(Standardized extract of Centella asiatica)Gotu kola

Centella for wrinkles

FWrinkles refer to thin, creased and sagging skin.

FWrinkles can be on the surface of the skin or can be quite deep.

FWrinkling in the skin is caused by aging, sun damage, smoking, poorhydration and various other factors.

Wrinkles

FAs we get older, two components of our skin; collagen and elastin degenerate, setting the stage for the appearance of wrinkles, creases, folds and urrows.

FThe breakdown of these components, accelerated by sun exposure and gravity, results in the sagging skin of old age.

Wrinkle formation

Standardized extract of Centella asiaticaA natural way to maintain healthy and wrinkle free skin*

Considerable research has been done to understand the aging process, and studies has now shown that natural products containing bioactive ingredients can benefit sun-damaged, discolored and aging skin, giving consumers new choice for restoring their overall appearance.

Asiaticoside, madecassoside, asiatic acid and madecassic acid are the principle terpenoids found in Centella asiatica, a plant which has traditionally

1been used to treat various skin disorders .

Centella asiatica has been used in the indigenous2

system of medicine as a tonic in skin diseases .

Traditional evidenceF

Clinical evidenceF

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Centella asiatica extract [as one of the ingredients] showed significant improvement in elasticity

3and firmness of the skin .

In a randomized trial, cream containingCentella asiatica extract [as one of the ingredients] appeared to help prevent the development of

4stretch marks in pregnancy .

In a double blind placebo-controlled trial, lipstick containing asiaticoside exhibited wrinkle improving effect by reducing the depth and

5number of wrinkles .

In a double blind clinical trial, cream containing

CollagenF Collagen is the most abundant protein of the

skin. Along with soft keratin, it is responsible for skin strength and elasticity, and its degradation leads to wrinkles that accompany

1aging .

FCollagen occurs in many places throughout the body. There are 28 types of collagen described in literature. Type I collagen is the most abundant in the human body. It is present in scar tissue, the end product of tissue repair .

What is Centella asiatica?Centella asiatica (L.) Urb. (Apiaceae), commonly known as “Gotu kola”, is a small herb, occupies an important place in the indigenous system of medicine. Its ability to treat skin conditions, heal wounds, improves mental clarity and promotes longevity were important reasons for its extensive use in Indian Ayurvedic system of medicine. Gotu kola shares its glory being identified by CHARAKA, and proudly resides as “Mandukaparni” in Charaka Samhita (400-200 BC).

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Pre-Clinical evidence

FAsiaticoside, asiatic acid and madecassic acid

isolated from Centella asiatica were observed to

increase collagen I synthesis both in presence and

absence of ascorbic acid in human skin fibroblast 1

in vitro .

SafetyF

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Regulatory Status

Except for a rare person who is allergic to Centella asiatica, no significant adverse effects are experienced with internal or topical use of the

14herb .

In a double blind clinical trial, no adverse reactions such as itching or irritation was reported with cream containing Centella asiatica

3extract as one of the ingredient .

Further, this herb has been used for centuries in traditional system of medicine.

Centella asiatica is listed in Indian Herbal Pharmacopoeia (IHP), British Herbal Pharmacopoeia (BHP), Medicines and Healthcare products Regulatory Agency (MHRA), Pharmacopoeial Standards for Ayurvedic formulations (PSAF) and Herbs of commerce-American Herbal Products Association (AHPA).

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E-mail : info@naturalremedy.com

Wrinkles and antioxidants

Centella asiatica as a potent

antioxidant

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It is well-known that aging of the skin with sagging

and wrinkling is a function of free radical damage.

Free radicals, the unstable oxygen molecules

produced by pollution, stress & sun - are a skincare

nightmare. They attack healthy skin cells & cause

collagen breakdown, all of which lead to wrinkles.

Antioxidants have been shown to protect skin cells 8-10from free radical damage .

Centella asiatica has scientific backup of various

studies to substantiate its beneficial effects as a 11-12

potential antioxidant .

Asiaticoside derived from Centella asiatica is 13known to possess good antioxidant property .

Influence of asiatic acid, madecassic acid andasiaticoside on human collagen I synthesis

References1. Bonte F et al., Planta Med. 1994: 60: pp 133-135.2. Chopra RN et al., Glossary of Indian Medicinal Plants. CSIR, New Delhi. 1956: pp 58.3. Martelli et al, “International Journal of Cosmetic Science, 2000:22(3): pp 201 -206.4. Young GL, et al, Cochrane Database Syst Rev. 2000;(2): Cd000066.5. Ryu JS et al., Skin Research and Technology. 2005: 11(3): pp 157-164. 6. Lee J et al., Planta Med. 2006 : 72(4) : pp 324-328.7. Maquart FX et al., Connect Tissue Res. 1990 : 24(2) : pp 107-120. 8. Rona C et al., J Cosmet Dermatol. 2004 : 3(1): pp 26-34. 9. Afaz F et al., Exp Dermatol. 2006:15(9): pp 678-84. 10. McCullough JL and Kelly KM. Ann N Y Acad Sci. 2006:1067: pp 323-31. 11. Jayashree G et al., Fitoterapia. 2003: 74(5): pp 431-434.12. Abdul Hamid et al., Food Chemistry. 2002: 77(4): pp 465-469.13. Arti Shukla et al., Phytother Res. 1999: 13: pp 50-54.14. Murray MT. The Healing Power of Herbs. Rocklin, CA: Prima Publishing, 1995: pp 173-183.

Why

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Centella asiatica extract from Natural Remedies?

Chemical standardization based on content of asiaticoside, madecassoside, asiatic acid and madecassic acid by HPLC.

A variety of grades are available for wide range of cosmetic applications.

Centella 1:Centella 2:Centella 3:

Centella 4:Centella 5:

Centella 6:

Centella 7:

Asiaticoside > 90% Asiatic acid > 90%Asiaticoside > 30%, asiatic acid > 30% and

madecassoside > 30% Asiatic acid > 40% and madecassic acid > 40% Asiaticoside > 15%, madecassoside > 15%,

asiatic acid and madecassic acid > 5% Asiaticoside > 10%, madecassoside > 10%,

asiatic acid and madecassic acid > 2% Asiaticoside > 1%

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Manufactured in a GMP and ISO 9001 2000 certified manufacturing facility.

The product is Kosher and Halal certified.

*Disclaimer : “These statements have not been evaluated by the Food and Drug

Administration or any other regulatory body. This product is not intended to diagnose, treat, cure or prevent any disease”.

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Asiaticoside can induce type I collagen synthesis

via the activation of the TβRI kinase 6

independent Smad pathway .

Centella asiatica extract increased collagen

synthesis in human foreskin fibroblasts in a dose 7 dependent manner .

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