Color key: Gene also differentially splicedGenes with multiple significant probes

Gene lists are sorted by decreasing fold-change for RNA-seq lists, Microarray lists are sorted alphabetically by MGI symbol

RNA-sequencing3M vs. >29M upregulated 3M vs. >29M downregulated

275 genes 48 genes

ENSEMBL-ID MGI Symbol ENSEMBL-ID

ENSMUSG00000073418 C4b 2.76 6.00E-300 ENSMUSG00000041261ENSMUSG00000079293 Clec7a 2.67 1.10E-18 ENSMUSG00000027820ENSMUSG00000050063 Klk6 2.52 7.35E-28 ENSMUSG00000029086ENSMUSG00000030789 Itgax 2.40 1.12E-11 ENSMUSG00000010797ENSMUSG00000024164 C3 2.18 2.88E-35 ENSMUSG00000027669ENSMUSG00000004707 Ly9 2.15 1.97E-08 ENSMUSG00000037892ENSMUSG00000026822 Lcn2 1.99 4.26E-07 ENSMUSG00000036913ENSMUSG00000033355 Rtp4 1.91 1.67E-11 ENSMUSG00000083327ENSMUSG00000001131 Timp1 1.90 1.70E-06 ENSMUSG00000025789ENSMUSG00000015340 Cybb 1.85 1.18E-06 ENSMUSG00000018589ENSMUSG00000057596 Trim30d 1.84 7.19E-11 ENSMUSG00000042834ENSMUSG00000068129 Cst7 1.81 7.28E-06 ENSMUSG00000046321ENSMUSG00000073409 H2-Q6 1.80 7.05E-07 ENSMUSG00000060594ENSMUSG00000030107 Usp18 1.70 6.16E-06 ENSMUSG00000082280ENSMUSG00000025479 Cyp2e1 1.68 2.91E-05 ENSMUSG00000025578ENSMUSG00000068699 Flnc 1.67 7.33E-26 ENSMUSG00000031210ENSMUSG00000041538 H2-Ob 1.66 2.91E-05 ENSMUSG00000071035ENSMUSG00000023943 Sult1c1 1.64 2.85E-05 ENSMUSG00000039385ENSMUSG00000062593 Lilrb4 1.62 9.66E-05 ENSMUSG00000039328ENSMUSG00000030577 Cd22 1.58 1.72E-04 ENSMUSG00000084416ENSMUSG00000060550 H2-Q7 1.57 1.09E-04 ENSMUSG00000046721ENSMUSG00000079017 Ifi27l2a 1.55 1.01E-05 ENSMUSG00000024534ENSMUSG00000034459 Ifit1 1.55 1.66E-05 ENSMUSG00000025140ENSMUSG00000037708 BC061194 1.54 9.18E-08 ENSMUSG00000043801ENSMUSG00000040170 Fmo2 1.54 1.66E-05 ENSMUSG00000083899ENSMUSG00000051965 Nanos2 1.48 3.10E-04 ENSMUSG00000093798ENSMUSG00000030921 Trim30a 1.48 4.15E-08 ENSMUSG00000057337ENSMUSG00000074896 Ifit3 1.48 4.98E-08 ENSMUSG00000028172ENSMUSG00000069516 Lyz2 1.46 2.03E-22 ENSMUSG00000068696ENSMUSG00000030745 Il21r 1.44 5.30E-07 ENSMUSG00000028364ENSMUSG00000079362 Gbp6 1.42 1.58E-06 ENSMUSG00000081051ENSMUSG00000033880 Lgals3bp 1.42 3.17E-23 ENSMUSG00000097814ENSMUSG00000015451 C4a 1.41 4.08E-05 ENSMUSG00000080776ENSMUSG00000029561 Oasl2 1.40 2.44E-09 ENSMUSG00000057068ENSMUSG00000063234 Gpr84 1.37 4.16E-05 ENSMUSG00000027750ENSMUSG00000046718 Bst2 1.36 2.32E-07 ENSMUSG00000069911ENSMUSG00000025498 Irf7 1.36 4.40E-06 ENSMUSG00000079297ENSMUSG00000037686 Aspg 1.35 3.44E-08 ENSMUSG00000022041ENSMUSG00000076609 Igkc 1.33 2.41E-03 ENSMUSG00000020090ENSMUSG00000043157 Arl11 1.31 1.35E-03 ENSMUSG00000030110ENSMUSG00000097507 AC114820.1 1.31 3.36E-03 ENSMUSG00000052229ENSMUSG00000066477 Gm16551 1.30 8.24E-04 ENSMUSG00000095588ENSMUSG00000040552 C3ar1 1.30 3.77E-05 ENSMUSG00000038135ENSMUSG00000068246 Apol9b 1.30 2.74E-03 ENSMUSG00000020914ENSMUSG00000027995 Tlr2 1.30 3.03E-05 ENSMUSG00000068240ENSMUSG00000000682 Cd52 1.30 8.67E-05 ENSMUSG00000032446ENSMUSG00000074151 Nlrc5 1.27 1.06E-03 ENSMUSG00000024027ENSMUSG00000069874 Irgm2 1.25 7.19E-11 ENSMUSG00000035551ENSMUSG00000002831 Plin4 1.25 1.12E-06ENSMUSG00000023122 Sult1c2 1.22 1.91E-07ENSMUSG00000049436 Upk1b 1.21 6.65E-04

log2 Fold Change

adjusted p-value [FDR]

ENSMUSG00000028268 Gbp3 1.21 8.39E-06ENSMUSG00000004328 Hif3a 1.18 1.14E-03ENSMUSG00000062488 I830012O16Rik 1.17 1.90E-04ENSMUSG00000029826 Zc3hav1 1.15 5.92E-15ENSMUSG00000078945 Naip2 1.15 2.89E-04ENSMUSG00000037411 Serpine1 1.14 4.40E-03ENSMUSG00000029816 Gpnmb 1.14 1.34E-06ENSMUSG00000059887 Olfr1507 1.14 1.70E-02ENSMUSG00000052776 Oas1a 1.14 1.72E-02ENSMUSG00000092274 Neat1 1.14 1.19E-27ENSMUSG00000050370 Ch25h 1.13 1.90E-02ENSMUSG00000022548 Apod 1.11 4.69E-22ENSMUSG00000030787 Lyve1 1.11 1.70E-02ENSMUSG00000034918 Cdhr2 1.11 9.33E-03ENSMUSG00000030124 Lag3 1.10 5.17E-09ENSMUSG00000026896 Ifih1 1.09 3.85E-07ENSMUSG00000094840 A630081J09Rik 1.09 2.41E-07ENSMUSG00000039013 Siglec5 1.08 2.21E-02ENSMUSG00000028965 Tnfrsf9 1.08 2.66E-02ENSMUSG00000037921 Ddx60 1.08 3.84E-03ENSMUSG00000032268 Tmprss5 1.08 3.94E-03ENSMUSG00000024066 Xdh 1.07 2.59E-13ENSMUSG00000018819 Lsp1 1.07 3.43E-05ENSMUSG00000034579 Pla2g3 1.07 2.39E-05ENSMUSG00000042353 Frem3 1.07 1.53E-03ENSMUSG00000003665 Has1 1.06 1.07E-02ENSMUSG00000069378 Prdm6 1.06 3.31E-02ENSMUSG00000023918 Gpr115 1.05 9.56E-04ENSMUSG00000043013 Onecut1 1.05 2.25E-03ENSMUSG00000026380 Tfcp2l1 1.05 4.73E-14ENSMUSG00000027376 Prom2 1.04 3.38E-02ENSMUSG00000070469 Adamtsl3 1.04 1.73E-03ENSMUSG00000022218 Tgm1 1.03 3.98E-02ENSMUSG00000057246 BC051142 1.01 1.62E-02ENSMUSG00000000290 Itgb2 1.01 3.29E-09ENSMUSG00000073489 Ifi204 1.01 4.73E-02ENSMUSG00000045876 Pcdhb8 1.01 6.24E-04ENSMUSG00000040296 Ddx58 1.00 7.05E-07ENSMUSG00000043943 Naalad2 0.99 1.97E-02ENSMUSG00000026548 Slamf9 0.99 1.10E-02ENSMUSG00000048215 A630023P12Rik 0.99 3.87E-02ENSMUSG00000029371 Cxcl5 0.99 2.05E-02ENSMUSG00000037405 Icam1 0.98 5.86E-04ENSMUSG00000044626 Liph 0.98 2.68E-02ENSMUSG00000076617 Ighm 0.97 2.05E-02ENSMUSG00000038224 Serpinf2 0.97 2.55E-02ENSMUSG00000020641 Rsad2 0.97 5.00E-02ENSMUSG00000082286 Pisd-ps1 0.97 2.76E-13ENSMUSG00000053113 Socs3 0.96 4.76E-03ENSMUSG00000020143 Dock2 0.96 2.21E-05ENSMUSG00000001119 Col6a1 0.96 5.83E-04ENSMUSG00000074060 Fbxw15 0.95 6.43E-04ENSMUSG00000074252 Gm10654 0.94 1.28E-02ENSMUSG00000063458 1700112E06Rik 0.94 3.09E-02ENSMUSG00000034422 Parp14 0.94 4.56E-03ENSMUSG00000086844 B230206H07Rik 0.94 1.86E-04ENSMUSG00000041515 Irf8 0.94 4.20E-08ENSMUSG00000026395 Ptprc 0.93 6.56E-04ENSMUSG00000027961 Lrrc39 0.93 4.16E-02ENSMUSG00000097267 AL603843.1 0.92 4.98E-03ENSMUSG00000035775 Krt20 0.92 2.52E-02

ENSMUSG00000086228 Gm514 0.92 1.88E-02ENSMUSG00000038007 Acer2 0.91 1.66E-07ENSMUSG00000097588 RP23-32L5.4 0.91 1.62E-02ENSMUSG00000071714 Csf2rb2 0.90 2.56E-02ENSMUSG00000052142 Rasal3 0.90 8.53E-04ENSMUSG00000015355 Cd48 0.90 4.76E-02ENSMUSG00000068758 Il3ra 0.90 4.55E-02ENSMUSG00000022146 Osmr 0.90 2.30E-06ENSMUSG00000024659 Anxa1 0.89 1.40E-02ENSMUSG00000026303 Mlph 0.89 8.00E-04ENSMUSG00000051599 Pcdhb2 0.89 3.29E-09ENSMUSG00000071713 Csf2rb 0.88 2.34E-02ENSMUSG00000073411 H2-D1 0.88 8.43E-11ENSMUSG00000075437 Gm11681 0.88 6.43E-04ENSMUSG00000032554 Trf 0.88 7.62E-12ENSMUSG00000026177 Slc11a1 0.87 1.90E-02ENSMUSG00000050335 Lgals3 0.87 2.33E-02ENSMUSG00000022901 Cd86 0.86 4.49E-03ENSMUSG00000040483 Xaf1 0.86 1.17E-04ENSMUSG00000035929 H2-Q4 0.85 2.09E-03ENSMUSG00000067212 H2-T23 0.85 1.87E-08ENSMUSG00000040253 Gbp7 0.85 1.95E-03ENSMUSG00000024610 Cd74 0.85 3.26E-07ENSMUSG00000051242 Pcdhb9 0.83 3.01E-24ENSMUSG00000021091 Serpina3n 0.83 1.51E-18ENSMUSG00000023992 Trem2 0.82 8.19E-11ENSMUSG00000028270 Gbp2 0.82 4.06E-05ENSMUSG00000074340 Ovgp1 0.81 9.52E-03ENSMUSG00000058498 Rnf207 0.81 1.60E-03ENSMUSG00000031103 Elf4 0.81 4.01E-02ENSMUSG00000019232 Agxt2l1 0.81 8.24E-04ENSMUSG00000038642 Ctss 0.81 8.94E-47ENSMUSG00000079547 H2-DMb1 0.80 1.87E-02ENSMUSG00000090272 Mndal 0.80 1.70E-02ENSMUSG00000046805 Mpeg1 0.80 4.21E-23ENSMUSG00000036594 H2-Aa 0.80 1.03E-02ENSMUSG00000025270 Alas2 0.80 8.90E-03ENSMUSG00000032596 Uba7 0.79 8.97E-04ENSMUSG00000020932 Gfap 0.79 1.96E-67ENSMUSG00000097877 AL714024.1 0.79 2.14E-03ENSMUSG00000003283 Hck 0.79 5.94E-03ENSMUSG00000030579 Tyrobp 0.78 1.57E-08ENSMUSG00000024300 Myo1f 0.78 1.06E-03ENSMUSG00000032369 Plscr1 0.77 2.07E-02ENSMUSG00000061232 H2-K1 0.77 3.40E-10ENSMUSG00000045672 Col27a1 0.77 9.20E-05ENSMUSG00000056737 Capg 0.77 1.95E-04ENSMUSG00000024338 Psmb8 0.77 8.84E-03ENSMUSG00000040751 Lat2 0.76 8.55E-03ENSMUSG00000092341 Malat1 0.76 3.11E-02ENSMUSG00000034810 Scn7a 0.76 1.01E-04ENSMUSG00000038147 Cd84 0.76 2.69E-03ENSMUSG00000004894 Hapln2 0.76 3.50E-11ENSMUSG00000025492 Ifitm3 0.76 1.10E-03ENSMUSG00000016493 Cd46 0.76 4.33E-02ENSMUSG00000072620 Slfn2 0.76 4.17E-02ENSMUSG00000074802 Gas2l3 0.75 1.02E-02ENSMUSG00000018774 Cd68 0.74 2.12E-08ENSMUSG00000030798 Cd37 0.74 1.62E-03ENSMUSG00000026728 Vim 0.74 1.43E-19ENSMUSG00000051678 Pcdhb6 0.74 2.16E-03

