5
YTBEPaCAEHO n p M K a 3 MHHHCTepCTBa 3Z (paBooxpaHeHnH YKpaHHbi PerHcxpauHOHHpe vflocxoBepeHHe HHCTPyKItHH n o M e ^ H i t H H C K O M y n p r n v i e H e H H i o j i e K a p c x B C H H o r o cpeacxaa AMEPOKCOJI Cocmae: deiicmeywu^ee eetqecmeo: ambroxol, 1 TaSjiexKa cojiep^Hx aM5p0KC0JTa ra/ipoxjiopHTiia 30 MT; ecnoMOzamejihUbie eeu^ecmea: jiaKT03Bi MOHorH/jpax, xpaxMaji KyKypyanbiH, uejuiiojiosa MHKpOKpHCxajuiHHecKaa, M a r n n s cxeapax, KpeMHna AHOKCHJI. JleKapcTBCHHafl (|)opMa. Ta5jiexKH. OcHosHbie (pu3UK0-xuMUHecKue ceoucmea: xaSjiexKH 6ejioro Hjm n o ^ H Sejioro iiBexa, c njiocKOH noBepxHOCTbio, pncKoii H 4 >acK0H. 0apMaKoxepaneBXHHecKaH rpynna. CpeacxBa, npHMenaeMtie npa KaujJie H npocxyjiHbix 3a5ojieBaHHax. MyKOJiHXH^ecKHe cpe^cxBa. K O A A T X R 0 5 C B 0 6 . 0apMaKOJiozuHecKue ceoucmea. /^OKjmHH^ecKH A0Ka3aH0, Hxo fleiicxByiomee semecxBo AMSPOKCOJI, xaSnexoK no 30 Mr, - aMSpoKcojia rn^poxjiopHa - yBejiHHHBaex ceKpenHio iKCJies ^bixaxejibHbix nyxefi. AMSPOKCOJI ycHJiHBaex BbmejieHHe JieroHHoro cyp(J)aKxaHxa n y r e M npsMoro B03AeHCXBHa na nneBMOijHXbi THn I I B ajibBeoJiax H KjiexKax Knapa B 5pOHXHOJiax, a xaK^Ke cxHMyjiHpyex UHJinapHyio aKXHBHOCXb, BCJie^cxBHe Hero o6jienaexca Bbi ^ejieHHe CJIH3H H ee BbiBe^eHHe (MyKOijHJiHapHbiH KJinpcHc). y j i y n n e H H c M y K o r t H J i H a p n o r o KJiHpenca Sbuio jtoKaaano BO BpeMa KJIHHHKO-^apMaKOJIOrH^eCKHX HCCJiejIOBaHHH. AKTHBaiiHs ceKpeiiHH acH ^KOCXH H yBejiMHenne MyKpnnanapHoro KJiHpenca o6jienaiox BbiBeAenne CJIH 3 H H oSiierHaiox Kainejib. MecxHbiH anecxesHpyiomHH 3IJ 4*^ KX aM5poKcojia rnjipoxjiopH/ia HaSjiio^ajiH na MO^ejiH Kpojmibero rjiaaa, ^ o Mo:»cex oGbflcnaxbca CBOHCXBaMH SJIOKHPOBKH naxpHCBHX xanajioB. HccjiejtOBaHHa in vitro noKaaajin, HXO aMSpoKCOJia rHflpoxjiopHA SjioKHpyex nenponHbie naxpneBbie KanajiLi; cBasbiBanHe Sbuio oSpaxHMbiM H 3aBHCHMbiM ox KonnenxpauHH. AM5poKcojia rnapoxjiopn;! npoflCMOHCxpHpoBan npoxHBOBocnajinxejibHoe snHanne in vitro. TaKHM o6pa30M, aMSpoKcojia rHApoxjiopn/i 3HaHHxejibH0 yMenbinaex BbicBoSo^enne UHxoKHHa c MOHonyKJieapHbix H nojiHMop{|)noHyKJieapnbix KHCXOK KpoBH n xKanefi. B pesyjibxaxe Kjinnn^eCKHx HcnbixaHHH c npHBJieHCHHeM nauncHTOB c ^JapHnrnxoM /joKasano snaHHxejibHoe yMeHbuienne GOJIH H noKpacneHna B ropjie n p n npuMeneHHH npenapaxa. Bjiarojiapa ^apMaKOJiorH^ecKHM cBoncxBaM aM6poKcojia Sbicxpo o6jierHajiacb 6oJib npn jieneKHH 3a5ojieBaHHH BepxHHX Atixaxejibnbix nyxen, HXO HaSjnoAaJiocb B xo^e nccjiejioBaHHH KJIHHHHeCKOH 34)Cf)eKXHBHOCXH H H r a J I H U H O H H b l X $ OpM aM6p0KC0Jia. npHMenenne aM6poKcojia rnjipoxjiopH/ia noBbiniaex KOHnenxpauHio anxnGHOTHKOB

