

growing its CMO offerings as cellular therapies emerge as a key focus for biopharmaceutical

development in coming years. In our view, the PCT business unit provides NeoStem with a high-

visibility, low-risk revenue stream; as the products of PCT’s clients advance through clinical

development and commercialization, and the number of clients grows (currently ~25), revenues can

also grow. In 2010, PCT's revenue was approximately $10MM, and we project that revenue can grow to

$25MM by 2015. Moreover, we believe this expertise can be leveraged to advance the development of

NeoStem's own proprietary therapeutic programs, including AMR-001, as well as provide unique

diligence insights on potential product acquisition candidates.

Amorcyte acquisition brings on board Phase II-ready asset. In July, NeoStem announced the

acquisition of Amorcyte for up to $18MM in NBS stock ($10MM up front, $2MM warrants, $6MM vesting

upon achievement of certain clinical milestones). Amorcyte's lead development candidate is AMR-001,

an autologous bone marrow-derived cellular therapeutic. This cellular product contains an enriched

population of CD34+CXCR4+ cells, which are believed to better satisfy energy requirements of heart

muscle following acute myocardial infarction, limiting apoptosis, promoting neoangiogenesis, and

reducing post-AMI tissue damage. AMR-001 is protected by a patent including composition of matter

claims through 2028. A completed Phase I trial (31 patients, 4 U.S. sites, 6 month duration) has

established a threshold dose for efficacy in acute myocardial infarction patients, and a Phase II trial is

expected to begin in 1Q12. The Phase I trial demonstrated positive signals of efficacy in terms in key

measures of cardiac function (hypoperfusion, ejection fraction, and end systolic volume) as well as a

favorable safety profile. The planned Phase II trial is expected to enroll approximately 150 patients at 30

sites in the U.S. for a treatment follow-up period of six months. The aim of this trial is to inform the

design of a Phase III program that best enables regulatory success. We look to gain further clarity on

enrollment timelines, but we currently believe results could be available in 2H13.

Proprietary technologies provide additional clinical candidates. In addition to Amorcyte, NeoStem

has two proprietary therapeutic platforms from which clinical candidates may emerge over the coming

12-24 months. The first is the company’s Athelos unit, a joint venture with Beckton Dickinson, of which

Neostem owns 80%. The Athelos technology is based on T cells that are harvested from peripheral

and/or cord blood and then activated and expanded. These cells are believed to have applications in

therapeutics for a range of auto-immune diseases. NeoStem is on track to begin Phase I trials for

therapeutic candidates from the Athelos platform in 2012 with possible indications including GvHD, solid

organ transplant rejection, and other in autoimmune diseases including asthma and diabetes.

NeoStem's second proprietary platform is VSEL (Very Small Embryonic Like) stem cells. VSELs have

the attractive attributes of embryonic stem cells (i.e., pluripotent) but without the ethical considerations.

In our view, this technology can be applicable to multiple regenerative medicine opportunities, and we

look to gain increased visibility in emerging clinical candidates.

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Intended divesture of profitable Chinese pharmaceuticals business can further strengthen

balance sheet. NeoStem is the majority (51%) stakeholder of Suzhou Erye, a Chinese pharmaceuticals

business focused primarily on generic antibiotics. Since NeoStem acquired its share in Suzhou Erye,

sales have more than doubled from $32MM in 2007 to $69MM in 2010. Growth in this business has

been driven both by strong growth in the Chinese healthcare sector as well as by development of a new

manufacturing facility built and validated with NeoStem's investment, doubling capacity. In 1H11,

NeoStem reported sales from Suzhou Erye of $35MM, and we project full year sales exceeding $70MM.

In line with its focus on high-value cellular therapeutic programs, NeoStem intends to divest this asset to

generate further cash to fund clinical development programs and/or further potential therapeutic asset

acquisitions. The company is progressing negotiations to sell Suzhou Erye, and we believe that it could

generate upwards of $35MM from this transaction (51% of 1x sales).

INVESTMENT RISKS

Clinical risk. NeoStem's development candidates could fail to generate expected results in current or

future clinical trials.

Regulatory risk. The FDA, and/or other ex-U.S. regulatory agencies, could reject any of the firm's, or its

partners', future regulatory filings or require additional studies prior to granting approval.

Commercial risk. If successfully developed, NeoStem's products may face competition both from

approved products and also potentially from new product candidates in development by biotechnology

and pharmaceutical companies.

Balance sheet risk. The expenses associated with drug development are high. It is possible that the

company will return to the capital markets to secure additional financing to fund current or future

development programs. As of June 30th, 2011, NeoStem had approximately $5MM in cash and

equivalents and subsequently raised net proceeds of $15MM from an equity financing. We do not

believe current funds will be sufficient to support operations through profitability.