ENSMUSG00000031389 Arhgap4 0.74 1.73E-02ENSMUSG00000046879 Irgm1 0.74 1.46E-03ENSMUSG00000036867 Smad6 0.74 2.03E-02ENSMUSG00000023031 Cela1 0.74 5.32E-03ENSMUSG00000024696 Lpxn 0.74 4.20E-02ENSMUSG00000053158 Fes 0.74 2.20E-03ENSMUSG00000045498 Pcdhb3 0.73 2.32E-05ENSMUSG00000004266 Ptpn6 0.73 4.63E-03ENSMUSG00000039304 Tnfsf10 0.73 2.03E-02ENSMUSG00000044811 AF251705 0.73 4.98E-03ENSMUSG00000070327 Rnf213 0.73 4.98E-08ENSMUSG00000084890 A830036E02Rik 0.73 5.24E-05ENSMUSG00000026656 Fcgr2b 0.72 2.48E-03ENSMUSG00000001020 S100a4 0.72 3.32E-02ENSMUSG00000097225 AC107641.1 0.72 3.09E-02ENSMUSG00000096727 Psmb9 0.71 3.67E-02ENSMUSG00000025488 Cox8b 0.70 1.12E-02ENSMUSG00000092981 Mir5125 0.70 8.22E-03ENSMUSG00000058715 Fcer1g 0.70 3.99E-05ENSMUSG00000034116 Vav1 0.69 3.97E-04ENSMUSG00000022148 Fyb 0.69 2.80E-02ENSMUSG00000002325 Irf9 0.69 6.95E-04ENSMUSG00000018217 Pmp22 0.69 9.75E-16ENSMUSG00000030681 Mvp 0.68 3.94E-04ENSMUSG00000036887 C1qa 0.68 1.05E-18ENSMUSG00000001930 Vwf 0.68 2.34E-02ENSMUSG00000037321 Tap1 0.67 5.16E-04ENSMUSG00000047735 Samd9l 0.67 3.16E-03ENSMUSG00000055172 C1ra 0.67 4.15E-02ENSMUSG00000020120 Plek 0.66 4.15E-08ENSMUSG00000023224 Serping1 0.66 2.14E-03ENSMUSG00000005087 Cd44 0.66 5.94E-03ENSMUSG00000001025 S100a6 0.66 4.99E-07ENSMUSG00000028859 Csf3r 0.65 4.94E-05ENSMUSG00000047216 Cdh19 0.65 6.41E-03ENSMUSG00000045555 Mettl24 0.65 4.44E-02ENSMUSG00000015950 Ncf1 0.65 4.17E-05ENSMUSG00000080316 Ncrna00085 0.65 9.86E-08ENSMUSG00000021268 Meg3 0.65 2.61E-11ENSMUSG00000035697 Hmha1 0.64 9.85E-04ENSMUSG00000060802 B2m 0.64 1.08E-14ENSMUSG00000022912 Pros1 0.64 1.17E-08ENSMUSG00000052160 Pld4 0.63 1.31E-05ENSMUSG00000039087 Rreb1 0.62 9.53E-08ENSMUSG00000021423 Ly86 0.62 4.23E-06ENSMUSG00000004730 Emr1 0.62 8.53E-04ENSMUSG00000020836 Coro6 0.62 5.28E-03ENSMUSG00000036905 C1qb 0.62 1.71E-10ENSMUSG00000035545 Leng8 0.62 7.49E-16ENSMUSG00000038879 Nipal2 0.62 1.97E-03ENSMUSG00000034330 Plcg2 0.61 1.75E-02ENSMUSG00000024339 Tap2 0.61 9.01E-05ENSMUSG00000055541 Lair1 0.61 1.26E-03ENSMUSG00000027078 Ube2l6 0.61 3.02E-03ENSMUSG00000029798 Herc6 0.61 1.67E-02ENSMUSG00000048865 Arhgap30 0.61 4.33E-03ENSMUSG00000029919 Hpgds 0.61 2.36E-03ENSMUSG00000024186 Rgs11 0.60 9.51E-06ENSMUSG00000063687 Pcdhb5 0.60 2.13E-04ENSMUSG00000042320 Prox2 0.60 4.57E-02ENSMUSG00000030711 Sult1a1 0.60 4.31E-03

ENSMUSG00000046186 Cd109 0.59 1.12E-04ENSMUSG00000006519 Cyba 0.59 1.29E-02ENSMUSG00000024965 Fermt3 0.59 1.65E-02ENSMUSG00000064215 Ifi27l1 0.58 1.72E-08ENSMUSG00000001665 Gstt3 0.58 1.70E-02ENSMUSG00000091712 Sec14l5 0.58 1.24E-02ENSMUSG00000036896 C1qc 0.57 1.84E-11ENSMUSG00000033467 Crlf2 0.57 2.42E-02ENSMUSG00000020573 Pik3cg 0.57 1.28E-02ENSMUSG00000090086 AI480526 0.57 4.82E-06ENSMUSG00000087042 Gm11611 0.56 1.04E-02ENSMUSG00000041828 Abca8a 0.56 2.22E-04ENSMUSG00000044349 Snhg11 0.56 6.50E-08ENSMUSG00000046056 Sbsn 0.56 6.32E-03ENSMUSG00000000275 Trim25 0.56 1.71E-05ENSMUSG00000048997 Atxn7l2 0.56 8.95E-07ENSMUSG00000024810 Il33 0.55 1.13E-04ENSMUSG00000050211 Pla2g4e 0.55 5.06E-04ENSMUSG00000038930 Rccd1 0.55 1.11E-02ENSMUSG00000040187 Arntl2 0.55 3.42E-03ENSMUSG00000026104 Stat1 0.54 2.21E-09ENSMUSG00000033327 Tnxb 0.54 1.26E-05ENSMUSG00000059498 Fcgr3 0.53 3.25E-06ENSMUSG00000034771 Tle2 0.53 5.32E-03ENSMUSG00000029484 Anxa3 0.53 1.70E-02ENSMUSG00000037280 Galnt6 0.53 5.99E-03ENSMUSG00000020256 Aldh1l2 0.53 2.95E-02ENSMUSG00000029771 Irf5 0.53 4.53E-02ENSMUSG00000050103 Agmo 0.52 2.88E-02ENSMUSG00000039004 Bmp6 0.52 1.28E-02ENSMUSG00000020399 Havcr2 0.52 2.20E-02ENSMUSG00000021876 Rnase4 0.52 1.86E-04ENSMUSG00000045932 Ifit2 0.51 4.38E-02ENSMUSG00000074264 Amy1 0.51 3.63E-03ENSMUSG00000040852 Plekhh2 0.51 2.89E-04ENSMUSG00000038507 Parp12 0.51 6.23E-03ENSMUSG00000033192 Lpcat2 0.51 3.41E-03ENSMUSG00000055044 Pdlim1 0.50 4.28E-02ENSMUSG00000097796 AC164431.1 0.50 2.87E-02ENSMUSG00000097767 Miat 0.50 1.01E-11ENSMUSG00000064246 Chi3l1 0.50 3.58E-03

Gene also differentially splicedGenes with multiple significant probes

Gene lists are sorted by decreasing fold-change for RNA-seq lists, Microarray lists are sorted alphabetically by MGI symbol

RNA-sequencing3M vs. >29M downregulated 3M vs. 24M upregulated

48 genes 313 genes

MGI Symbol ENSEMBL-ID MGI Symbol

Car8 -0.51 4.17E-02 ENSMUSG00000023943 Sult1c1Mme -0.52 5.00E-02 ENSMUSG00000068129 Cst7Prom1 -0.53 1.57E-04 ENSMUSG00000079293 Clec7aWnt2 -0.53 4.73E-02 ENSMUSG00000073418 C4bGnb4 -0.53 3.70E-06 ENSMUSG00000040170 Fmo2Pcdh18 -0.54 4.25E-02 ENSMUSG00000025479 Cyp2e1Trim67 -0.54 3.04E-02 ENSMUSG00000024164 C3Vcp-rs -0.56 3.86E-02 ENSMUSG00000037708 BC061194St8sia2 -0.56 1.07E-02 ENSMUSG00000050063 Klk6Glra2 -0.56 7.46E-03 ENSMUSG00000030577 Cd22Nrep -0.56 6.29E-06 ENSMUSG00000030789 ItgaxHs3st2 -0.56 5.86E-05 ENSMUSG00000004707 Ly9Layn -0.57 2.37E-02 ENSMUSG00000034855 Cxcl10Gm7901 -0.58 2.38E-02 ENSMUSG00000057596 Trim30dCbx8 -0.60 8.12E-04 ENSMUSG00000066477 Gm16551Gpr165 -0.60 7.29E-04 ENSMUSG00000027376 Prom2Gm5499 -0.65 2.56E-02 ENSMUSG00000076609 IgkcCdh6 -0.67 4.97E-04 ENSMUSG00000030921 Trim30aRnf122 -0.67 1.73E-03 ENSMUSG00000074896 Ifit3Rpl10a-ps1 -0.68 1.40E-02 ENSMUSG00000023122 Sult1c2Rpl14-ps1 -0.72 3.33E-02 ENSMUSG00000033383 Rtp1Sncaip -0.73 4.93E-04 ENSMUSG00000062488 I830012O16RikPycr1 -0.75 4.97E-02 ENSMUSG00000002831 Plin4Oaz1-ps -0.75 2.20E-02 ENSMUSG00000030107 Usp18Gm12346 -0.76 1.76E-02 ENSMUSG00000048489 8430408G22RikGm8355 -0.78 1.77E-02 ENSMUSG00000069516 Lyz2Chst3 -0.78 2.04E-02 ENSMUSG00000032690 Oas2Tacr3 -0.78 2.80E-02 ENSMUSG00000079017 Ifi27l2aGpr88 -0.78 4.68E-08 ENSMUSG00000002847 Pla1aTnc -0.78 7.50E-04 ENSMUSG00000074060 Fbxw15Gm15427 -0.81 3.63E-03 ENSMUSG00000029826 Zc3hav1AC102484.1 -0.82 2.10E-03 ENSMUSG00000047735 Samd9lGm12174 -0.82 4.51E-02 ENSMUSG00000015340 CybbFam47e -0.85 1.92E-02 ENSMUSG00000034459 Ifit1Postn -0.85 3.79E-02 ENSMUSG00000035352 Ccl12Fam196b -0.86 4.15E-02 ENSMUSG00000004328 Hif3aGm2223 -0.88 2.96E-02 ENSMUSG00000049436 Upk1bChrna2 -0.89 2.35E-02 ENSMUSG00000051242 Pcdhb9Npffr1 -0.91 2.20E-02 ENSMUSG00000051599 Pcdhb2Ret -0.93 2.49E-02 ENSMUSG00000043013 Onecut1Gpr17 -0.95 2.47E-22 ENSMUSG00000047996 Prrg1Gm12350 -1.00 2.94E-02 ENSMUSG00000041828 Abca8aCrygn -1.00 3.52E-02 ENSMUSG00000037466 4930427A07RikTop2a -1.05 1.78E-02 ENSMUSG00000021070 Bdkrb2Gm11808 -1.06 9.78E-03 ENSMUSG00000043943 Naalad2Eomes -1.22 8.90E-03 ENSMUSG00000021098 4930447C04RikGlp1r -1.51 1.26E-05 ENSMUSG00000095995 Gm24703Igfbpl1 -2.03 1.48E-08 ENSMUSG00000038007 Acer2

ENSMUSG00000004231 Pax2ENSMUSG00000067780 Pi15ENSMUSG00000036594 H2-Aa

log2 Fold Change

adjusted p-value [FDR]

ENSMUSG00000029561 Oasl2ENSMUSG00000022548 ApodENSMUSG00000048752 Prss50ENSMUSG00000035004 Igsf6ENSMUSG00000084616 Gm25047ENSMUSG00000025488 Cox8bENSMUSG00000084911 Gm16185ENSMUSG00000024210 Ip6k3ENSMUSG00000006179 Prss16ENSMUSG00000068699 FlncENSMUSG00000025270 Alas2ENSMUSG00000071068 Treml2ENSMUSG00000038642 CtssENSMUSG00000063458 1700112E06RikENSMUSG00000033355 Rtp4ENSMUSG00000076617 IghmENSMUSG00000079507 H2-Q1ENSMUSG00000071203 Naip5ENSMUSG00000038147 Cd84ENSMUSG00000039899 Fgl2ENSMUSG00000021390 OgnENSMUSG00000018927 Ccl6ENSMUSG00000037921 Ddx60ENSMUSG00000046718 Bst2ENSMUSG00000033880 Lgals3bpENSMUSG00000063804 Lin28bENSMUSG00000087182 Gm13334ENSMUSG00000063234 Gpr84ENSMUSG00000022014 Epsti1ENSMUSG00000034810 Scn7aENSMUSG00000042190 Cmklr1ENSMUSG00000060586 H2-Eb1ENSMUSG00000026303 MlphENSMUSG00000024810 Il33ENSMUSG00000086509 Nkx2-2asENSMUSG00000091509 Gm17066ENSMUSG00000048368 OmdENSMUSG00000033777 Tlr13ENSMUSG00000097340 CR293526.1ENSMUSG00000046805 Mpeg1ENSMUSG00000034923 Ly6g6fENSMUSG00000078945 Naip2ENSMUSG00000069919 Hba-a1ENSMUSG00000022146 OsmrENSMUSG00000025498 Irf7ENSMUSG00000001020 S100a4ENSMUSG00000027399 Il1aENSMUSG00000051678 Pcdhb6ENSMUSG00000044726 BC030476ENSMUSG00000031995 St14ENSMUSG00000092274 Neat1ENSMUSG00000047759 Hs3st3a1ENSMUSG00000018920 Cxcl16ENSMUSG00000032092 Mpzl2ENSMUSG00000082361 BtcENSMUSG00000071083 Gm10311ENSMUSG00000022575 GsdmdENSMUSG00000019936 EpycENSMUSG00000060843 Ctnna3ENSMUSG00000036446 LumENSMUSG00000031112 2610018G03Rik

