Cefotaxime (cephalosporin generasi III)

Cefotaxime (cephalosporin generasi III)

Pronunciation

U.S. Brand Names

Generic Available

Synonyms

Pharmacological Index

Use

Pregnancy Risk Factor

Contraindications

Warnings/Precautions

Adverse Reactions

Overdosage/Toxicology

Drug Interactions

Stability

Mechanism of Action

Pharmacodynamics/Kinetics

Usual Dosage

Monitoring Parameters

Test Interactions

Mental Health: Effects on Mental Status

Mental Health: Effects on Psychiatric Treatment

Dental Health: Local Anesthetic/Vasoconstrictor Precautions

Dental Health: Effects on Dental Treatment

Patient Information

Nursing Implications

Dosage Forms

References

Pronunciation

(sef oh TAKS eem)

U.S. Brand Names

Claforan

Generic Available

No

Synonyms

Cefotaxime Sodium

Pharmacological Index

Antibiotic, Cephalosporin (Third Generation)

Use

Treatment of susceptible infection in respiratory tract, skin and skin structure, bone and joint, urinary tract, gynecologic as well as septicemia, and documented or suspected meningitis. Active against most gram-negative bacilli (not Pseudomonas) and gram-positive cocci (not enterococcus). Active against many penicillin-resistant pneumococci.

Pregnancy Risk Factor

B

Contraindications

Hypersensitivity to cefotaxime, any component, or cephalosporins

Warnings/Precautions

Modify dosage in patients with severe renal impairment; prolonged use may result in superinfection; a potentially life-threatening arrhythmia has been reported in patients who received a rapid bolus injection via central line. Use caution in patients with colitis; minimize tissue inflammation by changing infusion sites when needed. Use with caution in patients with a history of penicillin allergy especially IgE-mediated reactions (eg, anaphylaxis, urticaria); may cause antibiotic-associated colitis or colitis secondary to C. difficile.

Adverse Reactions

1% to 10%:

Dermatologic: Rash, pruritus

Gastrointestinal: Diarrhea, nausea, vomiting, colitis

Local: Pain at injection site