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Mouse Double Minute 2 (MDM2). Kirubel Asfaw. MDM2 Discovery. Momand et al. MDM2 inhibits p53. p53.free.fr. p53 Cellular Functions. Master control of cell cycle It is a transcription factor. Responds to cellular stresses by activating growth arrest or apoptosis. - PowerPoint PPT Presentation
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Kirubel Asfaw
Momand et al
p53.free.fr
Master control of cell cycle
It is a transcription factor.
Responds to cellular stresses by activating growth arrest or apoptosis
p53.free.fr
p53.free.fr
Cell survival
Cell cycle progression
p53.free.frJones et al
MDM2 overexpression blocks p53-mediated cell-cycle arrest and apoptosis.
Analysis of 3000 tumor samples shows that MDM2 is amplified in 7% of these tissues.
Momand et al
Wikepedia.org
SNP309 polymorphism was detected in 232 (68%) of 343 familial breast cancer cases
Wasielewski et all
No MDM2 gene amplification was observed in the presence of mutated p53 gene
Pollock et al
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