David Yu-Yiao Huang, M.D., Ph.D., F.A.H.A. · Hwang ES, Zhang Z, Cai H, Huang DY, Huong SM, Cha CY, Huang ES. Human cytomegalovirus IE1-72 Human cytomegalovirus IE1-72 protein interacts

CURRICULUM VITAE – Standardized UNC SOM Format 09/23/13

David Yu-Yiao Huang, M.D., Ph.D., F.A.H.A. EDUCATION AND TRAINING 2001-2002 Fellowship in Stroke and Neurologic Critical Care, Massachusetts General Hospital,

Boston, MA Program Director: Walter J. Koroshetz, M.D.

1998-2001 Residency in Neurology, Partners Neurology (Massachusetts General Hospital, Brigham and Women’s Hospital, and Harvard Medical School), Boston, MA

Program Directors: Walter J. Koroshetz, M.D. and Steven K. Feske, M.D.

1997-1998 Internship in Internal Medicine, Massachusetts General Hospital, Boston, Massachusetts Program Director: Hasan Bazari, M.D.

1997 M.D., Medical Scientist Training (M.D.-Ph.D.) Program, Duke University School of Medicine, Durham, NC

Program Director: Salvatore V. Pizzo, M.D., Ph.D.

1996 Ph.D. in Neurobiology, The Graduate School, Duke University, Durham, NC Program Director: William D. Matthew, Ph.D. Thesis Advisor: Warren J. Strittmatter, M.D. Dissertation: Biochemical Interactions of Apolipoprotein E: Implications for Alzheimer's

Disease

1988 B.S. with Honors in Zoology, Trinity College, Duke University, Durham, NC CERTIFICATIONS AND LICENSURES 2012 Recertification in Neurology, American Board of Psychiatry and Neurology

2008 Board Certification in Vascular Neurology, American Board of Psychiatry and Neurology

2002 Board Certification in Neurology, American Board of Psychiatry and Neurology

2002-present Licensed Physician, State of North Carolina

2001-2010 Licensed Physician, Commonwealth of Massachusetts PROFESSIONAL EXPERIENCE AND EMPLOYMENT HISTORY 2009-present Clinical Associate Professor, Department of Neurology, University of North Carolina,

Chapel Hill, NC (start date 9/1/2009)

2005-2009 Assistant Professor, Department of Neurology, University of North Carolina, Chapel Hill, NC (start date 7/1/2005)

2002-present Attending Physician in Neurology, UNC Hospitals, Chapel Hill, NC (start date 10/1/2002)

2002-2005 Clinical Assistant Professor, Department of Neurology, University of North Carolina, Chapel Hill, NC (start date 8/1/2002)

2001-2002 Graduate Assistant Staff Physician in Neurology, Massachusetts General Hospital, Boston, MA

1997-2002 Clinical Fellow in Medicine and Neurology, Harvard Medical School, Harvard University, Boston, MA

Curriculum vitae: David Yu-Yiao Huang, M.D., Ph.D. 09/23/13

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1995-1996 Course Instructor, CLA 200 - Clinical Arts (Course Directors: Drs. Joseph Corless and Barbara Sheline), Duke University School of Medicine, Durham, NC

1994 Teaching Assistant, NBI 202- Basic Neurobiology (Course Directors: Drs. David Fitzpatrick and Anthony S. LaMantia), Duke University School of Medicine, Duke University, Durham, NC

1992-1994 Teaching Assistant, MED 49S - Current Topics in Biomedical Research (Course Director: Dr. Dan G. Blazer), Duke University School of Medicine, Durham, NC

1988-1989 Research Assistant, Surgical Virology Laboratory (Supervisors: Drs. Dani P. Bolognesi and Tom Matthews), Department of Surgery, Duke University Medical Center, Duke University, Durham, NC

1987 Research Internship, Cellular Genetics and Toxicology Branch (Supervisor: Dr. Michael A. Resnick), National Institute of Environmental Health Sciences, Research Triangle Park, NC

PROFESSIONAL SOCIETY MEMBERSHIPS 2009-present Association of University Professors of Neurology, Member

2006-present North Carolina Medical Society, Member

2003-present American Heart Association and American Stroke Association, Professional Member (2003-present) • Fellow (FAHA), Stroke Council (2012-present) • Member, NC AHA Policy Issue Advisory Committee (2012-present) • Member, NC AHA Advocacy Coordinating Committee (2010-2011)

o Health Systems Work Group (2010-2011)

1999-present American Academy of Neurology, Active Member • Consortium of Vascular Neurology Program Directors, Member (2010-present) • Consortium of Neurology Program Directors, Member (2009-present) • Neurohospitalist Section, Member (2009-present) • Stroke and Vascular Neurology Section, Member (2006-present)

AWARDS AND HONORS 2012 North Carolina’s Best Doctors, Business North Carolina

2012 Best Doctors in America® 2013 Database, Best Doctors, Inc.

2012 Fellow, American Heart Association/American Stroke Association

2005 Clinical Scientist Career Development Award, NIH/NINDS

2004 Scientist Development Award, American Heart Association (National Center Research Program)

1994 Pre-Doctoral Research Fellowship, Ruth K. Broad Biomedical Research Foundation

1989 Medical Scientist Training Program Fellowship, Duke University School of Medicine (NIH/NIGMS #5T32GM007171-30)

1989 Senior Leadership Award, Duke University

1988 Magna cum Laude Honors, Duke University

1988 Senior Marshal, Duke University

1987 Sirena WuDunn Memorial Scholarship, Duke University


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1986 Phi Beta Kappa (Junior-year Inductee), Duke University

1985 North Carolina Scholar, Duke University BIBLIOGRAPHY Books and Chapters:

1. Aucutt-Walter N, Jewells V, Huang DY. Neurology. In: Key N, Makris M, O’Shaughnessy D, Lillicrap D editors. Practical Hemostasis and Thrombosis. 2nd Ed. Oxford: Blackwell Publishing Ltd., 2009. p 209-217.

2. Huang DY. Disorders of Consciousness. In: Runge MS, Greganti MA, editors. Netter’s Internal Medicine. 2nd Ed. St. Louis: Elsevier; 2009. p 847-853.

3. Huang DY, Hinn AR. Stroke and Transient Ischemic Attacks. In: Runge MS, Greganti MA, editors. Netter’s Internal Medicine. 2nd Ed. St. Louis: Elsevier; 2009. p 883-889.

4. Strittmatter WJ, Burke JR, de Serrano VS, Huang DY, Matthew W, Saunders AM, Scott BL, Vance JM, Weisgraber KH, Roses AD. Protein-protein interactions in Alzheimer's disease and the CAG triplet repeat diseases. In: Cold Spring Harbor Symposia on Quantitative Biology, Volume LXI. Cold Spring Harbor Laboratory Press; 1997.

5. Strittmatter WJ, de Serrano V, Huang DY, Martin ME, Roses AD, Saunders AM. Interactions of apolipoprotein E with microtubule-associated proteins. In Roses AD, Weisgraber KH, Christen Y, editors. Apolipoprotein E and Alzheimer's Disease. Berlin: Springer-Verlag; 1995. p 145-150.

6. Roses AD, Saunders AM, Corder EH, Risch NJ, Haines JL, Pericak-Vance MA, Han S-H, Einstein G, Hulette C, Schmechel DE, Goedert M, Jakes R, Dong L-M, Weisgraber KH, Holsti M, Huang DY, Strittmatter WJ. Apolipoprotein E and Alzheimer's disease. In: Iqbal K, Mortimer JA, Winblad B, Wisniewski HM, editors. Research Advances in Alzheimer's Disease and Related Disorders. Chichester, England: John Wiley and Sons; 1995. p 85-96.

7. Strittmatter WJ, Huang DY, Saunders A, Schmechel D, Pericak-Vance M, Weisgraber KH, Goedert M, Roses AD. Apolipoprotein E and Alzheimer's disease: therapeutic implications. In: Giacobini E, Becker R, editors. Alzheimer's Disease: Therapeutic Strategies. Boston: Birkhaüser; 1994. p 65-71.

Refereed Papers/Articles (Original Research):

8. IMS III Investigators (Broderick JP, et al.). Endovascular Therapy after Intravenous t-PA versus t-PA for Stroke. N Engl J Med. 2013: Epub ahead of print February 7, 2013. DOI: 10.1056/NEJMoa1214300.