AMEPOKCOJI - ternopharm.com.ua...npHMCHeHHCM 1 xaSnexKH 2 pasa B cyxKH (sKBHsajieHXHO 60 Mr aMSpoKcojia rHApoxJiopH^a B cyxKH). B cjiynae Heo6xoflaMocxH xepaneBXHHecKHH 3(j)4)eKx jimi

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Page 1: AMEPOKCOJI - ternopharm.com.ua...npHMCHeHHCM 1 xaSnexKH 2 pasa B cyxKH (sKBHsajieHXHO 60 Mr aMSpoKcojia rHApoxJiopH^a B cyxKH). B cjiynae Heo6xoflaMocxH xepaneBXHHecKHH 3(j)4)eKx jimi

Y T B E P a C A E H O n p M K a 3 M H H H C T e p C T B a

3 Z ( p a B o o x p a H e H n H Y K p a H H b i

PerHcxpauHOHHpe vflocxoBepeHHe

H H C T P y K I t H H n o M e ^ H i t H H C K O M y n p r n v i e H e H H i o j i e K a p c x B C H H o r o c p e a c x a a

AMEPOKCOJI

C o c m a e : deiicmeywu^ee eetqecmeo: a m b r o x o l , 1 T a S j i e x K a c o j i e p ^ H x a M 5 p 0 K C 0 J T a r a / i p o x j i o p H T i i a 3 0 M T ; ecnoMOzamejihUbie eeu^ecmea: j i a K T 0 3 B i M O H o r H / j p a x , x p a x M a j i K y K y p y a n b i H , u e j u i i o j i o s a M H K p O K p H C x a j u i H H e c K a a , M a r n n s c x e a p a x , K p e M H n a A H O K C H J I .

J l e K a p c T B C H H a f l ( | ) o p M a . T a 5 j i e x K H . OcHosHbie (pu3UK0-xuMUHecKue ceoucmea: x a S j i e x K H 6 e j i o r o H j m n o ^ H S e j i o r o i i B e x a , c n j i o c K O H n o B e p x H O C T b i o , p n c K o i i H 4 > a c K 0 H .

0 a p M a K o x e p a n e B X H H e c K a H r p y n n a . CpeacxBa, n p H M e n a e M t i e n p a K a u j J i e H n p o c x y j i H b i x 3 a 5 o j i e B a H H a x . M y K O J i H X H ^ e c K H e c p e ^ c x B a .

K O A A T X R 0 5 C B 0 6 .

0apMaKOJiozuHecKue ceoucmea. / ^ O K j m H H ^ e c K H A 0 K a 3 a H 0 , H x o fleiicxByiomee s e m e c x B o A M S P O K C O J I , x a S n e x o K n o 3 0 Mr, -a M S p o K c o j i a r n ^ p o x j i o p H a - y B e j i H H H B a e x c e K p e n H i o i K C J i e s ^ b i x a x e j i b H b i x n y x e f i . A M S P O K C O J I y c H J i H B a e x B b m e j i e H H e J i e r o H H o r o c y p ( J ) a K x a H x a n y r e M n p s M o r o B 0 3 A e H C X B H a n a n n e B M O i j H X b i T H n I I B a j i b B e o J i a x H K j i e x K a x K n a p a B 5 p O H X H O J i a x , a x a K ^ K e c x H M y j i H p y e x U H J i n a p H y i o a K X H B H O C X b , B C J i e ^ c x B H e H e r o o 6 j i e n a e x c a B b i ^ e j i e H H e C J I H 3 H H e e B b i B e ^ e H H e ( M y K O i j H J i H a p H b i H K J i n p c H c ) . y j i y n n e H H c M y K o r t H J i H a p n o r o K J i H p e n c a S b u i o j t o K a a a n o B O B p e M a

