5288846 Cell specific gene regulators

PATENT ABSTRACTS 579

5288845 5288852

E I M E R I A N E C A T R I X 16S R D N A P R O B E S

H U M A N T U M O R N E C R O S I S F A C T O R P O L Y P E P T I D E S

Prasanta R Chakraborty, Michael Dashkevicz, Alex Elbrecht, Scott D Feighner, Paul A Liberator, Helen Profous-Juchelka assigned to Merck and Co Inc

Unique species-specific Eimeria necatrix DNA probes comprising divergent DNA sequences are disclosed. The probes are complementary to a small subunit ribosomal RNA gene of Eimeria necatrix.

Masaak Yamada, Yasuji Furutani, Mitsue Notake, Juniti Yamagishi, Kyoto, Japan as- signed to Dainippon Pharmaceutical Co Ltd

A novel cloned DNA encoding a human tumor necrosis factor (TNF), a vector having said DNA inserted thereinto, a host transformed with said vector and a novel human TNF poly- peptide, and processes for producing them.

5288855

5288846

C E L L S P E C I F I C G E N E R E G U L A T O R S

Thomas Quertermous, Mu-En Lee assigned to The General Hospital Corporation

Methods and compositions for cell-specific ex- pression of genes are provided. The invention utilizes the endotbelin-I promoter and promoter elements to direct expression of heterologous genes in endothelial cells. The promoters and ele- ments are useful for directing cell-specific expres- sion of therapies for vascular and cardiovascular diseases.

E X T R A C E L L U L A R F O R M O F T H E H U M A N F I B R O B L A S T G R O W T H

F A C T O R R E C E P T O R

Laura Bergonzoni, Gu Mazue, Antonell Isacchi, Romeo Roncucci, Paolo Sarmientos, Milan, Italy assigned to Farmitalia Carlo Erba

The present invention provides a polypeptide which is capable of binding specifically human basic fibroblast growth factor and human acidic fibroblast growth factor, a DNA sequence which encodes the polypeptide of the invention and a vector which incorporates a DNA sequence of the invention and which is capable, when pro- vided in a transformed host, of expressing the polypeptide of the invention encoded by the DNA sequence. A host transformed with such a vector forms part of the invention also.