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Costabile A | Keleszade E | Willner T | Kolida S | Patterson M| Trangmar S|
Impact of SlimBiomeâ on satiety, satiation, weight loss and gut microbiome composition in overweight & obese women
BackgroundSlimBiomeâ is a patented formulation designed to promotethe feeling of fullness, burn calories by promoting a healthymetabolism and to maintain blood sugar levels. SlimBiomeâreduces food cravings and as such helps reduce body weightand aids the sustainability of weight loss
Faecal microbiome analysis revealed notable increasesthe relative abundance of Christensenellaceae,Bacteroidetes and Actinobacteria
Methods
• 4-week, prospective, open label study• 12 females (18-65 years), BMI 25-35kg/m2
• Participants were asked to consume 9g SlimBiomeâdaily, delivered through the GoFigureâplan.
• Anthropometric, mood and craving parameters wererecorded weekly.
• Faecal samples were obtained at baseline and at theend of the 4-week study for metagenomic analysis
Objectives
Investigate the effect of SlimBiomeâ, as the functionalingredient in a calorie restricted diet plan (GoFigureâ),on weight loss, satiety, satiation, mood and gutmicrobiome composition in a human intervention study.
Results
SlimBiome® may be used as an effective meansof supporting hunger-free weight managementwhen combined with healthy eating
Health Sciences Research Centre, Life Sciences Department, Whitelands College
Baseline 4 weeks75
80
85
90
95
100
Wai
st c
ircum
fere
nce
(cm
)
Baseline 4 weeks80
90
100
110
120
130
Hip
circ
umfe
renc
e(c
m)
Baseline 4 weeks20
25
30
35
40
Bod
y m
ass
inde
x (k
g/m
2 )
Baseline 4 weeks50
60
70
80
90
100
110
Wei
gh (k
g)
P=0.065P=0.056
P=0.0001 P=0.029
Weight BMI
Waist Circumference Hip Circumference
SlimBiome significantly reduced:• Weight• BMI & % body fat• Waist &Hip circumference• Systolic blood pressure
Baseline 4 weeks100
110
120
130
140
mm
Hg
Systolic blood pressure
Wee
k 1
Wee
k 2
Wee
k 3
Wee
k 40.0
0.2
0.4
0.6
0.8
1.0
Mea
n M
ood
Sco
res
p = 0.0026
Wee
k 1
Wee
k 2
Wee
k 3
Wee
k 40.0
0.2
0.4
0.6
0.8
1.0
Mea
n S
AC
Sco
res
p = 0.0006
p = 0.0007
p = 0.0027
Mood Savoury craving
SlimBiome improved mood and decreased carvings forsavory foods accompanied by a trend for reduction insweet food cravings
Baseline 4-weeks
Dr Sofia Kolida| R&D Director | OptiBiotix Health PLC | Tel: ++ 44 (0) 7585001450 | skolida@optibiotix.com |Dr Adele Costabile| Senior Lecturer in Nutrition | University of Roehampton| adele.costabile@roehampton.ac.uk |
Study highlights
SlimBiomeâ reduced cravings for savoury and sweetfoods and had a positive impact on gut microbiome andmediated significant weight loss in overweight to obesewomen
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