K J I H H H K O - ^ a p M a K O J I O r H ^ e C K H X H C C J i e j I O B a H H H . A K T H B a i i H s c e K p e i i H H a c H ^ K O C X H H y B e j i M H e n n e M y K p n n a n a p H o r o K J i H p e n c a o 6 j i e n a i o x B b i B e A e n n e C J I H 3 H H o S i i e r H a i o x K a i n e j i b . M e c x H b i H a n e c x e s H p y i o m H H 3 I J 4 * ^ K X a M 5 p o K c o j i a r n j i p o x j i o p H / i a H a S j i i o ^ a j i H n a M O ^ e j i H K p o j m i b e r o r j i a a a , ^ o Mo:»cex o G b f l c n a x b c a C B O H C X B a M H S J I O K H P O B K H n a x p H C B H X x a n a j i o B . H c c j i e j t O B a H H a in vitro n o K a a a j i n , H X O a M S p o K C O J i a r H f l p o x j i o p H A S j i o K H p y e x n e n p o n H b i e n a x p n e B b i e K a n a j i L i ; c B a s b i B a n H e S b u i o o S p a x H M b i M H 3 a B H C H M b i M o x K o n n e n x p a u H H . A M 5 p o K c o j i a r n a p o x j i o p n ; ! n p o f l C M O H C x p H p o B a n n p o x H B O B o c n a j i n x e j i b H o e s n H a n n e in vitro. T a K H M o 6 p a 3 0 M , a M S p o K c o j i a r H A p o x j i o p n / i 3 H a H H x e j i b H 0 y M e n b i n a e x B b i c B o S o ^ e n n e U H x o K H H a c M O H o n y K J i e a p H b i x H n o j i H M o p { | ) n o H y K J i e a p n b i x K H C X O K K p o B H n x K a n e f i . B p e s y j i b x a x e K j i n n n ^ e C K H x H c n b i x a H H H c n p H B J i e H C H H e M n a u n c H T O B c ^ J a p H n r n x o M / j o K a s a n o s n a H H x e j i b H o e y M e H b u i e n n e G O J I H H n o K p a c n e H n a B r o p j i e n p n n p u M e n e H H H n p e n a p a x a . B j i a r o j i a p a ^ a p M a K O J i o r H ^ e c K H M c B o n c x B a M a M 6 p o K c o j i a S b i c x p o o 6 j i e r H a j i a c b 6 o J i b n p n j i e n e K H H 3 a 5 o j i e B a H H H B e p x H H X A t i x a x e j i b n b i x n y x e n , H X O H a S j n o A a J i o c b B x o ^ e n c c j i e j i o B a H H H K J I H H H H e C K O H 3 4 ) C f ) e K X H B H O C X H H H r a J I H U H O H H b l X $ O p M a M 6 p 0 K C 0 J i a . n p H M e n e n n e a M 6 p o K c o j i a r n j i p o x j i o p H / i a n o B b i n i a e x K O H n e n x p a u H i o a n x n G H O T H K O B

Page 2: AMEPOKCOJI - ternopharm.com.ua...npHMCHeHHCM 1 xaSnexKH 2 pasa B cyxKH (sKBHsajieHXHO 60 Mr aMSpoKcojia rHApoxJiopH^a B cyxKH). B cjiynae Heo6xoflaMocxH xepaneBXHHecKHH 3(j)4)eKx jimi

( a M O K C H i x H J u i H H a , a e ^ y p o K C H M a , a p H x p o M m ^ H H a H ^ o K C H U H K J i H H a ) B S p O H x o J i e r o ^ o M c e K p e x e H B M O K p O X e .