ENSMUSG00000038304 Cd160ENSMUSG00000093226 Gm25749ENSMUSG00000051455 Gm1564ENSMUSG00000008845 Cd163ENSMUSG00000097415 RP23-285C18.2ENSMUSG00000022766 Serpind1ENSMUSG00000037411 Serpine1ENSMUSG00000012819 Cdh23ENSMUSG00000040751 Lat2ENSMUSG00000034457 Eda2rENSMUSG00000039891 TxlnbENSMUSG00000038064 Cldn22ENSMUSG00000029994 Anxa4ENSMUSG00000022952 Runx1ENSMUSG00000038550 Gm129ENSMUSG00000025355 Mmp19ENSMUSG00000045876 Pcdhb8ENSMUSG00000024610 Cd74ENSMUSG00000069892 9930111J21Rik2ENSMUSG00000060802 B2mENSMUSG00000038732 Mboat1ENSMUSG00000029304 Spp1ENSMUSG00000047878 A4galtENSMUSG00000024066 XdhENSMUSG00000055172 C1raENSMUSG00000079491 H2-T10ENSMUSG00000062743 Zfp677ENSMUSG00000072845 Tmprss11aENSMUSG00000020467 Efemp1ENSMUSG00000020120 PlekENSMUSG00000082286 Pisd-ps1ENSMUSG00000030124 Lag3ENSMUSG00000059588 CalcrlENSMUSG00000029915 Clec5aENSMUSG00000027078 Ube2l6ENSMUSG00000047216 Cdh19ENSMUSG00000045498 Pcdhb3ENSMUSG00000079547 H2-DMb1ENSMUSG00000087103 Gm13344ENSMUSG00000024371 C2ENSMUSG00000050103 AgmoENSMUSG00000098160 RP23-275E20.1ENSMUSG00000081049 Rps24-ps3ENSMUSG00000043157 Arl11ENSMUSG00000021280 Exoc3l4ENSMUSG00000087524 Gm14285ENSMUSG00000094707 A830019P07RikENSMUSG00000063687 Pcdhb5ENSMUSG00000026222 Sp100ENSMUSG00000085105 Gm12758ENSMUSG00000020932 GfapENSMUSG00000022876 Samsn1ENSMUSG00000058498 Rnf207ENSMUSG00000010461 Eya4ENSMUSG00000029816 GpnmbENSMUSG00000021091 Serpina3nENSMUSG00000044067 Gpr22ENSMUSG00000037686 AspgENSMUSG00000097098 AC207128.1ENSMUSG00000070407 Hs3st3b1ENSMUSG00000086629 2810403D21Rik

ENSMUSG00000085334 Gm12940ENSMUSG00000085181 Gm12709ENSMUSG00000028602 Tnfrsf8ENSMUSG00000023992 Trem2ENSMUSG00000049493 Pls1ENSMUSG00000044811 AF251705ENSMUSG00000073427 Gm4924ENSMUSG00000081113 Gm7308ENSMUSG00000097225 AC107641.1ENSMUSG00000044583 Tlr7ENSMUSG00000078861 Zfp931ENSMUSG00000028369 Svep1ENSMUSG00000032344 Mb21d1ENSMUSG00000015401 Tmem27ENSMUSG00000003418 St8sia6ENSMUSG00000031380 FigfENSMUSG00000035208 Slfn8ENSMUSG00000031465 Angpt2ENSMUSG00000024766 Lipo1ENSMUSG00000026365 CfhENSMUSG00000057143 Trim12cENSMUSG00000028885 Smpdl3bENSMUSG00000040552 C3ar1ENSMUSG00000042759 ApobrENSMUSG00000020256 Aldh1l2ENSMUSG00000086844 B230206H07RikENSMUSG00000039005 Tlr4ENSMUSG00000026730 PterENSMUSG00000009378 Slc16a12ENSMUSG00000030579 TyrobpENSMUSG00000036777 AnlnENSMUSG00000027555 Car13ENSMUSG00000027199 GatmENSMUSG00000025492 Ifitm3ENSMUSG00000022123 ScelENSMUSG00000033082 Clec1aENSMUSG00000064215 Ifi27l1ENSMUSG00000020399 Havcr2ENSMUSG00000071267 Zfp942ENSMUSG00000020774 AspaENSMUSG00000042102 DmgdhENSMUSG00000040569 Slc26a7ENSMUSG00000021709 Erbb2ipENSMUSG00000026728 VimENSMUSG00000040229 Gpr34ENSMUSG00000084817 Gm5526ENSMUSG00000005087 Cd44ENSMUSG00000024300 Myo1fENSMUSG00000062980 Cped1ENSMUSG00000063406 Tmed5ENSMUSG00000031246 Sh3bgrlENSMUSG00000097462 AC136008.1ENSMUSG00000068428 GmncENSMUSG00000033715 Akr1c14ENSMUSG00000018217 Pmp22ENSMUSG00000042622 MaffENSMUSG00000043498 9330132A10RikENSMUSG00000026395 PtprcENSMUSG00000026830 ErmnENSMUSG00000043110 Lrrn4ENSMUSG00000026638 Irf6

ENSMUSG00000032419 Tbx18ENSMUSG00000086503 XistENSMUSG00000018819 Lsp1ENSMUSG00000032596 Uba7ENSMUSG00000036887 C1qaENSMUSG00000096433 Gm4944ENSMUSG00000029823 Luc7l2ENSMUSG00000045555 Mettl24ENSMUSG00000001025 S100a6ENSMUSG00000073131 Vma21ENSMUSG00000026656 Fcgr2bENSMUSG00000048040 Arxes2ENSMUSG00000026380 Tfcp2l1ENSMUSG00000073478 D730003I15RikENSMUSG00000092279 1500011B03RikENSMUSG00000033972 Zfp944ENSMUSG00000073411 H2-D1ENSMUSG00000039405 Prss23ENSMUSG00000000290 Itgb2ENSMUSG00000032554 TrfENSMUSG00000013707 Tnfaip8l2ENSMUSG00000025912 Mybl1ENSMUSG00000013584 Aldh1a2ENSMUSG00000028676 Srsf10ENSMUSG00000027737 Slc7a11ENSMUSG00000021903 Galnt15ENSMUSG00000062931 Zfp938ENSMUSG00000025176 Hoga1ENSMUSG00000031200 Mtcp1ENSMUSG00000075437 Gm11681ENSMUSG00000052160 Pld4ENSMUSG00000026739 Bmi1ENSMUSG00000029919 HpgdsENSMUSG00000048424 Ranbp3lENSMUSG00000041685 Fcho2ENSMUSG00000034795 Ccdc122ENSMUSG00000032113 Chek1ENSMUSG00000044043 Pcdhb14ENSMUSG00000037405 Icam1ENSMUSG00000037860 Aim2ENSMUSG00000078578 Ube2d3ENSMUSG00000041515 Irf8ENSMUSG00000039457 PplENSMUSG00000021624 Cd180ENSMUSG00000097375 mmu-let-7dENSMUSG00000019970 Sgk1ENSMUSG00000023959 Clic5ENSMUSG00000052142 Rasal3ENSMUSG00000022698 Naa50ENSMUSG00000073062 ZxdbENSMUSG00000055541 Lair1ENSMUSG00000056737 CapgENSMUSG00000025903 Lypla1ENSMUSG00000023064 SncgENSMUSG00000036131 Frmd7ENSMUSG00000034422 Parp14ENSMUSG00000059498 Fcgr3ENSMUSG00000040562 Gstm2ENSMUSG00000060002 Chpt1ENSMUSG00000021775 Nr1d2ENSMUSG00000037610 Kcnmb2

ENSMUSG00000033446 Lpar6ENSMUSG00000018774 Cd68ENSMUSG00000035597 Prpf39ENSMUSG00000073590 3222401L13RikENSMUSG00000047259 Mc4rENSMUSG00000001665 Gstt3ENSMUSG00000004894 Hapln2ENSMUSG00000081225 Cyp2j12ENSMUSG00000031838 Ifi30ENSMUSG00000098239 RP23-239L21.4ENSMUSG00000032423 SyncripENSMUSG00000030760 Acer3ENSMUSG00000066258 Trim12aENSMUSG00000027162 Lin7cENSMUSG00000028252 CcncENSMUSG00000054162 Spock3ENSMUSG00000062078 QkENSMUSG00000034768 Asb16

RNA-sequencing3M vs. 24M downregulated

164 genes

ENSEMBL-ID MGI Symbol

2.41 2.88E-28 ENSMUSG00000027400 Pdyn -0.50 2.46E-022.36 2.13E-14 ENSMUSG00000028364 Tnc -0.50 3.65E-022.14 1.08E-16 ENSMUSG00000029108 Pcdh7 -0.50 6.60E-032.07 2.73E-46 ENSMUSG00000032033 Barx2 -0.50 4.85E-022.07 1.35E-21 ENSMUSG00000036913 Trim67 -0.51 4.35E-041.90 1.19E-10 ENSMUSG00000086155 9430041J12Rik -0.51 4.02E-021.76 2.01E-15 ENSMUSG00000052133 Sema5b -0.51 1.04E-041.74 1.17E-23 ENSMUSG00000053164 Gpr21 -0.51 3.92E-021.72 2.01E-07 ENSMUSG00000029149 Krtcap3 -0.51 2.42E-021.70 4.94E-08 ENSMUSG00000020423 Btg2 -0.51 2.33E-031.61 8.30E-08 ENSMUSG00000042589 Cux2 -0.51 6.45E-041.61 1.52E-06 ENSMUSG00000056708 Ier5 -0.51 8.81E-061.56 1.09E-05 ENSMUSG00000045314 Sowahb -0.51 3.62E-021.47 1.27E-14 ENSMUSG00000030123 Plxnd1 -0.51 8.72E-041.43 8.30E-08 ENSMUSG00000036639 Nudt1 -0.51 2.90E-021.43 3.19E-06 ENSMUSG00000007944 Ttc9b -0.52 1.27E-041.42 1.27E-04 ENSMUSG00000026463 Atp2b4 -0.52 2.00E-041.34 2.53E-11 ENSMUSG00000081058 Hist2h3c2 -0.52 4.90E-021.32 1.88E-07 ENSMUSG00000056854 Pou3f4 -0.52 2.29E-021.30 4.61E-06 ENSMUSG00000027875 Hmgcs2 -0.52 1.59E-021.28 1.49E-04 ENSMUSG00000030223 Ptpro -0.52 2.03E-111.28 1.68E-06 ENSMUSG00000053004 Hrh1 -0.53 8.89E-041.25 4.73E-11 ENSMUSG00000040972 Igsf21 -0.53 1.37E-041.25 6.98E-04 ENSMUSG00000042834 Nrep -0.53 6.67E-051.16 2.53E-04 ENSMUSG00000031285 Dcx -0.53 7.41E-051.16 6.11E-07 ENSMUSG00000030796 Tead2 -0.53 1.82E-021.13 1.41E-03 ENSMUSG00000022103 Gfra2 -0.53 4.14E-051.12 2.43E-03 ENSMUSG00000026167 Wnt10a -0.53 2.71E-021.09 3.01E-05 ENSMUSG00000050541 Adra1b -0.53 7.33E-031.08 2.23E-06 ENSMUSG00000018634 Crhr1 -0.53 6.12E-041.06 9.80E-35 ENSMUSG00000053198 Prx -0.53 1.25E-021.05 6.83E-11 ENSMUSG00000026683 Nuf2 -0.53 9.33E-031.05 1.89E-03 ENSMUSG00000034282 Evpl -0.54 9.16E-041.05 6.32E-03 ENSMUSG00000029335 Bmp3 -0.54 1.27E-021.02 3.20E-03 ENSMUSG00000061186 Sfmbt2 -0.55 1.58E-031.02 7.30E-09 ENSMUSG00000045968 5830403L16Rik -0.55 4.67E-021.01 2.50E-06 ENSMUSG00000047606 Ankrd34c -0.55 3.92E-021.01 3.70E-35 ENSMUSG00000023067 Cdkn1a -0.55 2.48E-021.01 1.62E-14 ENSMUSG00000037279 Ovol2 -0.55 4.73E-021.01 1.60E-03 ENSMUSG00000036181 Hist1h1c -0.56 1.33E-030.99 4.06E-04 ENSMUSG00000037995 Igsf9 -0.56 1.53E-020.99 1.88E-24 ENSMUSG00000019874 Fabp7 -0.56 1.68E-040.99 1.43E-02 ENSMUSG00000029868 Trpv6 -0.56 2.59E-030.98 4.14E-03 ENSMUSG00000012443 Kif11 -0.56 1.63E-020.98 9.57E-07 ENSMUSG00000027716 Trpc3 -0.56 2.90E-020.98 2.48E-03 ENSMUSG00000034402 Kcnh5 -0.56 1.65E-040.98 1.29E-02 ENSMUSG00000038115 Ano2 -0.57 6.51E-030.96 2.02E-05 ENSMUSG00000022096 Hr -0.57 4.63E-030.96 3.70E-03 ENSMUSG00000027669 Gnb4 -0.57 8.96E-030.96 3.02E-05 ENSMUSG00000002083 Bbc3 -0.57 6.71E-060.96 2.20E-04 ENSMUSG00000027270 Lamp5 -0.58 5.30E-03

log2 Fold Change

adjusted p-value [FDR]

log2 Fold Change

adjusted p-value [FDR]

