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cobas® 4000 analyzer seriesFreedom to realize your lab’s potential
The comprehensive serum work area solution for workloads of up to 200 samples per day
cobas c 311 analyzer Passion for predictability in chemistry
•Unmatchedreagentefficiencies•Broadestmenuofchemistry
reagentsavailable•ProvenreliabilityofRoche/
Hitachiinstrumentation
cobas® e-services Labintelligenceatyourfingertips
•Immediatetroubleshooting viaremoteaccess
•Automaticallyupdatedassaylibrary•Advancedperformancemonitoring
cobas e 411 analyzer Peaceofmindinimmunology
•Unmatchedreagentefficiencies•FastestSTATassaysonthemarket
•Superiorperformance ofECLtechnology
Work area management solutions
Standardize&integrate yourdatamanagement
•Reducedvariability•Increasedefficiency
•EnhancedInformation
cobas® 4000 analyzer series
cobas c 311 analyzerPassion for predictability in chemistry
Thecobas c311analyzerofferstheultimateincon-venience,performanceandconfidenceforlaboratorieswithclinicalchemistryworkloadsof50-200samplesper day.
•Thecobas creagentpacksdelivermaximumhandlingconveniencewithminimumreagentwaste,liquidready-to-usereagentsand90dayaverageonboardreagentstability
•Withindustry-leadingparameterssuchasTina-quant® HbA1cwithautomatedpretreatmentofwholebloodsamples,thecobas c311analyzeroffersthebroadestassaymenuonthemarket
•Roche/Hitachiindesignandmanufacture,thecobas c311analyzercontinuesthelongtraditionofprovenreliability
cobas e 411 analyzerPeace of mind in immunology
SuccessortotheElecsys®2010,oneofthemost successfulimmunoanalyzerseverdeveloped,thecobas e411analyzerisaperfectcomplementtothecobas c311analyzer.
•Thecobas ereagentpacksofferbest-in-classhandlingconvenienceandreagentefficiencesforimmunochemistrytestingwithliquidready-to-usereagentsand60dayaverageonboardreagent stability
•9minuteSTATapplicationsfortroponin,CK-MB,myoglobin,hCGandPTHprovideunmatchedresponse times
•Astheheartofthecobas e411analyzer,ECL technologydeliverstheuniquecombinationofhighanalyticalsensitivity,widemeasuringrangesand 9minuteSTATapplicationsforunparalleledperfor-manceinimmunochemistry
Work area managementStandardize & integrate your data management
Oneworkareamanagementtoolextendingcapabilitiesofmostlaboratory information systems:
•Reducingvariabilitythroughconsistencyindecisionmanagement•Increasingefficiencybycomprehensiveworkflowtools•Activemanagementofresultsandpatientdataprovidingoptimal
informationmanagementforphysicians
cobas® e-servicesLab intelligence at your fingertips
•cobase-support–immediatetroubleshootingviaremoteaccessimprovingsystemuptimeandoperativeefficiency
•cobase-library–automaticupdatefunctionalitysafeguardingonlineaccesstomostrecentapplicationinformationonreagents,calibrators and controls
•cobase-LabPerformance*–offeringadvancedperformancemonitoringtoolsforefficientQCmanagement
•cobaslink-enablingcobase-servicesviasecuregatewayconnectionbetweenlaboratoryandRoche
* in preparation
Laboratory Network SolutionsWith the cobas® modular platform
Withthecobasmodularplatform,Rochehasdevelopedaplatformconceptthatdeliverscustomizedsolutionsbasedonacommonarchitectureforvariousworkloadsandtestingrequirements.Whetheryourunalargecentrallaboratoryormanageanetworkofsatellitelaboratories,Rochecanofferyouatailoredsolution.
Aboveyouwillfindourcurrentandfutureanalyzerseriesforyourlaboratory:
cobas 8000 modular analyzer series
cobas 6000 analyzer series
cobas 4000 analyzer series
Common applications forstandardizedpatientresults
Flexible configurations fortailor-madesolutions
Universal reagent carriers forsimplifiedlogistics
cobas user interface foreasytraining&flexiblestaff
cobas® modular platform – Benefits
COBAS,COBASC,COBASE,LIFENEEDSANSWERS, ELECSYSandTINA-QUANTaretrademarksofRoche.
