3 parts of Respiration Glycolysis – may be

anaerobic TCA – Kreb’s Cycle Electron Transport Chain

aerobic – require oxygen

Krebs Cycle Pyruvate enters the mitochondrial

matrix and enters a preparatory step before entering the Kreb’s Cycle.

Refer to handout

Krebs Cycle Pyruvate enters the mitochondrial

matrix and is converted into acetyl coenzyme A (2-carbon molecule)

Krebs Cycle Acetyl CoA combines with oxaloacetate to

form citrate (citric acid). CoA is released, awaiting another pyruvate molecule.

Citrate loses water, converts to cis-Aconitate. Cis-Aconitate gains water to become isocitrate

Kreb’s Cycle An NAD+ is reduced to NADH

converting isocitrate into oxalosuccinate.

Oxalosuccinate loses a Carbon and becomes α-Ketoglutarate

Krebs Cycle α-Ketoglutarate (5-C) loses a Carbon and

becomes succinyl-CoA; another NAD+ is reduced

Krebs Cycle Succinyl-CoA releases the CoA,

forming succinate. At the same time, a GDP molecule is phosphorylated to make GTP. GTP transfers its P to ADP to make ATP

Krebs Cycle Succinate is converted into fumarate

by reducing FAD+ into FADH2

Krebs Cycle Fumarate reacts with water to form

a molecule of malate

Krebs Cycle Malate is converted into

oxaloacetate by reducing another NAD+ into NADH + H+

Oxaloacetate gets recycled

Krebs Cycle Output of one

pyruvate From prep step

1 CO2

1NADH + H+

From Krebs alone 2 CO2

3 NADH + H+

1 FADH2

1 ATP

What would the output be of ONE GLUCOSE molecule after the Krebs Cycle?