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Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay: results from TIMI 35 by Marc S. Sabatine, David A. Morrow, James A. de Lemos, Petr Jarolim, and Eugene Braunwald EHJ Volume 30(2):162-169 January 14, 2009 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: [email protected]

Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay:

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Page 1: Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay:

Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial

ischaemia using an ultrasensitive assay: results from TIMI 35

by Marc S. Sabatine, David A. Morrow, James A. de Lemos, Petr Jarolim, and Eugene Braunwald

EHJVolume 30(2):162-169

January 14, 2009

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: [email protected]

Page 2: Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay:

Cardiac troponin I levels (median and interquartile range) measured using the ultrasensitive assay in patients with none (blue circles), mild (green triangles), and moderate-to-severe (red

squares) ischaemia at baseline (samples available in 44, 30, and 34 patients, respectively), immediately after stress testing (37, 26, and 27 patients), 2 h after stress testing (20, 15, and 16

patients), and 4 h after stress testing (44, 28, and 36 patients).

Marc S. Sabatine et al. Eur Heart J 2009;30:162-169

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: [email protected]

Page 3: Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay:

Change in cardiac troponin I levels (median and interquartile range) measured using the ultrasensitive assay from baseline to 4 h in patients with none (n = 39, blue circles), mild (n = 27,

green triangles), and moderate-to-severe (n = 33, red squares) ischaemia.

Marc S. Sabatine et al. Eur Heart J 2009;30:162-169

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: [email protected]

Page 4: Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay:

Odds ratios and 95% confidence intervals for prediction of inducible myocardial ischaemia.

Marc S. Sabatine et al. Eur Heart J 2009;30:162-169

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: [email protected]

Page 5: Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay:

Proportion with inducible ischaemia among patients categorized by the number of ischaemia predictors (limiting angina, ST depression >0.1 mV, >1.3 pg/mL rise in ultrasensitive cardiac

troponin I by 4 h, and post-stress test BNP ≥80 pg/mL).

Marc S. Sabatine et al. Eur Heart J 2009;30:162-169

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: [email protected]