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Dementia and Decision-Making: Functional Assessment of the Older Adult I. Myriam Edwards MD Geriatrician, Assistant Professor, and Geriatric Medicine Fellowship Program Director Hurley Medical Center / Michigan State University. Geriatric Education Center of Michigan. - PowerPoint PPT Presentation
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DEMENTIA AND DECISION-MAKING:
FUNCTIONAL ASSESSMENT OF THE OLDER ADULT I
Myriam Edwards MD Geriatrician, Assistant Professor, and
Geriatric Medicine Fellowship Program Director
Hurley Medical Center / Michigan State University
Geriatric Education Center of Michigan
Geriatric Education Center of Michigan activities are supported by a grant from the U.S. Department of Health and Human Services, Health Resources and Services Administration, Public Health Service Act, Title VII, Section 753(a).
This module was developed byMark Ensberg, MDGeriatric Education CenterMichigan State University
Define• Delirium• Dementia• Decision-
making capacity
• Competence
Identify• Tools to assess
cognitive status
Recognize:• Decision-
making ability includes• nature of the
decision• cognitive
capabilities of person
LEARNING OBJECTIVES
CognitionDecision-making capacity
Goal Setting
WHAT IS NORMAL?Recall may be
delayed
Memory storage is normal
Divided Attention Tasks (more difficulty with
multi-tasking)
Slide 6
NORMAL AGING● No consistent, progressive deviations on
testing of memory
● Some decline in processing and recall of new information: slower, harder
● Reminders work – visual tips, notes
● Absence of significant effects on ADLs or IADLs due to cognition
WHAT IS MCI?(MILD COGNITIVE IMPAIRMENT)
Memory Impairment
No Other Cognitive Deficits
Normal Daily Activities
WHAT IS DEMENTIA?Memory Impairment
• Language (word finding, naming)• Executive function (planning & organizing)• Apraxia or Agnosia
Other Cognitive Problems
Problems with Daily Activities
DEMENTIA IS SNEAKY
Stop, Look, and Listen
Look for Red Flags
( ‘Triggers’ )
Listen to Caregivers
Brief Screen of Cognitive
Function
Arrange Follow-up Evaluation
DAILY ACTIVITIES: IADLS INSTRUMENTAL ACTIVITIES OF DAILY LIVING
* relevant to the medical office visit
Shopping Transportation Housework Meal Prep
Finances* Medication* Telephone*
*
‘TEN WARNING SIGNS’
Alzheimer’s Association
1. Memory loss2. Difficulty performing familiar tasks 3. Problems with language4. Disorientation to time and place5. Poor or decreased judgment6. Problems with abstract thinking7. Misplacing things8. Changes in mood or behavior9. Changes in personality10. Loss of initiative
BRIEF SCREENS: COGNITIVE FUNCTION
■ Conversation■ Clock Drawing Test■ Mini-Cog
■ Three-Item Recall■ Clock Drawing
JAGS 1993; 41: 576.
CLOCK-DRAWING: 4-POINT SCORING
1 pt - Draws a closed circle1 pt - Numbers in correct positions1 pt - All 12 correct numbers included1 pt - Hands placed in correct position
MINI-COG
■ Negative Screen for Dementia■ Score of 3 on 3-item recall■ Normal Clock and a Score of 1 or 2
■ Positive Screen for Dementia■ Score of 0 on 3-item recall■ Abnormal Clock and a Score of 1 or 2
FOLLOW-UP EVALUATION■ Mini-Mental State Examination (MMSE)■ Montreal Cognitive Assessment (MoCA)
■ Functional Activities Questionnaire- Bills & Checks - Prepare Meals- Organizing Papers - Current Events- Shopping - TV Magazines- Games & Hobbies - Appointments- Making Coffee - Transportation
DSM IV CRITERIA FOR DEMENTIA1. Memory impairment
2. Additional Cognitive Problems
3. Deficits cause significant impairment in social or occupational function and represent a significant decline from a previous level of function
4. Exclude Acute Confusion (delirium)
5. Exclude Depression
SCREENING FOR DEPRESSION
• Do you feel sad or blue?• Have you lost interest in doing
things that you have enjoyed?PHQ - 2
• What are you looking forward to?• What do you do for enjoyment?
