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NATURE MEDICINE VOLUME 6 NUMBER 8 AUGUST 2000 847 NEWS He believes there may be some “iconic” value for the often-vilified Celera in sign- ing up a national government. Observers say the subscription cost is way below the commercial price offered to pharmaceutical companies and may even undercut Celera’s reduced “academic” rate. NHMRC research committee chair- man, Warwick Anderson, praised Celera’s “public spirited” offer, which allows re- searchers with existing commercial ties to fulfill those obligations and still access Celera information. Meanwhile, re- searchers without commercial partners have to give Celera first appraisal of their discoveries. “We will undoubtedly add function to [Celera’s] database, we’re guar- anteed an audience for what we find,” Wainwright says, meaning that Celera will look closely at any data originating from its databases. The subscription provides access to the Celera Discovery System (which includes tools for viewing and browsing), to the human genome database and to the mouse and annotated drosophila genomes, as well as its SNP database. Rada Rouse, Brisbane After abandoning plans to establish its own Ph.D.-granting program (Nature Med. 5, 1098; 1999), the US National Institutes of Health (NIH) will increase the number of graduate students undertaking doctoral re- search and working under university part- nerships in its laboratories. NIH will finance the research and students will be required to matriculate in a university graduate school. According to Joan P. Schwartz, Assistant Director of the NIH Office of Intramural Research, NIH will increase the number of graduate students from the current 145 to approximately 300 within five years. “I think it’s going to change the atmosphere of NIH very significantly,” says Schwartz. The organization already has partnership programs in place with Duke, Johns Hopkins, the University of Maryland and George Washington University. Mary DeLong, who was appointed as the new di- rector for the program on 17 July, adminis- tered a similar training program for Johns Hopkins University, is hoping to establish ties with new universities. NIH will begin advertising its partnership programs later this year, but already several universities have expressed interest includ- ing Cambridge University in the UK. Some medical schools hope to start M.D./Ph.D. courses in which students would transfer to NIH for their Ph.D. research. According to Schwartz, students need not necessarily be enrolled at partnership universities in order to come to NIH, but it seems likely, how- ever, that future students will come to NIH through applications handled by DeLong’s office, ending the ad hoc arrangements that have brought graduate students to NIH for more than 15 years. Schwartz does not believe partnership programs will be seen as a way for NIH to NIH expands graduate student training programs Australian academic research buys into Celera In the week that the completion of the working draft of the human genome was jointly announced by political leaders in the United States and Britain, Australia be- came the first nation to sign a deal with the Celera Genomics Corporation to provide the country’s publicly funded researchers with cut-price access to Celera databases. Health Minister Michael Wooldridge paid tribute to Australia’s National Health and Medical Research Council (NHMRC), for moving so quickly to sign the three-year agreement. Although full financial terms of the deal have not been disclosed, the NHMRC is known to have prepaid a three-year subscription, which it aims to recoup by charg- ing an annual license fee of around US$4,000 to principal in- vestigators. However, the govern- ment’s commitment does not yet represent any extra money for re- search, as the first year of the Celera subscription will come from the NHMRC’s A$4.2 million (US$2.4 million) medical genomics fund. NHMRC negotiator and deputy director of Australia’s Institute for Molecular Bioscience, Brandon Wainwright sealed the deal with Celera. “This idea of a na- tional subscription to Celera had been bub- bling away for about a year but it got to boiling point obviously because Celera knew the genome announcement was coming,” Wainwright told Nature Medicine. Comparison of number of genes in different organisms compete with universities for graduate stu- dents. She says NIH is most interested in of- fering students opportunities in research areas in which universities may not yet be very strong, citing NIH’s bioinformatics program and imaging research as examples. NIH partnerships may also bring oppor- tunities for students interested in non-de- gree training programs. Under discussion is are training programs in technology trans- fer and public health for which participants would receive a training certificate. Tom Hollon, Bethesda Courtesy of The Wellcome Trust Even before his much heralded, new cancer research institute has opened for business, Spanish oncologist Mariano Barbacid has been brought to the brink of resignation due to proposed bud- get cuts that would leave only enough money to complete building work on the National Center of Cancer Research (CNIO) and virtually no funds to support research. The Instituto de Salud Carlos III—the main national biomedical research funding agency oper- ated by the Ministry of Health (MoH)—had planned a 33% cut in baseline funding to CNIO, and Barbacid was notified that the overall budget for 2001 would probably not include a formerly agreed increase of Ptas 1 billion (US$5.7 million). Barbacid’s resignation threat led Minister of Health Celia Villalobos to meet with Spain’s Prime Minister, José Maria Aznar, to seek a solution. Barbacid has now been reassured that the promised budget will be forthcoming. The reasons behind the proposed funding freeze are not clear. Some feel that Villalobos, ap- pointed in May, is seeking short-term solutions to the problems of excessive healthcare expendi- ture on drugs. Villalobos told Nature Medicine that she is “exploring the possibility that the drug industry could become an important source of funding for CNIO.” The center has already signed a major supporting agreement with Pfizer. Villalobos is also understood to be considering the in- troduction of an additional tax on prescription drugs to be devoted to biomedical research. Xavier Bosch, Barcelona Spanish oncology center under threat © 2000 Nature America Inc. • http://medicine.nature.com © 2000 Nature America Inc. • http://medicine.nature.com

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NATURE MEDICINE • VOLUME 6 • NUMBER 8 • AUGUST 2000 847

NEWS

He believes there may be some “iconic”value for the often-vilified Celera in sign-ing up a national government.

