Algoritm Dg Lab Boli Autoimune

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    04-Mar-2016

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  • Algoritm de diagnostic de laborator pentru boli autoimune

    Anticorpi antinucleari (depistajIFI)

    Se repeta Anticorpi antinucleari (depistajIFI), daca suspiciunea

    persista (2-3 luni)

    Auto-anticorpi anti Jo1

    Aspect mitocondrial

    Aspect aparat Golgi

    Aspect ribozomal

    Aspect de tip Jo1

    Auto-anticorpi anti mitocondrii

    Aspect omogen

    Aspect inelar

    Aspect puncte

    nucleare

    Aspect PCNA

    Aspect de tip

    centromer

    Aspect nucleolar

    Aspect dens patat

    Aspect fin patat

    Antigene nucleare solubile

    + Profil ANA

    Auto anticorpi anti-Sm

    Auto anticorpi anti-RNP

    Auto anticorpi anti-SSA

    Auto anticorpi anti SSB

    Auto anticorpi

    anti Scl 70

    Auto antic. anti RNA Pol (III)

    Fara specificitate

    ADN nativ si sau

    cromatina

    Profil ANA Profil PBC

    Anticorpi antinucleari titrare (aspect, titru)

    Posibile granulatii citoplasmatice

    Nici o afectiune, remisiune, tratament

    Polimiozite % de LES

    Ciroza biliara primitiva

    Proteina P ribozomala

    intens

    slab

    Scleroza sistemica

    progresiva, Scleroderma

    overlap, S. Raynaud

    S. Crest, Scleroza

    sistemica, Fenomene Raynaud

    Marker pentru LES

    Ciroza biliara primitiva

    Posibil LES activ, Artrita

    reumatoida (AR), Lupus indus

    medicamentos

    Marker LES

    Conectivita mixta de

    tesut (MCTD)

    S. Sjogren, LES

    LES neonatal, S. Sjogren

    Marker scleroderma

    Scleroderma mai ales difuza

    cutanata

    LES, MCTD, AR, EBV, Hepatita cronica

    BIOCLINICA

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