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Crude drugs are substances having therapeutic properties and pharmacological action, derived from natural sources such as plants, animals, or minerals and have undergone no further treatment to advance medicinal value except collection and drying for preservation, packing or marketing.
Medicinal plant Collection &
drying Grinding packing or marketing
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Plant classified as a source for crude drugs based on the major component, such as glycosides (anthraquinone or cardiac), tannins, carbohydrates, alkaloids, phenolics, fixed fats, and proteins.
Solvent
Prepare crude drug extract
crude drug extract
cellulose
Sugar Lipids
glycosides
Separation & purification
1. Collecting of medicinal plants
Medicinal plant materials should be collected during the appropriate season or time
period to ensure the best possible quality of both source materials and finished
products. The amount of a constituent is usually not constant throughout the life of
a plant. The stage at which a plant is collected or harvested is, therefore, very
important for maximizing the yield of the desired constituent. The differences are
sometimes not only quantitative but also qualitative.
Production of crude drugs from their medicinal plants involves following steps:
1- selection & collection of medicinal plants. 2- drying of plants 3- grinding of the dried plants 4- storage & packing of crude drugs
1- Roots and rhizomes are collected at the end of the vegetation period, i.e. usually in the autumn. In most cases they must be washed free of adhering soil and sand.
2- Leaves and herbs are collected at the flowering stage
3- Flowers are usually gathered when fully developed.
4- Fruits and seeds are collected when fully ripe
General rules for collection of crude drugs:
5-Bark is collected in the spring
The choice of promising plant depends upon the following: 1-A plant which have a biological activity. 2-A plant used in folk medicine. 3- A plant which show a particular toxicity
6- whole plant should be collected during flowering stage
Drugs may be collected from both wild and cultivated sources .
1. Wild source:
collecting the drugs from wild sources care must be taken to avoid-
• Wrong identification of the source,
• admixture with similar looking plants,
• Collection from too young or too old or
diseased plants
2. Cultivated source:
Advantages of cultivation:
• It ensures a correct natural source of the drug.
• Drying and storage of the drugs from cultivated
sources can be regulated and controlled
• Purity of finished product is assured under cultivation as weeds and
other contaminations can be removed.
• Quality and production of the drug can be improved under cultivation.
Influence of time of collection on drugs quality: Camphor -1الكافور
From Cinnamomum camphora
it cultivated for camphor production. Camphor is a white,
crystalline substance with a strong odor and pungent taste;
there are many pharmaceutical applications for camphor such
as topical analgesic, antiseptic, anti-inflammatory, etc. Camphor
can normally start when the tree is 15 years oldhas the best
yield when it is obtained from old trees
3-Anthraquinone
From Rheum palmatum or rhubarb
is reported to contain no anthraquinone
derivatives in winter but anthranols which, on
the arrival of warmer weather, are converted by
oxidation into anthraquinones. It acts as a laxative to
treat constipation and deficiency of the blood.
راوند
Datura stramoniumالداتورا leaves ,collected in the morning ,containing a higher proportion of alkaloid than those of collected in the evening
2- Atropine
From Atropa belladonna
used to decrease saliva and other fluid
production during surgery. Is best collected when the plant
is 3 years old (young plant)
نبات ست الحسن
Preservation of plant material
The plant material must first be preserved so that the active compounds will remain
unchanged during transport and storage. The cells of living plants contain not only
low molecular-weight compounds and enzymes, but they also have many kinds of
barriers that keep these constituents apart.
When the plant dies, the barriers are quickly broken
down and the enzymes then get to promote various
chemical changes in the other cell constituents,
e.g. by oxidation or hydrolysis.
Preservation aims at limiting these processes
as far as possible
enzymes oxi
Hyd.
2-Drying
The most common method for preserving plant material is drying.
Enzymic processes take place in aqueous solution. Freshly collected
plant drugs contain as much as 55 to 82 precent of water. This high
percentage of water encourages enzymatic and other chemical
reactions and growth of moulds and bacteria in them, which bring about
many undesirable changes in their constituents. Immediately after
collection crude drugs should
be dried to stabilize the condition of
The drug and to fix their chemical
constituents.
leaves may contain… 60-90%
roots and rhizomes… 70-85%
lowest percentage, often no more than 5-10%, is found in seeds.
Living plant material has a high water content:
So , drying is necessary -
To keeping quality of the drug,
To prevent moulding,
To stop enzymatic hydrolysis,
To discourage growth of
bacteria and insects
To stop chemical and other
changes in the drug
Roles of drying 1. If enzymatic action is encouraged (support), for conversion some constituents from in active to active state, slow drying at a moderate temperature is
necessary used e.g. ‘vanilla pods’. Freshly pecked vanilla beans do not have any vanillin, whereas the fermentation of the pods causes its production, involving the enzymatic hydrolysis of glycoside
2- If enzymatic action is not desired, drying should be take place as
soon as possible after collection.
3-In other cases the drying process is not necessary for the part used
in case of the plants that containing Volatile Oils in order not to lose
the oils .Therefore the plant parts which contain Volatile Oils must be
either drying in shade
( at room temperature 25℃ ) or store under
either frozen or distilled immediately at the
time of collection
Medicinal plants can be dried by any of the following two
methods:
1. Drying in open air by natural heat,
2. Drying indoor by artificial heat.
4-Rapid drying helps flowers and leaves to retain their color and aromatic drugs their aroma, but the temperature used in each case must be governed by the constituents and the physical
nature of the drug. 5- Leaves herbs and flowers may be dried between 20 and 40 C°
while barks and roots between 30 and 65C°
Open air drying: may be done by either in the sun or in the shade,
depending on the material to be dried.
Sun drying is used for those drugs whose constituents are not affected by the direct action of sunlight
shade drying is employed for those drugs is desirable and whose constituents are affected on exposure to direct sunlight.
Indoor drying: it is most commonly used method. This method has the following two
advantages over open air drying method.
a) It stops enzymatic action more rapidly
b) Less time consuming
It involves the use of various mechanical drying devices , like oven.
3- Grinding of the dried plants Is grinding of the plant material to a powder of suitable particle size. It is important that the particles are of as uniform in size as possible. Excessive dust should be avoided, as it can clog percolators and result in a turbid extract which is hard to clarify. Large particles take a longer time for complete extraction than small ones and large differences in particle size thus slow down the extraction process.
4-Storage &Packing of crude drugs Storage of the plant drugs needs knowledge of their physical & chemical properties
• All drugs should be preserved in a well closed & filled container. Drugs containing glycosides and esters are usually less stable than those containing alkaloids
Alkaloid Ester Glycoside
Non-S
SU.
Drugs with volatiles oils deteriorate rather quickly through evaporation, oxidation and polymerization of the substances constituting the essential oil.
In order to keep crude drugs as long as possible:
1. It is essential to store them in a dry condition in carefully closed containers at low
temperature.
2. It is also advisable to exclude light, because - even if it does not affect the active
constituents - it almost causes changes in the appearance of the drug, especially loss
of color.
3. It is also necessary to protect the drug against insect attack.
Tannins on the other hand, have an almost unlimited durability. component as in
clove, cinnamon, peppermint