0apMaKOKUHemuKa. A 6 c o p 6 t { m . A S c o p S u H H a M 6 p 0 K C 0 J i a rmjjpoxsiopam c n e p o p a J i b H B i x 4 ) o p M H e M C A J i e H H o r o B H C B o d o a y i e H H S 6 B i c x p a f l H n o j i H a a , c J i H H e H H O H a a B H C H M O c x t i o o x A O S B I B x e p a n e B X H ^ e c K O M A H a n a s o H C . M a K C H M a i i b H b i H y p o B C H b B n j i a s M e K p o B H ; i o c x H r a e x c a ^ e p e s 1 - 2 , 5 ^ a c a n p H n e p o p a j i B H O M n p H C M C J i e K a p c x B C H H t i x 4 ) o p M S b i c x p o r o B b i C B o S o ^ i y i e H H a H B c p e / p i e M n o ^ e p e s 6 , 5 H a c a n p H n p H M e n e n n H cJ iopM M e a j i e n n o r o B b i c B o S o a g j e H H a . Pacnpedenenue. n p H n e p o p a j n . n o M n p n c M e p a c n p e a e j i c H n e a M 6 p o K c o J i a r H A p o x j i o p n / ^ a H 3 K p o B H B x K a H H S b i c x p o e H B b i p a ^ c e H H o e , c BbicoKOH K O H i i e H x p a i i H C H a K X H B H o r o B e m e c x B a B j i e x K H x . O a c H f l a e M L i H o 6 i . e M p a c n p e ^ e j i e n n s n p n n e p o p a j i b n o M n p n e i v i e c o c x a s j i a e x 5 5 2 J i . B n j i a 3 M e K p o B H B xepaneBTHHecKOM ; p i a n a 3 0 H e ]i03 n p H M e p n o 9 0 % n p e n a p a x a C B M 3 b i B a e x c a c 6 e j i K a M H . Mema6ojiu3M u ebieedenue. H p H M e p n o 3 0 % fl03bi n o c j i e n p n c M a B n y x p b B b i B O ^ ^ H x c f l n y x c M n p e c H c x e M H o r o M e x a 6 o j i H 3 M a . A i v i S p o K c o j i a r n A p o x j i o p n ; ! M e x a 6 o j i H 3 H p y e T C f l B n e i e n n n y x c M r j n o K y p o H H 3 a u H H H p a c m e n j i e n n f l ]\o flnSpoManxpanHJioBOH K H C J I O X B I ( n p H M e p n o 1 0 % ; i 0 3 b i ) . H c c j i e ; i O B a H H a n a M H K p o c o M a x n e n e n n TCJiOBeKa n o K a 3 a j i H , ^ x o C Y P 3 A 4 o T s e ^ a e x 3 a M e T a 6 o j i H 3 M a M S p o K c o J i a r n ^ p o x j i o p H j i a jxo / m S p o M a n x p a n n j i O B O H K H c n o x b i . ^ e p e 3 3 M H S n p n e M a O K O J I O 6 % j i o s b i B b i B O A n x c a c M O H O H B n e n s M e n e n n o M B H ^ C , O K O J I O 2 6 % A 0 3 b l - B K O H b l O r H p O B a H H O H $ O p M e . r i e p H o a n o j i y B b i B e ; i ; e H H f l H 3 n j i a s M b i K p o s n c o c x a s j i a e x O K O J I O 1 0 ^ a c o B . O S m n f l K J i n p e n c c o c x a B J i s e x n p i i M c p n o 6 6 0 M i i / M n n . r i o ^ e ^ b i n K j m p e n c c o c x a B J i a e x n p H M e p n o 8 % o x o G m e r o . H e p e 3 5 / m e f i n p H M e p n o 8 3 % o S m e f t A 0 3 b i B b i B O A H x c a c M O H O H . 0apMaKOKUHemuKa e oco6bix zpynn 6oJihnbix. Y n a n n e n x o B c H a p y i n c H n e M ^ysKixmi n e n e n H B b i B e f l C H H e a M 6 p o K c o j i a m ^ i p o x j i o p H ^ i a y M e n b m e H o , H X O n p H B O ^ H x B 1 ,3—2 p a 3 a B b i n i e y p o B e n b B n j i a 3 M e K p o B H . r i o c K O J i b K y x e p a n e B X H H e c K H H A H a n a 3 0 H a M S p o K c o j i a r n f l p o x j i o p H ^ ^ a A O c x a x o H H o i n n p o K , H 3 M e n a x b / l o s n p o B K y n e n y ^ n o .