0.95 8.36E-04 ENSMUSG00000041378 Cldn5 -0.58 1.97E-040.95 1.45E-18 ENSMUSG00000020599 Rgs9 -0.58 2.13E-020.94 5.14E-03 ENSMUSG00000032172 Olfm2 -0.59 2.73E-050.93 3.21E-03 ENSMUSG00000020649 Rrm2 -0.59 4.22E-020.93 1.32E-02 ENSMUSG00000096753 Fam181a -0.59 3.84E-020.92 1.38E-04 ENSMUSG00000038257 Glra3 -0.59 3.29E-020.92 1.22E-03 ENSMUSG00000034295 Fhod3 -0.60 5.44E-030.92 3.23E-03 ENSMUSG00000018589 Glra2 -0.60 1.77E-050.92 7.98E-03 ENSMUSG00000025400 Tac2 -0.61 7.08E-030.92 6.49E-14 ENSMUSG00000074480 Mex3a -0.61 1.44E-040.91 2.10E-02 ENSMUSG00000031210 Gpr165 -0.61 2.25E-030.91 8.15E-03 ENSMUSG00000083219 Gm11410 -0.62 4.78E-020.91 1.43E-21 ENSMUSG00000089762 Ier5l -0.62 3.26E-030.91 4.86E-03 ENSMUSG00000058152 Chsy3 -0.62 2.35E-050.91 8.02E-04 ENSMUSG00000023034 Nr4a1 -0.62 2.79E-020.91 8.65E-08 ENSMUSG00000025140 Pycr1 -0.63 2.25E-020.90 2.84E-02 ENSMUSG00000059791 Nrm -0.63 9.56E-030.89 1.34E-03 ENSMUSG00000054855 Rnd1 -0.63 1.59E-030.89 9.21E-09 ENSMUSG00000086905 Gm13716 -0.63 3.37E-030.89 2.74E-03 ENSMUSG00000024190 Dusp1 -0.63 1.80E-020.88 8.91E-05 ENSMUSG00000044364 Tmem74b -0.63 1.51E-030.87 5.10E-05 ENSMUSG00000050105 Grrp1 -0.65 1.38E-020.87 6.44E-04 ENSMUSG00000071341 Egr4 -0.65 6.74E-040.86 1.37E-03 ENSMUSG00000097404 AC131692.1 -0.65 4.05E-020.86 5.99E-05 ENSMUSG00000049608 Gpr55 -0.66 3.52E-020.85 1.11E-02 ENSMUSG00000054146 Krt15 -0.66 4.49E-020.84 1.38E-02 ENSMUSG00000086119 Gm2415 -0.66 1.09E-020.84 1.17E-02 ENSMUSG00000044006 Cilp2 -0.66 9.24E-030.84 3.82E-03 ENSMUSG00000010021 Kif19a -0.67 1.79E-040.84 3.88E-07 ENSMUSG00000087675 Gm11762 -0.67 4.16E-020.83 1.48E-07 ENSMUSG00000026043 Col3a1 -0.67 3.31E-020.83 7.63E-03 ENSMUSG00000097971 RP23-81C12.1 -0.67 8.94E-030.83 4.03E-06 ENSMUSG00000032511 Scn5a -0.67 1.23E-020.82 1.41E-23 ENSMUSG00000046321 Hs3st2 -0.68 2.71E-030.82 1.05E-02 ENSMUSG00000032323 Cyp11a1 -0.68 3.55E-030.81 2.49E-03 ENSMUSG00000038331 Satb2 -0.68 3.86E-050.81 3.44E-02 ENSMUSG00000044505 Lingo4 -0.68 3.01E-020.81 6.38E-05 ENSMUSG00000052837 Junb -0.68 8.69E-040.80 8.05E-04 ENSMUSG00000024027 Glp1r -0.69 3.09E-020.80 3.65E-24 ENSMUSG00000057337 Chst3 -0.69 9.59E-060.80 1.99E-02 ENSMUSG00000020914 Top2a -0.69 1.02E-020.79 8.43E-04 ENSMUSG00000036198 Arhgap36 -0.70 1.04E-020.78 4.95E-02 ENSMUSG00000021647 Cartpt -0.70 2.59E-020.78 1.21E-09 ENSMUSG00000039349 C130074G19Rik -0.70 1.68E-020.78 1.67E-02 ENSMUSG00000037169 Mycn -0.70 2.52E-090.78 4.01E-03 ENSMUSG00000096221 1500002C15Rik -0.70 2.32E-030.78 2.40E-02 ENSMUSG00000053399 Adamts18 -0.71 1.50E-020.78 4.72E-04 ENSMUSG00000041460 Cacna2d4 -0.71 2.95E-020.77 6.32E-03 ENSMUSG00000021219 Rgs6 -0.72 4.02E-040.77 1.89E-02 ENSMUSG00000011305 Plin5 -0.72 1.27E-020.77 1.32E-06 ENSMUSG00000029333 Rasgef1b -0.73 2.51E-040.77 1.37E-02 ENSMUSG00000025577 Cbx2 -0.73 5.73E-040.77 5.80E-04 ENSMUSG00000085316 D330050G23Rik -0.73 3.08E-030.77 2.90E-02 ENSMUSG00000062372 Otof -0.73 2.02E-020.77 1.38E-02 ENSMUSG00000047507 Baiap3 -0.73 6.47E-030.76 4.81E-02 ENSMUSG00000021469 Msx2 -0.74 3.94E-020.76 2.20E-04 ENSMUSG00000082362 Gm5187 -0.74 4.00E-020.75 6.59E-04 ENSMUSG00000039385 Cdh6 -0.74 5.22E-070.75 7.07E-04 ENSMUSG00000009092 Derl3 -0.74 1.39E-020.75 9.10E-04 ENSMUSG00000038135 Crygn -0.74 2.84E-020.75 5.48E-05 ENSMUSG00000039714 Cplx3 -0.74 1.16E-02

0.75 3.36E-02 ENSMUSG00000022097 Sftpc -0.74 3.00E-020.75 3.32E-02 ENSMUSG00000063632 Sox11 -0.74 3.07E-040.75 2.96E-02 ENSMUSG00000047904 Sstr2 -0.75 2.94E-050.74 9.56E-03 ENSMUSG00000084790 Gm15879 -0.75 1.86E-020.74 2.13E-02 ENSMUSG00000060284 Sp7 -0.75 3.21E-030.74 1.13E-03 ENSMUSG00000030898 Cckbr -0.76 3.55E-040.74 2.08E-02 ENSMUSG00000025578 Cbx8 -0.76 5.07E-080.73 3.74E-04 ENSMUSG00000053081 1700069B07Rik -0.76 4.57E-030.73 2.24E-04 ENSMUSG00000062393 Dgkk -0.76 1.81E-020.73 3.47E-02 ENSMUSG00000084898 Gm12371 -0.77 1.68E-020.73 9.03E-06 ENSMUSG00000046922 Gpr6 -0.77 3.57E-020.72 1.83E-03 ENSMUSG00000021702 Thbs4 -0.78 1.31E-060.72 1.61E-05 ENSMUSG00000024670 Cd6 -0.78 2.96E-020.72 3.42E-03 ENSMUSG00000070490 Gm10293 -0.79 3.04E-020.72 2.33E-09 ENSMUSG00000020178 Adora2a -0.80 4.76E-020.72 5.99E-03 ENSMUSG00000020123 Avpr1a -0.80 3.60E-020.72 2.35E-05 ENSMUSG00000085565 Gm15721 -0.81 1.16E-020.72 4.47E-02 ENSMUSG00000027568 Ntsr1 -0.81 5.82E-070.72 1.52E-02 ENSMUSG00000038418 Egr1 -0.83 2.22E-030.71 8.16E-05 ENSMUSG00000079466 Prdm12 -0.83 4.52E-020.71 1.20E-05 ENSMUSG00000047773 Ankfn1 -0.84 7.22E-030.71 3.17E-02 ENSMUSG00000097182 AC163292.1 -0.84 3.98E-020.71 3.82E-03 ENSMUSG00000076431 Sox4 -0.84 7.74E-080.71 6.32E-03 ENSMUSG00000002289 Angptl4 -0.85 4.39E-040.70 1.21E-03 ENSMUSG00000030110 Ret -0.86 2.01E-050.70 4.33E-02 ENSMUSG00000073164 2410018L13Rik -0.87 4.69E-030.70 1.02E-02 ENSMUSG00000048327 Ckap2l -0.87 1.83E-020.70 2.85E-02 ENSMUSG00000021032 Ngb -0.88 1.45E-030.69 1.39E-07 ENSMUSG00000045903 Npas4 -0.89 1.83E-020.69 8.30E-09 ENSMUSG00000023274 Cd4 -0.89 2.90E-020.69 9.09E-04 ENSMUSG00000053560 Ier2 -0.91 9.16E-040.69 2.82E-08 ENSMUSG00000056972 Magel2 -0.92 7.19E-060.69 2.53E-08 ENSMUSG00000022602 Arc -0.92 1.09E-020.69 4.58E-04 ENSMUSG00000026247 Ecel1 -0.93 1.25E-020.69 2.48E-03 ENSMUSG00000021250 Fos -0.95 1.87E-020.69 2.02E-06 ENSMUSG00000048721 Fndc9 -0.97 3.19E-060.69 8.86E-09 ENSMUSG00000020905 Usp43 -0.97 3.81E-030.68 3.89E-03 ENSMUSG00000032338 Hcn4 -0.98 2.50E-050.68 3.67E-02 ENSMUSG00000042607 Asb4 -0.99 1.18E-020.68 1.68E-02 ENSMUSG00000052229 Gpr17 -1.01 6.93E-200.68 5.99E-09 ENSMUSG00000028871 Rspo1 -1.04 3.37E-030.67 1.91E-02 ENSMUSG00000078958 Atp6ap1l -1.04 2.29E-030.67 2.99E-02 ENSMUSG00000032572 Col6a4 -1.05 1.20E-040.67 4.91E-02 ENSMUSG00000047490 4932411E22Rik -1.05 8.51E-040.67 1.47E-02 ENSMUSG00000030792 Dkkl1 -1.08 2.22E-030.67 2.03E-02 ENSMUSG00000054667 Irs4 -1.14 2.36E-030.66 3.01E-02 ENSMUSG00000098132 RASSF10 -1.19 4.44E-040.66 3.39E-08 ENSMUSG00000044254 Pcsk9 -1.26 3.38E-040.66 6.10E-03 ENSMUSG00000037868 Egr2 -1.31 7.68E-040.66 1.51E-02 ENSMUSG00000020374 Rasgef1c -1.35 4.19E-050.66 9.29E-25 ENSMUSG00000029005 Draxin -1.68 1.99E-090.66 3.57E-03 ENSMUSG00000035551 Igfbpl1 -1.71 1.40E-100.66 2.02E-020.66 1.68E-040.65 8.52E-130.65 1.39E-200.65 5.23E-080.65 1.30E-020.65 1.10E-020.65 1.75E-020.65 4.12E-02

0.65 7.42E-030.65 3.85E-030.65 2.69E-020.64 7.07E-110.64 3.80E-050.64 3.82E-030.63 4.91E-020.63 1.87E-020.63 3.59E-020.63 1.49E-040.63 1.28E-020.63 1.09E-020.63 1.69E-020.62 4.49E-020.62 1.44E-030.62 3.58E-020.62 3.59E-020.62 4.28E-030.62 5.72E-030.62 9.59E-060.62 1.03E-030.62 1.22E-020.62 2.01E-020.62 1.66E-020.61 1.57E-050.61 4.17E-020.61 4.53E-030.61 2.79E-040.61 7.35E-030.61 8.62E-090.61 3.07E-050.61 2.95E-030.61 1.40E-050.61 1.06E-020.61 1.81E-020.60 1.41E-020.60 6.20E-050.60 1.77E-040.60 5.57E-030.60 2.54E-030.60 2.75E-020.60 4.02E-030.60 3.11E-050.60 6.48E-210.60 1.02E-020.60 2.94E-020.60 2.36E-020.59 8.81E-030.59 2.08E-020.59 2.41E-030.59 3.13E-020.59 2.74E-030.59 2.48E-030.59 3.10E-020.59 2.70E-090.59 4.94E-020.59 2.74E-020.59 1.89E-020.58 4.86E-030.58 2.16E-020.58 1.61E-02

