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Did sex with Neanderthals and Denisovans shape our immune system?. A12 Erin McCaskey Mackenzie Williams Peyton Airington Arturo Salmeron Dongeun Kim. Our Immune Systems Resulted from Multiregional Admixture. Pinna 2011. Abi-Rached et al. 2011. Abi-Rached et al. 2011. - PowerPoint PPT Presentation
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Did sex with Neanderthals and
Denisovans shape our immune system?
A12Erin McCaskey
Mackenzie WilliamsPeyton AiringtonArturo Salmeron
Dongeun Kim
Our Immune Systems Resulted from Multiregional Admixture
Pinna 2011
Abi-Rached et al. 2011
Abi-Rached et al. 2011
Abi-Rached et al. 2011
Abi-Rached et al. 2011
Discussion & Conclusion
• Take-Home Message: Modern Human immune systems are possibly a result of breeding with Neanderthals many years ago.
Pinna 2011
Work CitedAbi-Rached, L.; Jobin, M.J.; Kulkami, S.; McWhinnie, A.; Dalva, K.; Gragert, L; Babrzadeh, F.; Gharizadeh, B.; Luo, M.;
Plummer, F.A.; Kimani, J.; Carrington, M.; Middleton, D.; Rajalingam, R.; Beksac, M.; Marsh, S.G.E.; Maiers, M.; Guethlein, L.A.; Tavoularis, S.; Little, A.; Green, R.E.; Norman, P.J.; and P. Parham. 2011. The Shaping of Modern Human Immune Systems by Multiregional Admixture with Archaic Humans. Science 334: 89-94.
Currat, M.; Ruedi, M.; Petit, R.J. and L. Excoffier. 2008. The Hidden Side of Invasions: Massive Introgression by Local Genes. Evolution 62(8): 1908-20.
Khan, M.A. 2011.Estimation of Linkage Disequilibrium (LD) Decay. PGBworks, USDA and NIFA.
National Center for Biotechnology Information. database. 2007. SNPs: A Variation on a Theme. <http://www.ncbi.nlm.nih.gov/About/primer/snps.html>
The International HapMap Consortium. 2003. The International HapMap Project. Nature 426: 789-96.
Pinna, S., 2011. Neanderthals Boost Our Immune System. <http://drpinna.com/neanderthal-genes-boosts-our-immune-system-23305>
Yong, E., 2011. Did sex with Neandethals and Denisovans shape our immune systems? The jury's still out. Discover Magazine.
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