©2010Roche
RocheDiagnosticsLtd.CH-6343RotkreuzSwitzerlandwww.roche.com 0
49
525
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cobas® 4000 analyzer seriescobas c 311 assay menu
Substrates Enzymes Proteins
Albumin (BCP+BCG) ACP a1-Acid Glycoprotein
Ammonia ALP a1-Antitrypsin
Bicarbonate ALT / GPT a1-Microglobulin
Bilirubin-direct Amylase-tot. b2-Microglobulin
Bilirubin-total Amylase–pancr. Albumin (immuno.)
Calcium AST / GOT APO A1
Cholesterol Cholinesterase Acetyl APO B
HDL Cholesterol Cholinesterase Butyryl ASLO
LDL Cholesterol Cholinesterase Dibucain C3c
Creatinine enz. CK C4
Creatinine Jaffé CK-MB Ceruloplasmin
Fructosamine GGT CRP
Glucose GLDH CRP High Sensitivity
Iron HBDH Cystatin C
Lactate LDH Ferritin
Magnesium Lipase Haptoglobin
Phosphorus HbA1c (whole blood + hemolysate)
Total Protein Homocysteine 2
Total Protein U / CSF Electrolytes (ISE) IgA
Triglycerides Chloride IgG
Triglycerides GB Potassium IgM
UIBC Sodium Kappa Light chains
Urea / BUN Freelite™ Human Lambda Free2
Uric Acid Lambda Light chains
Freelite™ Human Lambda Free2
Lipoprotein (a)
Myoglobin
Prealbumin
RF
Soluble Transferrin Receptor
Transferrin
COBAS, COBAS C and LIFE NEEDS ANSWERS are trademarks of Roche.
©2010 Roche
Roche Diagnostics Ltd.CH-6343 RotkreuzSwitzerlandwww.roche.com
Drugs of abuse (DAT) Therapeutic drug monitoring (TDM) Others
Amphetamines Acetaminophen D-Dimer
Barbiturates Amikacin Anti-Thrombin III
Benzodiazepines Carbamazepine
Cannabinoids Digitoxin
Cocaine Digoxin
LSD1 Gentamicin
Ethanol Lidocaine 1
Methadone Lithium
Methadone Methabolite (EDDP) MPA-T
Methaqualone NAPA
Opiates Phenobarbital
Oxycodone 1 Phenytoin
Phencyclidine Procainamide
Propoxyphene Quinidine1
Salicylate
Theophylline
Tobramycin
Valproic Acid
Vancomycin
1 Assays currently under development2 Partner Channel
Last Update 02/2010
cobas c 311 analyzerPassion for predictability in chemistry
Electronic updates & downloads via cobas® e-services
College of American Pathologists (CAP) HbA1c Survey Data; Source: http://www.ngsp.org/prog/index.html; May 2008
11.0
10.0
9.0NGSPTarget
%H
bA1c
8.0
7.0
Abbo
tt
Arch
itect
Beck
man
Sy
nchr
onBi
o-Ra
d
D-1
0Bi
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Varia
nt II
Turb
oO
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FS
cobas c 311 analyzerPassion for predictability in chemistry
Conveniencecobas c packs for convenient handling
•Liquid,ready-to-usecobas c reagent packs simplifyhandling
•All-in-onecassetteforeachparameterstreamlines logistics
•Electronicupdatesanddownloadsensureseamless,error-freedatahandling
•Assay-specificpacksizesenableeconomicusageofroutineandesotericparameters
PerformanceFullmenuofhighperformanceassays
•WholebloodHbA1coffersbest-in-classperformance
•Highonboardstabilityallowscontinuousavailabilityofover40assays
•Over100assaysofferacomprehensiveclini-calchemistrymenu
•Highcalibrationstabilityandlot-to-lotcali-brationoptimizereagentuse
ConfidenceRobustdesignandsampleintegritychecks
•cobas c311analyzercontinuestheRoche/Hitachitraditionofreliableinstrumentation
•Intelligentclotdetectionensuresreliableresultswithoutworkflowdisruptions
•Contact-freeultrasonicmixingeliminatescarry-over
•Test-specificserumindicesensureresultintegritywithoutmanualvalidation
CAP GH2-A 2008 mid level (mean ± 2SD)
Full workstation consolidation •Thecobas c311analyzerisdesigned
tobeatruework-horseonaccountofproventechnology
•Itconsolidatesclinicalchemistrywithspecialproteins,DATsandTDMs
Serum work area integration •Combinedwiththecobas e411
immunoanalyzer,thesystemcanpro-cessupto95%ofyourserumworkareaworkload
•Workareamanagementsolutionsinte-grate sample and data management acrosssystems
Seamless laboratory networking •Aspartofthecobasmodularplat-
form,thecobas c311analyzeroffersconsistentresultswithothercobas c systems
•Universalreagentcarriersandana-lyticalcomponentsenableflexiblenetworksolutions
1 108samplepositionswithcontinuousrandomaccess&flexibleSTATprioritysettings
4 RobustISEunitusingindirectmethod
7 cobas®userinterfacestandardizedtoother cobassystems
2 66semi-disposablereactioncuvetteswithultrasonicmixingforreducedwaterconsumption
5 Multi-functionalreagentprobeutilizestooltopuncturesealedreagentcasettes
3 Sampleprobeequippedwithclotdetec-tionandvacuumdrying
6 42cooledpositionsforcobascreagentpacksenablefullmenuconsolidation
1
2
3
4
5
6
7
COBAS,COBASC,COBASE,LIFENEEDSANSWERSandTINA-QUANTaretrademarksofRoche.
