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Blood glucose regulation
Dr. Sadaf Mumtaz14/02/11
• Insulin is associated with energy abundance
• Unbound form
Liver phosphorylase
glucokinase
Glycogen synthase
Liver cells
Phosphorylase & Glucose phosphatase
Glucose transporters
ERCa2+
IP3
Glut 4
receptor
Agonist Ca2+
Glucose
Tyrosine kinase
Fat metabolism
Glucose
Pyruvate
Acetyl CoA
Citrate, isocitrate ions
Acetyl CoA carboxylase
Acetyl CoA
Malonyl-CoATriglycerides
Lipoprotein lipase
Fatty acids Hormone sensitive lipase
Α-glycerol phosphate
Ketosis
Protein metabolism
Mechanism of insulin secretion
Sulphonylurea drugs
Glucagon
• Glycogenolysis• Gluconeogenesis
• Adrenal diabetes
• Pituitary diabetes
• Gestational diabetes
Thanks
Volunteers for OGTT
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