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Effects of DNA Mutationon Gene ExpressionFigures taken from
Campbell Biology, 9th Ed.
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Mutations: Awesome or awful?
www.fanpop.com
Whats a mutation,
anyway?
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Article:Carbs were key in wolves evolution to dogsComparing the
DNA
of dogs and wolves
shows that dogs'
ability to easily
digest
carbohydrates,
originally from
starch in scraps left
behind by humans,
helped enable theirdomestication, a
study finds.
www.facebook.com/evolutionarybiology
http://www.latimes.com/news/science/la-sci-how-dogs-evolved-20130124,0,1620029.storyhttp://www.latimes.com/news/science/la-sci-how-dogs-evolved-20130124,0,1620029.story
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Sickle-cell disease
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Mutations = ultimate source of new genes
http://www.zo.utexas.edu/faculty/antisense/downloadfilestol.html
http://www.zo.utexas.edu/faculty/antisense/downloadfilestol.htmlhttp://www.zo.utexas.edu/faculty/antisense/downloadfilestol.html
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Recall: Chromosomal aberrations (large-scale mutations)
Match the diagrams with these terms:
- translocation
(reciprocal/nonreciprocal)
- duplication
- deletion
- inversion
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Small-scale mutations: Substitutions, Insertions, Deletions1.
THEFATCATATETHEWEERAT.
2. THE FAT CAT ATE THE WEE RAT.
3. THE FAT HAT ATE THE WEE RAT.
4. THE FAT CAA TET HEW EER AT.
5. THE FAT ATE THE WEE RAT.
6. THE FAT QRY ATE THE WEE RAT.
7. THE FAT SCA TAT ETH EWE ERA T.
substitution
deletion
deletion
substitution
insertion
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Match the diagrams with these terms:- silent mutation
- missense mutation
- nonsense mutation
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Match the diagrams with these terms:- frameshift mutation caused
by deletion
- frameshift mutation caused by insertion
- deletion (no frameshift)
What is a frameshift mutation? When does
it occur?
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Sources of Mutations1. Mutagens
2. Spontaneous mutations
3. Jumping genes
faculty.southwest.tn.edu, academic.pgcc.edu
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Sources of Mutations1. Mutagens
2. Spontaneous mutations
3. Jumping genes
zlgc.seu.edu.cn, www.broadinstitute.org
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