Embed Size (px)
Citation preview
M AUDRAN
Dopage
Approche Pharmacologique
Acadeacutemie Nationale de Pharmacie Janvier 2013
ampheacutetamines eacutepheacutedrine cocaiumlne β2-agonistes helliphelliphelliphelliphelliphelliphellip
SAA hCG clenbuterol GH IGF-1 insuline SARMshelliphelliphelliphelliphelliphellip
canabinoiumldes β-bloquants alcool
corticoiumldes narcotiques
STIMULANTS
FORCE PUISSANCE
RELAXANTS
MASQUER LA DOULEUR
AUGMENTATION TRANSPORT d 02
ESA( eacutepoetines hellip) transfusion transporteurs drsquo02 Testo GH cortico
AGENTS MASQUANTS
diureacutetiques eacutepitestosterone probenecide succeacutedaneacutes plasmatiques helliphelliphelliphelliphelliphelliphellip
RECUPERATION
testosteacuterone GH IGF-1 insuline
PERFORMANCE
MODIFICATION METABOLISME CELLULAIRE
agonistes PPARβδ agonistes AMPK
- Force et puissance musculaire
- augmentation de lrsquoendurance
- les laquo designers raquo
anabolisants GH IGF-1 insuline secretagogues SARMs
transport de lrsquoO2
modification du meacutetabolisme cellulaire stabilisateurs du RyR
hormone de croissance
Force et puissance musculaire
anabolisants SAA exogegravenes endogegravenes hCG clenbuteacuterol
Pteacutes anabolisantes lipolytiques Difficulteacutes de deacutetection Effet sur la performance Effet sur la reacutecupeacuteration
GH IGF-1 SAA stimulent la synthegravese des proteacuteines lrsquoinsuline inhibe leur deacutegradation
Synergistic action between insulin IGF-1 and GH P H Sonksen Journal of endocrinology (2001)
IGF-1 R3-IGF-1 Long R3-IGF-1 IGF-IEc
Je sais que lors de la finale du 100m en 2000 quand Maurice Greene gagne lor ils eacutetaient tous dopeacutes la totaliteacute des finalistes Je sais aussi pertinemment que cinq des huit finalistes en 2003 eacutetaient dopeacutees puisque cest moi-mecircme qui les fournissait raquo
A quantitative approach for assessing significant improvements in elite sprint performance Has IGF-1 entered the arena Ernst S Simon P Drug Test Anal 2012 Aug 29
Victor Conte Novembre 2011
GH secretagogues GHRH et analogues mimeacutetiques de la ghreline acides amineacutes (arginine ornithine lysine)
sermorelin tesamorelin CJC-1295 GHRP-6 Pralmorelin capromorelin hexarelin tabimorelin MK-677 L-692429 SM-130686 TZP-101
GH + GHRP pour masquer la prise de GH
modulateurs seacutelectifs des reacutecepteurs aux androgegravenes (SARMs)
Mario Thevis Wilhelm Schaumlnzer Organogenesis Forum Lecture
fonte musculaire grand bruleacutes cancer maladies reacutenales osteacuteoporose hypogonadisme
SARM-S4 and metabolites detection in sports drug testingA case report Elia Grata Laurent Perrenoud Martial Saugy Norbert Baume Forensic Sci Int 2011 Dec 10213(1-3)104-8
Transport de lrsquooxygegravene
Transfusion sanguine
Agents stimulant lrsquoeacuterythropoiumlegravese
epoetines α β δ ω NESP Mircera Biosimilaires gt 120 moleacutecules
Peginesatide (Hematide)
Nouvelles formulations Epo-IgG Fc aeacuterosol
stabilisateurs de lrsquoHIF 2α (inhibiteurs des propyl hydroxylases)
FG-2216 FG-4592 GSK1278863 AKB-6548 BAY85-3934
GH IGF-1 insuline SARMs corticoiumldes
hormones thyroiumldiennes
autre substances actives sur lrsquoeacuterythropoiumlegravese
- SAA
Transport de lrsquooxygegravene
EPO
croissance
musculaire
IGF-1
Myostatine
Meacutetabolisme eacutenergeacutetique
surexpression de
PPAR-δβ
PEPCK-C
repression de NCoR1
helliphelliphelliphelliphelliphelliphelliphelliphelliphellip
Dopage geacuteneacutetique
Gegravene theacuterapie et modification du meacutetabolisme eacutenergeacutetique
Surexpression de PPAR βδ chez la souris transgeacutenique - augmentation des fibres de type 1 - augmentation de lrsquoendurance Wang et al 2004
exercice physique activation PPAR-δ AMPK oxydation des acides gras inhibition lipogenegravese neacuteoglucogenegravese
= + ATP = + performance
agonistes du PPAR- et AMPK
AICAR GW 1516 (GW510516X)
GW 0742
re programment le meacutetabolisme musculaire (meacutetabolisme oxydatif angiogeacutenegravese reacuteserve en glucose) drsquoougrave augmentation de lrsquoendurance
Mice that hadnt done any exercise but were given AICAR could run 23 percent longer and 44 percent farther than sedentary mice that didnt get the drug (Evans)
Trafficking of drug candidates relevant for sports drug testing detection of non-approved therapeutics categorized as anabolic and gene doping agents in products
distributed via the Internet Thevis et alDrug Test Anal 2011
The big problem with AICAR is the side effects Athletes would get a huge increase in lactic acid Theres also a molecular mutation in the heart that can lead to sudden death Certainly theres a
possibility that drugs could be developed to increase endurance But I dont believe AICAR would improve performance in humans raquo L Goodyear Harvard Medical School Joslin Diabetes Center N Engl J Med 2008 The exercise pill--too good to be true
It might actually have zero effect on athletic performance My 2007 study in the journal Diabetes found it doesnt activate AMPK and only marginally increases glucose uptake in muscles and you would have to take
bucket-loads There is a lot of unjustified hype about AICAR on the Internet and if I was an athlete planning to cheat he definitely wouldnt bother
Dan Cuthbertson a professor at Liverpool University in England
JTV-519 S-107
Modulateurs des canaux calciques stabilisateurs du
complexe Calstabin-Recepteurs de la Ryanodine
(RYCALs)
Heart failure Cardiac arrhythmias Skeletal muscle disorders Cognitive function
deacuteriveacutes de benzothiazeacutepines
Produits creacutees pour eacutechapper
aux controcircles anti-dopage
- laquo designer testosterone raquo
- laquo designer epoetins raquo
- laquo designers steroids raquo
Jusqursquoagrave preacutesenthellipdes meacutedicaments deacutetourneacutes de leur usage theacuterapeutique Aujourdrsquohui helliphellipune industrie speacutecifique au dopage capable - de mettre agrave disposition des sportifs des moleacutecules encore
en eacutetude clinique - de fabriquer des substances conccedilues pour eacutechapper aux controcircles antidopage
CONCLUSION
ampheacutetamines eacutepheacutedrine cocaiumlne β2-agonistes helliphelliphelliphelliphelliphelliphellip
SAA hCG clenbuterol GH IGF-1 insuline SARMshelliphelliphelliphelliphelliphellip
canabinoiumldes β-bloquants alcool
