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Patrick Balthrop, President and CEO of Luminex, an R&D life sciences company, presents an optimistic future for health care delivery if technology and public policy decisions are made correctly. With DNA mapping, certain medicines can be targeted to patients with DNA profiles that respond. the future is personalized medicine. There won't be one prescription for one diagnosis, or blockbuster medicines.
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Innovation and the Convergence of Technologies
in the 21st Century:
The Century of Life Science
November 24, 1859
Charles Darwin
• HMS Beagle and Captain Fitzroy
• Natural selection
• Immutability of species
• Church of England and Darwin’s mentors
• “Tree of Life”
• Adaptation: “Species theory”
• 1700’s: Biology
Science through the Centuries
• 1700’s: Biology
• 1800’s: Chemistry
Science through the Centuries
• 1700’s: Biology
• 1800’s: Chemistry
• 1900’s: Physics
Science through the Centuries
• 1700’s: Biology
• 1800’s: Chemistry
• 1900’s: Physics
• 2000’s: Life Science
Science through the Centuries
1700
Science through the Centuries
2009
1700 - Van Leeuwenhoek Microscope
Biology
1859 – DarwinNatural Selection
Biology
1866 – Mendel GeneticsBiology
1880 - PasteurBacteriology
Biology
1802 - DaltonAtomic Theory
Chemistry
1869 – MendeleevPeriodic TableChemistry
1950 - PaulingChemical Bonds
Chemistry 1983 - MullisPCR
Chemistry
2003 - CollinsHuman GenomeLife Science
1937 - TuringArtificial Intelligence
Physics
1900 - CurieRadioactivity
Physics
1850 – KelvinThermodynamics
Physics
1700 - NewtonGravityPhysics
1953 – Watson & CrickDNA
Biology
Human Genome and Human Proteome
Human Genome Project
Human Genome Project
Forbes’ 2009 Fastest Growing Technology Companies in America
BILL SIMILAR TO SENATE'S
Months of talks yield $894 billion package
HOW AN INSURANCE MANDATE COULD LEAVE
MANY WORSE OFF
Costs Keep Rising
Healthcare Reform
BUOYANT DEMOCRATS UNVEIL
HEALTHCARE LEGISLATION
Personalized Medicine
Personalized Medicine - Tamoxifen
Personalized Medicine
Tamoxifen Efficacy by Genetic Profile
Personalized Medicine
0
10
20
30
40
50
60
70
80
*4/*4 Wt/*4 Wt/Wt *4/*4 Wt/*4 Wt/Wt
Pe
rce
nta
ge
of
Pa
tien
ts
Relapse-free survival Overall survival
The US Healthcare System is Procedure-Based
The US Healthcare System is Procedure-Based
Help is on the Way• Medco's New Idea: PGx Program for
Generics to Dispense 'Smarter' Treatments and Increase Savings
• Breast Cancer: Genetics may hold key to prevention, treatment
• SAEC Conducting Feasibility Gene-Association
Study with HMO Network's E-Records
• Medco Study to Gauge Whether PGx-Based Plavix Dosing is as Effective as Higher-Priced Effient
• Generation Health Emulates the PBM Model to Optimize Genetic Testing for Payors
• National Survey Shows Physicians See Value in Genetic Testing
• Predicate device model
• Not innovation-friendly
• Critical Path Initiative
• User fees
• “Rearview Mirror Navigation”
• Review and reform underway
Regulation: Strategic Considerations
1700
Science through the Centuries
2000
1700 - Van Leeuwenhoek Microscope
Biology
1859 – DarwinNatural Selection
Biology
1866 – Mendel GeneticsBiology
1880 - PasteurBacteriology
Biology
1802 - DaltonAtomic Theory
Chemistry
1869 – MendeleevPeriodic TableChemistry
1950 - PaulingChemical Bonds
Chemistry 1983 - MullisPCR
Chemistry
2003 - CollinsHuman GenomeLife Science
1937 - TuringArtificial Intelligence
Physics
1900 - CurieRadioactivity
Physics
1850 – KelvinThermodynamics
Physics
1700 - NewtonGravityPhysics
1953 – Watson & CrickDNA
Biology
2009
Science through the Centuries1700 - Van Leeuwenhoek
1700 - Van Leeuwenhoek MicroscopeMicroscope
1859 – Darwin1859 – DarwinNatural Selection
Natural Selection
1866 – Mendel 1866 – Mendel Genetics
Genetics
1880 - Pasteur1880 - PasteurBacteriologyBacteriology1953 – Watson & Crick
1953 – Watson & CrickDNADNA
1937 - Turing1937 - Turing
Artificial Intelligence
Artificial Intelligence1900 - Curie1900 - Curie
RadioactivityRadioactivity
1850 – Kelvin1850 – Kelvin
Thermodynamics
Thermodynamics1700 - Newton1700 - Newton
GravityGravity
PhysicsPhysics
1802 - Dalton1802 - DaltonAtomic TheoryAtomic Theory
1869 – Mendeleev1869 – MendeleevPeriodic TablePeriodic Table
1950 - Pauling1950 - PaulingChemical BondsChemical Bonds
1983 - Mullis1983 - MullisPCRPCR
ChemistrChemistryy
Century Century of Life of Life
ScienceScience
BiologyBiology
R&D is Our Future
NIH Budget 1990-2008
1990 1995 2000 20080
10
15
20
30
5
25
$ Billion
1900 PresentDeath Rate per 100K Population, US
1,500 <800
Leading Causes of Death
Heart disease,
infectious disease
Heart disease, cancer
Treatment, Diabetes*
Arsenic Insulin, BGM
Treatment, Asthma*
Tobacco Corticosteriods
Treatment, Cardiac Disease*
Cocaine Statins, stents, CABG
Treatment, Insomnia*
Cannabis Zolpidem, eszopiclone
Progress Over the Last 100 Years
*per Merck Manual 1899
Innovation and the Convergence of Technologies
in the 21st Century:
The Century of Life Science
