Data Management and Biostatistics Amarin - Thai …...Data ManagementData Management Section for...

Data ManagementData Management andand

Biostatistics FacilitiesBiostatistics Facilitiesby

Ammarin Thakkinstian

Data ManagementData ManagementSection for Clinical Epidemiology and BiostatisticsSection for Clinical Epidemiology and Biostatistics,

Faculty of Medicine Ramathibodi Hospital (CEB-RAMA)

AND

Center of Excellence for Biomedical and Public HealthCenter of Excellence for Biomedical and Public Health

Informatics (BIOPHICS)

Faculty of Tropical Medicine

Mahidol University y

Roles & ResponsibilitiesRoles & Responsibilities• Study PreparationsStudy Preparations

Modify questionnaire format to comply with the DataFax softwareSetup databasesSetup databases Construct data-quality checking program for data quality-control

• Quality AssuranceQuality AssuranceEnter data to DataFax system

Validate data to source documentValidate data to source documentCheck quality of entered dataGenerate quality control reportq y pTransfer data for analysisLock database for data submission

TimelinesTimelinesD t C ll ti @ 4 EGAT it• Data Collection @ 4 EGAT sites

July – Oct 2013• Data Management @ BIOPHICS & CEB-Rama

Aug 2013 – Jan 2014Aug 2013 Jan 2014• EGAT Web-databases

F b A il 2014Feb – April 2014

EGAT Data Work FlowQuestionnaire

Questionnaire

Questionnaire Checking

Questionnaire sequencingRama-CEB &

BIOPHIC

Data delivery

Scan individual binder

DataFaxServer

Data Validation in DataFax System

Import to DataFax system

Insert DataFaxbarcode & save as pdf

Save as pdf

Data Validation Work Flow for DataFax Systemfor DataFax System

New questionnaires in DataFax format are in place

Final data validation & QC @ BIOPHICS & CEB-RAMA

Initial data validation @ BIOPHICS

QC @ BIOPHICS & CEB-RAMA

Data are validated until

Data verification

Data exportation

they are cleaned

Sites are able to view/enter/edit questionnaires online

verification @ site

DataFaxServer

Web-database

sDi

Sites are able to view/enter/edit questionnaires online

ssDisc Storage

Tape Backup

CEB-RamaCEB-RamaC• 3 Clinical Epidemiologists

• 7 Biostatisticians• 7 Biostatisticians• 1 Programmer

FacilitiesFacilities • Data management

– EGAT-Webdatabases– Retrieve data

R t f d t• Request for data– WWW.ceb-rama.org

• Lodge application form• Lodge application form – Contact

• Dittapol Muntham• Dittapol Muntham– Email: dittapol.mun@mahidol.ac.th– Tel: 022011269, 022011284Tel: 022011269, 022011284

Numbers of subject for EGAT2-2013

Site Expected Actual pN N

Bang Kruay 1438 1428Bang Kruay 1438 1428Srinagarind Dam 250 214Vajiralongkorn Dam 130 116Bh ibh l D 250 259Bhumibhol Dam 250 259Total 2068 2017

Data QC

FacilitiesFacilities • Data analysis

– Linear regressionLinear regression – Fractional polynomial regression – Logistic regression

Survival analysis– Survival analysis – Longitudinal data analysis – Survey data analysis

M t l i– Meta-analysis – Analysis for genetic association studies

• Request for data analysis – Contact

• Wipada Purawat– Email: wipada.pur@mahidol.ac.th– Tel: 022011269, 022011284

Thank you