corticoiumldes narcotiques
STIMULANTS
FORCE PUISSANCE
RELAXANTS
MASQUER LA DOULEUR
AUGMENTATION TRANSPORT d 02
ESA( eacutepoetines hellip) transfusion transporteurs drsquo02 Testo GH cortico
AGENTS MASQUANTS
diureacutetiques eacutepitestosterone probenecide succeacutedaneacutes plasmatiques helliphelliphelliphelliphelliphelliphellip
RECUPERATION
testosteacuterone GH IGF-1 insuline
PERFORMANCE
MODIFICATION METABOLISME CELLULAIRE
agonistes PPARβδ agonistes AMPK
- Force et puissance musculaire
- augmentation de lrsquoendurance
- les laquo designers raquo
anabolisants GH IGF-1 insuline secretagogues SARMs
transport de lrsquoO2
modification du meacutetabolisme cellulaire stabilisateurs du RyR
hormone de croissance
Force et puissance musculaire
anabolisants SAA exogegravenes endogegravenes hCG clenbuteacuterol
Pteacutes anabolisantes lipolytiques Difficulteacutes de deacutetection Effet sur la performance Effet sur la reacutecupeacuteration
GH IGF-1 SAA stimulent la synthegravese des proteacuteines lrsquoinsuline inhibe leur deacutegradation
Synergistic action between insulin IGF-1 and GH P H Sonksen Journal of endocrinology (2001)
IGF-1 R3-IGF-1 Long R3-IGF-1 IGF-IEc
Je sais que lors de la finale du 100m en 2000 quand Maurice Greene gagne lor ils eacutetaient tous dopeacutes la totaliteacute des finalistes Je sais aussi pertinemment que cinq des huit finalistes en 2003 eacutetaient dopeacutees puisque cest moi-mecircme qui les fournissait raquo
A quantitative approach for assessing significant improvements in elite sprint performance Has IGF-1 entered the arena Ernst S Simon P Drug Test Anal 2012 Aug 29
Victor Conte Novembre 2011
GH secretagogues GHRH et analogues mimeacutetiques de la ghreline acides amineacutes (arginine ornithine lysine)
sermorelin tesamorelin CJC-1295 GHRP-6 Pralmorelin capromorelin hexarelin tabimorelin MK-677 L-692429 SM-130686 TZP-101
GH + GHRP pour masquer la prise de GH
modulateurs seacutelectifs des reacutecepteurs aux androgegravenes (SARMs)
Mario Thevis Wilhelm Schaumlnzer Organogenesis Forum Lecture
fonte musculaire grand bruleacutes cancer maladies reacutenales osteacuteoporose hypogonadisme
SARM-S4 and metabolites detection in sports drug testingA case report Elia Grata Laurent Perrenoud Martial Saugy Norbert Baume Forensic Sci Int 2011 Dec 10213(1-3)104-8
Transport de lrsquooxygegravene
Transfusion sanguine
Agents stimulant lrsquoeacuterythropoiumlegravese
epoetines α β δ ω NESP Mircera Biosimilaires gt 120 moleacutecules
Peginesatide (Hematide)
Nouvelles formulations Epo-IgG Fc aeacuterosol
stabilisateurs de lrsquoHIF 2α (inhibiteurs des propyl hydroxylases)
FG-2216 FG-4592 GSK1278863 AKB-6548 BAY85-3934
GH IGF-1 insuline SARMs corticoiumldes
hormones thyroiumldiennes
autre substances actives sur lrsquoeacuterythropoiumlegravese
- SAA
Transport de lrsquooxygegravene
EPO
croissance
musculaire
IGF-1
Myostatine
Meacutetabolisme eacutenergeacutetique
surexpression de
PPAR-δβ
PEPCK-C
repression de NCoR1
helliphelliphelliphelliphelliphelliphelliphelliphelliphellip
Dopage geacuteneacutetique
Gegravene theacuterapie et modification du meacutetabolisme eacutenergeacutetique
Surexpression de PPAR βδ chez la souris transgeacutenique - augmentation des fibres de type 1 - augmentation de lrsquoendurance Wang et al 2004
exercice physique activation PPAR-δ AMPK oxydation des acides gras inhibition lipogenegravese neacuteoglucogenegravese
= + ATP = + performance
agonistes du PPAR- et AMPK
AICAR GW 1516 (GW510516X)
GW 0742
re programment le meacutetabolisme musculaire (meacutetabolisme oxydatif angiogeacutenegravese reacuteserve en glucose) drsquoougrave augmentation de lrsquoendurance
Mice that hadnt done any exercise but were given AICAR could run 23 percent longer and 44 percent farther than sedentary mice that didnt get the drug (Evans)
Trafficking of drug candidates relevant for sports drug testing detection of non-approved therapeutics categorized as anabolic and gene doping agents in products
distributed via the Internet Thevis et alDrug Test Anal 2011
The big problem with AICAR is the side effects Athletes would get a huge increase in lactic acid Theres also a molecular mutation in the heart that can lead to sudden death Certainly theres a
possibility that drugs could be developed to increase endurance But I dont believe AICAR would improve performance in humans raquo L Goodyear Harvard Medical School Joslin Diabetes Center N Engl J Med 2008 The exercise pill--too good to be true
It might actually have zero effect on athletic performance My 2007 study in the journal Diabetes found it doesnt activate AMPK and only marginally increases glucose uptake in muscles and you would have to take
bucket-loads There is a lot of unjustified hype about AICAR on the Internet and if I was an athlete planning to cheat he definitely wouldnt bother
Dan Cuthbertson a professor at Liverpool University in England
JTV-519 S-107
Modulateurs des canaux calciques stabilisateurs du
complexe Calstabin-Recepteurs de la Ryanodine
(RYCALs)
Heart failure Cardiac arrhythmias Skeletal muscle disorders Cognitive function
deacuteriveacutes de benzothiazeacutepines
Produits creacutees pour eacutechapper
aux controcircles anti-dopage
- laquo designer testosterone raquo
- laquo designer epoetins raquo
- laquo designers steroids raquo
Jusqursquoagrave preacutesenthellipdes meacutedicaments deacutetourneacutes de leur usage theacuterapeutique Aujourdrsquohui helliphellipune industrie speacutecifique au dopage capable - de mettre agrave disposition des sportifs des moleacutecules encore
en eacutetude clinique - de fabriquer des substances conccedilues pour eacutechapper aux controcircles antidopage
CONCLUSION
- Force et puissance musculaire
- augmentation de lrsquoendurance
- les laquo designers raquo
anabolisants GH IGF-1 insuline secretagogues SARMs
transport de lrsquoO2
modification du meacutetabolisme cellulaire stabilisateurs du RyR
hormone de croissance
Force et puissance musculaire
anabolisants SAA exogegravenes endogegravenes hCG clenbuteacuterol
Pteacutes anabolisantes lipolytiques Difficulteacutes de deacutetection Effet sur la performance Effet sur la reacutecupeacuteration
GH IGF-1 SAA stimulent la synthegravese des proteacuteines lrsquoinsuline inhibe leur deacutegradation