9. Shuaib A, Schwab S, Rutledge JN, Starkman S, Liebeskind D, Bernardini G, Boulos A, Abou-Chebl A, Huang DY, Vanhooren G, Cruz-Flores S, Klucznik R, Saver JL (for the SENTIS trial investigators). The importance of proper patient selection and endpoint selection in evaluation of new therapies in acute stroke: Further analysis of the SENTIS Trial. Journal of Neurointerventional Surgery. Epub ahead of print January 3, 2013. DOI: 10.1136/neurintsurg-2012-010562

10. COSS Investigators (Powers WJ, et al.). Extracranial-Intracranial Bypass Surgery for Stroke Prevention in Hemodynamic Cerebral Ischemia: The Carotid Occlusion Surgery Study Randomized Trial. JAMA. 2011; 306(18):1983-1992. DOI: 10.1001/jama.2011.1610.

11. SENTIS Trial Investigators (Shuaib A, et al.). Partial Aortic Occlusion for Cerebral Perfusion Augmentation: Safety and Efficacy of NeuroFlo in Acute Ischemic Stroke Trial. Stroke. 2011; 42(6):1680-90. DOI: 10.1161/STROKEAHA.110.609933.

12. Anderson LG, Meeker RB, Poulton W, Huang DY. Brain distribution of carboxy terminus of Hsc70-interacting protein (CHIP) and its nuclear translocation in cultured cortical neurons following heat stress or oxygen-glucose deprivation. Cell Stress Chaperones. 2010; 15(5): 487-495. DOI 10.1007/s12192-009-0162-5. PMID: 19953350.

13. MERCI and Multi-MERCI Trial Investigators (Shi ZS, et al.). Endovascular Thrombectomy for Acute Ischemic Stroke in Failed Intravenous Tissue Plasminogen Activator Versus Non–Intravenous Tissue


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Plasminogen Activator Patients Revascularization and Outcomes Stratified by the Site of Arterial Occlusions. Stroke. 2010; 41:1185-1192. doi: 10.1161/STROKEAHA.109.568451. PMID: 20431084.

14. MERCI and Multi-MERCI Trial Investigators (Shi ZS, et al.). Clinical outcomes in middle cerebral artery trunk occlusions versus secondary division occlusions after mechanical thrombectomy: pooled analysis of the Mechanical Embolus Removal in Cerebral Ischemia (MERCI) and Multi MERCI trials. Stroke. 2010; 41(5):953-960. doi: 10.1161/STROKEAHA.109.571943. PMID: 20378867.

15. Hwang ES, Zhang Z, Cai H, Huang DY, Huong SM, Cha CY, Huang ES. Human cytomegalovirus IE1-72 protein interacts with p53 and inhibits p53-dependent transactivation by a mechanism different from that of IE2-86 protein. J. Virol. 2009; 83:12388-12398. DOI: 10.1128/JVI.00304-09.

16. Sen S, Huang DY, Akhavan O, Wilson S, Verro P, Solander S. IV vs. IA TPA in Acute Ischemic Stroke with CT Angiographic Evidence of Major Vessel Occlusion: A Feasibility Study. Neurocrit Care. 2009;11(1):76-81. doi: 10.1007/s12028-009-9204-1. PMID: 19277904.

17. PRoFESS Study Group (Diener H-C, et al.). Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Eff ectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study. Lancet Neurol. 2008;7(10):875-84. doi: 10.1016/S1474-4422(08)70198-4. doi: 10.1016/S1474-4422(08)70198-4. PMID: 18757238.

18. PRoFESS Study Group (Sacco RL, et al.). Aspirin and Extended-Release Dipyridamole versus Clopidogrel for recurrent stroke. N Engl J Med. 2008;359(12):1238-51. doi: 10.1056/NEJMoa0805002. PMID: 18753638.

19. PRoFESS Study Group (Yusuf S, et al.). Telmisartan to Prevent Recurrent Stroke and Cardiovascular Events. N Engl J Med. 2008 Sep 18;359(12):1225-37. doi: 10.1056/NEJMoa0804593. PMID: 18753639.

20. NEST-2 Investigators (Zivin JA, et al.). Effectiveness and Safety of Transcranial Laser Therapy for Acute Ischemic Stroke. Stroke. 2009;40(4):1359-64. doi: 10.1161/STROKEAHA.109.547547. PMID: 19233936.

21. FAST Trial Investigators (Mayer SA, et al.). Efficacy and safety of recombinant activated Factor VII for acute intracerebral hemorrhage. N Engl J Med. 2008;358(20):2127-37. doi: 10.1056/NEJMoa0707534. PMID: 18480205.

22. Dai Q, Qian SB, Li HH, McDonough H, Borchers C, Huang D, Takayama S, Younger JM, Ren HY, Cyr DM, Patterson C. Regulation of the cytoplasmic quality control protein degradation pathway by BAG2. J. Biol. Chem. 2005;280: 38673-38681.

23. MERCI Trial Investigators (Smith W, et al.). Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke. 2005;36: 1432-1438. PMID: 15961709.

24. Wang X, Huang DY, Huong SM, Huang ES. Integrin αvβ3 is a coreceptor for human cytomegalovirus infection. Nature Medicine. 2005;11: 515-521.

25. Evers DL, Wang X, Huong SM, Huang DY, Huang ES. 3,4',5-Trihydroxy-trans-stilbene (resveratrol) inhibits human cytomegalovirus replication and virus-induced cellular signaling. Antiviral Res. 2004;63: 85-95.

26. Zhang Z, Huong SM, Wang X, Huang DY, Huang ES. Interactions between human cytomegalovirus IE1-72 and cellular p107: functional domains and mechanisms of up-regulation of cyclin E/cdk2 kinase activity. J. Virol. 2003;77: 12660-12670.

27. Montine TJ, Huang DY, Amarnath V, Valentine WM, Saunders A, Weisgraber KH, Graham D, Strittmatter WJ. Crosslinking of apolipoprotein E by products of lipid peroxidation. J. Neuropath. Exp. Neurol. 1996;55: 202-210.

28. Huang DY, Weisgraber KH, Strittmatter WJ, Matthew WD. Interaction of apolipoprotein E with laminin increases neuronal adhesion and alters neurite morphology. Exp. Neurol. 1995;36: 251-257.

29. Huang DY, Weisgraber KH, Goedert M, Saunders AM, Roses AD, Strittmatter WJ. ApoE3 binding to tau tandem repeat I is abolished by tau serine 262 phosphorylation. Neurosci. Letters. 1995; 92: 209-212.


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30. Strittmatter WJ, Saunders AM, Goedert M, Weisgraber KH, Dong LM, Jakes R, Huang DY, Pericak-Vance M, Schmechel D, Roses AD. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 1994;91: 11183-11186.

31. Sanan DA, Weisgraber KH, Russell SJ, Mahley RW, Huang D, Saunders A, Schmechel D, Wisniewski T, Frangione B, Roses AD, Strittmatter WJ. Apolipoprotein E associates with Aß amyloid peptide to form novel monofibrils: isoform E4 associates more efficiently than E3. J. Clin. Invest. 1994;94: 860-869.

32. Huang DY, Goedert M, Jakes R, Weisgraber KH, Garner CC, Saunders AM, Pericak-Vance MA, Schmechel DE, Roses AD, Strittmatter WJ. Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease. Neurosci. Letters. 1994;182: 55-58.

33. Strittmatter WJ, Huang DY, Bhasin R, Roses AD, Goldgaber D. Avid binding of ßA amyloid to its own precursor. Exp. Neurol. 1993;122: 327-334.

34. Strittmatter WJ, Weisgraber KH, Huang DY, Dong LM, Salvesen GS, Pericak-Vance M, Schmechel D, Saunders AM, Goldgaber D, Roses AD. Binding of human apolipoprotein E to synthetic amyloid peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proc. Natl. Acad. Sci. USA. 1993;90: 8098-8102.

35. Huang DY, Martin M, Hu D, Roses AD, Goldgaber D, Strittmatter WJ. Binding of IgG to amyloid ßA4 peptide via the heavy-chain hinge region with preservation of antigen binding. J. Neuroimmunology. 1993;48: 199-204.

