Pesquisas durante e pós epidemia do virus Zika

Celina Turchi Martelli

Public Health Emergency of International Concern

Notification of microcephaly cases Brazil 2015 – Feb 2016

Emergence and evolution of Zika virus vector-borne transmission

Gutiérrez-BugalloGetal.Vector-bornetransmissionandevolutionofZikavirus.NatEcolEvol.2019

Zika virus vector-borne transmission

Gutiérrez-BugalloGetal.Vector-bornetransmissionandevolutionofZikavirus.NatEcolEvol.2019

Microcephaly-definition

TORCH Infections: Toxoplasmosis Other (Syphilis, Varicella-zoster) Rubella, Cytomegalovirus Herpes infections

Rare neurodevelopmental disorder

Causes Genetic Environmental Toxic exposures Foetal alcohol S. Radiation Clinical/Infections

Cases series studies

DOI:10.2105/ Miranda et al. American Journal of Public Health - 2016

Modeoftransmission

Microcephaly Intracranialcalcification

Oculardisease

Hearingdeficits

Cytomegalovirus Persontoperson ++ + + ++

Toxoplasmosis Food + + + -

Rubella Persontoperson + - + ++

Herpessimplesvirus Persontoperson + - + +

ZikavirusVector-borneSexualTransfusion

++ + + +

DOI:10.2105/Mirandaetal.AmericanJournalofPublicHealth-2016

DOI10.1002/ajmg.a.38170

Case-control study

Arboviroses Laboratory LaboratoryofVaccinologyandExperimentalTherapeutics

Ø Isolation of ZIKV: Recife 2015 Ø Detection of Positive IgM for Zika virus

30 neonates with microcephaly in Brazil Cordeiro,et al. The Lancet 387, 2016)

Ø Reference laboratory for ZIKV

Funded by the Horizon 2020 Framework Programme of the European Union

CongenitalZikaSyndrome

NEURO-Zika

Non-VectorTransmission

NEURO-Zika:Pathogenesis

DiseaseBurdenRiskAssessment

COMMUNICATIONLatin-American

NETWORKConsortiumCoordination

DiagnosticsEvaluation

MODELLING

VaccinesinADE

ViralFitness

Source: Blog NE10. https://blogs.ne10.uol.com.br/social1/2019/03/14/premio-tacaruna-mulher/ Acesso em 18 de Março de 2019.

International Classification of Diseases The global standard for diagnostic health information

KA62ViralinfectioninthefoetusornewbornKA62.0CongenitalZikavirusinfection

https://icd.who.int/

June2018

PubMed Search

13911227

"Zika Virus Infection"

1954-2015 2016 2017 2018

“Congenital Zika Syndrome"

146 136

2016 2017 2018

Prioritizing Severe Emerging Diseases for Research and Development

EpidemicthreatPrioritypathogens

1.Humantransmission2.Medicalcountermeasures3.Severityorcasefatalityrate4.Thehuman/animalinterface5.Thepublichealthcontext6.Potentialsocietalimpacts7.Evolutionarypotential

•  Zika•  Crimean-CongoHemorrhagicFever•  EbolaViralDisease-MarburgViral•  LassaFever•  MERSandSARS•  Nipahandhenipaviraldiseases•  RiftValleyFever•  DiseaseX

Feb.2018http://www.who.int/blueprint/priority-diseases/en/

www.cpqam.fiocruz.br/merg/

RicardoXimenes

LauraRodrigues

CelinaTurchi

ThaliaAraujo

WaynerSouza

FátimaMilitão

ErnestoMarques

MarliTenório

EnriqueVazquez

CynthiaBraga

RafaelDhalia

SinvalBrandão

Pesquisas durante e pós epidemia do virus Zika - IPEA · Microcephaly-definition TORCH Infections:...

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