Other Good
Questions
TYPES OF DEMENTIA
Alzheimer’s disease
Vascular dementia
Lewy Body disease Other
Slide 23
THE EPIDEMIOLOGY OF ALZHEIMER’S DISEASE
• 6%‒8% of people age 65+ have AD
• Nearly 30% of those aged 85+ have AD
Slide 24
THE IMPACT OF DEMENTIA Economic• $100 billion annually for care and lost productivity• Medicare, Medicaid, private insurance provide only
partial coverage• Families bear greatest burden of expense
Emotional• Direct toll on patients• Nearly half of caregivers suffer depression
Slide 25
RISK FACTORS FOR DEMENTIADefinite
• Age
• Down’s syndrome
• Family history
• APOE4 allele
Possible
• Head injury
• Fewer years of education
• Late onset of major depression
• Cardiovascular risk factors
Slide 26
ASSESSMENT: HISTORY
Ask both the patient & a reliable informant about the patient’s:
• Current condition
• Medical history
• Current medications & medication history
• Patterns of alcohol use or abuse
• Living arrangements
Slide 27
ASSESSMENT: PHYSICAL Examine:• Neurologic status• Mental status• Functional status
Include:• Quantified screens for cognition
eg, Folstein’s MMSE, Mini-Cog• Neuropsychologic testing
ASSESSMENT: LABORATORY• Blood chemistries• CBC• Liver function tests• Urinalysis
• Serologic tests for:RPR
TSH
Vitamin B12 level
Folate level
Slide 29
ASSESSMENT: BRAIN IMAGING Consider imaging when:• Onset occurs at age <65 years• Symptoms have occurred for <2 years• Neurologic signs are asymmetric or focal• Clinical picture suggests normal-pressure hydrocephalus• Patient has had recent fall or other head trauma
Consider:• Noncontrast computed topography head scan• Magnetic resonance imaging• Positron emission tomography
Slide 30
DIFFERENTIAL DIAGNOSIS
• Normal aging• Mild cognitive impairment• Delirium• Depression• Alzheimer’s disease• Vascular (multi-infarct) dementia• Dementia associated with Lewy bodies• Other (alcohol, Parkinson's disease, Pick’s disease,
frontal lobe dementia, neurosyphilis)
Slide 31
DELIRIUM vs DEMENTIA
Delirium and dementia often occur together in older hospitalized patients; the distinguishing signs of delirium are:
Acute onset Cognitive fluctuations over hours or days Impaired consciousness and attention Altered sleep cycles
Slide 32
DEPRESSION vs DEMENTIA (1 of 2)
The symptoms of depression and dementiaoften overlap:
• Impaired concentration
• Lack of motivation, loss of interest, apathy
• Psychomotor retardation
• Sleep disturbance
Slide 33
DEPRESSION vs DEMENTIA (2 of 2)• Patients with primary depression are generally
unlike those with dementia in that they: Demonstrate motivation during cognitive testing Express cognitive complaints that exceed measured
deficits Maintain language and motor skills
• Effective treatment of depressive symptoms may improve cognition
Slide 34
ALZHEIMER’S DISEASE• Onset: gradual
• Cognitive symptoms: primarily memory with difficulty learning new
information
• Motor symptoms: rare early, apraxia later
• Progression: gradual, over 8–10 yr ave.
• Lab tests: normal
• Imaging: possible global atrophy, small hippocampal volumes
Slide 35
DSM-IV DIAGNOSTIC CRITERIA FOR AD• Development of cognitive deficits manifested by:
Impaired memory and Aphasia, apraxia, agnosia, disturbed executive function
• Significantly impaired social, occupational function
• Gradual onset, continuing decline
• Not due to CNS or other physical conditions (eg, PD, delirium)
• Not due to an Axis I disorder (eg, schizophrenia)
Slide 36
VASCULAR DEMENTIA
• Onset: may be sudden/stepwise
• Cognitive symptoms: depend on anatomy of ischemia
• Motor symptoms: correlates with ischemia
• Progression: stepwise with further ischemia
• Lab tests: normal• Imaging: cortical or subcortical
changes on MRI
Slide 37
DSM-IV DIAGNOSTIC CRITERIA FOR VASCULAR DEMENTIA
• Development of cognitive deficits manifested by: Impaired memory and Aphasia, apraxia, agnosia, disturbed executive function
• Significantly impaired social, occupational function
• Focal neurologic symptoms & signs or evidence of cerebrovascular disease
• Deficits occur in absence of delirium
Slide 38
LEWY BODY DEMENTIA• Onset: gradual
• Cognitive symptoms: memory, visuospatial, hallucinations,
fluctuations
• Motor symptoms: parkinsonism
• Progression: gradual, but usually fasterthan AD
• Lab tests: normal
• Imaging: possible global atrophy
Slide 39
FRONTOTEMPORAL DEMENTIA• Onset: gradual, usually age
<60• Cognitive symptoms: executive: disinhibition,
apathy, behavior changes
• Motor symptoms: none; may be associated
with ALS in rare cases• Progression: gradual but faster than
AD• Lab tests: normal• Imaging: atrophy in frontal and
temporal lobes
Slide 40
PRIMARY GOAL OF TREATMENT
To enhance quality of life
and maximize functional performance