Refereed Papers/Articles (Other peer reviewed articles):

36. Huang, DY. Racial difference in intracerebral hemorrhage. Journal Watch Neurology. 2005;7: 93-94.

37. Strittmatter WJ, Weisgraber KH, Goedert M, Saunders AM, Huang D, Corder EH, Dong LM, Jakes R, Alberts MJ, Gilbert JR, Han SH, Hulette C, Einstein G, Schmechel DE, Pericak-Vance MA, Roses AD. Hypothesis: Microtubule instability and paired helical filament formation in the Alzheimer disease brain as a function of apolipoprotein E genotype. Exp. Neurol. 1994;125: 163-171.

38. Roses AD, Saunders AM, Corder EH, Pericak-Vance MA, Han S-H, Einstein G, Hulette C, Schmechel DE, Holsti M, Huang DY, Risch NJ, Haines JL, Goedert M, Jakes R, Dong L-M, Weisgraber KH, Strittmatter WJ. Influence of the susceptibility genes Apolipoprotein E- ε4 and Apolipoprotein E- ε2 on the rate of disease expressivity of late-onset Alzheimer's disease. Arzneimittel-Forschung/Drug Research. 1995;45: 413-417.

39. Saunders AM, Huang DY, de Serrano V, Martin ME, Roses AD, Strittmatter WJ. Apolipoprotein E and neuronal cytoskeletal proteins. Dementia (Japan). 1996; 10: 185-189.

Refereed Papers/Articles (Published abstracts):

40. Burnett NM, Huang DY. Evolution of a Stroke Center Utilizing Systems Thinking and Collaborative Strategies. Stroke. 2013; 44(2): AWP350.

41. IMS III Investigators (Liebeskind DS, et al.). Collaterals in the Interventional Management of Stroke (IMS) III Trial. Stroke. 2013; 44(2): AWP5.

42. Vinikoor M, Napravnik S, Floris-Moore M, Wilson S, Huang DY, and Eron JJ. Incidence and clinical features of cerebrovascular events in HIV-infected adults in the Southeastern United States. XIX International AIDS Conference, International AIDS Society CD-ROM, 2012.

43. Lee YZ, Aylward S, Huang DY, Faber J, Smith JK. Automated Vessel Extraction for the Identification of Leptomeningeal Collaterals, 2012 ASNR Meeting, American Society of Neuroradiology eBook, 2012.

44. Wilson SE, Huang DY, Aucutt-Walter N, Jordan D, Marino S, Knafl GJ, Benjamin BA. Acute Stroke Nurse Response Pilot Program. Stroke. 2012; 43: A3074.

45. SENTIS Investigators (Shuab A). Older Age and Shorter Time from Symptom Onset Positively Impacts Outcomes in Moderate Severity Stroke Patients in SENTIS Trial. Stroke. 2012;43: A129.


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46. SENTIS Investigators (Liebeskind DS, et al.). Recanalization of Proximal Arterial Occlusion in the SENTIS Trial. Stroke. 2012;43: A1911.

47. Powers W, Aucutt-Walter N, Huang D, Sheikh A, Ivanovic M. Inflammation in Human Intracerebral Hemorrhage Demonstrated In Vivo with 99mTc-HMPAO Labeled Leukocytes. Neurology. 2011, 76 (Supplement 4): A426.

48. SENTIS Steering Committee and Investigators. Effect of NeuroFlo Treatment on Stroke Outcome - A Subgroup Analysis of the SENTIS Study. Stroke. 2011; 42(3): e47.

49. Lee YZ, Jones T, Solander S, Huang D, Faber J, Smith JK. Collateral estimation using an MR dynamic susceptibility contrast based correlation analysis with DSA validation. RSNA 2010 Meeting Program, Abstract VN41-09.

50. Sen S, Huang D, Akhavan O, Wilson S, Verro P, Solander S. IV vs. IA tPA (Activase) in acute ischemic stroke with CTA evidence of major vessel occlusion: a feasibility study. Int J Stroke. 2008; 3 (Supplement 1):2-474.

51. Sen S, Simmons JW, Huang DY, Wilson SE, Barnwell J, Hyslop WB, Hinderliter AL. Cardiovascular MRI in detection and measurement of aortic atheroma in stroke/TIA patients. Stroke. 2008;39: 582.

52. Wilson SE, Huang DY, Doggett F, Holzmacher K, Sen S. Disparities in stroke thrombolytic administration: Academic versus local community hospitals. Stroke. 2007;38: 509.

53. Wilson S, Shah H, Haven K, Huang D, Robertson K, Doggett F, Holzmacher K, Sen S. Stroke Screening Program for African Americans (SSPAA). Stroke. 2007;38: 609.

54. Anderson LG, Meeker RB, Huang DY. Carboxy terminus of heat shock cognate 70 (CHIP) localization following in vitro heat stress and oxygen glucose deprivation. Program No. 613.1. 2006 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2006. CD-ROM.

55. Sen S, Felix AC, Huang DY, Varanasi J, Hinderliter A, Wilson S, Simmons J, Duch PM, Oppenheimer SM. Leukocyte count and plasma homocysteine levels are associated with aortic arch plaque thickness in stroke/TIA patients. Neurology. 2005;64(Supplement 1): P01.118.

56. Anderson LG, Meeker RB, Huang DY. Nuclear translocation of a novel ubiquitin ligase in response to cellular stress. Program No. 104.19. 2004 Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, 2004. CD-ROM.

57. Strittmatter WJ, Huang DY, Goedert M, Jakes R, Dong LM, Weisgraber K, Pericak-Vance M, Saunders AM, Schmechel D, Roses AD. Apolipoprotein E isoform-specific interactions with cytoskeletal proteins. Neurobiol. Aging. 1994;15(Supplement 1): S77.

58. Huang DY, Goedert M, Jakes R, Dong LM, Weisgraber KH, Pericak-Vance MA, Saunders AM, Schmechel DE, Roses AD, Strittmatter WJ. Isoform-specific interactions of apolipoprotein E and microtubule-associated proteins. Inter. J. Develop. Neurosci. 1994;12 (Supplement 1): 53.

In Press or Submitted Papers/Articles/Abstracts:

59. Schellinger PD, Shuaib A, Köhrmann M, Liebeskind DS, Jovin T, Hammer MD, Sen S, Huang DY, Solander S, Gupta R, Leker RR, Saver JL (for the SENTIS Trial Investigators). Reduced mortality and severe disability rates in the SENTIS Trial (original manuscript). AJNR. 2013; in press (manuscript #AJNR-13-00011.R1).

60. Vinikoor M, Napravnik S, Floris-Moore M, Wilson S, Huang DY, and Eron JJ. Incidence and clinical features of cerebrovascular disease among HIV-infected adults in the Southeastern United States (original manuscript). AIDS Research and Human Retroviruses. 2013; in press (manuscript #AID-2012-0334.R1).

Unpublished Oral Presentations and Posters:

61. Wilson SE, Huang DY, Aucutt-Walter N, Jordan D, Marino S, Knafl GJ, Benjamin BA. Acute Stroke Nurse Response Pilot Program (Poster), 2011 UNC School of Nursing Research Day, Chapel Hill, NC


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62. Invited Speaker Presentation, “Advances in the Treatment and Prevention of Stroke: Focus on Geriatric Practice,” American Association of Geriatric Psychiatry 2005 Meeting, San Diego, CA

63. Invited Speaker Presentation, "Biochemical Interactions of Apolipoprotein E: Implications for Alzheimer's Disease," 1996 Broad Foundation Symposium, Durham, NC

TEACHING RECORD Program Director:

2010-present Vascular Neurology Residency Training Program, UNC Department of Neurology (Division of Stroke and Vascular Neurology) and UNC Office of GME

2009-present Adult Neurology Residency Training Program, UNC Department of Neurology and UNC Office of GME

Course Director:

2003-2007 Neurology Grand Rounds CME Program, UNC Department of Neurology and UNC School of Medicine CME Program (co-sponsors)

Lectures:

2010-present Neurology Brain and Behavior Small Group Sessions (4 sessions: Neurodegenerative Diseases; Neuroanatomy 1; Neuroanatomy 2; Neuromuscular Diseases), UNC School of Medicine and UNC Neuroscience Center

