Dolghii Xenia Dolghii Xenia Dr. Melania Macarie Dr. Melania Macarie EPIDEMIOLOGICAL AND CLINICAL...

Dolghii Xenia

Dr. Melania Macarie

EPIDEMIOLOGICAL AND CLINICAL FEATURES OF LIVER CIRRHOSIS

Faculty of Medicine, UMPh Tîrgu MureșDepartment of Gastroenterology I, Faculty of Medicine, UMPh Tîrgu Mureș

• Cirrhosis is a liver disease defined by extensive fibrosis with regenerative nodule formation and distorsion of liver structure.

• It is an ireversible condition that also has serious complications including ascites, variceal hemorrhage,hepatic encephalopathy, hepatocellular carcinoma and hepatorenal syndrome.

• Alcohol abuse and viral infection are the worldwide most common causes of cirrhosis.

Introduction

• The aim of this study is to establish the main epidemiological and clinical aspects of this disease in our geographical area.

Aim

• A retrospective study was performed which included patients with liver cirrhosis admitted in Gastroenterology department of Tîrgu Mureș Emergency County Hospital between 01.01.2013-31.12.2013.

• The readmissions were excluded.• According to age the patients were stratified into 2

groups: under the age of 50 years old and the ones aged over 50 years old.

• Data were collected with Microsoft Excel program and analyzed with GraphPad InStat program. Categorical data analysis was conducted with Fisher Exact Test.

Material and Method<50

YEARS OLD

>50 YEARS OLD

• During the studied period 302 cirrhotic patients were admitted in the Gastroenterology division of Tîrgu Mureș Emergency County Hospital.

• There were included in the research 239 patients with a median age of 58.13 years old.

Results

Total239

patients

<50 years old

49 patients

>50 years old190

patients

Mean Age 58,13 42,20 62,27

Urban 111 21 90

Rural 128 28 100

Gender( M/F)

149/90 35/14 115/75

Demographical Data

Distribution by gender• Male prevalence of cirrhotic patients (M/F ratio of

1.65/1).

62%

38%male

female

(149)

(90)

<50 years old >50 years old0

20

40

60

80

100

120

14

75

35

115

femalemale

p>0,05

Distribution by gender and age

Male prevalence of cirrhotic patients in “<50 years old”. (Ratio of 2.5/1).

Series10.00%

10.00%

20.00%

30.00%

40.00%

50.00%

60.00%

70.00%62.34%

27.19%

9.62%

Toxic etiologyHCVHBV

Distribution by etiology• Prevalence of toxic etiology (n=149 patients), followed

by viral etiology (HCV) (n=65 patients) and HBV (n=23).

<50 years old >50 years old0

20

40

60

80

100

120

38

112

8

56

4

19

Toxic etiolgyHCVHBV

Distribution by etiology and age

<50 years old >50 years old0.00%

10.00%

20.00%

30.00%

40.00%

50.00%

60.00%

70.00%

80.00%

90.00%

100.00%Столбец1

77,55%

58,94%p<0,05

• Predominance of toxic etiology in “<50 years old” sample.

• Prevalence of Variceal bleeding among cirrhotic patients in “<50 years old ”vs “>50 years old” samples.

<50 years old>50 years old

0

20

40

60

80

100

120

140

160

13(26,5%) 41(21,5%)

36

149

UGI bleed(+)UGI bleed (-)

p>0,05

Other clinical data(I)

<50 years old>50 years old

0

20

40

60

80

100

120

140

160

180

8(16,3%) 25(13,1%)

41

165

Hepatic En-cephalopathy(+)Hepatic En-cephalopathy(-)

p>0,05

• Prevalence of hepatic encephalopathy among cirrhotic patients in “<50 years old ”vs “>50 years old” samples.

Other clinical data(II)

• Cirrhosis is a common end result of liver damage ( Mostly caused by alcohol and viral hepatitis)

• Cirrhosis is a frequently encountered disease even among the young population.

• Cirrhosis prevalently affects male population.• In its terminal stages, cirrhosis is frequently associated

with other diseases and may have fatal complications.

Conclusions

THANK YOU!