AMORCYTE

NeoStem announced the acquisition of Amorcyte in July 2011 in an all-stock transaction valued at up to

$18MM. The transaction included an upfront payment of $10MM in NBS stock as well as warrants for

$2MM in NBS stock and up to a further $6MM in NBS vesting on the achievement of certain clinical

milestones. The primary reason for the acquisition was Amorcyte's lead product candidate AMR-001, a

cellular therapy being developed to reduce heart muscle damage following a heart attack. Amorcyte has

completed a 31-patient, randomized, controlled Phase I trial for AMR-001 that established preliminary

evidence of safety and efficacy as well as a threshold dose for progression in to Phase II development.

Through this transaction, NeoStem acquired a Phase II-ready asset that we believe demonstrates solid

execution on its transition to a development-stage therapeutics company.

Scientific rationale and clear mechanism of action provide basis for clinical utility. AMR-001 is

comprised of an enriched population of autologous bone marrow-derived stem cells, co-expressing

CD34 and CXCR4 (CD34+CXCR4+). The cells are harvested from a patient following an acute

myocardial infarction (AMI), are enriched, and are then infused into the infarct-related artery six to ten

days post-AMI, within the timeframe required for clinical benefit. The cells do not undergo expansion

during this procedure. Preclinical studies have provided insight into the mechanism of action, which, in

our view, informs the potential for clinical success. Following an AMI, the body acts to rescue damaged

tissue, and preclinical data have demonstrated that CD34+CXCR4+ cells play a role in this process. A

distress signal, hypoxia induced factor (HIF), is released by the damaged heart muscle, which, in turn,

induces synthesis of stromal cell-derived factor (SDF) and vascular endothelial growth factor (VEGF).

This process mobilizes CD34+CXCR4+ cells, which travel along the SDF gradient to the area of

damage, the peri-infarct zone. The cells are then involved in preventing apoptosis and effecting

neoangiogenesis. Further tissue damage results from a limited natural availability of regenerative

CD34+CXCR4+ cells, and AMR-001 serves to reduce this burden, reducing or preventing progressive

tissue damage.

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AMR-001 Phase I results provide sufficient evidence of efficacy to progress development.

Amorcyte completed a 31 patient Phase I trial for AMR-001, providing what we view to be encouraging

preliminary evidence of safety and efficacy. The results demonstrated that patients treated in the two

higher dose cohorts (10 to 15 million cells) achieved improved cardiac perfusion. In our view, results

from the Phase I trial established the feasibility and reproducibility of AMR-001 treatment, including cell

harvest, enrichment, and infusion, and provided a sufficient basis to progress development into a Phase

II trial. Furthermore, we believe the data establish a threshold dose for AMR-001, an important concept

in the development of cellular therapies. The trial demonstrated that while improved cardiac perfusion

was observed in the higher dose cohorts, no therapeutic benefit was seen with the low dose cohort or

the control group.

Phase II well designed and powered to build on Phase I experience. NeoStem is preparing to

initiate a 150-patient Phase II trial assessing AMR-001 in patients following acute myocardial infarction.

The design of this trial is based on the Phase I trial while providing substantially greater statistical

power. The aim of this trial is to inform the design of a Phase III program that best enables clinical and

regulatory success. As with the Phase I trial, the primary efficacy measure will be preservation of

cardiac function. We expect the trial to begin enrolling patients in 1Q12, based on which we believe

results could be available in 2H13.

Baxter experience establishes clinical evidence of effect, but candidate therapy leaves room for

improvement. Baxter previously completed a randomized, placebo controlled Phase II trial using

autologous CD34+ stem cells in patients with chronic myocardial ischemia. The aim of this 150 patient

trial was to assess the potential for this cellular product to reduce the frequency of angina episodes. The

results demonstrated that, at six months after treatment, patients treated with the cellular therapy had

significantly fewer episodes of angina per week than patients treated with placebo (6.8 vs. 10.9), a

difference that was maintained at one year (6.3 vs. 11.0). In addition, patients in the treatment arm of

the trial were able to exercise significantly longer at six months (139 seconds vs. 69 seconds). These

results were published in August in the journal Circulation Research (Circulation Research

2011;109:428-436). In contrast to AMR-001, Baxter's product is derived from G-CSF mobilized CD34+

cells. G-CSF has been demonstrated to neutralize CXCR4+ cells, therefore implying that Baxter's

product would not be able to home to the peri-infarct zone, a key differentiating attribute of AMR-001.

Given that Baxter's product cannot rely on a targeting mechanism, the company is pursuing a Phase III

program in cardiac ischemia that employs local delivery of the therapeutic candidate using a NOGA

"mapping" catheter.

AMR-001 Clinical Development

NeoStem is preparing to initiate a 150 patient, placebo-controlled trial to assess the safety and efficacy

of AMR-001 in the preservation of cardiac function in patients following acute myocardial infarction.