30 medical students (second year)

2009-present Guest Lecture (annual), “Administrator-Physician Communication in Hospital Settings,” Leadership and Management of Healthcare Organizations (HPM 730), UNC School of Public Health

First-year MHA students

2008 Neurology Resident Lecture (annual), “Hemorrhagic Stroke,” UNC Department of Neurology

15 residents per year

2008-present Neuroscience Third Year Clerkship Conference, Stroke Cases, UNC School of Medicine 14 medical students (third year) per lecture, 8-10 lectures per year

2008 Pulmonary/ICU Conference, “Stroke Management in the ICU,” UNC Department of Medicine

Pulmonary/ICU attendings and fellows

2007-2011 Neurology Resident Lecture (annual), “Uncommon Causes of Ischemic Stroke,” UNC Department of Neurology


2007-2010 Neurology Resident Lecture (annual), “Coma and Disorders of Consciousness,” UNC Department of Neurology


2006-2007 Neuroscience Third Year Clerkship Lecture (bi-monthly), “Disorders of Consciousness,” UNC School of Medicine

26 medical students (third year) per lecture, six lectures per year

2006 Neuroscience Case Presentations (2 sessions: Parkinson’s Disease; Myasthenia Gravis), UNC School of Medicine and UNC Neuroscience Center

40 medical students (first year)

2005 MICU Resident Lecture, “Current Issues in Neurologic Critical Care,” UNC Department of Medicine


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MICU attendings, fellows, and residents

2005-2007 Neurology Resident Lecture (annual), “Evaluation of the Acute Stroke Patient,” UNC Department of Neurology


2004-2007 Neurology Resident Lecture (annual), “Intracranial Hemorrhage,” UNC Department of Neurology


2003-2007 Neurology Resident Lecture (annual), “Hypercoagulable State and Stroke,” UNC Department of Neurology


2003-2004 Neurology Resident Lecture (annual), “Interventions for Acute Stroke,” UNC Department of Neurology


2003 Developmental Neurobiology Seminar, “CHIP in the Nervous System,” UNC Neuroscience Center

Faculty researchers, postdoctoral fellows and graduate students Grand Rounds (UNC and Other Institutions):

2012 “Strokes and TIAs,” Internal Medicine Grand Rounds, Rex Healthcare, Raleigh, NC

2011 “UNC Hospitals Stroke Center Update,” UNC Neurology Grand Rounds, UNC Department of Neurology and UNC School of Medicine CME Program (co-sponsors), Chapel Hill, NC

2007 “ICH: Management and Guidelines,” Grand Rounds, Department of Medicine, Georgetown University Hospital, Washington, D.C.

2007 “Acute Stroke Trials: The UNC Experience,” Grand Rounds, Department of Neurology, Wake Forest University Medical Center, Winston-Salem, NC

2006 “ICH: Management Update,” UNC Neurovascular Rounds, UNC Department of Neurology and UNC School of Medicine CME Program (co-sponsors), Chapel Hill, NC

CME/CE Presentations (UNC and AHEC):

2012 “Strokes and TIAs,” Area L AHEC CME Program, Nash General Hospital, Rocky Mount, NC

2011 “2011 Stroke Update,” WakeMed Stroke Center and Wake AHEC CME Program, Raleigh, NC

2011 “Treating a Stroke,” Saving Lives: Understanding Stroke, Area L AHEC CE Program, Chapel Hill, NC

2010 “IV t-PA Beyond 3 Hours: How did we get here?” 4th MAHEC Biennial Stroke Conference, Mountain AHEC CME Program, Asheville, NC

2010 “Acute Stroke Treatments,” UNC Air Care CE Program, UNC Hospitals, Chapel Hill, NC

2010 “Improving Outcomes in Stroke Patients,” UNC School of Medicine CME Program (AHEC, Area L), Wilson Medical Center, Wilson, NC

2009 “Thrombolysis for Acute Stroke: Present and Future,” Greensboro AHEC CME Program, Greensboro, NC

2008 “Stroke Treatments: rt-PA and Beyond,” ACLS-EP Certification Program, UNC Health Care, Chapel Hill, NC


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2008 “Improving Outcomes in Stroke Patients,” UNC School of Medicine CME Program (AHEC), Halifax Regional Medical Center, Roanoke Rapids, NC

2008 “Clinical Trials of Stroke Therapies,” 2008 UNC Mini Medical School, UNC School of Medicine Outreach Program, Chapel Hill, NC

2007 “Acute Stroke Treatments,” Annie Penn Hospital, UNC School of Medicine CME Program (AHEC), Reidsville, NC

2006 “Acute Stroke: 2006 Update,” UNC Hospitals Stroke Center and Orange County EMS CE Program (co-sponsors, two programs), Chapel Hill, NC

2006 “ICH: Epidemiology, Diagnosis, and Acute Management,” UNC Hospitals Stroke Center CME Program, Chapel Hill, NC

2006 “Improving Outcomes in Stroke Patients,” UNC School of Medicine CME Program (AHEC), Nash General Hospital, Rocky Mount, North Carolina

2006 “Telestroke: New Technology for Rural Stroke Care,” Western NC Regional Stroke Conference, Mountain AHEC CME Program, Asheville, NC

2006 “Novel Treatments for ICH,” Western NC Regional Stroke Conference, Mountain AHEC Program, Asheville, NC

2005 “Advances in the Treatment and Prevention of Stroke,” UNC School of Medicine CME Program (AHEC), Halifax Regional Medical Center, Roanoke Rapids, NC

2005 “2005: The State of Stroke in North Carolina,” JCAHO/GWTG Getting Started Workshop (CME/CE), American Heart Association and UNC Friday Center for Continuing Education (co-sponsors), Chapel Hill, NC

2004 “Treatment and Management of Acute Stroke in Older Adults,” Challenges in Geriatric Practice, UNC School of Medicine CME Program, Chapel Hill, NC

2003 “Management of Acute Stroke,” UNC Fall Medical Alumni Weekend: New Therapies in Neurology, UNC School of Medicine CME Program, Chapel Hill, NC

CME/CE Presentations (Outside UNC):

2013 “Stroke 101,” FirstHealth EMS CE Programs, Pittsboro, NC

2013 “Stroke 101,” What’s the Big Idea? Continuing Education Lecture Series, UNC Friday Center, Chapel Hill, NC

2012 “Ischemic Stroke 101,” Alamance County EMS CE Programs, Burlington, NC

2011 “’Unexplained’ thromboembolic stroke – Work-up and management,” 2011 Annual Scientific Symposium of the Hemostasis Thrombosis Research Society, Chicago, IL

2011 “Acute Stroke Update,” Orange County EMS CE Program, Hillsborough, NC

2010 “Acute Stroke Care,” Alamance County EMS CE Program, Burlington, NC

2010 “Acute Stroke Care: rt-PA and Beyond,” Advancing Exceptional Acute Stroke Practices, American Heart Association CME/CE Program, Winston-Salem, NC

2009 “The Joint Commission Stroke Core Measures,” Rex Healthcare CME, Raleigh, NC

2009 “Thrombolysis: rt-PA and Beyond,” Rex Healthcare CME, Raleigh, NC

2009 “Systems of Care: t-PA Protocols, Transfers, and Telemedicine,” Stroke Care in New Hampshire: Building & Maintaining a Successful Stroke Program, American Heart Association CME/CE Program, Nashua, NH

2009 “Thrombolysis: rt-PA and Beyond,” American Association of Critical Care Nurses (Wake County Chapter) CE Program, Durham, NC


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2007 “ICH: Diagnosis and Management,” ICH Critical Pathways Regional CME Workshop, Memphis, TN

2007 “Acute Stroke Treatments,” 2007 Pinehurst Medical Symposium, FirstHealth Moore Regional Hospital CME Program, Pinehurst, NC

2006 “ICH Epidemiology and Etiology,” ICH Critical Pathways Regional CME Workshop, Atlanta, GA

2006 “Update on Treatment Options for ICH,” Moore County Pharmacists Association CE Program, Southern Pines, NC

2005 “Stroke Update,” Stroke Rapid Response Training Program (CME/CE), National Stroke Association, Chapel Hill, NC