B o 3 p a c x H n o j i n e H M e i o x K J i n H H ^ e c K H s n a ^ H M o r o B J i H a n n a n a ^ J a p M a K O K H H e x H K y a M 6 p o K c o j i a raapoxjiopHfla, n o a x o M y J i i o G a a K o p p e K u n a fl03bi n e x p e S y e x c a .

K j I H H H H e C K H e x a p a K x e p H C T H K H . IIoKaiaHiiM. C e K p e x o j i H X H H e c K a a x e p a n a a n p H o c x p b i x H x p o H H ^ e c K H X S p o n x o n y j i b M o n a j i b n b i x 3 a 6 o j T e B a H H a x , C B a s a n n b i x c n a p y i n e H H a M H S p o n x H a j i b H O H c e K p e i j H H H o c j i a S j i e H H e M n p o A B H ^ e n n a C J I H S H .

I l p o m u e o n OKasan iin. A M S P O K C O J I , x a G j i e x K H n o 3 0 Mr, n e j i b s a n p H M e n a x b n a i x n e n x a M c r n n e p ^ i y B c x B H x e j i b H O C X b K ) K a M S p o K c o j i y m A p o x a o p n j i i y H J I H / i p y r H M K O M n o n e n x a M n p e i i a p a x a .

A M ^ p o K c o j i , x a 6 j i e x K H n o 3 0 M X , n e n p e ; x H a 3 H a H e H m.9L n p H M e n e H H a y flexefl B B o s p a c x e m 6 J i e x B CBa3H c A O s n p o B K O H . J l e x a M ; x o 6 J i e x p e K O M e n A y e x c a / v i a n p H M e n e H H a A M S P O K C O J I , c a p o n

1 5 M r / 5 Mji.

B j a u M o d e i i c m e u e c d p y e i m u jieKapcmecHHbiMu cpedcmeoMU u dpyeue eudbi e s a m i o d e i i c m e u u . O j m o B p e M c n n o e n p H M e n e n n e n p e n a p a x a A M 5 P O K C O J I , x a S j i e x o k n o 3 0 M r , n c p e ^ c x B , y r n e x a i o m n x K a u i e j i b , M O M C C X n p H s e c x H K H s S b i x o n n o M y H a K o n n e H H i o C J T H 3 H B C J i e ^ c x B H e n o / ] , a B J i e H H a K a n i J i e B o r o p e ^ J i e K c a . n o 3 X O M y x a K a a K O M G i i H a u H a B 0 3 M 0 ^ H a X O J I B K O n o c j i e x m a x e j i b H O H o n e H K H s p a ^ M c o o x n o n i e n H a O M C H A a e M O H n o j i b s b i H B 0 3 M o a ; H o r o p n c x a n p H M e H e n n a .

Page 3: AMEPOKCOJI - ternopharm.com.ua...npHMCHeHHCM 1 xaSnexKH 2 pasa B cyxKH (sKBHsajieHXHO 60 Mr aMSpoKcojia rHApoxJiopH^a B cyxKH). B cjiynae Heo6xoflaMocxH xepaneBXHHecKHH 3(j)4)eKx jimi

O c o d e u H o c m u npuMeHeuuM. B c e r o H e c K O J i b K O c o o G m e H H H n o c x y n H J i o o x j i a c e j i b i x n o p a ^ c e H H a x K O ) K H : C H H ^ p o M C T H B e n c a -^»coHCOHa H T O K C H H e c K H H 3 n H ; t e p M a j i b H b r i i H C K p o j i H S ( c H H Z t p o M J l a i i e j i J i a ) , C B f l s a n n b i e c n p H M e n e H H e M o x x a p K H B a i o n i H x c p e ; i C T B , x a K H X K a K a M 6 p o K c o j i a F H f l p o x j i o p H A . B O C H O B H O M H X M O M C H O 6 B U I O o S - b f l C H n x b x M ^ e c x b K ) x e n e E H J i o c n o B H o r o 3 a 6 o j i e B a H H K y n a i i n e n x o B H o f l H O B p e M e H H b i M n p H M e n e H H e M A p y r o r o n p e n a p a x a .

