PREFACE Following its meeting in Bournemouth, UK, in 1993, Committee 1 of ICRP (the International Commission on Radiological Protection) proposed a Task Group to prepare a report on risk estimation for multifactorial diseases, including the possible implications for radiological protection. The Commission accepted this recommen- dation and established a Task Group, which began its work late in 1993. The purpose was to review comprehensively all existing literature on multifactorial diseases in man, examine models to estimate the impact of an increase in mutation rate on the prevalence of such diseases, and develop, to the extent possible, a scientiﬁc framework which will allow at least some tentative conclusions to be reached on the risk of multifactorial diseases and which will set the stage for further work in this area. The membership of the Task Group was as follows: K. Sankaranarayanan (Chairperson) E.A. Boerwinkle R. Chakraborty A.E. Czeizel C. Denniston N. Yasuda During the period of data review (1993–1998), the Task Group received assistance on the scope, data sources, and content of the report from the following corre- sponding members: J.F. Crow S.E. Humphries (until 1994) G. Michaeletzky (until 1995) W.J. Schull G. Tusnady (until 1995) The comments of J.F. Crow and W.J. Schull were particularly valuable to the Task Group. The Task Group also wishes to acknowledge the help of Dr. Y. Zhong with the illustrations and the assistance of Mrs. J. Pleging with the Tables. The membership of Committee 1 during the period of preparation of this report was: (1993–1997) W.K. Sinclair (Chairman) R. Cox (Secretary) R.J.M. Fry (Vice-Chairman) J.H. Hendry L.-E. Holm A.M. Kellerer C.E. Land J.B. Little K. Mabuchi R. Masse R.J. Preston P.V. Ramzaev K. Sankaranarayanan R.E. Shore C. Streer H.R. Withers D.-C. Wu ix

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PREFACE

Following its meeting in Bournemouth, UK, in 1993, Committee 1 of ICRP (theInternational Commission on Radiological Protection) proposed a Task Group toprepare a report on risk estimation for multifactorial diseases, including the possibleimplications for radiological protection. The Commission accepted this recommen-dation and established a Task Group, which began its work late in 1993.The purpose was to review comprehensively all existing literature on multi-

factorial diseases in man, examine models to estimate the impact of an increase inmutation rate on the prevalence of such diseases, and develop, to the extent possible,a scienti®c framework which will allow at least some tentative conclusions to bereached on the risk of multifactorial diseases and which will set the stage for furtherwork in this area.The membership of the Task Group was as follows:

K. Sankaranarayanan (Chairperson) E.A. Boerwinkle R. ChakrabortyA.E. Czeizel C. Denniston N. Yasuda

During the period of data review (1993±1998), the Task Group received assistanceon the scope, data sources, and content of the report from the following corre-sponding members:

J.F. Crow S.E. Humphries (until 1994) G. Michaeletzky (until 1995)W.J. Schull G. Tusnady (until 1995)

The comments of J.F. Crow and W.J. Schull were particularly valuable to theTask Group. The Task Group also wishes to acknowledge the help of Dr. Y. Zhongwith the illustrations and the assistance of Mrs. J. Pleging with the Tables.

The membership of Committee 1 during the period of preparation of this reportwas:

(1993±1997)W.K. Sinclair (Chairman) R. Cox (Secretary) R.J.M. Fry (Vice-Chairman)J.H. Hendry L.-E. Holm A.M. KellererC.E. Land J.B. Little K. MabuchiR. Masse R.J. Preston P.V. RamzaevK. Sankaranarayanan R.E. Shore C. Stre�erH.R. Withers D.-C. Wu

(1997±2001)R. Cox (Chairman) A.V. Akleyev R.J.M. Fry (Vice-Chairman)J.H. Hendry A.M. Kellerer C.E. LandJ.B. Little K. Mabuchi R. MasseC.R. Muirhead (Secretary) R.J. Preston K. SankaranarayananRE. Shore C. Stre�er K. WeiH.R. Withers

The report was approved for publication by the Commission in 1998 followingtheir input into the introductory and ®nal sections (dealing with implications forradiological protection).

ICRP Publication 83