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remember the cell is trying to release NAD + to allow glycolysis to continue produce ATP
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D. KREBS CYCLE
2. occurs in the matrix of the mitochondria
3. only occurs if oxygen is present
1. Krebs cycle allows the cell to get more energy out of the acetyl-CoA product of the oxidation of pyruvate
remember the cell is trying to
release NAD+ to allow glycolysis to continue
produce ATP
COOHO=C CH2
COOH
COOH CH2
HOC – COOH CH2
COOH
acetyl-CoA
CH3
C=O S-CoA
4. Details
H2O
CoA-SH
hydrase
oxaloacetate
citrate
COOH CH2
HOC – COOH CH2
COOH
COOH CH2
HC – COOH HOCH COOH
isomerase
citrate
isocitrate
COOH CH2
HC – COOH HOCH COOH
COOH CH2
CH2 C=0 COOH
NAD+
NADH + H+
CO2
dehydrogenase
decarboxylase
isocitrate
alpha-ketoglutarate
COOH CH2
CH2 C=0 COOH
COOHCH2
CH2
C=OS – CoA
NAD+
NADH + H+
CO2
CoASH
dehydrogenase
decarboxylase
alpha-ketoglutarate
succinyl-CoA
COOHCH2
CH2
C=OS – CoA
COOHCH2
CH2
COOH
CoASH
GTP
GDP + Pi
ADP
ATP
phosphorylase
H2O
hydrase
succinyl-CoA
succinate
COOHCH2
CH2
COOH
COOH CH llHC COOH
FAD+
H2
dehydrogenase
FAD
succinate
fumarate
COOH CH llHC COOH
COOHHOCH CH2
COOH
H2O
hydrase
fumarate
malate
COOHHOCH CH2
COOH
COOHO=C CH2
COOH
NAD+
NADH + H+
dehydrogenase
malate
oxaloacetate
START AGAIN
COOHO=C CH2
COOH
COOH CH2
HOC – COOH CH2
COOH
acetyl-CoA
CH3
C=O S-CoA
Oxaloacetate
citric acid
so this is sometimes called the citric acid cycle
5. EQUATION:
acetyl-CoA + 3 NAD+ + FAD+ + H20 + ADP + Pi
2 CO2 + 3 [NADH + H+] + FADH2 + ATPCoASH +
E. SUMMARY – so far for HIGH ENERGY PRODUCTS
where
glucose glycolysis
cytoplasm
2 ATP
oxidation of pyruvate
oxidation of pyruvate
matrix of mitochondria
2 [NADH + H+]
4 ATP
oxidation of pyruvate
oxidation of pyruvate Kreb’s cycle
Kreb’s cycle
2 [NADH + H+] 2 ATP6 [NADH + H+]
2 FADH2
matrix of mitochondria
where
remember the cell is trying to
release NAD+ to allow glycolysis to continue
produce ATP
Krebs made no NAD+, it used 6
Krebs made only 2 more ATP
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