Enrollment is expected to begin in 1Q12, and patients will be recruited at 30 clinical sites in the U.S.

The design of the trial is based on the Phase I trial but will provide greater statistical power. Patients will

be randomized to receive a single administration of AMR-001 or placebo and assessed following a six

month treatment period. The dose of AMR-001 is release of at least ten million cells. The primary

endpoint is increased cardiac perfusion (RTSS) measured by SPECT at six months post infusion.

Secondary endpoints include a composite of measures of cardiac function (preservation of LVEV,

LVEF, prevention of adverse remodeling) and quality of life measures (KCQQ and SAQ).

Phase I Results

Amorcyte completed a 31-patient, randomized Phase I trial with AMR-001, demonstrating meaningful

biological activity of the product candidate in patients following myocardial infarction as well as

establishing a threshold dose. The trial was completed at four clinical sites in the U.S., and results were

published earlier this year in the American Heart Journal (Quyyumi et al., Am Heart J 2011; 161: 98-

105). The aim of this study was to establish preliminary evidence of the therapy's safety; however, a

composite of measures of cardiac function including perfusion (RTSS) was included.

Patients were randomized into one of four treatment groups (escalating doses of AMR-001 or placebo)

following an ST elevation myocardial infarction (STEMI). Eligible patients had received an intracoronary

stent, implanted within three days of a myocardial infarction, and had an LVEF of less than 50%. A total

of 15 patients were enrolled in the control group and 16 were enrolled to receive one of three escalating

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doses (5, 10, or 15 million cells) of AMR-001. Between five and eight days after stent implantation,

patients in the AMR-001 group underwent bone marrow harvest following which, harvested cells were

selected for CD34 and enriched to 5, 10, and 15 million cell doses. The cells were infused via the

infarct-related artery 7-11 days following the STEMI.

The primary efficacy measure in the trial was hypoperfusion, measured as the resting total severity

score (RTSS) by single-photon emission computed tomography (SPECT). RTSS was measured at

baseline and three and six months after treatment. The study results demonstrated that, in patients

receiving 10 to 15 million cells, there was a significant improvement (reduction) in RTSS at six months

as compared to patients receiving 5 million cells and control (p=0.11). In addition, there was a trend

towards improvement in ejection fraction and infarct size with increasing cell doses.

FIGURE 5: Phase I Results - Hypoperfusion

Control

5mil 10mil 15mil

Patient numbers 15 5 5 5

RTSS

Baseline 259 714 999 584

6 mos 273 722 636 462

Change 14 8 -363 -122

% change 5.4% 1.1% -36.3% -20.9%

AMR-001

Source: Company reports

It is important to note that patients in the control group had a smaller baseline RTSS than patients in the

treatment groups (p=0.04), implying that these patients were less sick. However, the five million cell

dose cohort, which did not demonstrate an improvement in RTSS, had a more similar baseline score to

the 10 and 15 million cell dose cohorts, providing a more robust comparison, in our view. We believe

these data demonstrate an encouraging signal of efficacy.

FIGURE 6: Phase I Results - Subgroup Analyses

Below Threshold Above Threshold

% change

RTSS 3.3% -31.4%Ejection fraction 1.3% 9.4%

End systolic volume 4.6% -6.1%

Source: Company reports

As shown in Figure 6, subgroup analyses, combining data for groups below the threshold dose (control

group and 5 million cell dose cohort) and above threshold dose (5 and 10 million cell dose cohorts)

further supports the treatment effect above this threshold, demonstrating improvements in additional

measures of cardiac function.

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PROGENITOR CELL THERAPIES

Progenitor Cell Therapies (PCT) is a cell therapy services business that provides development,

manufacturing, and regulatory expertise participating in the advancement of candidate cellular

therapeutics. PCT was acquired by NeoStem in January 2011 in an all-stock transaction valued at

approximately $20MM. The business unit has core expertise in manufacturing cell-based products,

through which it has demonstrated success facilitating the progression of product candidates through

preclinical and clinical development, most notably with Dendreon's Provenge. Contract manufacturing

services are provided through state of the art, cGMP-compliant facilities in Allendale, NJ, and Mountain

View, CA. In 2010, PCT generated revenues of approximately $10MM, which we believe can grow

substantially through further recognition of its industry-leading capabilities as well as more broadly

through increased investment in the development of cellular therapies.

Established expertise and execution in cellular therapies. PCT was founded in 1997 by Drs.

Andrew Pecora, MD, and Robert Preti, PhD, who remain active members of NeoStem's leadership. Dr.

Pecora currently serves as NeoStem's Chief Medical Officer and Dr. Preti as PCT's President and Chief

Scientific Officer. In our view, the continued contribution of PCT's management team can drive further

success both in the growth of the contract manufacturing business and in the progressing development

of NeoStem's therapeutic candidates. To date, PCT has provided contract manufacturing services for

upwards of 100 clients, assisting in more than 15,000 cell therapy procedures in over 5,000 patients.