Clinical Teaching:

2004-2006 Examiner, Neurology Residency Mock Oral Boards, UNC Department of Neurology 2 residents per year, 4 hours per year

2002-2007 Neurology Resident Teaching, General Neurology Clinic, UNC Hospitals 1-4 residents per week, 4 hours per week

2002-present Medical Student Supervision, Neurology Clerkship, UNC School of Medicine 2-4 medical students per week, 6-10 weeks per year Research Teaching:

2003 Holderness Medical Research Fellowship Mentor/Preceptor, UNC School of Medicine Medical student: Christopher Watson, M.D. Attending on Clinical Service:

2002-present General Neurology In-Patient Service, UNC Hospitals 5 residents per week, 4-12 weeks per year

2002-present Neurology Consult Service, UNC Hospitals 2 residents per week, up to 2 weeks per year Graduate Supervision/Committees:

2004-2008 Graduate Thesis Committee Member and Primary Research Mentor (2006-2008), Neurobiology Curriculum, UNC School of Medicine

Graduate Student: Lauren Anderson, Ph.D. Dissertation: Carboxy Terminus of Heat shock cognate 70 Interacting Protein (CHIP)

following cellular stress Mentorship and Other Supervision:

2009-present UNC Neurovascular Research Fellowship, UNC Departments of Neurology and Radiology

Current fellows: Adomas Bunevicius, M.D., Anahit Mehrabyan, M.D.

2004-present Medical Student Career Goal Advisor, UNC School of Medicine Current student: James “Trey” Bateman Past students: Danilo Bernardo, M.D; Karissa Gable, M.D.; Brijesh Mehta, M.D.

2004-2010 Resident Faculty Advisor, Neurology Residency Program, UNC Department of Neurology

Past residents: Gaurang Palikh, M.D.; David N. Johnson, M.D.


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2004-present UNC Vascular Neurology Fellowship, UNC Hospitals and UNC Department of Neurology

Current Fellow: Michael Wang, M.D. Past fellows: Matthew Smith, M.D., Matthew Ostrander, M.D., Natalie Aucutt-Walter,

M.D.; Nydia Melendez, M.D. Community Education:

2013 “What Stroke Systems of Care Mean for You,” Lee County Stroke Support Group, Sanford, NC

2012 “A Conversation about Stroke,” Lee County Stroke Support Group, Sanford, NC

2011 “Your Stroke Center,” UNC Stroke Support Group, Chapel Hill, NC

2006 “Stroke: Recognition and Treatment,” Fearrington Cares Health Education Program, Chapel Hill, NC

2006 “Brain Attack,” Carolina Meadows Education Program, Chapel Hill, NC

2005 “What is a stroke and how do you treat it?” Fit for Life Educational Outreach Program, UNC Hospitals Stroke Center, Chapel Hill, NC

2005 “What is Stroke?” 2nd Annual Stroke Lunch and Learn, UNC Hospitals Stroke Center, Chapel Hill, NC

2004 “A Conversation about Stroke,” UNC Stroke Support Group, Chapel Hill, NC GRANTS FUNDED (at UNC) 2011-present Co-Investigator, “ARFI Ultrasound for Noninvasive, Diagnostic Atherosclerosis

Imaging,” UNC Joint Department of Biomedical Engineering Principal Investigator: Caterina M. Gallippi, Ph.D. Sponsor: NIH/NHLBI #5R01HL092944

2005-2009 Principal Investigator, “CHIP in Murine Models of Cerebral Ischemia,” UNC Department of Neurology

Budget: $828,505 (5 years); terminated at the end of year 4 due to job change Sponsor: NIH/NINDS #K08NS050164

2004-2005 Principal Investigator, “CHIP in Murine Models of Cerebral Ischemia,” UNC Department of Neurology

Budget: $264,000 (4 years); relinquished in 2005 due to overlap with NIH/NINDS grant #K08NS050164

Sponsor: American Heart Association (National Center Scientist Development Grant) #0435011N

2004 Principal Investigator, “CHIP in Murine Models of Cerebral Ischemia,” UNC Department of Neurology

Budget: $132,000 (2 years); declined due to overlap with AHA grant #0435011N Sponsor: American Heart Association (Mid-Atlantic Affiliate Beginning Grant-in-Aid)

#0465427U

2004 Primary Mentor, “Improving Knowledge and Response Time to Access Acute Medical Care for Young African Americans with Ischemic Strokes by using the American Heart Association 3R’s Program: Recognize warning signs of stroke, Respond immediately to stroke and Reduce risk of stroke,” UNC Department of Neurology

Principal Investigator: Susan Wilson, MSN, FNP Sponsor: Stroke Belt Consortium


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2003-2005 Co-Investigator and Project Principal Investigator (Stroke), “Korean Acupuncture in Central Nervous System Disorders,” UNC Department of Neurology

Principal Investigator: J. Douglas Mann, M.D. Budget: $254,217 (2 years) Sponsor: NIH/NCCAM #5R21-AT001952

2002-2005 Co-Investigator, “Progression of Aortic Atheroma in Stroke/TIA Patients,” UNC Department of Neurology

Principal Investigator: Souvik Sen, M.D. Sponsor: UNC GCRC project # 2061 (funded by NIH/GCRC # RR00046) PROFESSIONAL SERVICE – STATE, NATIONAL, and INTERNATIONAL State:

2011-2012 Contributing Author, A Strategic Plan for Cardiovascular Health in North Carolina: Acute/Sub-acute Section, Justus-Warren Heart Disease and Stroke Prevention Task Force, North Carolina Department of Health and Human Services (Division of Public Health)

2011-present Appointed Member, Justus-Warren Heart Disease and Stroke Prevention Task Force, North Carolina State Legislature and North Carolina Department of Health and Human Services (Division of Public Health)

2010-2011 Planning Participant and Contributing Author, Association of State and Territorial Health Officials (ASTHO) North Carolina Stroke System of Care Plan, North Carolina Department of Health and Human Services (Division of Public Health) • Co-Chair, Acute/Sub-Acute Work Group

2006-present Appointed Member, North Carolina Stroke Advisory Council, Justus-Warren Heart Disease and Stroke Prevention Task Force, North Carolina State Legislature and North Carolina Department of Health and Human Services (Division of Public Health) • Co-Chair, Acute/Sub-Acute Care Work Group (2008-2011) • Member, Rehabilitation Work Group (2008-2010) • Member, North Carolina Hospital Facilities Survey Work Group (2007-2010)

2006-present Appointed Member, Advisory Council for the North Carolina Stroke Care Collaborative (formerly the North Carolina Collaborative Stroke Registry), North Carolina Department of Health and Human Services (Division of Public Health) and Centers for Disease Control • Member, Innovative Grant Review Committee (2008-present)

2006-2010 Advisor, EMS Performance Improvement Stroke Toolkit Development, EMS Performance Improvement Center, North Carolina Office of EMS and Centers for Disease Control

2004-2011 Medical Resource, Justus-Warren Heart Disease and Stroke Prevention Task Force, North Carolina State Legislature and North Carolina Department of Health and Human Services (Division of Public Health)

National:

2012-present Steering Committee, Study of ALD-401 via Intracarotid Infusion in Ischemic Stroke Subjects, Aldagen, Inc., ClinicalTrials.gov Identifier: NCT01273337.