0.58 2.90E-020.58 2.84E-020.58 1.22E-030.58 5.49E-030.57 2.87E-070.57 2.84E-020.57 6.32E-040.57 3.46E-020.57 7.74E-080.57 8.28E-030.57 2.32E-030.57 8.41E-030.56 4.59E-070.56 1.54E-020.56 9.33E-030.56 1.47E-020.56 1.05E-020.56 2.83E-030.56 1.92E-030.56 6.81E-050.55 1.18E-020.55 8.81E-030.55 3.32E-020.55 1.24E-040.55 3.83E-040.55 1.97E-020.55 1.44E-030.55 3.39E-020.55 4.11E-020.55 1.38E-020.55 2.06E-070.55 3.07E-040.55 2.86E-030.55 3.86E-030.54 2.23E-030.54 1.43E-020.54 4.70E-020.54 1.12E-050.54 1.72E-020.54 2.21E-020.54 6.99E-030.54 6.45E-060.54 9.02E-030.53 6.71E-030.53 3.25E-020.53 2.31E-030.53 1.13E-080.53 5.97E-030.53 1.49E-030.53 3.46E-020.53 1.44E-030.53 3.13E-030.53 1.87E-020.52 3.21E-030.52 2.31E-020.52 2.48E-020.52 4.50E-060.52 1.65E-020.52 5.62E-030.52 3.86E-050.52 5.96E-03

0.52 3.41E-020.52 8.43E-040.52 8.96E-030.52 4.85E-020.52 1.42E-020.51 3.23E-020.51 3.42E-030.51 2.88E-020.51 1.36E-020.51 3.41E-020.51 9.96E-030.51 1.95E-030.51 7.34E-030.51 7.37E-040.50 4.46E-030.50 2.15E-030.50 2.14E-030.50 6.09E-03

Microarray3M vs. >29M upregulated 3M vs. >29M downregulated

423 (373 genes) 330 probes (283 genes)

ENSMUSG00000028589 1700012P22Rik 1700091H14Rik NAENSMUSG00000091707 1700016D02Rik 9530057J20Rik ENSMUSG00000037971ENSMUSG00000079271 1700049E17Rik1 AA414992 ENSMUSG00000098318ENSMUSG00000090462 1700091H14Rik Apod ENSMUSG00000029248ENSMUSG00000037600 1810019J16Rik BC061194 NAENSMUSG00000095620 2010005H15Rik C1ra ENSMUSG00000009114ENSMUSG00000041789 2700046A07Rik C3 ENSMUSG00000020491NA 2700089I24Rik Cd300lf NAENSMUSG00000075389 2810410L24Rik Cd68 NAENSMUSG00000073590 3222401L13Rik Csf1 ENSMUSG00000097619NA 4930401C15Rik Cxcr6 NANA 4930529F21Rik Cyp2e1 ENSMUSG00000050883ENSMUSG00000081793 5730416F02Rik Frem3 NAENSMUSG00000054672 5830411N06Rik Gfap ENSMUSG00000086209NA A230001M10Rik Gm4955 ENSMUSG00000049357ENSMUSG00000089633 A230009B12Rik Gm5622 NANA A330015K06Rik Gm8220 ENSMUSG00000025058NA A330049N07Rik I830012O16Rik NAENSMUSG00000072109 A530040E14Rik Ifi204 ENSMUSG00000073755NA A930026B05Rik LOC101056136 ENSMUSG00000062470NA AA414992 LOC666692 NAENSMUSG00000033213 AA467197 Lgals3bp ENSMUSG00000098097ENSMUSG00000011148 Adssl1 Lilrb4 NAENSMUSG00000020473 Aebp1 Obox1 NAENSMUSG00000069833 Ahnak Prss50 ENSMUSG00000097736ENSMUSG00000073490 AI607873 S100a4 NAENSMUSG00000021213 Akr1c13 Serpina1a NAENSMUSG00000015134 Aldh1a3 Serpina1d ENSMUSG00000097784ENSMUSG00000020256 Aldh1l2 Slc44a1 NAENSMUSG00000032807 Alox12b Speer5-ps1 NAENSMUSG00000025701 Alox5 Srebf2 ENSMUSG00000086693ENSMUSG00000027460 Angpt4 Tnfaip2 NAENSMUSG00000033544 Angptl1 Trdn ENSMUSG00000053399ENSMUSG00000036777 Anln Trf ENSMUSG00000078247ENSMUSG00000022548 Apod Vmn1r168 ENSMUSG00000022016ENSMUSG00000057346 Apol9a Wipf1 ENSMUSG00000020790ENSMUSG00000068246 Apol9b Zc3hav1 ENSMUSG00000058589ENSMUSG00000043157 Arl11 ENSMUSG00000035152ENSMUSG00000037686 Aspg ENSMUSG00000062444ENSMUSG00000050961 AY358078 ENSMUSG00000071847ENSMUSG00000043740 B430306N03Rik ENSMUSG00000042348ENSMUSG00000026630 Batf3 ENSMUSG00000033952ENSMUSG00000037708 BC061194 ENSMUSG00000034958ENSMUSG00000072145 BC061237 ENSMUSG00000031376ENSMUSG00000071561 BC100530 ENSMUSG00000021460ENSMUSG00000053175 Bcl3 ENSMUSG00000025432ENSMUSG00000032556 Bfsp2 ENSMUSG00000097871ENSMUSG00000008999 Bmp7 NAENSMUSG00000046718 Bst2 NAENSMUSG00000052477 C130026I21Rik ENSMUSG00000037593ENSMUSG00000036887 C1qa ENSMUSG00000049658

ENSEMBL-ID (if applicable)

MGI Symbol / Gene name

Genes with multiple significant probes

ENSEMBL-ID (if applicable)

ENSMUSG00000036905 C1qb NAENSMUSG00000055172 C1ra ENSMUSG00000040118ENSMUSG00000024371 C2 ENSMUSG00000020723ENSMUSG00000024164 C3 ENSMUSG00000028222ENSMUSG00000073418 C4b ENSMUSG00000025577ENSMUSG00000056737 Capg ENSMUSG00000025578ENSMUSG00000025888 Casp1 ENSMUSG00000070883ENSMUSG00000007655 Cav1 ENSMUSG00000028795ENSMUSG00000020676 Ccl11 ENSMUSG00000028637ENSMUSG00000035352 Ccl12 ENSMUSG00000049305ENSMUSG00000035385 Ccl2 ENSMUSG00000022665ENSMUSG00000018930 Ccl4 ENSMUSG00000041431ENSMUSG00000035373 Ccl7 ENSMUSG00000000184ENSMUSG00000009185 Ccl8 ENSMUSG00000024286ENSMUSG00000027863 Cd2 ENSMUSG00000079355ENSMUSG00000062082 Cd200r4 ENSMUSG00000034652ENSMUSG00000031494 Cd209a ENSMUSG00000028873ENSMUSG00000051906 Cd209f ENSMUSG00000019942ENSMUSG00000047798 Cd300lf ENSMUSG00000070777ENSMUSG00000004609 Cd33 ENSMUSG00000028137ENSMUSG00000030798 Cd37 ENSMUSG00000001128ENSMUSG00000032094 Cd3d ENSMUSG00000018474ENSMUSG00000018774 Cd68 ENSMUSG00000030157ENSMUSG00000038147 Cd84 ENSMUSG00000030155ENSMUSG00000053977 Cd8a ENSMUSG00000022748ENSMUSG00000047216 Cdh19 ENSMUSG00000028444ENSMUSG00000044303 Cdkn2a ENSMUSG00000016356ENSMUSG00000014686 Ceacam16 ENSMUSG00000025650ENSMUSG00000023031 Cela1 ENSMUSG00000025607ENSMUSG00000030159 Clec1b ENSMUSG00000026240ENSMUSG00000030144 Clec4d ENSMUSG00000025867ENSMUSG00000079293 Clec7a ENSMUSG00000023968ENSMUSG00000022483 Col2a1 ENSMUSG00000032384ENSMUSG00000025488 Cox8b ENSMUSG00000056763ENSMUSG00000003617 Cp ENSMUSG00000027797ENSMUSG00000014599 Csf1 ENSMUSG00000026648ENSMUSG00000071713 Csf2rb ENSMUSG00000062393ENSMUSG00000062783 Csprs ENSMUSG00000056752ENSMUSG00000068129 Cst7 ENSMUSG00000024136ENSMUSG00000004552 Ctse ENSMUSG00000003812ENSMUSG00000038642 Ctss ENSMUSG00000035711ENSMUSG00000052336 Cx3cr1 ENSMUSG00000033554ENSMUSG00000034855 Cxcl10 ENSMUSG00000061576ENSMUSG00000023078 Cxcl13 ENSMUSG00000020648ENSMUSG00000048521 Cxcr6 ENSMUSG00000020888ENSMUSG00000006519 Cyba ENSMUSG00000020483ENSMUSG00000024365 Cyp21a1 ENSMUSG00000055657ENSMUSG00000026170 Cyp27a1 NAENSMUSG00000025479 Cyp2e1 ENSMUSG00000027524ENSMUSG00000028713 Cyp4b1 ENSMUSG00000036698ENSMUSG00000073478 D730003I15Rik ENSMUSG00000027236ENSMUSG00000017734 Dbndd2 ENSMUSG00000037174ENSMUSG00000061313 Ddhd2 ENSMUSG00000004415ENSMUSG00000040296 Ddx58 ENSMUSG00000030172ENSMUSG00000037921 Ddx60 ENSMUSG00000040857ENSMUSG00000044748 Defb1 ENSMUSG00000017802ENSMUSG00000020871 Dlx4 ENSMUSG00000039599ENSMUSG00000033335 Dnm2 ENSMUSG00000073805ENSMUSG00000044719 E230025N22Rik ENSMUSG00000069911ENSMUSG00000059606 Ear5 ENSMUSG00000039187ENSMUSG00000021367 Edn1 ENSMUSG00000006369

ENSMUSG00000022468 Endou ENSMUSG00000028086ENSMUSG00000028434 Epb4.1l4b ENSMUSG00000049122ENSMUSG00000026383 Epb4.1l5 ENSMUSG00000021765ENSMUSG00000021709 Erbb2ip ENSMUSG00000024462ENSMUSG00000036552 Ermard ENSMUSG00000023333ENSMUSG00000026830 Ermn ENSMUSG00000073558ENSMUSG00000021280 Exoc3l4 ENSMUSG00000085568ENSMUSG00000030630 Fah ENSMUSG00000072934ENSMUSG00000041930 Fam222a ENSMUSG00000058934ENSMUSG00000042377 Fam83g ENSMUSG00000078117ENSMUSG00000021186 Fbln5 ENSMUSG00000096323ENSMUSG00000026656 Fcgr2b NAENSMUSG00000059498 Fcgr3 NAENSMUSG00000027356 Fermt1 NAENSMUSG00000048373 Fgfbp1 ENSMUSG00000091595ENSMUSG00000005320 Fgfr4 ENSMUSG00000087235ENSMUSG00000068699 Flnc ENSMUSG00000068879NA Flo11 NAENSMUSG00000042353 Frem3 NAENSMUSG00000037280 Galnt6 NAENSMUSG00000025858 Get4 ENSMUSG00000023120ENSMUSG00000020932 Gfap ENSMUSG00000053861ENSMUSG00000039264 Gimap3 ENSMUSG00000052229ENSMUSG00000060956 Gm10092 ENSMUSG00000008734ENSMUSG00000067698 Gm10220 ENSMUSG00000024459ENSMUSG00000073403 Gm10499 ENSMUSG00000035929ENSMUSG00000073738 Gm10567 ENSMUSG00000028778ENSMUSG00000074303 Gm10664 ENSMUSG00000031936NA Gm10725 ENSMUSG00000069301NA Gm10791 ENSMUSG00000069307ENSMUSG00000090222 Gm16340 ENSMUSG00000060639ENSMUSG00000091718 Gm16506 ENSMUSG00000081058NA Gm3161 ENSMUSG00000027875NA Gm3643 ENSMUSG00000031245ENSMUSG00000092624 Gm3654 ENSMUSG00000063730ENSMUSG00000055942 Gm4745 ENSMUSG00000020361ENSMUSG00000037849 Gm4955 ENSMUSG00000020429ENSMUSG00000079244 Gm5622 ENSMUSG00000035551NA Gm6521 ENSMUSG00000037995ENSMUSG00000091131 Gm7945 ENSMUSG00000041324ENSMUSG00000092148 Gm8005 ENSMUSG00000028894ENSMUSG00000096446 Gm8104 ENSMUSG00000035578ENSMUSG00000091725 Gm8220 ENSMUSG00000051243ENSMUSG00000091569 Gm8232 ENSMUSG00000021767ENSMUSG00000091122 Gm8247 ENSMUSG00000037610ENSMUSG00000091605 Gm8256 NAENSMUSG00000090555 Gm8893 ENSMUSG00000016346ENSMUSG00000073402 Gm8909 ENSMUSG00000002778ENSMUSG00000090440 Gm9732 ENSMUSG00000030180ENSMUSG00000033219 Gm9758 ENSMUSG00000079553ENSMUSG00000089672 Gp49a ENSMUSG00000029414ENSMUSG00000029816 Gpnmb ENSMUSG00000035606ENSMUSG00000063234 Gpr84 ENSMUSG00000022802ENSMUSG00000042351 Grap2 ENSMUSG00000024590ENSMUSG00000021095 Gsc NAENSMUSG00000030206 Gsg1 NAENSMUSG00000001665 Gstt3 NAENSMUSG00000016206 H2-M3 ENSMUSG00000075224ENSMUSG00000024334 H2-Oa ENSMUSG00000039108ENSMUSG00000004894 Hapln2 ENSMUSG00000068205ENSMUSG00000020399 Havcr2 ENSMUSG00000046942