Synergistic action between insulin IGF-1 and GH P H Sonksen Journal of endocrinology (2001)
IGF-1 R3-IGF-1 Long R3-IGF-1 IGF-IEc
Je sais que lors de la finale du 100m en 2000 quand Maurice Greene gagne lor ils eacutetaient tous dopeacutes la totaliteacute des finalistes Je sais aussi pertinemment que cinq des huit finalistes en 2003 eacutetaient dopeacutees puisque cest moi-mecircme qui les fournissait raquo
A quantitative approach for assessing significant improvements in elite sprint performance Has IGF-1 entered the arena Ernst S Simon P Drug Test Anal 2012 Aug 29
Victor Conte Novembre 2011
GH secretagogues GHRH et analogues mimeacutetiques de la ghreline acides amineacutes (arginine ornithine lysine)
sermorelin tesamorelin CJC-1295 GHRP-6 Pralmorelin capromorelin hexarelin tabimorelin MK-677 L-692429 SM-130686 TZP-101
GH + GHRP pour masquer la prise de GH
modulateurs seacutelectifs des reacutecepteurs aux androgegravenes (SARMs)
Mario Thevis Wilhelm Schaumlnzer Organogenesis Forum Lecture
fonte musculaire grand bruleacutes cancer maladies reacutenales osteacuteoporose hypogonadisme
SARM-S4 and metabolites detection in sports drug testingA case report Elia Grata Laurent Perrenoud Martial Saugy Norbert Baume Forensic Sci Int 2011 Dec 10213(1-3)104-8
Transport de lrsquooxygegravene
Transfusion sanguine
Agents stimulant lrsquoeacuterythropoiumlegravese
epoetines α β δ ω NESP Mircera Biosimilaires gt 120 moleacutecules
Peginesatide (Hematide)
Nouvelles formulations Epo-IgG Fc aeacuterosol
stabilisateurs de lrsquoHIF 2α (inhibiteurs des propyl hydroxylases)
FG-2216 FG-4592 GSK1278863 AKB-6548 BAY85-3934
GH IGF-1 insuline SARMs corticoiumldes
hormones thyroiumldiennes
autre substances actives sur lrsquoeacuterythropoiumlegravese
- SAA
Transport de lrsquooxygegravene
EPO
croissance
musculaire
IGF-1
Myostatine
Meacutetabolisme eacutenergeacutetique
surexpression de
PPAR-δβ
PEPCK-C
repression de NCoR1
helliphelliphelliphelliphelliphelliphelliphelliphelliphellip
Dopage geacuteneacutetique
Gegravene theacuterapie et modification du meacutetabolisme eacutenergeacutetique
Surexpression de PPAR βδ chez la souris transgeacutenique - augmentation des fibres de type 1 - augmentation de lrsquoendurance Wang et al 2004
exercice physique activation PPAR-δ AMPK oxydation des acides gras inhibition lipogenegravese neacuteoglucogenegravese
= + ATP = + performance
agonistes du PPAR- et AMPK
AICAR GW 1516 (GW510516X)
GW 0742
re programment le meacutetabolisme musculaire (meacutetabolisme oxydatif angiogeacutenegravese reacuteserve en glucose) drsquoougrave augmentation de lrsquoendurance
Mice that hadnt done any exercise but were given AICAR could run 23 percent longer and 44 percent farther than sedentary mice that didnt get the drug (Evans)
Trafficking of drug candidates relevant for sports drug testing detection of non-approved therapeutics categorized as anabolic and gene doping agents in products
distributed via the Internet Thevis et alDrug Test Anal 2011
The big problem with AICAR is the side effects Athletes would get a huge increase in lactic acid Theres also a molecular mutation in the heart that can lead to sudden death Certainly theres a
possibility that drugs could be developed to increase endurance But I dont believe AICAR would improve performance in humans raquo L Goodyear Harvard Medical School Joslin Diabetes Center N Engl J Med 2008 The exercise pill--too good to be true
It might actually have zero effect on athletic performance My 2007 study in the journal Diabetes found it doesnt activate AMPK and only marginally increases glucose uptake in muscles and you would have to take
bucket-loads There is a lot of unjustified hype about AICAR on the Internet and if I was an athlete planning to cheat he definitely wouldnt bother
Dan Cuthbertson a professor at Liverpool University in England
JTV-519 S-107
Modulateurs des canaux calciques stabilisateurs du
complexe Calstabin-Recepteurs de la Ryanodine
(RYCALs)
Heart failure Cardiac arrhythmias Skeletal muscle disorders Cognitive function
deacuteriveacutes de benzothiazeacutepines
Produits creacutees pour eacutechapper
aux controcircles anti-dopage
- laquo designer testosterone raquo
- laquo designer epoetins raquo
- laquo designers steroids raquo
Jusqursquoagrave preacutesenthellipdes meacutedicaments deacutetourneacutes de leur usage theacuterapeutique Aujourdrsquohui helliphellipune industrie speacutecifique au dopage capable - de mettre agrave disposition des sportifs des moleacutecules encore
en eacutetude clinique - de fabriquer des substances conccedilues pour eacutechapper aux controcircles antidopage
CONCLUSION
hormone de croissance
Force et puissance musculaire
anabolisants SAA exogegravenes endogegravenes hCG clenbuteacuterol
Pteacutes anabolisantes lipolytiques Difficulteacutes de deacutetection Effet sur la performance Effet sur la reacutecupeacuteration
GH IGF-1 SAA stimulent la synthegravese des proteacuteines lrsquoinsuline inhibe leur deacutegradation
Synergistic action between insulin IGF-1 and GH P H Sonksen Journal of endocrinology (2001)
IGF-1 R3-IGF-1 Long R3-IGF-1 IGF-IEc
Je sais que lors de la finale du 100m en 2000 quand Maurice Greene gagne lor ils eacutetaient tous dopeacutes la totaliteacute des finalistes Je sais aussi pertinemment que cinq des huit finalistes en 2003 eacutetaient dopeacutees puisque cest moi-mecircme qui les fournissait raquo
A quantitative approach for assessing significant improvements in elite sprint performance Has IGF-1 entered the arena Ernst S Simon P Drug Test Anal 2012 Aug 29
Victor Conte Novembre 2011
GH secretagogues GHRH et analogues mimeacutetiques de la ghreline acides amineacutes (arginine ornithine lysine)
sermorelin tesamorelin CJC-1295 GHRP-6 Pralmorelin capromorelin hexarelin tabimorelin MK-677 L-692429 SM-130686 TZP-101
GH + GHRP pour masquer la prise de GH
modulateurs seacutelectifs des reacutecepteurs aux androgegravenes (SARMs)
Mario Thevis Wilhelm Schaumlnzer Organogenesis Forum Lecture
fonte musculaire grand bruleacutes cancer maladies reacutenales osteacuteoporose hypogonadisme
SARM-S4 and metabolites detection in sports drug testingA case report Elia Grata Laurent Perrenoud Martial Saugy Norbert Baume Forensic Sci Int 2011 Dec 10213(1-3)104-8