PCT has participated in more than 50 regulatory filings in the U.S. and EU PCT participates in all

aspects of a candidate stem cell product's advancement from bench to patient including establishing

product characterization and comparability, cell processing, manufacturing scale up, storage, and

distribution and delivery logistics.

Proven record of success with pivotal role in the pioneering of Provenge manufacturing.

Dendreon's Provenge is an autologous stem cell therapy approved by the FDA in April 2010 for the

treatment of advanced prostate cancer. PCT played a key role in the development of the Provenge,

manufacturing more than 60% of clinical trial product, supporting all stages of clinical development as

well as BLA submission and approval. In our view, this experience demonstrates PCT's execution and

success in the development and manufacture of a commercially viable asset. Furthermore, we believe

that PCT has gained valuable expertise with regulatory authorities that could be leveraged as cellular

therapies emerge as investable development options. Beyond Dendreon, PCT currently has more than

25 clients with product candidates in or near clinical stage development.

CM growth potential from multiple sources. We believe that revenue growth for PCT's contract

manufacturing business can be driven both by advancement of product candidates into later stages of

development, where larger trials require greater amounts of product, as well as increasing the number

of clients, including the potential for a broadened client pool as development of cellular therapies

becomes an increasingly attractive strategic investment. Approximately 50% of PCT’s current clients

are conducting, or preparing to initiate, Phase I trials; another ~25% are in or preparing to commence

Phase II or Phase III trials; and ~5% are preparing for commercial production. As products progress

through clinical development, the size of trials increases as does the requirement for drug, which in the

case of cellular therapies has a limited shelf life (vs., e.g., a small molecule). Importantly, PCT's revenue

potential can continue to grow independent of the success of an individual development program.

Additionally, in our view, cellular-based therapies can become a key focus for biopharmaceutical

development in coming years. We draw a parallel to the emergence of monoclonal antibodies in the

early 2000s that were at first viewed with investor skepticism due to manufacturing and development

challenges but now represent a $20+ billion global market.

Opportunity to leverage PCT expertise for proprietary programs and conduct due diligence on

new opportunities. In addition to providing potential for near-term revenue growth, NeoStem is able to

leverage PCT's expertise as a cellular therapy service provider to advance the development of the

company's proprietary therapeutic programs, including AMR-001. Prior to being acquired by NeoStem,

Amorcyte was a PCT client, and AMR-001 development to date has been facilitated by PCT's

contributions. PCT's experience has the potential to maximize the cost and time efficiency of product

development decisions. In addition to providing NeoStem with expertise and infrastructure to progress

current development programs, we believe PCT provides the company with a unique insight into the

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10

development landscape of emerging cellular therapeutics. PCT's technical, scientific, clinical, and

business capabilities can, we believe, enable NeoStem to more optimally evaluate opportunities for

further strategic collaborations of asset acquisitions.

PIPELINE DEVELOPMENT OPPORTUNITIES

In addition to the recent Amorcyte acquisition, NeoStem is pursuing development of proprietary

therapeutic candidates through two stem cell platforms, the Athelos joint venture and VSEL technology.

While these programs are still early in development, we believe that they further demonstrate

NeoStem's renewed focus on high-value therapeutic candidates. We expect increasing visibility from

both of these platforms over the next 12-18 months but currently view these assets as upside to our

valuation.

Athelos

Athelos is a joint venture between NeoStem and Beckton Dickinson, of which NeoStem holds 80%

ownership. The joint venture was established to focus on development of cellular therapeutics for a

range of autoimmune diseases. These therapeutics are based on restoring the balance between T

effector cells and T regulatory (T reg) cells, an imbalance of which is thought to result in, or at least

contribute to, immune-mediated and autoimmune diseases. While there is recognition that T reg cells

can suppress immune responses, clinical application of this effect has been challenged by cell scarcity,

activity, and lack of specificity. Athelos is pursuing an approach that is intended to enhance both T reg

cell numbers and function. In this approach, T reg cells are harvested from peripheral and/or cord blood

by apheresis and isolated using surface markers including CD4+, CD25+, and FoxP3+. The cells are

then activated and expanded before being re-administered to the patient.

There are currently several investigator-led INDs exploring T reg cells and Athelos is planning to begin

Phase I trials in 2012 for the most promising candidates as determined by these ongoing studies.

Target indications currently being considered include graft-vs.-host disease (GvHD), solid organ

transplant rejection, and autoimmune diseases including asthma and diabetes. The intellectual property

covering the Athelos product candidates was in-licensed from the University of Pennsylvania and

University of Southern California, providing worldwide rights to approximately 30 issued patents and 50

pending patent applications. This broad intellectual property estate includes composition of matter and

method patents.