ENSMUSG00000024986 Hhex ENSMUSG00000047238ENSMUSG00000000628 Hk2 ENSMUSG00000026941ENSMUSG00000024165 Hn1l ENSMUSG00000040390ENSMUSG00000071001 Hrct1 ENSMUSG00000092035ENSMUSG00000047759 Hs3st3a1 ENSMUSG00000022269ENSMUSG00000064267 Hvcn1 ENSMUSG00000028979ENSMUSG00000062488 I830012O16Rik ENSMUSG00000059436ENSMUSG00000073489 Ifi204 ENSMUSG00000018160ENSMUSG00000064215 Ifi27l1 ENSMUSG00000030291ENSMUSG00000079017 Ifi27l2a ENSMUSG00000070462ENSMUSG00000010358 Ifi35 ENSMUSG00000074480ENSMUSG00000026896 Ifih1 ENSMUSG00000038244ENSMUSG00000034459 Ifit1 ENSMUSG00000022724ENSMUSG00000074896 Ifit3 ENSMUSG00000097391ENSMUSG00000076617 Ighm ENSMUSG00000031004ENSMUSG00000076555 Igkv4-57-1 ENSMUSG00000018623ENSMUSG00000016524 Il19 ENSMUSG00000028709ENSMUSG00000027399 Il1a ENSMUSG00000066415ENSMUSG00000024810 Il33 ENSMUSG00000037795ENSMUSG00000024210 Ip6k3 ENSMUSG00000044442ENSMUSG00000026638 Irf6 ENSMUSG00000039396ENSMUSG00000025498 Irf7 ENSMUSG00000055761ENSMUSG00000041515 Irf8 ENSMUSG00000033768ENSMUSG00000031738 Irx6 ENSMUSG00000066392ENSMUSG00000030789 Itgax ENSMUSG00000059146ENSMUSG00000000708 Kat2b ENSMUSG00000037857ENSMUSG00000050063 Klk6 ENSMUSG00000075124NA Krt85 ENSMUSG00000094878ENSMUSG00000091212 Krtap11-1 ENSMUSG00000094488ENSMUSG00000030124 Lag3 ENSMUSG00000060888ENSMUSG00000055541 Lair1 ENSMUSG00000094380ENSMUSG00000037295 Ldlrap1 ENSMUSG00000042616ENSMUSG00000033880 Lgals3bp ENSMUSG00000020745ENSMUSG00000062593 Lilrb4 ENSMUSG00000039913ENSMUSG00000063804 Lin28b ENSMUSG00000007440ENSMUSG00000022500 Litaf ENSMUSG00000054728NA LOC102636283 ENSMUSG00000045140NA LOC102641463 ENSMUSG00000051177ENSMUSG00000018819 Lsp1 ENSMUSG00000026173ENSMUSG00000073413 Ly6g6d ENSMUSG00000038943ENSMUSG00000069515 Lyz1 ENSMUSG00000021938ENSMUSG00000069516 Lyz2 ENSMUSG00000041552ENSMUSG00000042622 Maff ENSMUSG00000020154ENSMUSG00000004864 Mapk13 ENSMUSG00000025314ENSMUSG00000021936 Mapk8 ENSMUSG00000030223ENSMUSG00000038732 Mboat1 ENSMUSG00000025140ENSMUSG00000001493 Meox1 ENSMUSG00000020175ENSMUSG00000045555 Mettl24 ENSMUSG00000021700ENSMUSG00000026303 Mlph ENSMUSG00000020907ENSMUSG00000043613 Mmp3 ENSMUSG00000049191ENSMUSG00000061778 Mospd2 ENSMUSG00000071772ENSMUSG00000046805 Mpeg1 NAENSMUSG00000056290 Ms4a4b ENSMUSG00000041740ENSMUSG00000024675 Ms4a4c ENSMUSG00000032128ENSMUSG00000030681 Mvp ENSMUSG00000031309ENSMUSG00000000386 Mx1 ENSMUSG00000020649ENSMUSG00000041361 Myzap ENSMUSG00000000037ENSMUSG00000078945 Naip2 ENSMUSG00000057182ENSMUSG00000082956 Naip3 ENSMUSG00000016763ENSMUSG00000092274 Neat1 ENSMUSG00000027879ENSMUSG00000045502 Niacr1 ENSMUSG00000035139

ENSMUSG00000058669 Nkx2-9 ENSMUSG00000035093ENSMUSG00000041309 Nkx6-2 ENSMUSG00000038384ENSMUSG00000015721 Nlrp5 ENSMUSG00000033732ENSMUSG00000041596 Nlrp5-ps ENSMUSG00000061186ENSMUSG00000014776 Nol3 ENSMUSG00000042216ENSMUSG00000052776 Oas1a ENSMUSG00000042743ENSMUSG00000053765 Oas1f ENSMUSG00000053550ENSMUSG00000041827 Oasl1 ENSMUSG00000027932ENSMUSG00000029561 Oasl2 ENSMUSG00000085028ENSMUSG00000042694 Obfc1 ENSMUSG00000030307ENSMUSG00000054310 Obox1 ENSMUSG00000054640ENSMUSG00000074366 Obox5 ENSMUSG00000046699ENSMUSG00000079239 Olfr1082 NAENSMUSG00000095893 Olfr884 ENSMUSG00000071669ENSMUSG00000043013 Onecut1 ENSMUSG00000063632ENSMUSG00000074063 Osgin1 ENSMUSG00000045179ENSMUSG00000022146 Osmr ENSMUSG00000022519ENSMUSG00000029468 P2rx7 ENSMUSG00000055436ENSMUSG00000028927 Padi2 ENSMUSG00000040287ENSMUSG00000051599 Pcdhb2 ENSMUSG00000015981ENSMUSG00000045498 Pcdhb3 ENSMUSG00000042473ENSMUSG00000045689 Pcdhb4 ENSMUSG00000006642ENSMUSG00000045062 Pcdhb7 ENSMUSG00000016150ENSMUSG00000045876 Pcdhb8 ENSMUSG00000047146ENSMUSG00000051242 Pcdhb9 ENSMUSG00000028640ENSMUSG00000004347 Pde1c ENSMUSG00000021702ENSMUSG00000044703 Phf11a ENSMUSG00000036151ENSMUSG00000091649 Phf11b ENSMUSG00000058569ENSMUSG00000023452 Pisd ENSMUSG00000061702ENSMUSG00000082286 Pisd-ps1 ENSMUSG00000024793NA Pisd-ps3 ENSMUSG00000021071ENSMUSG00000002847 Pla1a ENSMUSG00000043909ENSMUSG00000038349 Plcl1 ENSMUSG00000091166ENSMUSG00000052160 Pld4 ENSMUSG00000030276ENSMUSG00000020120 Plek ENSMUSG00000045136ENSMUSG00000018217 Pmp22 ENSMUSG00000001403ENSMUSG00000046008 Pnlip ENSMUSG00000029203ENSMUSG00000039457 Ppl ENSMUSG00000062151ENSMUSG00000045679 Pqlc3 ENSMUSG00000090115ENSMUSG00000028591 Pramef12 ENSMUSG00000067215ENSMUSG00000041669 Prima1 ENSMUSG00000057363ENSMUSG00000029053 Prkcz ENSMUSG00000070844ENSMUSG00000027376 Prom2 ENSMUSG00000039951ENSMUSG00000022912 Pros1 ENSMUSG00000037029ENSMUSG00000091080 Prr23a ENSMUSG00000036036ENSMUSG00000006179 Prss16 ENSMUSG00000089857ENSMUSG00000048752 Prss50 ENSMUSG00000059423ENSMUSG00000026730 Pter ENSMUSG00000034557ENSMUSG00000026735 Ptf1a ENSMUSG00000026974ENSMUSG00000024518 RaxENSMUSG00000031167 Rbm3ENSMUSG00000021876 Rnase4ENSMUSG00000081640 Rplp0-ps1ENSMUSG00000027422 Rrbp1ENSMUSG00000033355 Rtp4ENSMUSG00000001020 S100a4ENSMUSG00000001025 S100a6ENSMUSG00000047735 Samd9lENSMUSG00000035673 Sbno2ENSMUSG00000057135 ScimpENSMUSG00000066366 Serpina1a

ENSMUSG00000079015 Serpina1cENSMUSG00000071177 Serpina1dENSMUSG00000072849 Serpina1eENSMUSG00000021091 Serpina3nENSMUSG00000037411 Serpine1ENSMUSG00000038224 Serpinf2ENSMUSG00000005202 ShbgENSMUSG00000039013 Siglec5ENSMUSG00000053318 Slamf8ENSMUSG00000009378 Slc16a12ENSMUSG00000018566 Slc2a4ENSMUSG00000028412 Slc44a1ENSMUSG00000030109 Slc6a12ENSMUSG00000072621 Slfn10-psENSMUSG00000035208 Slfn8ENSMUSG00000036867 Smad6ENSMUSG00000073458 Smok2aENSMUSG00000073457 Smok2bENSMUSG00000079711 Smok4aENSMUSG00000028885 Smpdl3bENSMUSG00000039452 Snx22ENSMUSG00000053113 Socs3ENSMUSG00000070031 Sp140ENSMUSG00000048703 Speer4bENSMUSG00000070933 Speer4dENSMUSG00000091255 Speer4eENSMUSG00000091358 Speer5-ps1ENSMUSG00000029304 Spp1ENSMUSG00000022463 Srebf2ENSMUSG00000027007 Ssfa2ENSMUSG00000031995 St14ENSMUSG00000032437 Stt3bENSMUSG00000027882 Stxbp3aENSMUSG00000023122 Sult1c2ENSMUSG00000050315 Synpo2ENSMUSG00000009097 Tbx1ENSMUSG00000026380 Tfcp2l1ENSMUSG00000022218 Tgm1ENSMUSG00000001131 Timp1ENSMUSG00000044583 Tlr7ENSMUSG00000068327 Tlx2ENSMUSG00000050854 Tmem125ENSMUSG00000034435 Tmem30bENSMUSG00000041737 Tmem45bENSMUSG00000019961 TmpoENSMUSG00000021281 Tnfaip2ENSMUSG00000063727 Tnfrsf11bENSMUSG00000028965 Tnfrsf9ENSMUSG00000022015 Tnfsf11ENSMUSG00000014846 Tppp3ENSMUSG00000019787 TrdnENSMUSG00000023992 Trem2

ENSMUSG00000071068 Treml2ENSMUSG00000032554 TrfENSMUSG00000030921 Trim30aENSMUSG00000052749 Trim30bENSMUSG00000057596 Trim30dENSMUSG00000034317 Trim59ENSMUSG00000039691 Tspan10ENSMUSG00000030579 TyrobpENSMUSG00000026956 Uap1l1ENSMUSG00000036908 Unc93b1ENSMUSG00000049436 Upk1bENSMUSG00000030107 Usp18ENSMUSG00000026175 Vil1ENSMUSG00000026728 VimENSMUSG00000073131 Vma21ENSMUSG00000092496 Vmn1r-ps84ENSMUSG00000074291 Vmn1r168ENSMUSG00000001930 VwfENSMUSG00000075284 Wipf1ENSMUSG00000040483 Xaf1NA XM_006535594.1ENSMUSG00000047412 Zbtb44ENSMUSG00000029826 Zc3hav1ENSMUSG00000014198 Zfp385cENSMUSG00000066838 Zfp772ENSMUSG00000039599 Fam149b

Microarray3M vs. >29M downregulated

330 probes (283 genes)

1110006E14Rik Col20a11110032A03Rik Copg2RP23-45G16.5 Gabbr11700023E05Rik Hspa42310005E17Rik Masp22610028H24Rik Mki672810021J22Rik Oscp14122401K19Rik Sfmbt24833421G17Rik Tubb2b4833422M21Rik Ube2c4930452G13Rik Zmynd194930523C07Rik Igh4930563J15Rik4933405E24Rik4933408B17Rik5330439B14Rik5430427O19Rik5430431A17Rik5730409E04Rik5730577I03Rik5930433N17Rik6530403H02Rik6720407P12Rik7530428D23Rik9530059O14Rik9630013A20RikA130077B15RikA430105J06RikA630031M23RikA630073K07RikA730081D07RikIghAdamts18AirnAkap11Ankfy1Anks1bAp2b1Ap3b2Apcdd1Arl15AspmAtcayAtp2b3AuhAvilB230104I21RikB930025P03RikB930095M22RikBC030499Bdp1

MGI Symbol / Gene name

Genes with multiple significant probes

C230037L09Cacna2d1Cacng4Calb1Cbx2Cbx8Ccdc173Ccdc28bCcdc30Ccdc71Ccdc80Ccnb1Ccnd2CcnyAckr4Cd300aCdca8Cdk1Ceacam20Celf3CfpChd3Clec2dClec2eCmss1CntfrCol20a1Col7a1Copg2Cops7bCplx2Crip3Csnk1g1Cspp1Dclk1Dclre1cDgkkDnah9Dnase1l2Dnase2aDok3Dph5Dpp6Dus4lDvl2Dynll2E030030I06RikE130101M22Edn3Ago2Eif3j1Elf2Col26a1Erc1ErfFam134cFam149bFam196aFam196bFanciFbln1

Fbxw7Frmd3FstGabbr1Gcm1Gm10536Gm14858Gm15070Gm16176Gm16485Gm20767Gm2483Gm2545Gm2710Gm3344Gm4750Gm5773Gm5785Gm5820Gm8479Gm853Gm9925Gpr17Gprc5bH2-M5H2-Q4Hcrtr1Hephl1Hist1h2agHist1h2bqHist1h4iHist2h3c2Hmgcs2Hmgn5Hsd3b2Hspa4Igfbp1Igfbpl1Igsf9InhbaInpp5bIqcgIslr2Kat6bKcnmb2Kcnq1ot1Kcnq2Kdelr1Kdm5aKifc1Kntc1KyLmlnLmnb1LOC101055656LOC552873LOC553089Lrrc55Lsm14bMacrod2Mageb16