Transport de lrsquooxygegravene
Transfusion sanguine
Agents stimulant lrsquoeacuterythropoiumlegravese
epoetines α β δ ω NESP Mircera Biosimilaires gt 120 moleacutecules
Peginesatide (Hematide)
Nouvelles formulations Epo-IgG Fc aeacuterosol
stabilisateurs de lrsquoHIF 2α (inhibiteurs des propyl hydroxylases)
FG-2216 FG-4592 GSK1278863 AKB-6548 BAY85-3934
GH IGF-1 insuline SARMs corticoiumldes
hormones thyroiumldiennes
autre substances actives sur lrsquoeacuterythropoiumlegravese
- SAA
Transport de lrsquooxygegravene
EPO
croissance
musculaire
IGF-1
Myostatine
Meacutetabolisme eacutenergeacutetique
surexpression de
PPAR-δβ
PEPCK-C
repression de NCoR1
helliphelliphelliphelliphelliphelliphelliphelliphelliphellip
Dopage geacuteneacutetique
Gegravene theacuterapie et modification du meacutetabolisme eacutenergeacutetique
Surexpression de PPAR βδ chez la souris transgeacutenique - augmentation des fibres de type 1 - augmentation de lrsquoendurance Wang et al 2004
exercice physique activation PPAR-δ AMPK oxydation des acides gras inhibition lipogenegravese neacuteoglucogenegravese
= + ATP = + performance
agonistes du PPAR- et AMPK
AICAR GW 1516 (GW510516X)
GW 0742
re programment le meacutetabolisme musculaire (meacutetabolisme oxydatif angiogeacutenegravese reacuteserve en glucose) drsquoougrave augmentation de lrsquoendurance
Mice that hadnt done any exercise but were given AICAR could run 23 percent longer and 44 percent farther than sedentary mice that didnt get the drug (Evans)
Trafficking of drug candidates relevant for sports drug testing detection of non-approved therapeutics categorized as anabolic and gene doping agents in products
distributed via the Internet Thevis et alDrug Test Anal 2011
The big problem with AICAR is the side effects Athletes would get a huge increase in lactic acid Theres also a molecular mutation in the heart that can lead to sudden death Certainly theres a
possibility that drugs could be developed to increase endurance But I dont believe AICAR would improve performance in humans raquo L Goodyear Harvard Medical School Joslin Diabetes Center N Engl J Med 2008 The exercise pill--too good to be true
It might actually have zero effect on athletic performance My 2007 study in the journal Diabetes found it doesnt activate AMPK and only marginally increases glucose uptake in muscles and you would have to take
bucket-loads There is a lot of unjustified hype about AICAR on the Internet and if I was an athlete planning to cheat he definitely wouldnt bother
Dan Cuthbertson a professor at Liverpool University in England
JTV-519 S-107
Modulateurs des canaux calciques stabilisateurs du
complexe Calstabin-Recepteurs de la Ryanodine
(RYCALs)
Heart failure Cardiac arrhythmias Skeletal muscle disorders Cognitive function
deacuteriveacutes de benzothiazeacutepines
Produits creacutees pour eacutechapper
aux controcircles anti-dopage
- laquo designer testosterone raquo
- laquo designer epoetins raquo
- laquo designers steroids raquo
Jusqursquoagrave preacutesenthellipdes meacutedicaments deacutetourneacutes de leur usage theacuterapeutique Aujourdrsquohui helliphellipune industrie speacutecifique au dopage capable - de mettre agrave disposition des sportifs des moleacutecules encore
en eacutetude clinique - de fabriquer des substances conccedilues pour eacutechapper aux controcircles antidopage
CONCLUSION
GH IGF-1 SAA stimulent la synthegravese des proteacuteines lrsquoinsuline inhibe leur deacutegradation
Synergistic action between insulin IGF-1 and GH P H Sonksen Journal of endocrinology (2001)
IGF-1 R3-IGF-1 Long R3-IGF-1 IGF-IEc
Je sais que lors de la finale du 100m en 2000 quand Maurice Greene gagne lor ils eacutetaient tous dopeacutes la totaliteacute des finalistes Je sais aussi pertinemment que cinq des huit finalistes en 2003 eacutetaient dopeacutees puisque cest moi-mecircme qui les fournissait raquo
A quantitative approach for assessing significant improvements in elite sprint performance Has IGF-1 entered the arena Ernst S Simon P Drug Test Anal 2012 Aug 29
Victor Conte Novembre 2011
GH secretagogues GHRH et analogues mimeacutetiques de la ghreline acides amineacutes (arginine ornithine lysine)
sermorelin tesamorelin CJC-1295 GHRP-6 Pralmorelin capromorelin hexarelin tabimorelin MK-677 L-692429 SM-130686 TZP-101
GH + GHRP pour masquer la prise de GH
modulateurs seacutelectifs des reacutecepteurs aux androgegravenes (SARMs)
Mario Thevis Wilhelm Schaumlnzer Organogenesis Forum Lecture
fonte musculaire grand bruleacutes cancer maladies reacutenales osteacuteoporose hypogonadisme
SARM-S4 and metabolites detection in sports drug testingA case report Elia Grata Laurent Perrenoud Martial Saugy Norbert Baume Forensic Sci Int 2011 Dec 10213(1-3)104-8
Transport de lrsquooxygegravene
Transfusion sanguine
Agents stimulant lrsquoeacuterythropoiumlegravese
epoetines α β δ ω NESP Mircera Biosimilaires gt 120 moleacutecules
Peginesatide (Hematide)
Nouvelles formulations Epo-IgG Fc aeacuterosol
stabilisateurs de lrsquoHIF 2α (inhibiteurs des propyl hydroxylases)
FG-2216 FG-4592 GSK1278863 AKB-6548 BAY85-3934
GH IGF-1 insuline SARMs corticoiumldes
hormones thyroiumldiennes
autre substances actives sur lrsquoeacuterythropoiumlegravese
- SAA
Transport de lrsquooxygegravene
EPO
croissance
musculaire
IGF-1
Myostatine
Meacutetabolisme eacutenergeacutetique
surexpression de
PPAR-δβ
PEPCK-C
repression de NCoR1
helliphelliphelliphelliphelliphelliphelliphelliphelliphellip
Dopage geacuteneacutetique
Gegravene theacuterapie et modification du meacutetabolisme eacutenergeacutetique
Surexpression de PPAR βδ chez la souris transgeacutenique - augmentation des fibres de type 1 - augmentation de lrsquoendurance Wang et al 2004
exercice physique activation PPAR-δ AMPK oxydation des acides gras inhibition lipogenegravese neacuteoglucogenegravese
= + ATP = + performance
agonistes du PPAR- et AMPK
AICAR GW 1516 (GW510516X)
GW 0742
re programment le meacutetabolisme musculaire (meacutetabolisme oxydatif angiogeacutenegravese reacuteserve en glucose) drsquoougrave augmentation de lrsquoendurance
Mice that hadnt done any exercise but were given AICAR could run 23 percent longer and 44 percent farther than sedentary mice that didnt get the drug (Evans)