T a K M c e n a n a H a j i B H O H c x a ^ H H c H H f l p O M a C x H B e n c a ~ ^ a c o H c o n a H J I H C H H ^ i p o M a J l a i i e j i J i a y n a u H e n x o B M o r y x 6 B I T B H e c n e n n ^ H H e c K H e , n o A o G n B i e n p H s n a K a M H a n a j i a r p n n n a C H M H T O M B I , x a K H e K a K j i H x o p a ; j K a , J i o M o x a , p H H H X , K a m e J i s H S O H B B r o p j i e . O H I H G O I H O n p n x a K H X H e c n e i p i 4 ) H H e c K H X , n o ; t o 6 H B i x n p H s n a K a M n a n a j i a r p n n n a C H M n x o M a x M O ? K H O n p H M e n H x t c H M H x o M a x H H e c K o e j i e ^ e H H e n p e n a p a x a M H n p o x H B K a n u i a H n p o c x y a b i . H p n n o A B J i e n H H H O B B K n o p a ^ e H H H K O ^ H H J I H C J I H 3 H C X B I X o S o j i o n e K c n e ^ y e x n e M e A J i e n n o o 6 p a x H X b C H 3 a M e ; i H H H H C K O H n o M o m t i o H n p e K p a x H X b j i e H e n n e a M S p o K c o j i a r H ^ p o x j i o p H a o M .

A M 6 p O K c o n , x a S j i e x K H n o 3 0 M F , c o A e p > K H X 1 4 7 M r J i a K X 0 3 B i B M a K C H M a j i b H O H p e K O M e n ^ o B a n n o H c y x o H H O H J i 0 3 e 1 2 0 M X . n a n n e H x a M c p e / i K o f i H a c J i e / x c x B e H H o i i n e n e p e H o c H M O C x b i o r a j i a K X 0 3 b i , ; i e 4 ) H D [ H x o M j i a K x o s b i J I a n n a H J I H H a p y m e n n e M B c a c b i B a n H H r j n o K 0 3 b i H r a j i a K X 0 3 b i n e c j i e ^ y e x n p n n H M a x b 3 X 0 X n p e n a p a x . H o c K O J i b K y a M S p o K c o j i a r H Z [ p o x j i o p H ^ M O H c e x y c H J i H s a x b c e K p e u H i o c n H 3 H , A M 6 P O K C O J I , xaQjiexKH n o 3 0 M r , c j i C A y e x n p H M e n a x b c o c x o p o a c H o c x b i o n p H n a p y i n e n H H S p o n x H a j i b n O H M O x o p H K H H y c H J i e n n o H c e K p e n H H C J I H 3 H ( n a n p H M e p , n p H x a K O M p e ^ K O M 3 a 6 o j i e B a H H H , K a K n e p B H H H a a n n j i n a p n a a flHCKHHe3Ha).

I l a H H e n x a M c n a p y i n e H H O H ( J ) y n K H H e H n o n e K H J I H x a a c e j i O H c x e n e n b i o n e q e n o H H o f t n e f l o c x a x o n n o c x H c j i e ^ y e x n p H H H M a x b A M S P O K C O J I , x a S j i e x K H n o 3 0 M r , x o j i b K O n o c j i e K O H c y j i b x a n H H c B p a n o M . I l p n n p H M e n e n n H a M S p o K c o j i a , KaK H J i i o 6 o r o ^ e H C X B y i o m e r o B e m e c x B a , K o x o p o e M e x a S o j i H s n p y e x c a B n e n e H H , a 3 a x e M B b i B O j p i x c a n o H K a M H , n p o H c x o A H X H a K o n j i e n n e M e x a S o j i H X O B , o 6 p a 3 y i o m H x c f l B n e n e n H y n a n n e n x o B c x f l H c e j i o H n o n e H H O H H e f l o c x a x o H H O C X b i o .