Mageh1Mamdc4Map3k10Peg10March11Masp2MaxMed1Med21Mesdc1Mex3aMical2MinaMirgMki67Mmp7Mob3cMsl2N4bp2N6amt1Neil3Nkain3Nrxn2Nrxn3Ntrk3Nufip2Olfr1182Olfr130Olfr393Olfr566Olfr904Oscp1Pafah1b1Pak7Pcdha2Phactr1PigwPlcb1Plcd4Prc1Pspc1Ptchd1PtprbPtprjPtproPycr1Rab36Rab3cRcvrnRgag4Rhox3aRn28s1Rnf10Robo3Rps6ka3Rrm2Scml2Scn3aScube1Sec22bSecisbp2

Secisbp2lSetd1bSf3b3Sfmbt2Sgsm1SgtbShisa7Slc27a3Slc2a4rg-psSlc6a11Slc8a1Slitrk4SlySnx29Sox11Sox3SrlSrsf11Stac3Stk32cTbc1d8bTcf23Tenm1Tet1Tfap2cThbs4Tm6sf2Tmed9Tmem91Tnfrsf25Trim9Trp53bp1Tstd1Ttll3Tubb2bUbe2cUbe2kUnc13cUsp49Usp51Uxs1Vmn2r42Wfdc3Zfp146Zfp57Zfp882Zfp933Zfyve9Zmynd19

Commonly up-regulated genes in 24- and 29-month-old mice

Cd44Lsp1CtssCd74Fcgr3C1raFlncI830012O16RikIghmCybbUsp18Ifit3B2mSamd9lLat2TyrobpPcdhb9Uba7Hapln2H2-D1Arl11S100a6CapgUbe2l6GfapHavcr2Myo1fCdh19Scn7aAgmoLag3Ifi27l1Cd22C1qaTfcp2l1Ly9Onecut1Zc3hav1Lgals3bpMlphH2-AaC4bXdhItgax

1700112E06RikItgb2Prom2TrfPld4Fcgr2bNeat1Parp14Gpr84Pcdhb6C3Klk6BC061194Serpine1IgkcGm16551Hif3aPisd-ps1Il33Oasl2Alas2Fbxw15H2-DMb1Pcdhb2Gstt3Ddx60Aldh1l2Trim30aIrf7Cst7Mettl24Trim30dLair1PlekHpgdsVimCd68Ifit1ApodCyp2e1Sult1c2Pcdhb3S100a4GpnmbAF251705Aspg

Naalad2Icam1Ifi27l2aIfitm3Cox8bSult1c1B230206H07RikPcdhb5Irf8Mpeg1Rtp4Acer2Abca8aPtprcLyz2Clec7aPmp22C3ar1Pcdhb8Rasal3Gm11681Upk1bPlin4Fmo2Naip2OsmrTrem2Cd84Serpina3nAC107641.1Rnf207Bst2

Commonly down-regulated genes in 24- and 29-month-old mice

Gpr165Pycr1CrygnRetGlra2Hs3st2Gpr17Trim67NrepIgfbpl1Chst3TncCbx8Cdh6Top2aGlp1rGnb4

706 MGI genes 461 MGI genes1500011B03Rik 1110006E14Rik1700012P22Rik 1110032A03Rik1700016D02Rik 1500002C15Rik1700049E17Rik1 1700023E05Rik1700091H14Rik 1700069B07Rik1700112E06Rik 2310005E17Rik1810019J16Rik 2410018L13Rik2010005H15Rik 2610028H24Rik2610018G03Rik 2810021J22Rik2700046A07Rik 4122401K19Rik2700089I24Rik 4833421G17Rik2810403D21Rik 4833422M21Rik2810410L24Rik 4930452G13Rik3222401L13Rik 4930523C07Rik4930401C15Rik 4930563J15Rik4930427A07Rik 4932411E22Rik4930447C04Rik 4933405E24Rik4930529F21Rik 4933408B17Rik5730416F02Rik 5330439B14Rik5830411N06Rik 5430427O19Rik8430408G22Rik 5430431A17Rik9330132A10Rik 5730409E04Rik9930111J21Rik2 5730577I03RikA230001M10Rik 5830403L16RikA230009B12Rik 5930433N17RikA330015K06Rik 6530403H02RikA330049N07Rik 6720407P12RikA4galt 7530428D23RikA530040E14Rik 9430041J12RikA630023P12Rik 9530059O14RikA630081J09Rik 9630013A20RikA830019P07Rik A130077B15RikA830036E02Rik A430105J06RikA930026B05Rik A630031M23RikAA414992 A630073K07RikAA467197 A730081D07RikAbca8a AC102484.1AC107641.1 AC131692.1AC114820.1 AC163292.1AC136008.1 Ackr4AC164431.1 Adamts18AC207128.1 Adora2aAcer2 Adra1bAcer3 Ago2Adamtsl3 AirnAdssl1 Akap11Aebp1 Angptl4AF251705 Ankfn1Agmo Ankfy1Agxt2l1 Ankrd34cAhnak Anks1bAI480526 Ano2AI607873 Ap2b1Aim2 Ap3b2

Genes upregulated (3M vs. Aging)

Genes downregulated (3M vs. Aging)

Akr1c13 Apcdd1Akr1c14 ArcAL603843.1 Arhgap36AL714024.1 Arl15Alas2 Asb4Aldh1a2 AspmAldh1a3 AtcayAldh1l2 Atp2b3Alox12b Atp2b4Alox5 Atp6ap1lAmy1 AuhAngpt2 AvilAngpt4 Avpr1aAngptl1 B230104I21RikAnln B930025P03RikAnxa1 B930095M22RikAnxa3 Baiap3Anxa4 Barx2Apobr Bbc3Apod BC030499Apol9a Bdp1Apol9b Bmp3Arhgap30 Btg2Arhgap4 C130074G19RikArl11 C230037L09Arntl2 Cacna2d1Arxes2 Cacna2d4Asb16 Cacng4Aspa Calb1Aspg Car8Atxn7l2 CartptAY358078 Cbx2B230206H07Rik Cbx8B2m Ccdc173B430306N03Rik Ccdc28bBatf3 Ccdc30BC030476 Ccdc71BC051142 Ccdc80BC061194 CckbrBC061237 Ccnb1BC100530 Ccnd2Bcl3 CcnyBdkrb2 Cd300aBfsp2 Cd4Bmi1 Cd6Bmp6 Cdca8Bmp7 Cdh6Bst2 Cdk1Btc Cdkn1aC130026I21Rik Ceacam20C1qa Celf3C1qb CfpC1qc Chd3C1ra Chrna2C2 Chst3C3 Chsy3C3ar1 Cilp2C4a Ckap2l

C4b Cldn5Calcrl Clec2dCapg Clec2eCar13 Cmss1Casp1 CntfrCav1 Col20a1Ccdc122 Col26a1Ccl11 Col3a1Ccl12 Col6a4Ccl2 Col7a1Ccl4 Copg2Ccl6 Cops7bCcl7 Cplx2Ccl8 Cplx3Ccnc Crhr1Cd109 Crip3Cd160 CrygnCd163 Csnk1g1Cd180 Cspp1Cd2 Cux2Cd200r4 Cyp11a1Cd209a D330050G23RikCd209f Dclk1Cd22 Dclre1cCd300lf DcxCd33 Derl3Cd37 DgkkCd3d Dkkl1Cd44 Dnah9Cd46 Dnase1l2Cd48 Dnase2aCd52 Dok3Cd68 Dph5Cd74 Dpp6Cd84 DraxinCd86 Dus4lCd8a Dusp1Cdh19 Dvl2Cdh23 Dynll2Cdhr2 E030030I06RikCdkn2a E130101M22Ceacam16 Ecel1Cela1 Edn3Cfh Egr1Ch25h Egr2Chek1 Egr4Chi3l1 Eif3j1Chpt1 Elf2Cldn22 EomesClec1a Erc1Clec1b ErfClec4d EvplClec5a Fabp7Clec7a Fam134cClic5 Fam149bCmklr1 Fam181aCol27a1 Fam196aCol2a1 Fam196b

Col6a1 Fam47eCoro6 FanciCox8b Fbln1Cp Fbxw7Cped1 Fhod3CR293526.1 Fndc9Crlf2 FosCsf1 Frmd3Csf2rb FstCsf2rb2 Gabbr1Csf3r Gcm1Csprs Gfra2Cst7 Glp1rCtnna3 Glra2Ctse Glra3Ctss Gm10293Cx3cr1 Gm10536Cxcl10 Gm11410Cxcl13 Gm11762Cxcl16 Gm11808Cxcl5 Gm12174Cxcr6 Gm12346Cyba Gm12350Cybb Gm12371Cyp21a1 Gm13716Cyp27a1 Gm14858Cyp2e1 Gm15070Cyp2j12 Gm15427Cyp4b1 Gm15721D730003I15Rik Gm15879Dbndd2 Gm16176Ddhd2 Gm16485Ddx58 Gm20767Ddx60 Gm2223Defb1 Gm2415Dlx4 Gm2483Dmgdh Gm2545Dnm2 Gm2710Dock2 Gm3344E230025N22Rik Gm4750Ear5 Gm5187Eda2r Gm5499Edn1 Gm5773Efemp1 Gm5785Elf4 Gm5820Emr1 Gm7901Endou Gm8355Epb4.1l4b Gm8479Epb4.1l5 Gm853Epsti1 Gm9925Epyc Gnb4Erbb2ip Gpr165Ermard Gpr17Ermn Gpr21Exoc3l4 Gpr55Eya4 Gpr6Fah Gpr88Fam149b Gprc5b

Fam222a Grrp1Fam83g H2-M5Fbln5 H2-Q4Fbxw15 Hcn4Fcer1g Hcrtr1Fcgr2b Hephl1Fcgr3 Hist1h1cFcho2 Hist1h2agFermt1 Hist1h2bqFermt3 Hist1h4iFes Hist2h3c2Fgfbp1 Hmgcs2Fgfr4 Hmgn5Fgl2 HrFigf Hrh1Flnc Hs3st2Flo11 Hsd3b2Fmo2 Hspa4Frem3 Ier2Frmd7 Ier5Fyb Ier5lGalnt15 Igfbp1Galnt6 Igfbpl1Gas2l3 IghGatm Igsf21Gbp2 Igsf9Gbp3 InhbaGbp6 Inpp5bGbp7 IqcgGet4 Irs4Gfap Islr2Gimap3 JunbGm10092 Kat6bGm10220 Kcnh5Gm10311 Kcnmb2Gm10499 Kcnq1ot1Gm10567 Kcnq2Gm10654 Kdelr1Gm10664 Kdm5aGm10725 Kif11Gm10791 Kif19aGm11611 Kifc1Gm11681 Kntc1Gm12709 Krt15Gm12758 Krtcap3Gm129 KyGm12940 Lamp5Gm13334 LaynGm13344 Lingo4Gm14285 LmlnGm1564 Lmnb1Gm16185 LOC101055656Gm16340 LOC552873Gm16506 LOC553089Gm16551 Lrrc55Gm17066 Lsm14bGm24703 Macrod2Gm25047 Mageb16

Gm25749 Mageh1Gm3161 Magel2Gm3643 Mamdc4Gm3654 Map3k10Gm4745 March11Gm4924 Masp2Gm4944 MaxGm4955 Med1Gm514 Med21Gm5526 Mesdc1Gm5622 Mex3aGm6521 Mical2Gm7308 MinaGm7945 MirgGm8005 Mki67Gm8104 MmeGm8220 Mmp7Gm8232 Mob3cGm8247 Msl2Gm8256 Msx2Gm8893 MycnGm8909 N4bp2Gm9732 N6amt1Gm9758 Neil3Gmnc NgbGp49a Nkain3Gpnmb Npas4Gpr115 Npffr1Gpr22 Nr4a1Gpr34 NrepGpr84 NrmGrap2 Nrxn2Gsc Nrxn3Gsdmd Ntrk3Gsg1 Ntsr1Gstm2 Nudt1Gstt3 Nuf2H2-Aa Nufip2H2-D1 Oaz1-psH2-DMb1 Olfm2H2-Eb1 Olfr1182H2-K1 Olfr130H2-M3 Olfr393H2-Oa Olfr566H2-Ob Olfr904H2-Q1 Oscp1H2-Q4 OtofH2-Q6 Ovol2H2-Q7 Pafah1b1H2-T10 Pak7H2-T23 Pcdh18Hapln2 Pcdh7Has1 Pcdha2Havcr2 Pcsk9Hba-a1 PdynHck Peg10Herc6 Phactr1Hhex Pigw