Trafficking of drug candidates relevant for sports drug testing detection of non-approved therapeutics categorized as anabolic and gene doping agents in products
distributed via the Internet Thevis et alDrug Test Anal 2011
The big problem with AICAR is the side effects Athletes would get a huge increase in lactic acid Theres also a molecular mutation in the heart that can lead to sudden death Certainly theres a
possibility that drugs could be developed to increase endurance But I dont believe AICAR would improve performance in humans raquo L Goodyear Harvard Medical School Joslin Diabetes Center N Engl J Med 2008 The exercise pill--too good to be true
It might actually have zero effect on athletic performance My 2007 study in the journal Diabetes found it doesnt activate AMPK and only marginally increases glucose uptake in muscles and you would have to take
bucket-loads There is a lot of unjustified hype about AICAR on the Internet and if I was an athlete planning to cheat he definitely wouldnt bother
Dan Cuthbertson a professor at Liverpool University in England
JTV-519 S-107
Modulateurs des canaux calciques stabilisateurs du
complexe Calstabin-Recepteurs de la Ryanodine
(RYCALs)
Heart failure Cardiac arrhythmias Skeletal muscle disorders Cognitive function
deacuteriveacutes de benzothiazeacutepines
Produits creacutees pour eacutechapper
aux controcircles anti-dopage
- laquo designer testosterone raquo
- laquo designer epoetins raquo
- laquo designers steroids raquo
Jusqursquoagrave preacutesenthellipdes meacutedicaments deacutetourneacutes de leur usage theacuterapeutique Aujourdrsquohui helliphellipune industrie speacutecifique au dopage capable - de mettre agrave disposition des sportifs des moleacutecules encore
en eacutetude clinique - de fabriquer des substances conccedilues pour eacutechapper aux controcircles antidopage
CONCLUSION
GH secretagogues GHRH et analogues mimeacutetiques de la ghreline acides amineacutes (arginine ornithine lysine)
sermorelin tesamorelin CJC-1295 GHRP-6 Pralmorelin capromorelin hexarelin tabimorelin MK-677 L-692429 SM-130686 TZP-101
GH + GHRP pour masquer la prise de GH
modulateurs seacutelectifs des reacutecepteurs aux androgegravenes (SARMs)
Mario Thevis Wilhelm Schaumlnzer Organogenesis Forum Lecture
fonte musculaire grand bruleacutes cancer maladies reacutenales osteacuteoporose hypogonadisme
SARM-S4 and metabolites detection in sports drug testingA case report Elia Grata Laurent Perrenoud Martial Saugy Norbert Baume Forensic Sci Int 2011 Dec 10213(1-3)104-8
Transport de lrsquooxygegravene
Transfusion sanguine
Agents stimulant lrsquoeacuterythropoiumlegravese
epoetines α β δ ω NESP Mircera Biosimilaires gt 120 moleacutecules
Peginesatide (Hematide)
Nouvelles formulations Epo-IgG Fc aeacuterosol
stabilisateurs de lrsquoHIF 2α (inhibiteurs des propyl hydroxylases)
FG-2216 FG-4592 GSK1278863 AKB-6548 BAY85-3934
GH IGF-1 insuline SARMs corticoiumldes
hormones thyroiumldiennes
autre substances actives sur lrsquoeacuterythropoiumlegravese
- SAA
Transport de lrsquooxygegravene
EPO
croissance
musculaire
IGF-1
Myostatine
Meacutetabolisme eacutenergeacutetique
surexpression de
PPAR-δβ
PEPCK-C
repression de NCoR1
helliphelliphelliphelliphelliphelliphelliphelliphelliphellip
Dopage geacuteneacutetique
Gegravene theacuterapie et modification du meacutetabolisme eacutenergeacutetique
Surexpression de PPAR βδ chez la souris transgeacutenique - augmentation des fibres de type 1 - augmentation de lrsquoendurance Wang et al 2004
exercice physique activation PPAR-δ AMPK oxydation des acides gras inhibition lipogenegravese neacuteoglucogenegravese
= + ATP = + performance
agonistes du PPAR- et AMPK
AICAR GW 1516 (GW510516X)
GW 0742
re programment le meacutetabolisme musculaire (meacutetabolisme oxydatif angiogeacutenegravese reacuteserve en glucose) drsquoougrave augmentation de lrsquoendurance
Mice that hadnt done any exercise but were given AICAR could run 23 percent longer and 44 percent farther than sedentary mice that didnt get the drug (Evans)
Trafficking of drug candidates relevant for sports drug testing detection of non-approved therapeutics categorized as anabolic and gene doping agents in products
distributed via the Internet Thevis et alDrug Test Anal 2011
The big problem with AICAR is the side effects Athletes would get a huge increase in lactic acid Theres also a molecular mutation in the heart that can lead to sudden death Certainly theres a
possibility that drugs could be developed to increase endurance But I dont believe AICAR would improve performance in humans raquo L Goodyear Harvard Medical School Joslin Diabetes Center N Engl J Med 2008 The exercise pill--too good to be true
It might actually have zero effect on athletic performance My 2007 study in the journal Diabetes found it doesnt activate AMPK and only marginally increases glucose uptake in muscles and you would have to take
bucket-loads There is a lot of unjustified hype about AICAR on the Internet and if I was an athlete planning to cheat he definitely wouldnt bother
Dan Cuthbertson a professor at Liverpool University in England
JTV-519 S-107
Modulateurs des canaux calciques stabilisateurs du
complexe Calstabin-Recepteurs de la Ryanodine
(RYCALs)
Heart failure Cardiac arrhythmias Skeletal muscle disorders Cognitive function
deacuteriveacutes de benzothiazeacutepines
Produits creacutees pour eacutechapper
aux controcircles anti-dopage
- laquo designer testosterone raquo
- laquo designer epoetins raquo
- laquo designers steroids raquo
Jusqursquoagrave preacutesenthellipdes meacutedicaments deacutetourneacutes de leur usage theacuterapeutique Aujourdrsquohui helliphellipune industrie speacutecifique au dopage capable - de mettre agrave disposition des sportifs des moleacutecules encore
en eacutetude clinique - de fabriquer des substances conccedilues pour eacutechapper aux controcircles antidopage
CONCLUSION
modulateurs seacutelectifs des reacutecepteurs aux androgegravenes (SARMs)
Mario Thevis Wilhelm Schaumlnzer Organogenesis Forum Lecture
fonte musculaire grand bruleacutes cancer maladies reacutenales osteacuteoporose hypogonadisme