npUMeneHue e nepuod depeueHHocmu ujiu KopMJienun epydbJO. E e p e M e H H o c x b . A j v i S p o K c o j i a raflpoxjiopH/i n p o H H K a e x H e p e 3 n j i a n e n x a p H b i n 6 a p b e p . H c c j i e ; i ; o B a H H H n a H C H B O X H b i x n e B b M B H j m n p a M o r o H J I H K O C B e n n o r o B p e ; i H o r o B O S A C H C X B H A n a x e n e H H e G e p e M e n n o c x H , p a 3 B H X H e 3 M 5 p H O H a / n j i o A a , p o ^ b i H J I H n o c x H a x a j i b H o e p a 3 B H X H e . B p e s y j i b x a x e K J i n n n n e c K H x n c c j i C A O B a n H H n p H M e n e n n H n p e n a p a x a n o c j i e 2 8 - H n e ^ e J i H S e p e M e H H O c x H n e B b i H B J i e n o B p e a n o r o B J I H A H H ^ n a n j i o f l . O f l H a K O n y a c H O c o S j n o ^ a x b o S m n e M e p b i 6 e 3 o n a c H o c x H , K a c a i o m H e c a n p n e M a J i e K a p c x B B O B p e M K S e p e M e n n o c T H . B n a c x H o c x H , B n e p B O M x p H M e c x p e 6 e p e M e H H 0 C T H n e p e x o M e n j i y e x c f l n p H M e n a x b A M S P O K C O J I , x a S j i e x K H n o 3 0 M r .

K o p M J i e n n e r p v j b i o . A M S p o K c o j i a r H ^ p o x j i o p H / i n p o H H K a e x B r p y A H O e M O J I O K O . A M 6 p o K c o n , x a 6 j i e x K H n o 3 0 M r , n e p c K O M e n / i y e x c a n p H M e n f l X b B n e p n o ^ K o p M J i e n H f l r p y A b i o .

Cnocodnocfnb ejiunmb u a cKopocmb peaKtfuu npu ynpaenenuu aemompaHcnopmoM win dpyauMU MexanusMOMu. H e x flaHHbix o B j i H a n n n n a C K O p o c x b p e a K i ^ n n n p n y n p a B J i e n n n a B X O T p a n c n o p x o M H J I H pa6oTe c flpyrHMH M e x a H H 3 M a M H . C o o x s e x c x B y i o m n e H c c j i e A O B a n n a n e n p O B O A H J i H C b .

Cnocod npimcHeHUH u dosbi. E c j i H H e n p o n H c a n o a p y r o e , p e K O M e n A O B a H n a a z i ; o 3 a n p e n a p a x a A M S P O K C O J I , x a S j i e x o K n o 3 0 M r , c o c x a B n a e x :

demu 6 eospacme om 6 do 12 jiem: V2 x a 6 j i e x K H 2 - 3 p a s a B c y x K H ( 3 K B H B a j i e H X H 0 3 0 - 4 5 M r a M S p O K c o j i a r n j i p o x j i o p H / i a B c y x K n ) ;

espocjibie u demu e eospacme om 12 Jiem: 1 x a 5 j i e T K a 3 p a a a B x e H e n n e n e p B W X 2—3 / m e i i ( s K B H B a j i e H X H O 9 0 M r a M 6 p o K c o j i a r H A p o x j i o p n a a B c y x K n ) . J l e ^ e H H e n p o f l O J U K a x b

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n p H M C H e H H C M 1 x a S n e x K H 2 p a s a B c y x K H ( s K B H s a j i e H X H O 6 0 M r a M S p o K c o j i a r H A p o x J i o p H ^ a B c y x K H ) .

B c j i y n a e H e o 6 x o f l a M o c x H x e p a n e B X H H e c K H H 3 ( j)4 ) eKx jimi B S p o c n t i x H a e x e f i c x a p i n e 1 2 j i e x M o ^ e x G B I X B y c H j i e H npHMeneHHeM 2 x a S j i e x o K 2 pa3a B c y x K H ( s K E H B a j i e n x H O 1 2 0 M r a M 6 p O K C o n a r H A p o x j i o p H j i a B c y x K H ) .

T a S j i e x K H c j i e ^ y e x r j i o x a x t H C J I B I M H , s a n n a a a z ^ o c x a x o H H B i M K O J I H H C C X B O M ^ C H ^ K O C X H ( B o ; i a , n a n H J I H ^ p y K x o B B i H C O K ) , HOCJie n p n c M a n n n x H . A M G p o K c o n , x a 6 j i e x K H n o 3 0 M r , n e c j i e ; f i y e x n p H M C H ^ x B A O J i B U i e 4 - 5 A H B H 6e3 K o n c y j i L x a i i H H c B p a H O M .

/Jlemu. n p H M e n a i o x z t e x H M c x a p i n e 6 Jiex, n e n e p e n o c a m n M c n p o n H J I H p a c T B o p fljia H H r a j i a n H H H npHCMa B H y x p b .