Otherbrandorproductnamesaretrademarks oftheirrespectiveholders.
©2010Roche
RocheDiagnosticsLtd.CH-6343RotkreuzSwitzerlandwww.roche.com
cobas c 311 analyzerTechnical specifications
System Fullyautomated,randomaccessanalyzerforClinicalChemistry,Electrolytes&HomogeneousImmunoassays(HIA)
TestThroughput Upto300tests/hr(photometry),450tests/hr(ISEonly)and300tests/hr(mixed)
Reagent concept Barcodedcobas creagentpackswithconvenientpackaging&ready-to-usereagents
Onboardreagentcapacity Upto45assays(42cooledcassetteslots+3channelsforISE)
Programmableparameters Upto117photometric,3ISEtests,8calculatedparameters&3serumindices
Sampletypes Serum,Plasma,Urine,CSF&WholeBlood
Onboardsamplecapacity 108positionswithcontinuousaccess&STATinterruptcapability
Samplecontainertypes Primarytubes: 5–10mL(16x100,16x75,13x100,13x75mm)Samplecup: 2.5mLMicrocup: 1.5mLCupontube
Samplevolume 1.0to35µLin0.1µLsteps
Sampleclotdetection Yes
Minimumsamplevolume Primarytubes: 700µLSamplecup: 100µLMicrocup: 50µL
Samplebarcodetypes Code128,Codabar(NW7),Interleaved2of5,Code39
Systeminterfaces TouchscreenPC,RS232serialinterface,bi-directional,cobas®link(TeleServiceandautodownload)
Sampledatabase 10,000routine/STATsamples
Testmethods 1point,1point+prozonecheck,2point,2pointkinetic,2point+prozonecheck,3point,1point+kinetics,RateA,RateA+serumindex,RateAwithblank,RateB
Calibrationmethods Linear,non-linearmulti-points,2pointcalibration,K-factor,upto100calibratorspre-programmable, storageofupto180curves;Preventivecalibrationofstand-bycassettes.
QCmethods Real-time,individual&cumulativeQC;AutoQC;Upto100differentcontrolspre-programmable;PreventiveQCaftercalibrationofstand-bycassettes
Rerun/repeat/reflex Automaticrerun/manualreruns,repeats&automaticreflexsupported
Electricalrequirements Powerrequirements: 230/400VoltsAC3/N/PE,110VoltsAC1.5kVAFrequency: 50Hzor60Hz+/–0.5%
Water/wasterequirements Waterquality: Bacteriafree,de-ionisedwatersupplyresistanceof1.0µS/cmmax.Waterconsumption: Upto12l/hrduringoperationWaterpressure: 0.5–3.5kg/cm3(49–343KPa)Watertemperature: 15to30°CBiohazardswaste: SeparatecontainerlocatedinthesystemWalldrainforwaste: 100mmabovethefloor
Regulatorycompliance GS,CE,UL,C-ULcompliant
Operatingconditions Ambienttemperature/humidity: 15to32°C/30to85%(RH,withoutcondensation)Heat&noiseoutput: 2kcal/h;<65dB
Physicaldimensions Width: 134cmDepth: 86cmHeight: 126cmWeight: 270kg
cobas® 4000 analyzer seriescobas e 411 assay menu
Thyroid function Tumor markers Infectious diseases
Anti-TG AFP Anti-HAV total
Anti-TPO CA 125 II Anti-HAV IgM
Anti-TSHR CA 15-3 Anti-HBc
Calcitonin1 CA 19-9 Anti-HBc IgM
FT3 CA 72-4 Anti-HBe
FT4 CEA Anti-HBs
T3 CYFRA 21-1 Anti-HCV
T4 free PSA HBeAg
T-Uptake NSE HBsAg
Tg total PSA HBsAg confirmatory
Tg hs1 HBsAg quantification
TSH CMV lgG
Cardiac CMV lgM
CK-MB (mass) CMV IgG Avidity 1
Fertility / hormones CK-MB (mass) STAT HSV-11
ACTH Digoxin HSV-2 1
C peptide Digitoxin HIV Antigen
Cortisol Myoglobin HIV Antigen confirmatory
DHEA-S Myoglobin STAT HIV combi
Estradiol NT-proBNP HIV combi PT1
FSH Troponin T Rubella IgG
hCG+b Troponin T hs Rubella IgM
hCG STAT Troponin T hs STAT Toxo IgG
Insulin Troponin T STAT Toxo IgM
LH
Progesterone
Prolactin
SHBG
Testosterone
COBAS, COBAS E and LIFE NEEDS ANSWERS are trademarks of Roche.
