A

A

A

AA

A

A

A

A

A

A

A

A

A

A

A

A

T AC GT

C

G

AT

T

T

A

A

A

C

C

C

G

G

G

TT T

AA A

GG G

CC C

C

C T AC GT

C

G

AT

T

T

A

A

A

C

C

C

G

G

G

TT T

AA A

GG G

CC C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

T T T AT C T GT

C

G

AT T

T T

T T

T A

T A

T A

T C

T C

T CT G

T G

T G

TT T

AA

GG G

C

A

CC

G T AC GT

C

G

AT

T

T

A

A

A

C

C

C

G

G

G

TT T

A

A

A

G G

C

C

C

G

G

G

G

G

G

G

G

G

G

G

G

G

G

GG

A

A

A

A

AA

A

A

A

A

A

A

A

A

A

A

A

A

U AC GU

C

G

AU

U

U

A

A

A

C

C

C

G

G

G

UU U

AA A

GG G

CC C

C

C U AC GU

C

G

AU

U

U

A

A

A

C

C

C

G

G

G

UU U

AA A

GG G

CC C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

U U U AU C U GU

C

G

AU U

U U

U U

U A

U A

U A

U C

U C

U CU G

U G

U G

UU U

AA

GG G

C

A

CC

G U AC GU

C

G

AU

U

U

A

A

A

C

C

C

G

G

G

UU U

A

A

A

G G

C

C

C

G

G

G

G

G

G

G

G

G

G

G

G

G

G

GG

A

A

A

A

AA

A

A

A

A

A

A

A

A

A

A

A

A

U AC GU

C

G

AU

U

U

A

A

A

C

C

C

G

G

G

UU U

AA A

GG G

CC C

C

C U AC GU

C

G

AU

U

U

A

A

A

C

C

C

G

G

G

UU U

AA A

GG G

CC C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

U U U AU C U GU

C

G

AU U

U U

U U

U A

U A

U A

U C

U C

U CU G

U G

U G

UU U

AA

GG G

C

A

CC

G U AC GU

C

G

AU

U

U

A

A

A

C

C

C

G

G

G

UU U

A

A

A

G G

C

C

C

G

G

G

G

G

G

G

G

G

G

G

G

G

G

GG

A

Phe

Phe

Leu

Leu

Leu

Leu

Leu

Leu

Ile

Ile

Ile

Met

Val

Val

Val

Val

Ser

Ser

Ser

Ser

Pro

Pro

Pro

Pro

Thr

Thr

Thr

Thr

Ala

Ala

Ala

Ala

Tyr

Tyr

Stop

Stop

Stop

His

His

Gln

Gln

Asn

Asn

Lys

Lys

Asp

Glx

Glx

Asp

Cys

Cys

Arg

Arg

Ser

Ser

Arg

Arg

Arg

Arg

Gly

Gly

Gly

Gly

Trp

http://www.pnas.org/content/102/18/6368.figures-only

Comparative analysis of human and mouse CFTR exon 12 sequences evaluated for splicing efficiency.

Pagani F et al. PNAS 2005;102:6368-6372

©2005 by National Academy of Sciences