2006-2010 Member, Tri-State Stroke Network, North Carolina Department of Health and Human Services (Division of Public Health)


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2006-2009 Member, Executive Committee, “Warfarin in Intracerebral Hemorrhage Study (WINCH),” Transfusion Medicine/Hemostasis Clinical Trials Network (TMH Network), NHLBI/NIH

International:

2011 Invited Participant, 3rd Stem Cell Therapies as an Emerging Paradigm in Stroke Meeting (STEPS 3), Washington, DC

2011 Invited Faculty, 2011 Annual Scientific Symposium of the Hemostasis Thrombosis Research Society, Chicago, IL

2011 Invited Faculty, 2011 International Stroke Conference, American Heart Association/American Stroke Association, Los Angeles, CA

2010-present Member, Abstract Grading Subcommittee, International Stroke Conference Program Committee, American Heart Association/American Stroke Association

2008 Invited Reviewer, Neurohospitalist Project Commissioning, Medicine Section, Cambridge University Press

2008 Invited Reviewer, Diffusion/Perfusion MRI in Stroke, Practice Guidelines Development, American Academy of Neurology

2007-2009 Annual Meeting Abstract Reviewer, Cerebrovascular Disease Topic, American Academy of Neurology

2007 Contributor, Stroke Guidelines Project, Stroke Practice Work Group, Stroke and Vascular Neurology Section, American Academy of Neurology

2005 Contributing Editor, Journal Watch Neurology, Massachusetts Medical Society

PROFESSIONAL SERVICE – AD HOC MANUSCRIPT REVIEW

Antioxidants & Redox Signaling

Cerebral Cortex

BMC Neurology

International Journal of Neuroscience

Journal of the Neurological Sciences

Journal of Stroke and Cerebrovascular Diseases

Neurology PROFESSIONAL SERVICE – UNC COMMITTEES UNC Department of Neurology:

2012-present Member, Ad Hoc Clinic Move Committee

2009-present Member, Faculty Compensation Committee

2009-present Member, Medical Student Education Committee

2004-present Member and Chairman (2005-7/2008, 6/2009-present), Neurology Residency Education and Training Committee

2003-present Member, Faculty and Clinical Staff Search Committees • Associate Chair for Administration • Basic Research (UNC Neuroscience Center)


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• Behavioral Neurology • Cognitive Neuroscience • EEG/Epilepsy • General Neurology • Movement Disorders • Multiple Sclerosis • Neuro-Intensive Care • Stroke

2003-present Interviewer, Neurology Residency Candidate Selection

2002-2007 Member and Chairman (2003-2007), Neurology Grand Rounds Committee UNC Department of Physical Medicine and Rehabilitation:

2011 Member, Neuro-rehabilitation Faculty Search Committee UNC School of Medicine:

2005-2009 Ad Hoc Interviewer, Admissions Committee, UNC Medical Scientist Training (M.D.-Ph.D.) Program, UNC School of Medicine

2008-2010 Ad Hoc Interviewer, Admissions Committee, Biological and Biomedical Science Program (BBSP), UNC School of Medicine

UNC Hospitals:

2013 Stroke Center Representative, Working group to establish the UNC Blunt Cerebrovascular Injury (BCVI) Treatment Protocol

2012-2013 Medical Director, Working group for Joint Commission Comprehensive Stroke Center certification

2011-present Stroke Center Representative, Neurosciences Quality Committee

2011-present Chairman, GMEC Moonlighting Sub-Committee, UNC Hospitals GME Committee

2010-present Neurology/Stroke Center Representative, Neurosciences ICU Multidisciplinary Committee

2009-present Chairman and Neurology/Stroke Center Representative, BAT Leadership Team • Leader, BAT Algorithm Implementation

2009-present Voting Member, UNC Hospitals GME Committee

2007 Neurology Representative, Working group to establish the UNC Induced Hypothermia (Induced Cooling to Eliminate Deficits - ICED) Protocol

2005-2006 Neurology/Stroke Representative, Working group to establish the UNC Multidisciplinary Endovascular Carotid Center

2005 Neurology/Stroke Representative, Working group to establish credentialing criteria for carotid stenting (CMS - Medicare Part A)

2004-2010 Member, Working groups (2004, 2006, 2008, 2010) for JCAHO Primary Stroke Center certification

2003-present Member, UNC HealthCare Stroke Center Multispecialty Committee PROFESSIONAL SERVICE – UNC ADMINISTRATIVE APPOINTMENTS UNC Department of Neurology:


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2010-present Program Director, Vascular Neurology Residency Training Program, UNC Department of Neurology, UNC Hospitals and UNC Office of GME

2009-present Chief, Division of Stroke and Vascular Neurology, UNC Department of Neurology

2009-present Program Director, Adult Neurology Residency Training Program, UNC Department of Neurology, UNC Hospitals and UNC Office of GME

2006-2009 Director, Inpatient and Emergency Neurology, UNC Department of Neurology

2006-2007 Director, Neurovascular Fellowship Program, UNC Department of Neurology

2003-2007 Course Director, Neurology Grand Rounds, UNC Department of Neurology and UNC School of Medicine CME Program

2003 Interim Program Director, Neurovascular Fellowship Program, UNC Department of Neurology

UNC Hospitals:

2013-present Director, UNC Health Care Comprehensive Stroke Center, UNC Hospitals and UNC Departments of Neurology and Neurosurgery

2011-present Core Faculty, UNC Hereditary Hemorrhagic Telangiectasia Center of Excellence, UNC Hospitals

2009-2013 Director, UNC Hospitals (Primary) Stroke Center, UNC Hospitals and UNC Department of Neurology

2008-2009 Co-Director, UNC Hospitals (Primary) Stroke Center, UNC Hospitals and UNC Department of Neurology

2006-2008 Associate Director, UNC Hospitals (Primary) Stroke Center, UNC Hospitals and UNC Department of Neurology

2006-2009 Co-Medical Director, Stroke Treatment and Prevention Unit (STPU), UNC Hospitals UNC School of Medicine:

2010-present Medical Student Career Goal Advisor, Office of Student Affairs, UNC School of Medicine

2010-present Affiliate Graduate Faculty, Curriculum in Neurobiology, UNC School of Medicine

2007-present Affiliate Graduate Faculty, Biological and Biomedical Science Program (BBSP), UNC School of Medicine

2006-2010 Primary Graduate Faculty, Curriculum in Neurobiology, UNC School of Medicine 2005-present Faculty, UNC McAllister Heart Institute (formerly the Carolina Cardiovascular Biology

Center), UNC School of Medicine UNC:

2012-present Affiliate Faculty, Rehabilitation Engineering Center, Joint Department of Biomedical Engineering, UNC and N.C. State University

PROFESSIONAL SERVICE – OTHER ACTIVITIES (at UNC) UNC Department of Neurology:

2007 Directed the implementation of electronic notes (WebCIS) for adult neurology services

2007 Directed the Department’s evaluation of the CMS PQRI


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2006-present Construct and manage faculty attending schedules for the Adult Neurology inpatient services and resident continuity clinic

2006-2007 Directed the re-structuring of resident continuity clinic

2005 Directed the re-structuring of resident triage clinic

2005-2006 Directed a fiscal analysis of the in-patient consult service and the re-organization of in-patient consult attending duties

2004 Directed the redesign of the Department’s web site PROFESSIONAL ACTIVITIES – FACULTY DEVELOPMENT

2011 TeamSTEPPS Master Training, UNC Hospitals

2010 Faculty Leadership Initiative, Program in Leadership Development, UNC School of Medicine

2010 Neurology Program Directors Boot Camp, Association of University Professors of Neurology

2010 Chief Resident Leadership Program, Office of GME, UNC Hospitals

2009 UNC Hospitals Residency Program Director Retreat, Office of GME, UNC Hospitals PROFESSIONAL ACTIVITIES – CLINICAL STUDIES/TRIALS (at UNC)

Principal Investigator:

2013 Principal Site Investigator, “Futility Study of Deferoxamine Mesylate in Intracerebral Hemorrhage (HI-DEF in ICH) ,” UNC Department of Neurology

Sponsor: NIH/NINDS

2012-present Principal Site Investigator, “A Phase 2 Multicenter, Randomized, Double-Blind, Placebo Controlled Study of the Safety and Efficacy of Pf-03049423 in Subjects with Ischemic Stroke,” UNC Department of Neurology

Sponsor: Pfizer

2012-present Principal Site Investigator, “The North Carolina Stroke Care Collaborative Registry,” UNC Hospitals Stroke Center and UNC Department of Neurology

Sponsors: Centers for Disease Control (Paul Coverdell National Acute Stroke Registry Grant) and the North Carolina Department of Health and Human Services

2011-2012 Principal Site Investigator, “A Multicenter Observational Study to Evaluate the Simplified-Stroke Rehabilitation Assessment of Movement (S-STREAM) Scale in Subjects Obtained Between 24 and 48 Hours of a Nonhemorrhagic Stroke,” UNC Department of Neurology