VSEL Technology

VSEL (Very Small Embryonic Like) stem cell technology is NeoStem's novel, proprietary approach to

cellular therapeutics. This cell population has many of the properties of embryonic stem cells

(pluripotent) but can be harvested from a patient's bone marrow or peripheral or cord blood. Importantly,

these cells do not undergo inducted pluripotency. Preliminary data support that significant quantities of

VSEL stem cells can be harvested from peripheral blood utilizing granulocyte-colony stimulating factor

(GCSF), and storage is straightforward through cryopreservation. In addition, data have been generated

providing evidence that VSEL stem cells are mobilized by the body in response to injury or stress

including acute myocardial infarction and stroke. The cells have also been shown to migrate to sites of

injury and, importantly, then differentiate into target cell types.

NeoStem licensed the VSEL technology from the University of Louisville, gaining worldwide rights to a

patent estate covering cell isolation, purification, and therapeutic use. We believe this technology may

have application in multiple regenerative medicine opportunities and look to gain further visibility on

clinical development plans.

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11

CHINA OPERATIONS

NeoStem's activities in China are focused in two areas: 1) expansion of its stem cell technologies into

this geography and 2) Suzhou Erye, a pharmaceuticals division 51% owned by the company. We view

the company's China operations as non-core assets and do not expect it to commit substantial capital to

these efforts going forward. Furthermore, we believe that the intended divesture of Suzhou Erye will be

a source of cash, strengthening NeoStem's balance sheet to fund further clinical advancement of its

high-value therapeutic programs.

Suzhou Erye

NeoStem acquired a 51% controlling interest in Suzhou Erye in 2009, since which time it has grown

revenues at a CAGR of approximately 30%. Suzhou Erye was established in the 1960s and has more

than 160 approved products that it sells in China. Most products in Suzhou Erye's portfolio are

antibiotics, with more than 90% of revenues being derived from products containing penicillin or

cephalosporin as the key active ingredient. The Chinese pharmaceutical industry has been growing

rapidly at an annual rate of over 20% for the past 10 years, reaching $184 billion in 2010, according to

the Chinese State Department. Infectious diseases are an important therapeutic area in the country,

and drug sales from this category contribute 24% of total hospital drug sales. Within this, antibiotics are

a major drug category representing an estimated market size of $12 billion in 2009, according to the

Chinese State Food and Drug Administration (SFDA).

Regenerative Medicine

NeoStem has expanded its stem cell technology applications to China, where the company has ongoing

initiatives to advance cellular therapies in regenerative medicine. Since 2009, the company has initiated

and completed construction of a stem cell research and development laboratory and processing and

manufacturing facility in Beijing. In addition, it has in-licensed several cellular therapeutic development

candidates and has begun to establish relationships with hospitals in China to advance these therapies,

specifically, the company’s proprietary autologous mesenchymal stem cells extracted from bone

marrow for use in orthopedic indications. In 2010, NeoStem formed a collaboration with Shandong

Wendeng Orthopaedic Hospital to offer cellular-based orthopaedic treatments. Following this, additional

collaborations were formed with Shijiazhuang Third Hospital, in the provincial capital of Hebei Province,

and Tianjin Nankai Hospital, located approximately 80 miles from Beijing.

MANAGEMENT

Robin L. Smith, M.D., MBA

Chairman & Chief Executive Officer

Dr. Smith joined NeoStem in September 2005 as Chairman of its Advisory Board and in June 2006 was

appointed CEO and Chairman of the Board. Prior to joining the company, from 2000 to 2003, Dr. Smith

served as President and CEO of IP2M, a multi-platform media company specializing in healthcare sold

to a publicly-traded company in 2003. Previously, from 1998 to 2000, she was Executive Vice President

and CMO of HealthHelp, Inc., a National Radiology Management company that managed 14% of the

healthcare dollars spent by large insurance companies. In addition, Dr. Smith currently serves on the

Board of Trustees of the NYU Medical Center Board and is past Chairman of the Board of Directors for

the New York University Hospital for Joint Diseases. She is also the President and serves on the Board

of Directors of The Stem for Life Foundation. Dr. Smith received a medical degree from Yale University

in 1992 and a master's degree in business administration from the Wharton School in 1997.

Andrew L. Pecora, M.D., F.A.C.P.

Chief Medical Officer

Dr. Pecora joined NeoStem following the company's acquisition of Progenitor Cell Therapies, where he

was Chairman and Chief Executive Officer. In addition, Dr. Pecora currently serves as Vice President of

Cancer Services and Chief Innovations Officer of the John Theurer Cancer Center at Hackensack

University Medical Center (HUMC) and Co-Managing Partner of the Northern New Jersey Cancer

Center, a private physicians practice group affiliated with HUMC. He is a Professor of Medicine at the

University of Medicine and Dentistry of New Jersey. He also serves as Chairman of the Board of

Page 12: Neostem Research Report by JMP Securites

12

Directors of Tetralogics, a private venture-funded biotechnology company developing small molecules

for cancer therapy, and of Cancer Genetics, a private venture-funded cancer diagnostics company. Dr.