©2010 Roche
Roche Diagnostics Ltd.CH-6343 RotkreuzSwitzerlandwww.roche.com
Maternal care Anemia Bone markers
free b hCG Ferritin b-CrossLaps
PAPP-A Folate Vitamin D3 (25-OH)
PlGF RBC Folate Intact PTH
sFLT-1 Vitamin B12 N-MID Osteocalcin
P1NP
PTH STAT
Rheumatoid Arthritis Critical care
Anti-CCP IL6
BRAHMS PCT Others
S100 IgE
1 Assays currently under development
Last Update 02/2010
cobas e 411 analyzerPeace of mind in immunology
11.0
10.0
9.0NGSPTarget
%H
bA1c
8.0
7.0
Abbo
tt
Arch
itect
Beck
man
Sy
nchr
onBi
o-Ra
d
D-1
0Bi
o-Ra
d
Varia
nt II
Turb
oO
lympu
s AU
Roch
e
Tina
-qua
nt® II
Toso
h A1
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2.2
Plus
Vitro
s
5.1
FS
Bayer Centaur Abbott Architect Roche Elecsys DPC I‘lite 2000
PTH Precision Monitoring NEQAS 2006
Met
hod
prec
isio
n C
V %
Sample No.
4
369
6
8
10
12
14
16
18
370
371
372
373
374
375
376
377
378
379
380
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
Bayer Centaur Abbott Architect Roche Elecsys DPC I‘lite 2000
Met
hod
prec
isio
n C
V %
Sample No.
369
6
8
10
12
14
16
18
370
371
372
373
374
375
376
377
378
379
380
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
cobas e 411 analyzerPeace of mind in immunology
Conveniencecobas e packs for convenient handling
•cobas e reagent packs are liquid, ready-to-use and simplify handling
•All-in-onecassettepackagingforeachparameter combined with calibrators stream-lines logistics
•Automaticpackopening/closingensureslonger onboard stability
•Programming-by-loadingconceptensuresseamless, precise data handling
•Datareviewscreenprovidesquickresulttraceability
Enhanced data review screen
Elecsys assay performance in external ring-trials
Electrochemiluminescence (ECL) reaction principle
Performance9 min applications for speed and quality
•Over75assaysoffercomprehensivecover-ageof7indicationareas
•Highonboardstabilityandshelf-lifeallowcontinuous availability of both routine and esoteric parameters
•Disposabletipsandassaycupsforreactioneliminate risk of carryover
•Integratedsafetyfeaturesensureresultintegrity
ConfidenceECL technology: The gold standard
•Highanalyticalsensitivityenableslargemea-suring ranges and low sample volume
Measuringranges:Estradiol4-4,300pg/mL; Progesterone0-6ng/mL; TotalPSA0-100ng/mL;
SampleVolume: b-hCGrequires10µL;3rdGen TSHrequires50µL
•Activationwithvoltageforacontrolledreac-tion allows high precision to avoid unneces-sary repeats and reruns
•Shortincubationtimeenablesthetimelyavailability of innovative applications
Magnet
Ru2base state
TPA
PPP Photon
Platinum Electrode
PTH Precision Monitoring
Reaction Phase - Measuring Cell
Full workstation consolidation •Thecobas e411analyzerisdesigned
to deliver accurate results on account of proven ECL technology
•Itconsolidatesroutineendocrinologywith cardiac, cancer, bone and infec-tious disease markers
Serum work area integration •Combinedwiththecobas c311ana-
lyzer,thesystemprocessesupto95%of your serum work area workload
•Workareamanagementsolutionsinte-grate sample and data management across systems
Seamless laboratory networking •Aspartofthecobasmodularplat-
form, the cobas e411analyzeroffersconsistent results with other cobas e systems
•Universalreagentcarriersandana-lytical components enable flexible network solutions
1 CD-ROM,USB&printerportsenableefficient data management
4 cobas® touchscreen user interface is standardizedtoothercobassystems
7 Disposabletipsandcupseliminatecarryover
8 Measuring cell provides unmatched detection using ECL technology
9 Consumables and liquid waste are easily accessible
2 Alsoavailablerackversionwith75sample positions
5 18channelsenableuseofupto18parameters simultaneously
3 30 continuous random access sample positionswithSTATpriority
6 Easy removal of disposables via solid waste container
12 3
4
5
6
7
8
9
COBAS,COBASC,COBASE,LIFENEEDSANSWERS andELECSYSaretrademarksofRoche.