Sponsor: Asubio

2010-2013 Principal Site Investigator, “NeuroThera® Efficacy and Safety Trial - 3 (NEST-3): A Double-blind, Randomized, Sham-controlled, Parallel Group, Multicenter, Pivotal Study to Assess the Safety and Efficacy of Transcranial Laser Therapy With the NeuroThera® Laser System for the Treatment of Acute Ischemic Stroke Within 24 Hours of Stroke Onset.,” UNC Department of Neurology

Sponsor: PhotoThera

2010-present Principal Site Investigator, “ALIAS II: Albumin in Acute Stroke, part II,” UNC Department of Neurology

Sponsor: NIH/NINDS


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2010-2013 Principal Site Investigator, “IMS-III: Interventional Management of Stroke III,” UNC Department of Neurology

Sponsor: NIH/NINDS

2010-2011 Principal Site Investigator, “A Phase I, Double-Blind, Placebo-Controlled, Ascending-Dose, Clinical Study Investigating the Safety, Tolerability, and Pharmacokinetics of MP-124 in Acute, Ischemic Stroke Patients,” UNC Department of Neurology

Sponsor: Mitsubishi Tanabe Pharma

2010 Principal Site Investigator, “SENTIS: Safety and Efficacy of NeuroFlo Technology in Ischemic Stroke with SCION (A Study of Care Intensity and Outcomes of NeuroFlo),” UNC Department of Neurology

Sponsor: CoAxia

2008-2009 Co-Principal Site Investigator, “The North Carolina Stroke Care Collaborative Registry,” UNC Department of Neurology

Sponsors: Centers for Disease Control (Paul Coverdell National Acute Stroke Registry Grant) and the North Carolina Department of Health and Human Services

2007-2009 Principal Site Investigator, “NeuroThera® Effectiveness and Safety Trial – 2 (NEST-2): A double blind, randomized, controlled, parallel group, multicenter, pivotal study to assess the safety and effectiveness of the treatment of acute ischemic stroke with the NeuroThera® Laser System within 24 hours from Stroke Onset.,” UNC Department of Neurology

Sponsor: PhotoThera

2007-2008 Principal Site Investigator, “Comparison of Aggrenox vs. Plavix in Secondary Stroke Prevention (PROFESS),” UNC Department of Neurology

Sponsor: Boerhinger Ingelheim

2006-2007 Principal Site Investigator, “FAST: Randomised, Double-Blind, Placebo Controlled, Multi-Centre, Parallel Groups Confirmatory Efficacy and Safety Trial of Activated Recombinant Factor VII (NovoSeven) in Acute Intracerebral Hemorrhage,” UNC Department of Neurology

Sponsor: NovoNordisk A/S Co-Investigator or Sub-Investigator:

2012-present Co-Investigator, “A Multicenter Observational Study to Evaluate the Simplified-Stroke Rehabilitation Assessment of Movement (S-STREAM) Scale in Subjects Obtained Between 24 and 48 Hours of a Nonhemorrhagic Stroke,” UNC Department of Neurology

Sponsor: Asubio

2012-present Co-investigator, “Magnetic Resonance Imaging of Cerebral Hemodynamics in Patients with Carotid Artery Occlusion,” UNC Department of Neurology

Principal Investigator: William J. Powers, M.D.

2011-present Co-Investigator, “Platelet-Oriented Inhibition in New TIA and minor ischemic stroke (POINT) Trial,” UNC Department of Neurology

Principal Site Investigator: Natalie Aucutt-Walter, M.D. Sponsor: NIH/NINDS

2010 Co-Investigator, “Cardiac MRI to Detect and Measure AA Atheroma Progression” UNC Department of Radiology

Principal Site Investigator: Brian Hyslop, M.D. Sponsor: The North Carolina Translational and Clinical Sciences (NC TraCS) Institute

2009-2011 Co-Investigator, “Evaluation of Dotarem-enhanced MRA compared to Time-Of-Flight (TOF) MRA in the diagnosis of cervical arterial disease,” UNC Department of Radiology


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Principal Site Investigator: Benjamin Y. Huang, M.D. Sponsor: Guerbet

2009-2010 Co-Investigator, “Determination of Perihematomal Inflammation in Intracerebral Hemorrhage with Tc-HMPAO Labeled Leukocytes,” UNC Department of Neurology

Principal Investigator: Natalie Aucutt-Walter, M.D. Sponsor: NC TraCS Institute

2009-2010 Co-Investigator, “A Phase I, Double-Blind, Placebo-Controlled, Ascending-Dose, Clinical Study Investigating the Safety, Tolerability, and Pharmacokinetics of MP-124 in Acute, Ischemic Stroke Patients,” UNC Department of Neurology

Principal Site Investigator: Souvik Sen, M.D. Sponsor: Mitsubishi Tanabe Pharma

2009-2010 Co-Investigator, “Implant for Augmentation of Cerebral Blood Flow Trial, Effectiveness and Safety in a 24 Hour Window (ImpACT-24),” UNC Department of Neurology

Principal Site Investigator: Natalie Aucutt-Walter, M.D. Sponsor: BrainsGate

2009-2010 Co-Investigator, “ALIAS II: Albumin in Acute Stroke, part II,” UNC Department of Neurology

Principal Site Investigator: Souvik Sen, M.D. Sponsor: NIH/NINDS

2008-2010 Co-Investigator, “Carotid Occlusion Surgery Study (COSS),” UNC Department of Neurology

Principal Satellite Site Investigator: Susan Wilson, F.N.P. Sponsor: NIH/NINDS

2007-2009 Co-Investigator, “Siblings with Ischemic Stroke Study (SWISS),” UNC Department of Neurology


2007-2010 Co-Investigator, “IMS-III: Interventional Management of Stroke III,” UNC Department of Neurology


2007-2008 Co-Investigator, “ALIAS: Albumin in Acute Stroke,” UNC Department of Neurology Principal Site Investigator: Souvik Sen, M.D. Sponsor: NIH/NINDS

2007-2009 Co-Investigator, “FLO-24: Safety and Efficacy of NeuroFlo in 8-24 Hour Stroke Patients,” UNC Department of Neurology

Principal Site Investigator: Souvik Sen, M.D. Sponsor: CoAxia

2007-2009 Co-Investigator, “Development and Evaluation of Hemorrhagic Stroke Classification System,” UNC Department of Neurology

Principal Investigators: Souvik Sen, M.D. and Donald Lynch, M.D. Sponsor: UNC Stroke Center

2006-2009 Co-Investigator, “CRESCENDO: Randomized, Multinational, Multicenter, Double-Blind, Placebo-Controlled, Two-Arm Parallel Group Trial of Rimonabant 20 mg OD for Reducing the Risk of Major Cardiovascular Events in Abdominally Obese Patients With Clustering Risk Factors,” UNC Department of Neurology

Principal Site Investigator: Souvik Sen, M.D. Sponsor: Sanofi-Aventis


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2005-2010 Co-Investigator, “SENTIS: Safety and Efficacy of NeuroFlo Technology in Ischemic Stroke with SCION (A Study of Care Intensity and Outcomes of NeuroFlo),” UNC Department of Neurology

Principal Site Investigator: Souvik Sen, M.D. Sponsor: CoAxia

2005-present Sub-Investigator, “Warfarin-Aspirin Reduced Cardiac Ejection Fraction Study (WARCEF),” UNC Department of Medicine (Division of Cardiology)

Principal Site Investigator: Patricia Chang, M.D. Sponsor: NIH/NINDS

2005-2007 Co-Investigator, “Peripheral Artery Disease and Biomarkers for Cerebrovascular Disease in Patients with Ischemic Stroke and Transient Ischemic Attack,” UNC Department of Neurology

Principal Investigator: Souvik Sen, M.D Sponsors: UNC Department of Neurology and Sanofi (grant for investigator-initiated

study)

2005-2007 Co-Investigator, “Temporal Characterization of Stroke Lesion Evolution During the Hyperacute State,” UNC Departments of Radiology and Neurology

Principal Investigator: Weili Lin, Ph.D. Sponsors: UNC Departments of Radiology and Neurology

2005-2006 Co-Investigator, “Use of Contrast-Enhanced MRI to Evaluate for Sources of Stroke Emboli,” UNC Department of Radiology

Principal Investigator: W.B. Hyslop, M.D. Sponsor: UNC Departments of Neurology (Stroke Division) and Radiology

