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Acta Medica OkayamaVolume 33, Issue 4 1979 Article 5
AUGUST 1979
Lipoprotein Abnormalities in Cholestasis I.Electro-phoretic and Ultracentrifugal Analyses
Makoto Watanabe∗
∗Okayama University,
Copyright c©1999 OKAYAMA UNIVERSITY MEDICAL SCHOOL. All rights reserved.
Lipoprotein Abnormalities in Cholestasis I.Electro-phoretic and Ultracentrifugal
Analyses∗
Makoto Watanabe
Abstract
The alterations of lipid composition in sera of patients with liver diseases, particularly intra-hepatic cholestasis and biliary obstruction, were studied by ultracentrifugation and polyacrylamide-gel disc-electrophoresis of lipoproteins and apoproteins. The elevation of serum cholesterol inintrahepatic cholestasis was greater than in biliary obstruction. The appearance of lipoprotein X inobstructive disease accounted for most of the increased cholesterol. The level of non-lipoproteinX cholesterol in intrahepatic cholestasis was significantly elevated, this being in part ascribed tothe appearance of a new class of cholestatic lipoprotein, Slow-migrating HDL. The electrophoreticpattern of lipoprotein in cholestasis was generally characterized by a decrease in alpha band in-tensity and, in some types of cholestasis, by the appearance of Slow-migrating HDL. In addition,other abnormal lipoproteins exhibiting the characteristics of triglyceride-rich LDL (LP-Y), LP-X-like HDL and LDL-like HDL were found in some cases of intrahepatic cholestasis and biliaryobstruction.
KEYWORDS: intrahepatic cholestasis, biliary obstruction, cholestatic lipoprotein, polyacrylamide-gel disc-electrophoresis, ultracentrifugation
∗PMID: 227230 [PubMed - indexed for MEDLINE]Copyright (C) OKAYAMA UNIVERSITY MEDICAL SCHOOL
1
Watanabe: Lipoprotein Abnormalities in Cholestasis I. Electro-phoretic
Produced by The Berkeley Electronic Press, 1979
2
Acta Medica Okayama, Vol. 33 [1979], Iss. 4, Art. 5
http://escholarship.lib.okayama-u.ac.jp/amo/vol33/iss4/5
3
Watanabe: Lipoprotein Abnormalities in Cholestasis I. Electro-phoretic
Produced by The Berkeley Electronic Press, 1979
4
Acta Medica Okayama, Vol. 33 [1979], Iss. 4, Art. 5
http://escholarship.lib.okayama-u.ac.jp/amo/vol33/iss4/5
5
Watanabe: Lipoprotein Abnormalities in Cholestasis I. Electro-phoretic
Produced by The Berkeley Electronic Press, 1979
6
Acta Medica Okayama, Vol. 33 [1979], Iss. 4, Art. 5
http://escholarship.lib.okayama-u.ac.jp/amo/vol33/iss4/5
7
Watanabe: Lipoprotein Abnormalities in Cholestasis I. Electro-phoretic
Produced by The Berkeley Electronic Press, 1979
8
Acta Medica Okayama, Vol. 33 [1979], Iss. 4, Art. 5
http://escholarship.lib.okayama-u.ac.jp/amo/vol33/iss4/5
9
Watanabe: Lipoprotein Abnormalities in Cholestasis I. Electro-phoretic
Produced by The Berkeley Electronic Press, 1979
10
Acta Medica Okayama, Vol. 33 [1979], Iss. 4, Art. 5
http://escholarship.lib.okayama-u.ac.jp/amo/vol33/iss4/5
11
Watanabe: Lipoprotein Abnormalities in Cholestasis I. Electro-phoretic
Produced by The Berkeley Electronic Press, 1979
12
Acta Medica Okayama, Vol. 33 [1979], Iss. 4, Art. 5
http://escholarship.lib.okayama-u.ac.jp/amo/vol33/iss4/5
13
Watanabe: Lipoprotein Abnormalities in Cholestasis I. Electro-phoretic
Produced by The Berkeley Electronic Press, 1979
14
Acta Medica Okayama, Vol. 33 [1979], Iss. 4, Art. 5
http://escholarship.lib.okayama-u.ac.jp/amo/vol33/iss4/5
15
Watanabe: Lipoprotein Abnormalities in Cholestasis I. Electro-phoretic
Produced by The Berkeley Electronic Press, 1979
16
Acta Medica Okayama, Vol. 33 [1979], Iss. 4, Art. 5
http://escholarship.lib.okayama-u.ac.jp/amo/vol33/iss4/5
17
Watanabe: Lipoprotein Abnormalities in Cholestasis I. Electro-phoretic
Produced by The Berkeley Electronic Press, 1979