Pecora received his medical degree from the University of Medicine and Dentistry of New Jersey and

completed his medical education in internal medicine at New York Hospital and in hematology and

oncology at Memorial Sloan-Kettering Cancer Center. He is board certified in internal medicine,

hematology, and oncology.

Robert A. Preti, Ph.D.

President and Chief Scientific Officer, Progenitor Cell Therapy

Dr. Preti joined NeoStem following the company's acquisition of Progenitor Cell Therapies where he

was co-founder, President, and Chief Scientific Officer. Previously, Dr. Preti served as Scientific and

Laboratory Director of Hackensack University Medical Center's stem cell processing and research

laboratory and Scientific Director of the Clinical Services Division at the New York Blood Center. Dr.

Preti is a founding member of the International Society for Cellular Therapies (ISCT, formerly the

International Society for Hematotherapy and Graft Engineering) and also serves on professional, state,

and federal regulatory committees charged with the development and refinement of regulations for the

developing field of cellular therapy. Dr. Preti received his Doctor of Philosophy degree from New York

University.

Jason Kolbert, MBA

Vice President of Strategic Business Development

Jason Kolbert joined NeoStem in March 2011 as Vice President of Strategic Business Development.

Prior to joining NeoStem, Mr. Kolbert spent 16 years on Wall Street as a sell side and buy side analyst

focused on biotechnology companies. Most recently, he was a managing director of National Securities

where he founded the firm's research effort in emerging biotechnology companies. Before his career on

Wall Street, Mr. Kolbert spent several years in the pharmaceutical industry with Schering-Plough in

Japan. Mr. Kolbert has an undergraduate degree in Chemistry (New Paltz) and an MBA in Finance

(University of New Haven).

Larry A. May

Chief Financial Officer

Mr. May joined NeoStem in 2003 and was appointed CFO in 2006 following the company's acquisition

of NS California where he had served as CFO and then CEO. Previously, from 2000 to 2003, Mr. May

served as the CFO of Saronyx, Inc., a company focused on developing productivity tools and secure

communication systems for research scientists. From 1998 to 2000, Mr. May served as the Senior Vice

President, Finance and Chief Financial Officer of Biosource International, Inc., a provider of biologic

research reagents and assays. He is the former Treasurer of Amgen where he served in roles of

increasing responsibility from 1983 to 1998, including as Corporate Controller (1983 to 1988), Vice

President/Corporate Controller/Chief Accounting Officer (1988 to 1997), and Vice President/Treasurer

(1997 to 1998). Mr. May received a Bachelor of Science degree in Business Administration &

Accounting from the University of Missouri.

Page 13: Neostem Research Report by JMP Securites

FIGURE 7: NeoStem, Inc. Income Statement ($MMs)

2008 2009 1Q10 2Q10 3Q10 4Q10 2010 1Q11 2Q11 3Q11E 4Q11E 2011E 2012E 2013E 2014E 2015E

Revenue

Pharmaceutical product sales 0.0 11.4 15.8 19.4 16.4 18.1 69.6 18.1 16.2 18.0 18.5 70.8 0.0 0.0 0.0 0.0

Stem cell service revenue 0.1 0.2 0.1 0.1 0.1 0.0 0.2 1.5 2.3 2.6 3.1 9.5 12.0 15.0 20.0 25.0

Total Revenue 0.1 11.6 15.8 19.4 16.5 18.1 69.8 19.6 18.5 20.6 21.6 80.3 12.0 15.0 20.0 25.0

Cost of goods sold 0.0 9.7 10.9 12.9 11.2 14.7 49.7 14.3 13.5 15.0 15.8 58.6 11.2 13.2 16.4 19.5

Gross Profit 0.1 1.9 5.0 6.5 5.2 3.4 20.2 5.3 4.9 5.6 5.8 21.7 0.8 1.8 3.6 5.5

Operating Expenses

R&D 0.8 4.3 1.3 2.1 1.7 2.6 7.7 2.9 2.4 2.4 2.5 10.2 8.1 8.9 9.8 10.8

SG&A 8.5 23.4 6.3 7.9 9.3 7.9 31.3 10.4 12.6 12.8 13.1 49.0 9.8 10.8 11.8 13.0

Total Operating Expenses 9.3 27.7 7.6 10.0 11.0 10.5 39.0 13.3 15.0 15.3 15.6 59.1 17.9 19.7 21.7 23.9