by improving cognition, mood, and behavior
Slide 41
NONPHARMACOLOGIC MANAGEMENT
• Cognitive rehabilitation
• Individual and group therapy
• Physical and mental activity
• Regular appointments
• Family and caregiver education and support
• Environmental modification
• Attention to safety
Slide 42
PHARMACOLOGIC MANAGEMENT
• Treatment should be individualized• Cholinesterase inhibitors:
donepezil, rivastigmine, galantamine• Memantine• Other cognitive enhancers• Antidepressants• Psychoactive medications
WE DETERMINE DECISION-MAKING CAPACITY
Courts determine competence
DECISION-MAKINGIADLs ( medications and finances)
Live safely at home
Drive a car
Informed Consent
Appoint DPOA –HC
Transact business
Make a will
DECISION-MAKING CAPACITY
Communication
Culture
Circumstances
Choices
Consequences
Consistency
Slide 46
ASSESSMENT OFDECISIONAL CAPACITY
Overarching factor is the patient’s ability to understand the consequences of a decision
Evaluate each patient individually, considering his or her beliefs, values, and goals of care
Avoid assuming on the basis of ethnic background that a patient holds certain beliefs
Slide 47
ELEMENTS OF CAPACITY TO MAKEMEDICAL DECISIONS
Ability to understand: The disease process The proposed therapy and alternative therapies The advantages, adverse effects, and potential
complications of each therapy The possible course of the disease without intervention
Ability to communicate a decision
Slide 48
ELEMENTS OF CAPACITY TO MAKEDECISIONS ABOUT SELF-CARE
Ability to care for oneself
or
Ability to accept the needed help to keep oneself safe
Slide 49
ELEMENTS OF CAPACITY TO MAKEFINANCIAL DECISIONS
Ability to manage bill payment
Ability to appropriately calculate and monitor funds
Slide 50
ELEMENTS OF CAPACITY TO MAKEA LAST WILL AND TESTAMENT
Ability to identify the individuals involved Ability to remember estate plans Ability to express the logic behind choices
Slide 51
STANDARDIZED TESTSOF DECISIONAL CAPACITY
Mini-Mental State Examination (limited utility) Executive Interview 25-item examination
(EXIT 25) of executive function Capacity to Consent to Treatment Instrument MacArthur Competency Assessment Tool –
Treatment
Slide 52
HIERARCHY OF DECISION-MAKING STRATEGIES
Use substituted judgment
Respect the patient’s last competent indication of their wishes
Use the principle of beneficence
Slide 53
LAST COMPETENTINDICATION OF WISHES
Most relevant when patients can foresee that they will become incapacitated, as when entering the terminal phase of an illness
Patients should be encouraged to give detailed advance directives (called advanced care plans in some contexts)
As long as the circumstances remain substantially as predicted, other persons should not be allowed to reverse these decisions
Slide 54
SUBSTITUTED JUDGMENT Defined as the process of constructing what the person
would have wanted if he or she had been able to foresee the circumstances and give direction for care
A patient can appoint someone to hold durable power of attorney for health affairs (called a health care agent or health care proxy)
A person granted durable power of attorney takes precedence over the next of kin
Slide 55
PRINCIPLE OF BENEFICENCE Making medical decisions for an incapacitated
person on the basis of the benefits and burdens of treatment and interventions
The analysis is best done by someone who is very aware of: What gives that patient pleasure What causes agitation, fear, pain, or discomfort How the patient reacts to a change in setting, use of
restraints, and similar matters
Slide 56
CONSERVATORS Appointed by a court in the absence of next of kin or
durable power of attorney Called guardians in some states Two types:
Conservator of finance Conservator of person (the patient can no longer make
personal decisions, such as medical decisions, or endangers himself and cannot understand or accept the need for help)
Slide 57
ADVANCE DIRECTIVES (LIVING WILLS)
Attempt to demonstrate what decisions a person would make in hypothetical clinical situations (eg, vegetative state, terminal illness)
Limited utility because of vagueness and lack of generalizability to decisions that commonly need to be made
Can be used by surrogate decision maker as evidence of preferences
SETTING GOALS OF CARE
Identify Decision-maker (include person)
Understand Patient as a Person (QoL)
The Condition/Diagnoses (prognoses)
Establish Plan of Care• Discuss ‘Best Guess’ transitions
and/or decision points
Review Plan
SETTING GOALS
Make sure goals are shared goals
Make goals as explicit as possible and be sure all involved understand
them
Make sure you make time to review (and revise if necessary)
goals, especially when condition changes.