Observers say the subscription cost isway below the commercial price offered topharmaceutical companies and may evenundercut Celera’s reduced “academic”rate. NHMRC research committee chair-man, Warwick Anderson, praised Celera’s“public spirited” offer, which allows re-searchers with existing commercial ties tofulfill those obligations and still accessCelera information. Meanwhile, re-searchers without commercial partnershave to give Celera first appraisal of theirdiscoveries. “We will undoubtedly addfunction to [Celera’s] database, we’re guar-anteed an audience for what we find,”Wainwright says, meaning that Celera willlook closely at any data originating fromits databases.

The subscription provides access to theCelera Discovery System (which includestools for viewing and browsing), to thehuman genome database and to the mouseand annotated drosophila genomes, as wellas its SNP database.

Rada Rouse, Brisbane

After abandoning plans to establish its ownPh.D.-granting program (Nature Med. 5,1098; 1999), the US National Institutes ofHealth (NIH) will increase the number ofgraduate students undertaking doctoral re-search and working under university part-nerships in its laboratories. NIH will financethe research and students will be required tomatriculate in a university graduate school.According to Joan P. Schwartz, AssistantDirector of the NIH Office of IntramuralResearch, NIH will increase the number ofgraduate students from the current 145 toapproximately 300 within five years. “Ithink it’s going to change the atmosphere ofNIH very significantly,” says Schwartz.

The organization already has partnershipprograms in place with Duke, JohnsHopkins, the University of Maryland andGeorge Washington University. MaryDeLong, who was appointed as the new di-rector for the program on 17 July, adminis-tered a similar training program for JohnsHopkins University, is hoping to establishties with new universities.

NIH will begin advertising its partnershipprograms later this year, but already severaluniversities have expressed interest includ-ing Cambridge University in the UK. Somemedical schools hope to start M.D./Ph.D.courses in which students would transfer to

NIH for their Ph.D. research. According toSchwartz, students need not necessarily beenrolled at partnership universities in orderto come to NIH, but it seems likely, how-ever, that future students will come to NIHthrough applications handled by DeLong’soffice, ending the ad hoc arrangements thathave brought graduate students to NIH formore than 15 years.

Schwartz does not believe partnershipprograms will be seen as a way for NIH to

NIH expands graduate student training programs

Australian academic research buys into Celera

In the week that the completion of theworking draft of the human genome wasjointly announced by political leaders inthe United States and Britain, Australia be-came the first nation to sign a deal with theCelera Genomics Corporation to providethe country’s publicly funded researcherswith cut-price access to Celera databases.

Health Minister Michael Wooldridgepaid tribute to Australia’s National Health

and Medical Research Council(NHMRC), for moving so quicklyto sign the three-year agreement.Although full financial terms ofthe deal have not been disclosed,the NHMRC is known to haveprepaid a three-year subscription,which it aims to recoup by charg-ing an annual license fee ofaround US$4,000 to principal in-vestigators. However, the govern-ment’s commitment does not yetrepresent any extra money for re-search, as the first year of theCelera subscription will comefrom the NHMRC’s A$4.2 million

(US$2.4 million) medical genomics fund.NHMRC negotiator and deputy director

of Australia’s Institute for MolecularBioscience, Brandon Wainwright sealedthe deal with Celera. “This idea of a na-tional subscription to Celera had been bub-bling away for about a year but it got toboiling point obviously because Celeraknew the genome announcement wascoming,” Wainwright told Nature Medicine.

Comparison of number of genes in different organisms

compete with universities for graduate stu-dents. She says NIH is most interested in of-fering students opportunities in researchareas in which universities may not yet bevery strong, citing NIH’s bioinformaticsprogram and imaging research as examples.

NIH partnerships may also bring oppor-tunities for students interested in non-de-gree training programs. Under discussion isare training programs in technology trans-fer and public health for which participantswould receive a training certificate.

Tom Hollon, Bethesda

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Even before his much heralded, new cancer research institute has opened for business, Spanishoncologist Mariano Barbacid has been brought to the brink of resignation due to proposed bud-get cuts that would leave only enough money to complete building work on the National Centerof Cancer Research (CNIO) and virtually no funds to support research.

The Instituto de Salud Carlos III—the main national biomedical research funding agency oper-ated by the Ministry of Health (MoH)—had planned a 33% cut in baseline funding to CNIO, andBarbacid was notified that the overall budget for 2001 would probably not include a formerlyagreed increase of Ptas 1 billion (US$5.7 million). Barbacid’s resignation threat led Minister ofHealth Celia Villalobos to meet with Spain’s Prime Minister, José Maria Aznar, to seek a solution.Barbacid has now been reassured that the promised budget will be forthcoming.

The reasons behind the proposed funding freeze are not clear. Some feel that Villalobos, ap-pointed in May, is seeking short-term solutions to the problems of excessive healthcare expendi-ture on drugs. Villalobos told Nature Medicine that she is “exploring the possibility that the drugindustry could become an important source of funding for CNIO.” The center has already signeda major supporting agreement with Pfizer. Villalobos is also understood to be considering the in-troduction of an additional tax on prescription drugs to be devoted to biomedical research.

Xavier Bosch, Barcelona

Spanish oncology center under threat

© 2000 Nature America Inc. • http://medicine.nature.com©

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