Operating Income (Loss) (9.2) (25.9) (2.6) (3.5) (5.7) (7.0) (18.9) (8.0) (10.0) (9.7) (9.7) (37.4) (17.1) (17.9) (18.1) (18.4)

Interest income 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.1

Interest expense (0.0) (0.0) (0.0) (0.0) (0.0) (0.5) (0.5) (0.9) (1.0) (1.0) (1.0) (3.9) 0.0 0.0 0.0 0.0

Other income (expense) 0.0 (0.0) (0.2) 0.1 0.0 0.5 0.5 (0.3) 0.6 0.0 0.0 0.3 0.0 0.0 0.0 0.0

Total other income (expense) (0.0) (0.0) (0.2) 0.1 0.0 0.0 0.0 (1.1) (0.4) (1.0) (0.9) (3.4) 0.0 0.0 0.1 0.1

Net Income Before Taxes (9.2) (25.9) (2.8) (3.4) (5.7) (7.0) (18.8) (9.1) (10.4) (10.7) (10.7) (40.9) (17.1) (17.9) (18.0) (18.3)

Provision (benefit) for income taxes 0.0 0.0 0.5 0.4 0.3 (0.6) 0.6 0.6 0.1 0.0 0.0 0.7 0.0 0.0 0.0 0.0

Tax rate 0.0% 0.0% 0.0% 0.0% 0.0% 0.0%

Net Income (Loss) (9.2) (25.9) (3.3) (3.8) (6.0) (6.4) (19.4) (9.7) (10.5) (10.7) (10.7) (41.6) (17.1) (17.9) (18.0) (18.3)

Attributable to non-controlling interest 0.0 0.2 1.3 1.6 1.1 (0.2) 3.9 0.5 0.1 0.2 0.2 0.9 0.0 0.0 0.0 0.0

Preferred dividends 0.0 5.6 0.1 0.1 0.0 0.1 0.2 0.2 0.2 0.2 0.2 0.8 0.8 0.8 0.8 0.8

Net Loss attributable to NBS (9.2) (31.8) (4.7) (5.4) (7.1) (6.3) (23.5) (10.4) (10.8) (11.1) (11.1) (43.3) (17.8) (18.7) (18.7) (19.0)

EPS

Basic ($1.53) ($2.44) ($0.12) ($0.11) ($0.13) ($0.10) ($0.46) ($0.14) ($0.13) ($0.12) ($0.12) ($0.50) ($0.18) ($0.18) ($0.17) ($0.17)

Diluted ($1.53) ($2.44) ($0.12) ($0.11) ($0.13) ($0.10) ($0.46) ($0.14) ($0.13) ($0.12) ($0.12) ($0.50) ($0.18) ($0.18) ($0.17) ($0.17)

Weighted shares outstanding

Basic 6.1 13.0 40.0 48.8 56.8 61.0 51.6 73.7 80.6 94.5 94.7 85.8 96.6 106.5 108.6 110.8

Diluted 6.1 13.0 40.0 48.8 56.8 61.0 51.6 73.7 80.6 94.5 94.7 85.8 96.6 106.5 108.6 110.8

Cash Flow

GAAP Net Income (9.2) (31.8) (4.7) (5.4) (7.1) (6.3) (23.5) (10.4) (10.8) (11.1) (11.1) (43.3) (17.8) (18.7) (18.7) (19.0)

Depreciation and amortization 0.1 0.7 0.8 0.7 1.1 2.6 5.1 2.2 2.4 2.4 2.4 9.3 9.3 9.3 9.3 9.3

Stock Based Compensation 3.9 12.3 2.1 2.3 3.1 0.5 7.9 2.0 4.6 2.0 2.0 10.7 3.0 3.0 3.0 3.0

Other adjustments 0.5 10.4 (0.7) 1.6 3.3 (2.1) 2.1 (4.1) 0.7 0.0 0.0 (3.4) 0.0 0.0 0.0 0.0Operating Burn (4.7) (8.4) (2.6) (0.9) 0.3 (5.3) (8.5) (10.2) (3.1) (6.7) (6.7) (26.6) (5.5) (6.3) (6.4) (6.7)

Cash at start of period 2.3 0.4 7.2 11.4 11.0 4.1 7.2 15.6 9.4 4.9 13.4 15.6 6.7 1.3 25.0 18.6

Cash from operations (4.7) (8.4) (2.6) (0.9) 0.3 (5.3) (8.5) (10.2) (3.1) (6.7) (6.7) (26.6) (5.5) (6.3) (6.4) (6.7)

Cash from investing (0.0) (2.7) (4.6) (3.4) (3.0) (6.1) (17.1) (3.1) (3.3) 0.0 0.0 (6.4) 0.0 0.0 0.0 0.0