SARM-S4 and metabolites detection in sports drug testingA case report Elia Grata Laurent Perrenoud Martial Saugy Norbert Baume Forensic Sci Int 2011 Dec 10213(1-3)104-8
Transport de lrsquooxygegravene
Transfusion sanguine
Agents stimulant lrsquoeacuterythropoiumlegravese
epoetines α β δ ω NESP Mircera Biosimilaires gt 120 moleacutecules
Peginesatide (Hematide)
Nouvelles formulations Epo-IgG Fc aeacuterosol
stabilisateurs de lrsquoHIF 2α (inhibiteurs des propyl hydroxylases)
FG-2216 FG-4592 GSK1278863 AKB-6548 BAY85-3934
GH IGF-1 insuline SARMs corticoiumldes
hormones thyroiumldiennes
autre substances actives sur lrsquoeacuterythropoiumlegravese
- SAA
Transport de lrsquooxygegravene
EPO
croissance
musculaire
IGF-1
Myostatine
Meacutetabolisme eacutenergeacutetique
surexpression de
PPAR-δβ
PEPCK-C
repression de NCoR1
helliphelliphelliphelliphelliphelliphelliphelliphelliphellip
Dopage geacuteneacutetique
Gegravene theacuterapie et modification du meacutetabolisme eacutenergeacutetique
Surexpression de PPAR βδ chez la souris transgeacutenique - augmentation des fibres de type 1 - augmentation de lrsquoendurance Wang et al 2004
exercice physique activation PPAR-δ AMPK oxydation des acides gras inhibition lipogenegravese neacuteoglucogenegravese
= + ATP = + performance
agonistes du PPAR- et AMPK
AICAR GW 1516 (GW510516X)
GW 0742
re programment le meacutetabolisme musculaire (meacutetabolisme oxydatif angiogeacutenegravese reacuteserve en glucose) drsquoougrave augmentation de lrsquoendurance
Mice that hadnt done any exercise but were given AICAR could run 23 percent longer and 44 percent farther than sedentary mice that didnt get the drug (Evans)
Trafficking of drug candidates relevant for sports drug testing detection of non-approved therapeutics categorized as anabolic and gene doping agents in products
distributed via the Internet Thevis et alDrug Test Anal 2011
The big problem with AICAR is the side effects Athletes would get a huge increase in lactic acid Theres also a molecular mutation in the heart that can lead to sudden death Certainly theres a
possibility that drugs could be developed to increase endurance But I dont believe AICAR would improve performance in humans raquo L Goodyear Harvard Medical School Joslin Diabetes Center N Engl J Med 2008 The exercise pill--too good to be true
It might actually have zero effect on athletic performance My 2007 study in the journal Diabetes found it doesnt activate AMPK and only marginally increases glucose uptake in muscles and you would have to take
bucket-loads There is a lot of unjustified hype about AICAR on the Internet and if I was an athlete planning to cheat he definitely wouldnt bother
Dan Cuthbertson a professor at Liverpool University in England
JTV-519 S-107
Modulateurs des canaux calciques stabilisateurs du
complexe Calstabin-Recepteurs de la Ryanodine
(RYCALs)
Heart failure Cardiac arrhythmias Skeletal muscle disorders Cognitive function
deacuteriveacutes de benzothiazeacutepines
Produits creacutees pour eacutechapper
aux controcircles anti-dopage
- laquo designer testosterone raquo
- laquo designer epoetins raquo
- laquo designers steroids raquo
Jusqursquoagrave preacutesenthellipdes meacutedicaments deacutetourneacutes de leur usage theacuterapeutique Aujourdrsquohui helliphellipune industrie speacutecifique au dopage capable - de mettre agrave disposition des sportifs des moleacutecules encore
en eacutetude clinique - de fabriquer des substances conccedilues pour eacutechapper aux controcircles antidopage
CONCLUSION
fonte musculaire grand bruleacutes cancer maladies reacutenales osteacuteoporose hypogonadisme
SARM-S4 and metabolites detection in sports drug testingA case report Elia Grata Laurent Perrenoud Martial Saugy Norbert Baume Forensic Sci Int 2011 Dec 10213(1-3)104-8
Transport de lrsquooxygegravene
Transfusion sanguine
Agents stimulant lrsquoeacuterythropoiumlegravese
epoetines α β δ ω NESP Mircera Biosimilaires gt 120 moleacutecules
Peginesatide (Hematide)
Nouvelles formulations Epo-IgG Fc aeacuterosol
stabilisateurs de lrsquoHIF 2α (inhibiteurs des propyl hydroxylases)
FG-2216 FG-4592 GSK1278863 AKB-6548 BAY85-3934
GH IGF-1 insuline SARMs corticoiumldes
hormones thyroiumldiennes
autre substances actives sur lrsquoeacuterythropoiumlegravese
- SAA
Transport de lrsquooxygegravene
EPO
croissance
musculaire
IGF-1
Myostatine
Meacutetabolisme eacutenergeacutetique
surexpression de
PPAR-δβ
PEPCK-C
repression de NCoR1
helliphelliphelliphelliphelliphelliphelliphelliphelliphellip
Dopage geacuteneacutetique
Gegravene theacuterapie et modification du meacutetabolisme eacutenergeacutetique
Surexpression de PPAR βδ chez la souris transgeacutenique - augmentation des fibres de type 1 - augmentation de lrsquoendurance Wang et al 2004
exercice physique activation PPAR-δ AMPK oxydation des acides gras inhibition lipogenegravese neacuteoglucogenegravese
= + ATP = + performance
agonistes du PPAR- et AMPK
AICAR GW 1516 (GW510516X)
GW 0742
re programment le meacutetabolisme musculaire (meacutetabolisme oxydatif angiogeacutenegravese reacuteserve en glucose) drsquoougrave augmentation de lrsquoendurance
Mice that hadnt done any exercise but were given AICAR could run 23 percent longer and 44 percent farther than sedentary mice that didnt get the drug (Evans)
Trafficking of drug candidates relevant for sports drug testing detection of non-approved therapeutics categorized as anabolic and gene doping agents in products
distributed via the Internet Thevis et alDrug Test Anal 2011
The big problem with AICAR is the side effects Athletes would get a huge increase in lactic acid Theres also a molecular mutation in the heart that can lead to sudden death Certainly theres a
possibility that drugs could be developed to increase endurance But I dont believe AICAR would improve performance in humans raquo L Goodyear Harvard Medical School Joslin Diabetes Center N Engl J Med 2008 The exercise pill--too good to be true
It might actually have zero effect on athletic performance My 2007 study in the journal Diabetes found it doesnt activate AMPK and only marginally increases glucose uptake in muscles and you would have to take
bucket-loads There is a lot of unjustified hype about AICAR on the Internet and if I was an athlete planning to cheat he definitely wouldnt bother
