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©2005 Surgical Planning Laboratory, ARR Slide 1
COPD: Phenotypes from CT analysis
Raul San Jose Estepar, Ph.D.
©2005 Surgical Planning Laboratory, ARR Slide 2
Clinical relevance
COPD is characterized by:•Airway narrowing/remodeling.•Parenchymal destruction.
Hypothesis: Improve diagnosis and therapeutic strategies by better understanding the mechanisms leading to airflow obstruction. This means that we can provide the therapy that is best suited for a given phenotype.
Goal: •Development of robust automated tool for analysis of CT chest scans.•Definition of COPD phenotypes.
©2005 Surgical Planning Laboratory, ARR Slide 3
Challenges for the Phenotype quest
Definition of lung mask
Airway analysis:•Lumen segmentation•Wall segmentation
Quantitative analysis
©2005 Surgical Planning Laboratory, ARR Slide 4
Lung mask
Lung mask extraction for a High Resolution CT scan
Definition of a lung mask is the first step of the processing pipeline.
Mask extraction allows lung mask density analysis.
©2005 Surgical Planning Laboratory, ARR Slide 5
Migration of methods originally developed for brain segmentation and vascular segmentationVessel segmentation: Lorigo et al. , 2001.
Brain segmentation: Pichon et al, 2003
Airways: From the brain to the lungs
Sponsored by NAC
©2005 Surgical Planning Laboratory, ARR Slide 6
Airway centerlines
Segmented airway and extracted centerline.
Airway centerlines serve as a tree representation of the airway structure
©2005 Surgical Planning Laboratory, ARR Slide 7
Airway inspection
Focusing on the airway wall by traveling along the airway.
New CT view in planes orthogonal to the airway.
©2005 Surgical Planning Laboratory, ARR Slide 8
Airway wall
Development of new methods for the segmentation of airway wall.
Challenge: wall not always visible due to occlusion with pulmonary vessels.
©2005 Surgical Planning Laboratory, ARR Slide 9
Quantitative analysis
Lung mask density.
Wall thickness.
Percentage of wall area.
Geometric measures: curvature of airway lumen.
Rate of change across airway generations.