Hif3a Plcb1Hk2 Plcd4Hmha1 Plin5Hn1l Plxnd1Hoga1 PostnHpgds Pou3f4Hrct1 Prc1Hs3st3a1 Prdm12Hs3st3b1 Prom1Hvcn1 PrxI830012O16Rik Pspc1Icam1 Ptchd1Ifi204 PtprbIfi27l1 PtprjIfi27l2a PtproIfi30 Pycr1Ifi35 Rab36Ifih1 Rab3cIfit1 Rasgef1bIfit2 Rasgef1cIfit3 RASSF10Ifitm3 RcvrnIghm RetIgkc Rgag4Igkv4-57-1 Rgs6Igsf6 Rgs9Il19 Rhox3aIl1a Rn28s1Il21r Rnd1Il33 Rnf10Il3ra Rnf122Ip6k3 Robo3Irf5 RP23-45G16.5Irf6 RP23-81C12.1Irf7 Rpl10a-ps1Irf8 Rpl14-ps1Irf9 Rps6ka3Irgm1 Rrm2Irgm2 Rspo1Irx6 Satb2Itgax Scml2Itgb2 Scn3aKat2b Scn5aKcnmb2 Scube1Klk6 Sec22bKrt20 Secisbp2Krt85 Secisbp2lKrtap11-1 Sema5bLag3 Setd1bLair1 Sf3b3Lat2 Sfmbt2Lcn2 SftpcLdlrap1 Sgsm1Leng8 SgtbLgals3 Shisa7Lgals3bp Slc27a3Lilrb4 Slc2a4rg-psLin28b Slc6a11

Lin7c Slc8a1Liph Slitrk4Lipo1 SlyLitaf SncaipLOC102636283 Snx29LOC102641463 SowahbLpar6 Sox11Lpcat2 Sox3Lpxn Sox4Lrrc39 Sp7Lrrn4 SrlLsp1 Srsf11Luc7l2 Sstr2Lum St8sia2Ly6g6d Stac3Ly6g6f Stk32cLy86 Tac2Ly9 Tacr3Lypla1 Tbc1d8bLyve1 Tcf23Lyz1 Tead2Lyz2 Tenm1Maff Tet1Malat1 Tfap2cMapk13 Thbs4Mapk8 Tm6sf2Mb21d1 Tmed9Mboat1 Tmem74bMc4r Tmem91Meg3 TncMeox1 Tnfrsf25Mettl24 Top2aMiat Trim67Mir5125 Trim9Mlph Trp53bp1Mmp19 Trpc3Mmp3 Trpv6mmu-let-7d Tstd1Mndal Ttc9bMospd2 Ttll3Mpeg1 Tubb2bMpzl2 Ube2cMs4a4b Ube2kMs4a4c Unc13cMtcp1 Usp43Mvp Usp49Mx1 Usp51Mybl1 Uxs1Myo1f Vcp-rsMyzap Vmn2r42Naa50 Wfdc3Naalad2 Wnt10aNaip2 Wnt2Naip3 Zfp146Naip5 Zfp57Nanos2 Zfp882Ncf1 Zfp933Ncrna00085 Zfyve9

Neat1 Zmynd19Niacr1Nipal2Nkx2-2asNkx2-9Nkx6-2Nlrc5Nlrp5Nlrp5-psNol3Nr1d2Oas1aOas1fOas2Oasl1Oasl2Obfc1Obox1Obox5OgnOlfr1082Olfr1507Olfr884OmdOnecut1Osgin1OsmrOvgp1P2rx7Padi2Parp12Parp14Pax2Pcdhb14Pcdhb2Pcdhb3Pcdhb4Pcdhb5Pcdhb6Pcdhb7Pcdhb8Pcdhb9Pde1cPdlim1Phf11aPhf11bPi15Pik3cgPisdPisd-ps1Pisd-ps3Pla1aPla2g3Pla2g4ePlcg2Plcl1Pld4Plek

Plekhh2Plin4Pls1Plscr1Pmp22PnlipPplPqlc3Pramef12Prdm6Prima1PrkczProm2Pros1Prox2Prpf39Prr23aPrrg1Prss16Prss23Prss50Psmb8Psmb9PterPtf1aPtpn6PtprcQkRanbp3lRasal3RaxRbm3Rccd1Rgs11Rnase4Rnf207Rnf213RP23-239L21.4RP23-275E20.1RP23-285C18.2RP23-32L5.4Rplp0-ps1Rps24-ps3Rrbp1Rreb1Rsad2Rtp1Rtp4Runx1S100a4S100a6Samd9lSamsn1Sbno2SbsnScelScimpScn7a

Sec14l5Serpina1aSerpina1cSerpina1dSerpina1eSerpina3nSerpind1Serpine1Serpinf2Serping1Sgk1Sh3bgrlShbgSiglec5Slamf8Slamf9Slc11a1Slc16a12Slc26a7Slc2a4Slc44a1Slc6a12Slc7a11Slfn10-psSlfn2Slfn8Smad6Smok2aSmok2bSmok4aSmpdl3bSncgSnhg11Snx22Socs3Sp100Sp140Speer4bSpeer4dSpeer4eSpeer5-ps1Spock3Spp1Srebf2Srsf10Ssfa2St14St8sia6Stat1Stt3bStxbp3aSult1a1Sult1c1Sult1c2Svep1SyncripSynpo2Tap1

Tap2Tbx1Tbx18Tfcp2l1Tgm1Timp1Tle2Tlr13Tlr2Tlr4Tlr7Tlx2Tmed5Tmem125Tmem27Tmem30bTmem45bTmpoTmprss11aTmprss5Tnfaip2Tnfaip8l2Tnfrsf11bTnfrsf8Tnfrsf9Tnfsf10Tnfsf11TnxbTppp3TrdnTrem2Treml2TrfTrim12aTrim12cTrim25Trim30aTrim30bTrim30dTrim59Tspan10TxlnbTyrobpUap1l1Uba7Ube2d3Ube2l6Unc93b1Upk1bUsp18Vav1Vil1VimVma21Vmn1r-ps84Vmn1r168VwfWipf1

Xaf1XdhXistXM_006535594.1Zbtb44Zc3hav1Zfp385cZfp677Zfp772Zfp931Zfp938Zfp942Zfp944Zxdb

RNA-seq3M vs >29M upregulated 3M vs >29M downregulated

15 ncRNAs 1 ncRNAENSEMBL-ID Gene Name Gene Biotype ENSEMBL-IDENSMUSG00000015451 C4a processed_transcript ENSMUSG00000043801ENSMUSG00000021268 Meg3 lincRNA ENSMUSG00000046721ENSMUSG00000048215 A630023P12Rik lincRNA ENSMUSG00000079297ENSMUSG00000066477 Gm16551 lincRNA ENSMUSG00000080776ENSMUSG00000075437 Gm11681 lincRNA ENSMUSG00000081051ENSMUSG00000082286 Pisd-ps1 pseudogene ENSMUSG00000082280ENSMUSG00000084890 A830036E02Rik antisense ENSMUSG00000083327ENSMUSG00000086844 B230206H07Rik processed_transcript ENSMUSG00000083899ENSMUSG00000087042 Gm11611 sense_intronic ENSMUSG00000084416ENSMUSG00000090086 AI480526 lincRNA ENSMUSG00000093798ENSMUSG00000092274 Neat1 lincRNA ENSMUSG00000095588ENSMUSG00000092341 Malat1 lincRNA ENSMUSG00000097814ENSMUSG00000092981 Mir5125 miRNAENSMUSG00000097225 A330076H08Rik lincRNAENSMUSG00000097267 1700109K24Rik lincRNAENSMUSG00000097507 Gm26538 lincRNAENSMUSG00000097588 Gm17388 lincRNAENSMUSG00000097767 Miat lincRNAENSMUSG00000097796 Gm16702 lincRNAENSMUSG00000097877 Gm26703 lincRNA

Color key:Overlapping ncRNAsPart of aging core gene set

ENSMUSG00000066477 Gm16551 lincRNA

RNA-seq3M vs >29M downregulated 3M vs 24Mm upregulated

1 ncRNA 19 ncRNAsGene Name Gene Biotype ENSEMBL-ID Gene Name Gene BiotypeOaz1-ps pseudogene ENSMUSG00000043498 9330132A10Rik pseudogeneRpl14-ps1 pseudogene ENSMUSG00000066477 Gm16551 lincRNAGm2223 pseudogene ENSMUSG00000073478 D730003I15Rik processed_transcriptGm12174 pseudogene ENSMUSG00000075437 Gm11681 lincRNAGm15427 pseudogene ENSMUSG00000079491 H2-T10 polymorphic_pseudogeneGm7901 pseudogene ENSMUSG00000081049 Rps24-ps3 pseudogeneVcp-rs pseudogene ENSMUSG00000081113 Gm7308 pseudogeneGm12346 pseudogene ENSMUSG00000082286 Pisd-ps1 pseudogeneRpl10a-ps1 pseudogene ENSMUSG00000084616 Gm25047 snRNAGm8355 pseudogene ENSMUSG00000084817 Gm5526 pseudogeneGm12350 pseudogene ENSMUSG00000084911 Gm16185 antisenseGm5101 lincRNA ENSMUSG00000085105 Gm12758 processed_transcript

ENSMUSG00000085181 Gm12709 antisenseENSMUSG00000085334 Gm12940 processed_transcriptENSMUSG00000086503 Xist lincRNAENSMUSG00000086509 Nkx2-2os antisenseENSMUSG00000086629 2810403D21Rik processed_transcriptENSMUSG00000086844 B230206H07Rik processed_transcriptENSMUSG00000087103 Gm13344 antisenseENSMUSG00000087524 Gm14285 antisenseENSMUSG00000091509 Gm17066 processed_transcriptENSMUSG00000092274 Neat1 lincRNAENSMUSG00000093226 Gm25749 miRNAENSMUSG00000094707 A830019P07Rik lincRNAENSMUSG00000097098 9330111N05Rik lincRNAENSMUSG00000097225 A330076H08Rik lincRNAENSMUSG00000097340 Gm26617 lincRNAENSMUSG00000097375 6720427I07Rik lincRNAENSMUSG00000097415 AU020206 lincRNAENSMUSG00000097462 9530026P05Rik lincRNAENSMUSG00000098160 Gm26974 processed_transcriptENSMUSG00000098239 Pclo lincRNA

RNA-seq Microarray3M vs 24Mm downregulated 3M vs >29M upregulated

8 ncRNAs 5 ncRNAsENSEMBL-ID Gene Name Gene Biotype ENSEMBL-IDENSMUSG00000070490 Gm10293 pseudogene NAENSMUSG00000073164 2410018L13Rik lincRNA NAENSMUSG00000082362 Gm5187 pseudogene NAENSMUSG00000083219 Gm11410 pseudogene ENSMUSG00000041596ENSMUSG00000084790 Gm15879 antisense ENSMUSG00000072109ENSMUSG00000084898 Gm12371 lincRNA ENSMUSG00000072621ENSMUSG00000085316 D330050G23Rik lincRNA ENSMUSG00000073403ENSMUSG00000085565 Gm15721 processed_transcript ENSMUSG00000073478ENSMUSG00000086119 Gm2415 lincRNA ENSMUSG00000074303ENSMUSG00000086155 9430041J12Rik processed_transcript ENSMUSG00000075389ENSMUSG00000086905 Gm13716 antisense ENSMUSG00000081640ENSMUSG00000087675 Gm11762 processed_transcript ENSMUSG00000081793ENSMUSG00000097182 A830009L08Rik lincRNA ENSMUSG00000082286ENSMUSG00000097404 Gm10814 lincRNA ENSMUSG00000082956ENSMUSG00000097971 Gm26917 processed_transcript ENSMUSG00000089633

ENSMUSG00000090222ENSMUSG00000090462ENSMUSG00000090555ENSMUSG00000091358ENSMUSG00000091605ENSMUSG00000091707ENSMUSG00000092274ENSMUSG00000092496ENSMUSG00000092624

Microarray3M vs >29M upregulated 3M vs >29M downregulated

5 ncRNAs 22nc RNAsGene Name Gene Biotype ENSEMBL-ID Gene Name2700089I24MRik ncRNA NA 2310005E17Rik4930401C15Rik ncRNA NA 4930452G13RikA330049N07Rik ncRNA NA 5330439B14RikNlrp5-ps pseudogene NA 5430431A17RikA530040E14Rik antisense NA 7530428D23RikSlfn10-ps pseudogene NA 9630013A20RikGm10499 pseudogene NA A130077B15RikD730003I15Rik processed_transcript NA B930025P03RikGm10664 processed_transcript NA Kcnq1ot12810410L24Rik processed_transcript NA LOC101055656Rplp0-ps1 pseudogene ENSMUSG00000058934 Gm161765730416F02Rik pseudogene ENSMUSG00000062470 5730577I03RikPisd-ps1 pseudogene ENSMUSG00000072934 Gm15070Naip3 pseudogene ENSMUSG00000078247 AirnA230009B12Rik antisense ENSMUSG00000085028 Slc2a4rg-psGm16340 pseudogene ENSMUSG00000085568 Gm148581700091H14Rik pseudogene ENSMUSG00000086209 4933405E24RikGm8893 pseudogene ENSMUSG00000086693 A730081D07RikSpeer5-ps1 pseudogene ENSMUSG00000087235 Gm4750Gm8256 pseudogene ENSMUSG00000091595 Gm3344Gm8224 pseudogene ENSMUSG00000097391 MirgNeat1 lincRNA ENSMUSG00000097619 4833422M21RikVmn1r-ps84 pseudogene ENSMUSG00000097736 9530059O14RikGm3654 pseudogene ENSMUSG00000097784 A430105J06Rik

ENSMUSG00000098097 6530403H02RikENSMUSG00000098318 RP23-45G16.5

Microarray3M vs >29M downregulated

22nc RNAsGene BiotypencRNAncRNAncRNAncRNAncRNAncRNAncRNAncRNAncRNAncRNAantisenseantisenseantisenseantisensepseudogeneprocessed_transcriptlincRNAprocessed_transcriptpseudogenepseudogenelincRNAlincRNAlincRNAlincRNAlincRNAlincRNA