2004-2007 Co-Investigator, “A Multi-Center, Randomized, Double-Blind, Placebo-controlled, Ascending-Dose Study of the Safety, Pharmacokinetics, and Pharmacodynamics of a Single, 1-Hour Infusion of TS-011 in Acute Ischemic Stroke (AIS) Patients,” UNC Department of Neurology

Principal Site Investigator: Souvik Sen, M.D. Sponsor: Taisho

2004-2006 Sub-Investigator, “The North Carolina Collaborative Stroke Registry,” UNC Department of Neurology

Principal Site Investigator: Ana Felix, M.D. Sponsors: Centers for Disease Control and the North Carolina Department of Health and

Human Services

2004-2008 Co-Investigator, “IV vs. IA rt-PA (Activase) in Acute Ischemic Stroke with CTA Evidence of Major Vessel Occlusion,” UNC Department of Neurology

Principal Investigator: Souvik Sen, M.D. Sponsors: UNC Department of Neurology and Genentech (grant for investigator-initiated

study)

2004-2007 Co-Investigator, “Comparison of Aggrenox vs. Plavix in Secondary Stroke Prevention (PROFESS),” UNC Department of Neurology

Principal Site Investigator: Souvik Sen, M.D. Sponsor: Boerhinger Ingelheim

2004-2008 Sub-Investigator, “Evaluation of the STARflex® Septal Closure System in Patients with a Stroke or Transient Ischemic Attack due to Presumed Paradoxical Embolism through a PFO (CLOSURE I),” UNC Department of Neurology

Principal Site Investigator: Ana Felix, M.D. Sponsor: NMT Medical

2004-2006 Sub-Investigator, “A Double Blind, Randomized, Placebo Controlled, Parallel Group, Multicenter, Phase IIb/III Study to Assess the Efficacy and Safety of Intravenous NXY-059 in Acute Ischemic Stroke (SAINT II),” UNC Department of Neurology


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Principal Site Investigator: Ana Felix, M.D. Sponsor: AstraZeneca

2004-2005 Sub-Investigator, “An Open-Label, Randomized, Parallel-Group, Multi-Center Study to Evaluate the Efficacy of Enoxaparin versus Unfractionated Heparin in the Prevention of Venous Thromboembolism in Patients Following Acute Stroke (PREVAIL, Protocol XRP4563H/4001),” UNC Department of Neurology

Principal Site Investigator: Ana Felix, M.D. Sponsor: Aventis Pharmaceuticals

2003-2005 Sub-Investigator, “A Randomized, Double-blind, Placebo-controlled, Multi center Study of the Effects of ONO-2506 Intravenous Infusion on the Amelioration of Neurological Damage and Improvement of Stroke Assessment Scale Scores in Patients with Acute Ischemic Stroke (RREACT trial),” UNC Department of Neurology

Principal Site Investigator: Souvik Sen, M.D. Sponsor: Ono Pharma

2003-2004 Sub-Investigator, “A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic Effects of a Targeted Exposure of Intravenous Repinotan in Patients with Acute Ischemic Stroke (Modified RECT trial),” UNC Department of Neurology

Principal Site Investigator: Souvik Sen, M.D. Sponsor: Bayer

2003 Co-Investigator, “Safety and efficacy of the MERCI retriever in the treatment of thrombotic occlusion originating in the internal carotid, middle cerebral (M1 & M2 segments), basilar or vertebral arteries (MERCI trial),” UNC Department of Radiology

Principal Site Investigator: Sten Solander, M.D. Sponsor: Concentric Medical

2002-2005 Co-Investigator, “Progression of Aortic Atheroma in Stroke/TIA Patients,” UNC Department of Neurology

Principal Investigator: Souvik Sen, M.D. Sponsor: UNC GCRC

2002-2003 Sub-Investigator, “The North Carolina Collaborative Stroke Registry,” UNC Department of Neurology

Principal Site Investigator: Ana Felix, M.D. Sponsor: Centers for Disease Control PROFESSIONAL ACTIVITIES - CLINICAL STUDIES/TRIALS (at Other Sites)

2001-2002 Co-Investigator, “A Multi-center, Phase II, Randomized, Placebo-Controlled, Dose-Escalation Study to Evaluate the Safety and Preliminary Efficacy of Activated Recombinant Factor VII (NovoSeven) for Preventing Early Hematoma Growth in Acute Intracerebral Hemorrhage (ICH) Within 3 Hours of Onset,” Department of Neurology, Massachusetts General Hospital, Boston, MA

Principal Site Investigator: Jonathan Rosand, M.D. Sponsor: NovoNordisk A/S

2001-2002 Co-Investigator, “Investigation of MRI Diffusion/Perfusion Mismatch in Acute Ischemic Human Stroke,” Department of Neurology, Massachusetts General Hospital, Boston, MA

Principal Investigator: Walter Koroshetz, M.D. Sponsor: NIH/NINDS


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2001-2002 Co-Investigator, “A Study to Investigate the Utility of Magnetic Resonance Imaging as a Predictor of Final Infarct Volume in Stroke,” Department of Neurology, Massachusetts General Hospital, Boston, MA

Principal Investigator: Walter Koroshetz, M.D. Sponsor: GlaxoSmithKline (grant for investigator-initiated study)

2001-2002 Co-Investigator, “Clinical Efficacy and Cost-Effectiveness of Treatments with Patients with Acute Stroke,” Department of Neurology, Massachusetts General Hospital, Boston, MA

Principal Investigator: Walter Koroshetz, M.D.

2001-2002 Co-Investigator, “A Descriptive Pilot Study of Current Emergency Care Practices for Acute Stroke,” Department of Neurology, Massachusetts General Hospital, Boston, MA

Principal Investigator: Lee Schwamm, M.D. Sponsor: American Heart Association

2001-2002 Co-Investigator, “CT Perfusion Imaging in Patients with Acute Embolus Stroke: Predicting Final Infarct Size,” Department of Radiology, Massachusetts General Hospital, Boston, MA

Principal Investigator: Michael H. Lev, M.D. PROFESSIONAL ACTIVITIES – STROKE ADVOCACY

2007 Invited Expert Commentary for House Bill 50 (“Recommendations of the Stroke Advisory Council”), House Health Committee, North Carolina State Legislature, Raleigh, NC

2007 Invited Expert Commentary for Senate Bill 42 (“An Act to Appropriate Funds to Implement the Recommendations of the Stroke Advisory Council”), Senate Health Committee, North Carolina State Legislature, Raleigh, NC

2006 Invited Expert Commentary for House Bill 1860 (“Primary Stroke Centers”), House Health Committee, North Carolina State Legislature, Raleigh, NC

2005 Invited Speaker, “Stroke Telemedicine for North Carolina,” Management of Risk Factors Committee, Justus-Warren Heart Disease and Stroke Prevention Task Force (North Carolina State Legislature and North Carolina Department Health and Human Services, Division of Public Health), Raleigh, NC

2004 Invited Speaker, “Stroke in 2004: Issues for North Carolina,” Meeting of the Freshman Caucus of the North Carolina State Legislature (sponsored by the American Heart Association), Raleigh, NC

PROFESSIONAL ACTIVITIES - OTHER

2012-present Consultant, Ischemic Stroke Trial Steering Committee, Aldagen

2010 Consultant, Stroke Trial Protocol Development, Aldagen

2009 Consultant, NEST-3 Protocol Development, PhotoThera

2008-2011 Consultant, Genentech

2007 Consultant, CSL Behring

2007-2008 Consultant, Pfizer

2007 Speakers Bureau, Boehringer Ingelheim

2005-2006 National Advisory Board, CV Emerging Brand Products, AstraZeneca


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2005 Regional Advisory Board, IV Keppra Development, UCB Pharma

2004-2005 Consultant, Telemedicine Systems Development, Brain Saving Technologies

2003-2009 Consultant, Healthcare Council, Gerson Lehrman Group

Documents

David Yu-Yiao Huang, M.D., Ph.D., F.A.H.A. · Hwang ES, Zhang Z, Cai H, Huang DY, Huong SM, Cha CY, Huang ES. Human cytomegalovirus IE1-72 Human cytomegalovirus IE1-72 protein interacts