Dan Cuthbertson a professor at Liverpool University in England
JTV-519 S-107
Modulateurs des canaux calciques stabilisateurs du
complexe Calstabin-Recepteurs de la Ryanodine
(RYCALs)
Heart failure Cardiac arrhythmias Skeletal muscle disorders Cognitive function
deacuteriveacutes de benzothiazeacutepines
Produits creacutees pour eacutechapper
aux controcircles anti-dopage
- laquo designer testosterone raquo
- laquo designer epoetins raquo
- laquo designers steroids raquo
Jusqursquoagrave preacutesenthellipdes meacutedicaments deacutetourneacutes de leur usage theacuterapeutique Aujourdrsquohui helliphellipune industrie speacutecifique au dopage capable - de mettre agrave disposition des sportifs des moleacutecules encore
en eacutetude clinique - de fabriquer des substances conccedilues pour eacutechapper aux controcircles antidopage
CONCLUSION
SARM-S4 and metabolites detection in sports drug testingA case report Elia Grata Laurent Perrenoud Martial Saugy Norbert Baume Forensic Sci Int 2011 Dec 10213(1-3)104-8
Transport de lrsquooxygegravene
Transfusion sanguine
Agents stimulant lrsquoeacuterythropoiumlegravese
epoetines α β δ ω NESP Mircera Biosimilaires gt 120 moleacutecules
Peginesatide (Hematide)
Nouvelles formulations Epo-IgG Fc aeacuterosol
stabilisateurs de lrsquoHIF 2α (inhibiteurs des propyl hydroxylases)
FG-2216 FG-4592 GSK1278863 AKB-6548 BAY85-3934
GH IGF-1 insuline SARMs corticoiumldes
hormones thyroiumldiennes
autre substances actives sur lrsquoeacuterythropoiumlegravese
- SAA
Transport de lrsquooxygegravene
EPO
croissance
musculaire
IGF-1
Myostatine
Meacutetabolisme eacutenergeacutetique
surexpression de
PPAR-δβ
PEPCK-C
repression de NCoR1
helliphelliphelliphelliphelliphelliphelliphelliphelliphellip
Dopage geacuteneacutetique
Gegravene theacuterapie et modification du meacutetabolisme eacutenergeacutetique
Surexpression de PPAR βδ chez la souris transgeacutenique - augmentation des fibres de type 1 - augmentation de lrsquoendurance Wang et al 2004
exercice physique activation PPAR-δ AMPK oxydation des acides gras inhibition lipogenegravese neacuteoglucogenegravese
= + ATP = + performance
agonistes du PPAR- et AMPK
AICAR GW 1516 (GW510516X)
GW 0742
re programment le meacutetabolisme musculaire (meacutetabolisme oxydatif angiogeacutenegravese reacuteserve en glucose) drsquoougrave augmentation de lrsquoendurance
Mice that hadnt done any exercise but were given AICAR could run 23 percent longer and 44 percent farther than sedentary mice that didnt get the drug (Evans)
Trafficking of drug candidates relevant for sports drug testing detection of non-approved therapeutics categorized as anabolic and gene doping agents in products
distributed via the Internet Thevis et alDrug Test Anal 2011
The big problem with AICAR is the side effects Athletes would get a huge increase in lactic acid Theres also a molecular mutation in the heart that can lead to sudden death Certainly theres a
possibility that drugs could be developed to increase endurance But I dont believe AICAR would improve performance in humans raquo L Goodyear Harvard Medical School Joslin Diabetes Center N Engl J Med 2008 The exercise pill--too good to be true
It might actually have zero effect on athletic performance My 2007 study in the journal Diabetes found it doesnt activate AMPK and only marginally increases glucose uptake in muscles and you would have to take
bucket-loads There is a lot of unjustified hype about AICAR on the Internet and if I was an athlete planning to cheat he definitely wouldnt bother
Dan Cuthbertson a professor at Liverpool University in England
JTV-519 S-107
Modulateurs des canaux calciques stabilisateurs du
complexe Calstabin-Recepteurs de la Ryanodine
(RYCALs)
Heart failure Cardiac arrhythmias Skeletal muscle disorders Cognitive function
deacuteriveacutes de benzothiazeacutepines
Produits creacutees pour eacutechapper
aux controcircles anti-dopage
- laquo designer testosterone raquo
- laquo designer epoetins raquo
- laquo designers steroids raquo
Jusqursquoagrave preacutesenthellipdes meacutedicaments deacutetourneacutes de leur usage theacuterapeutique Aujourdrsquohui helliphellipune industrie speacutecifique au dopage capable - de mettre agrave disposition des sportifs des moleacutecules encore
en eacutetude clinique - de fabriquer des substances conccedilues pour eacutechapper aux controcircles antidopage
CONCLUSION
Transport de lrsquooxygegravene
Transfusion sanguine
Agents stimulant lrsquoeacuterythropoiumlegravese
epoetines α β δ ω NESP Mircera Biosimilaires gt 120 moleacutecules
Peginesatide (Hematide)
Nouvelles formulations Epo-IgG Fc aeacuterosol
stabilisateurs de lrsquoHIF 2α (inhibiteurs des propyl hydroxylases)
FG-2216 FG-4592 GSK1278863 AKB-6548 BAY85-3934
GH IGF-1 insuline SARMs corticoiumldes
hormones thyroiumldiennes
autre substances actives sur lrsquoeacuterythropoiumlegravese
- SAA
Transport de lrsquooxygegravene
EPO
croissance
musculaire
IGF-1
Myostatine
Meacutetabolisme eacutenergeacutetique
surexpression de
PPAR-δβ
PEPCK-C
repression de NCoR1
helliphelliphelliphelliphelliphelliphelliphelliphelliphellip
Dopage geacuteneacutetique
Gegravene theacuterapie et modification du meacutetabolisme eacutenergeacutetique
Surexpression de PPAR βδ chez la souris transgeacutenique - augmentation des fibres de type 1 - augmentation de lrsquoendurance Wang et al 2004
exercice physique activation PPAR-δ AMPK oxydation des acides gras inhibition lipogenegravese neacuteoglucogenegravese
= + ATP = + performance
agonistes du PPAR- et AMPK
AICAR GW 1516 (GW510516X)
GW 0742
re programment le meacutetabolisme musculaire (meacutetabolisme oxydatif angiogeacutenegravese reacuteserve en glucose) drsquoougrave augmentation de lrsquoendurance
Mice that hadnt done any exercise but were given AICAR could run 23 percent longer and 44 percent farther than sedentary mice that didnt get the drug (Evans)
Trafficking of drug candidates relevant for sports drug testing detection of non-approved therapeutics categorized as anabolic and gene doping agents in products
distributed via the Internet Thevis et alDrug Test Anal 2011
The big problem with AICAR is the side effects Athletes would get a huge increase in lactic acid Theres also a molecular mutation in the heart that can lead to sudden death Certainly theres a