Otherbrandorproductnamesaretrademarks oftheirrespectiveholders.
©2010Roche
RocheDiagnosticsLtd.CH-6343RotkreuzSwitzerlandwww.roche.com
cobas e 411 analyzerTechnical specifications
System
Fullyautomated,continuousloadingandrandomaccesssystemforimmunoassayanalysisbasedonECLtechnology.Availableasadiskandracksystem.Systemcomponents:AnalyticalmoduleincludingtouchscreenPC
Test Throughput Upto86tests/hr
Reagentconcept cobasereagentpack: Ready-to-usereagentsOnboardreagentcapacity: 18channels/reagentslotsforupto18differentassaysEvaporationprotection: Automaticclosureofreagentlids
Programmableparameters Max60assaysdefinablevia2D-barcodeincludingallnecessaryinformation(programmingbyloading)
Sampletypes Serum,Plasma,Urineandothers
Onboardsamplecapacity Load/unloadcapacity: Disk: 30samples Rack:75sampleson15RDstandard5positionrackRacktypes: Routine,STAT,Control,CalibratorSTAThandling: Disk:Anyunoccupiedpositiononthesampledisk Rack:DedicatedSTATportonrackfeeder
Samplecontainertypes Primarytubes: 5–10mL;16x100,16x75,13x100,13x75mmSamplecup: 2.5mLCups on tube
Samplevolume 10to50µLpertest,dependingonassayprotocol
Sampleprobe Disposabletipsforindividualsampletoavoidcarryover;Sampleclotdetection;Liquidleveldetection
Samplebarcodetypes PDF417,Code128,Codabar(NW7),Interleaved2of5,Code39
Systeminterfaces TouchscreenPC,RS232serialinterface,bi-directionalStandardPCports(USB,ethernet,serialetc)forothercommunicationdevices
Sampledatabase 2,000resultsforroutine,STATandcontrols
Test methods Pre-definedassayprotocols(sandwich,competitive,titration)
Calibration methods 2-point calibration per lot or per cobas e reagent pack
QC methods IndividualQC;CumulativeQC;PreventiveQCaftercalibration
Rerun/repeat/reflex Rerun,repeatandreflexsupported
Electrical requirements Powerrequirements: 100–120VAC50/60Hzsinglephase or200–240VAC50/60HzsinglephasePowerconsumption: 1,000VA
Water/wasterequirements Watersupply: 3lcontainerWaterquality: ≤10µS/cmor≥0.1megaOhm,bacteria-freeLiquidwaste: 4lcontainerwithoverflowdetectionordirectdrainWaterconsumption: Approx.3lfor250tests/approx.12mL/cycle
Regulatorycompliance GS,CE,UL,C-UL,CB-reportandcertificate
Operatingconditions Ambienttemperature: 8to32°C(64.4°Fto89.6°F)Ambienthumidity: 20%to80%Noiseoutput: 60dbA(stand-bymode),63dbA(avg.duringoperation)
Physicaldimensions Width: 120to170cm(disk/rack)Depth: 73to95cm(disk/rack)Height: 56cm(w/oPCunit)Weight: Approx.170kg(disk)and210kg(rack)