IIepedo3upoe/<a. H a c e r o f l H a n e x c o o G m e n H g o c j i y n a a x nepefl03HpoBKH y j n o / i e H . C H M H T O M B I , n s B e c x n b i e H 3 e f l H H H H n b i x c o o 6 m e H H H o n e p e a o 3 H p O B K e H / H J I H c j i y n a a x o m n S o H H o r o n p H M e n e H H a n e x a p c x B , o x B e n a i o x H 3 B e c x H b i M n o G o H H b i M / l e H C X B H f l M A M 6 p o K c o J i a , x a S j i e x o K n o 3 0 Mr, B p e K O M C H A O B a n H b i x A 0 3 a x H x p e S y i o x C H M n x o M a x H H e c K o r o J i e n e i i H a .

IIo6oHHbie p e a K n u u . , H l I S O H C H K H HaCXOXbl H o S O H H b l X HBHeHHH 6 b I J I O HCnOJIb30BaHO C J i e f l y i O m y K ) K J T a C C H ( } ) H K a U H I O :

0 4 e n b ^ a c x o > i O % ; HacTO > 1 % H < 1 0 % ; H c n a c x o > 0 , 1 % H < 1 % ; peflKO > 0 , 0 1 % H < 0 , 1 % ; o ^ e n b p e a K O < 0 , 0 1 %; HeH3BecxH0 H C B o s M o ^ o o n c H H X b Ha ocHOBaHHH H M e i o m n x c H z i a H i i b i x . Odufue p a c c m p o i i c m e a : n e n a c T O - p e a K i i H H c o c x o p o H b i c j T H 3 H c x b i x O S O J I O H C K , n n x o p a ^ K a . Co cmopoubi UMMyunou c u c m e M u , Kootcu u nodKOOtcuou KJiemnamKu: pe^KO - K o a c n a a c b n i b , K p a n H B n n n a ; HeH3BecTH0 - a n x H o n e B p o x H ^ e c K H H o x e K , -iyjj., aHa(|)HjiaKXHHecKHe p e a K i i , H H , B i u n o ^ a a ana ( J )HJiaKXH^ecKHH m o K , z t p y m e a j i J ieprnHecKne p e a K n n n , a p n x c M a , x a ^ e j i b i e n o p a j K e n n a K O > K H : C H H a p o M C x H B e n c a — ^ ^ o n c o n a H x o K C H ^ e c K H H a n n f l e p M a j i b H b i H H e K p o j i H 3 ( C H H A P O M J l a f i e n j i a ) . Co cmopoHbi ofcenydoHHO-KumeHHOao mpaKma: Hacxo - T o i u H o x a ; H e n a c x o - p B o x a , OTcnencna, 6 o n b B ^ H B O T C , ^ H a p e a ; OHCHb pe / iKO — c j i T O H O x e H C H n e . Co cmopoHbi dbixameiibHOu cucmeMbi:

H e H 3 B e c x H 0 ~ o ^ b i n i K a ( K a K p e a i o i H a r H n e p ^ y B C X B H x e n b H o c x H ) .

CpoK z o d u o c m u , 3 r o ^ a .

y c j i o B H H x p a i i e H H t i .

X p a n H X b B c y x o M , s a n i H i i i e H H O M o x c B e x a M e c x e n p n x c M n e p a x y p e n e B b n n e 2 5 °C. X p a n n x b B H e / i o c x y H H O M jxm. a e x e n M e c x e .

Y n a K O B K a .

T a S j i e x K H 2 0 ( 1 0 x 2 ) B 5 j i H C T e p a x .

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K a x e r o p H H oxnycKa. Be3 peiienxa.

n p 0H3BOAHXeJII>/3aHBHXeJlb. 0 0 0 «TepHo$apM».

M e c x o H a x o n g i e H n e n p o H S B O A H x e j i n H a A p e c M e c x a o c y m e c x B j i e H H H e r o ACHxejibHOCXH. 0 0 0 «TepHo$apM». YKpaHHa, 46010, r. TepnonoJib, yji. OaSpHHnaa, 4. Teji./{^aKc: (0352) 521-444, http://www.temopharm.com.ua

^ a r a n o c j i e A H e r o n e p e c M o x p a .

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