Cash from financing 2.9 17.8 11.5 3.7 (4.2) 22.9 33.9 7.1 1.8 15.3 24.1 0.0 30.1 0.0 0.0

Shares issued 13.8 8.0

Price per share 1.2 4.0

Effect of Fx 0.0 0.0 0.0 0.1 0.0 0.1 0.2 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0

Cash at end of period 0.4 7.2 11.4 11.0 4.1 15.6 15.6 9.4 4.9 13.4 6.7 6.7 1.3 25.0 18.6 12.0

Source: Company reports and JMP Securities, LLC

13

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14

JMP FACTS AND DISCLOSURES

Analyst Certification: The research analyst(s) who prepared this report does/do hereby certify that the views presented in this report are in accordance with my/our personal views on the securities and issuers discussed in this report. As mandated by SEC Regulation AC no part of my/our compensation was, is or will be directly or indirectly related to the specific views or recommendations expressed herein. This certification is made under the obligations set forth in SEC Regulation AC. Any other person or entity may not use it for any other purpose. This certification is made based on my/our analysis on the date of this report’s publication. I/We assume no obligation to update this certification to reflect any facts, circumstances or events that may subsequently come to my/our attention. Signed Jason N. Butler, PhD

Publicly Traded Companies Mentioned in This Report (as of September 15, 2011):

Company Disclosures

NeoStem, Inc. (1,3)

JMP Securities Disclosure Definitions: (1) JMP Securities currently makes a market in this security. (2) JMP Securities has received compensation for banking or other services rendered to this company in the past 12 months. (3) JMP Securities was manager or co-manager of a public offering for this company in the past 12 months. (4) JMP Securities participated as an underwriting or selling group member of a public offering by this company in the past 12 months. (5) JMP Securities and/or its affiliates have obtained a position of at least 1% in the equity securities of this company during the ordinary course of its/their business/investments. (6) An officer of JMP Securities is a director or officer of this company. (7) The analyst covering this company (as defined in NASD Rule 2711) or a member of the analyst's household has a financial interest in this company. (8) The analyst covering this company or a member of the analyst’s household serves as an officer, director, or advisory board member of this company. (9) The analyst covering this company has had discussions of employment with the company.

JMP Securities Investment Opinion Definitions: Market Outperform (MO): JMP Securities expects the stock price to outperform relevant market indices over the next 12 months. Market Perform (MP): JMP Securities expects the stock price to perform in line with relevant market indices over the next 12 months. Market Underperform (MU): JMP Securities expects the stock price to underperform relevant market indices over the next 12 months.

JMP Securities Research Ratings and Investment Banking Services: (as of July 7, 2011)

# Co's % # Co's % # Co's

Receiving % of Co's

Regulatory Under of Regulatory Under of IB Services in With This

JMP Rating Equivalent Coverage Total Rating Coverage Total Past 12 Months Rating

Market Outperform Buy 208 66% Buy 208 66% 54 26%

Market Perform Hold 106 33% Hold 106 33% 16 15%

Market Underperform Sell 3 1% Sell 3 1% 0 0%

TOTAL:

317 100%

317 100% 70 22%

Stock Price Chart of Rating and Target Price Changes: Note: First annotation denotes initiation of coverage or 3 years, whichever is shorter. If no target price is listed, then the target price is N/A. In accordance with NASD Rule 2711, the chart(s) below reflect(s) price range and any changes to the rating or price target as of the end of the most recent calendar quarter. The action reflected in this note is not annotated in the stock price chart. Source: Jovus and JMP Securities.

JMP Disclaimer: JMP Securities LLC (the “Firm”) compensates research analysts, like other Firm employees, based on the Firm’s profitability, which includes revenues from the Firm’s institutional sales, trading, and investment banking departments as well as on the quality of the services and activities performed that are intended to benefit the Firm’s institutional clients. These data have been prepared by JMP Securities LLC for informational purposes only and are based on information available to the public from sources that we believe to be reliable, but we do not guarantee their accuracy or completeness. Any opinions and projections expressed herein reflect our judgment at this date and are subject to change without notice. These data are neither intended nor should be considered as an offer to sell or a solicitation or a basis for any contract for the purchase of any security or other financial product. JMP Securities LLC, its affiliates, JMP Group LLC, Harvest Capital Strategies LLC, and their respective partners, directors, officers, and associates may have a long or short position in, may act as a market maker for, or may purchase or sell a position in the securities mentioned herein. JMP Securities LLC or its affiliates may be performing, have performed, or seek to perform investment banking, advisory, or other services and may have acted as manager or co-manager for a public offering of securities for any company mentioned herein. The reader should assume that JMP Securities LLC will solicit business from the company covered in this report. © Copyright 2011. All rights reserved by JMP Securities LLC. JMP Securities LLC is a member of FINRA, NYSE Arca, NASDAQ, and SIPC.

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