possibility that drugs could be developed to increase endurance But I dont believe AICAR would improve performance in humans raquo L Goodyear Harvard Medical School Joslin Diabetes Center N Engl J Med 2008 The exercise pill--too good to be true
It might actually have zero effect on athletic performance My 2007 study in the journal Diabetes found it doesnt activate AMPK and only marginally increases glucose uptake in muscles and you would have to take
bucket-loads There is a lot of unjustified hype about AICAR on the Internet and if I was an athlete planning to cheat he definitely wouldnt bother
Dan Cuthbertson a professor at Liverpool University in England
JTV-519 S-107
Modulateurs des canaux calciques stabilisateurs du
complexe Calstabin-Recepteurs de la Ryanodine
(RYCALs)
Heart failure Cardiac arrhythmias Skeletal muscle disorders Cognitive function
deacuteriveacutes de benzothiazeacutepines
Produits creacutees pour eacutechapper
aux controcircles anti-dopage
- laquo designer testosterone raquo
- laquo designer epoetins raquo
- laquo designers steroids raquo
Jusqursquoagrave preacutesenthellipdes meacutedicaments deacutetourneacutes de leur usage theacuterapeutique Aujourdrsquohui helliphellipune industrie speacutecifique au dopage capable - de mettre agrave disposition des sportifs des moleacutecules encore
en eacutetude clinique - de fabriquer des substances conccedilues pour eacutechapper aux controcircles antidopage
CONCLUSION
Peginesatide (Hematide)
Nouvelles formulations Epo-IgG Fc aeacuterosol
stabilisateurs de lrsquoHIF 2α (inhibiteurs des propyl hydroxylases)
FG-2216 FG-4592 GSK1278863 AKB-6548 BAY85-3934
GH IGF-1 insuline SARMs corticoiumldes
hormones thyroiumldiennes
autre substances actives sur lrsquoeacuterythropoiumlegravese
- SAA
Transport de lrsquooxygegravene
EPO
croissance
musculaire
IGF-1
Myostatine
Meacutetabolisme eacutenergeacutetique
surexpression de
PPAR-δβ
PEPCK-C
repression de NCoR1
helliphelliphelliphelliphelliphelliphelliphelliphelliphellip
Dopage geacuteneacutetique
Gegravene theacuterapie et modification du meacutetabolisme eacutenergeacutetique
Surexpression de PPAR βδ chez la souris transgeacutenique - augmentation des fibres de type 1 - augmentation de lrsquoendurance Wang et al 2004
exercice physique activation PPAR-δ AMPK oxydation des acides gras inhibition lipogenegravese neacuteoglucogenegravese
= + ATP = + performance
agonistes du PPAR- et AMPK
AICAR GW 1516 (GW510516X)
GW 0742
re programment le meacutetabolisme musculaire (meacutetabolisme oxydatif angiogeacutenegravese reacuteserve en glucose) drsquoougrave augmentation de lrsquoendurance
Mice that hadnt done any exercise but were given AICAR could run 23 percent longer and 44 percent farther than sedentary mice that didnt get the drug (Evans)
Trafficking of drug candidates relevant for sports drug testing detection of non-approved therapeutics categorized as anabolic and gene doping agents in products
distributed via the Internet Thevis et alDrug Test Anal 2011
The big problem with AICAR is the side effects Athletes would get a huge increase in lactic acid Theres also a molecular mutation in the heart that can lead to sudden death Certainly theres a
possibility that drugs could be developed to increase endurance But I dont believe AICAR would improve performance in humans raquo L Goodyear Harvard Medical School Joslin Diabetes Center N Engl J Med 2008 The exercise pill--too good to be true
It might actually have zero effect on athletic performance My 2007 study in the journal Diabetes found it doesnt activate AMPK and only marginally increases glucose uptake in muscles and you would have to take
bucket-loads There is a lot of unjustified hype about AICAR on the Internet and if I was an athlete planning to cheat he definitely wouldnt bother
Dan Cuthbertson a professor at Liverpool University in England
JTV-519 S-107
Modulateurs des canaux calciques stabilisateurs du
complexe Calstabin-Recepteurs de la Ryanodine
(RYCALs)
Heart failure Cardiac arrhythmias Skeletal muscle disorders Cognitive function
deacuteriveacutes de benzothiazeacutepines
Produits creacutees pour eacutechapper
aux controcircles anti-dopage
- laquo designer testosterone raquo
- laquo designer epoetins raquo
- laquo designers steroids raquo
Jusqursquoagrave preacutesenthellipdes meacutedicaments deacutetourneacutes de leur usage theacuterapeutique Aujourdrsquohui helliphellipune industrie speacutecifique au dopage capable - de mettre agrave disposition des sportifs des moleacutecules encore
en eacutetude clinique - de fabriquer des substances conccedilues pour eacutechapper aux controcircles antidopage
CONCLUSION
stabilisateurs de lrsquoHIF 2α (inhibiteurs des propyl hydroxylases)
FG-2216 FG-4592 GSK1278863 AKB-6548 BAY85-3934
GH IGF-1 insuline SARMs corticoiumldes
hormones thyroiumldiennes
autre substances actives sur lrsquoeacuterythropoiumlegravese
- SAA
Transport de lrsquooxygegravene
EPO
croissance
musculaire
IGF-1
Myostatine
Meacutetabolisme eacutenergeacutetique
surexpression de
PPAR-δβ
PEPCK-C
repression de NCoR1
helliphelliphelliphelliphelliphelliphelliphelliphelliphellip
Dopage geacuteneacutetique
Gegravene theacuterapie et modification du meacutetabolisme eacutenergeacutetique
Surexpression de PPAR βδ chez la souris transgeacutenique - augmentation des fibres de type 1 - augmentation de lrsquoendurance Wang et al 2004
exercice physique activation PPAR-δ AMPK oxydation des acides gras inhibition lipogenegravese neacuteoglucogenegravese
= + ATP = + performance
agonistes du PPAR- et AMPK
AICAR GW 1516 (GW510516X)
GW 0742
re programment le meacutetabolisme musculaire (meacutetabolisme oxydatif angiogeacutenegravese reacuteserve en glucose) drsquoougrave augmentation de lrsquoendurance
Mice that hadnt done any exercise but were given AICAR could run 23 percent longer and 44 percent farther than sedentary mice that didnt get the drug (Evans)
Trafficking of drug candidates relevant for sports drug testing detection of non-approved therapeutics categorized as anabolic and gene doping agents in products
distributed via the Internet Thevis et alDrug Test Anal 2011
The big problem with AICAR is the side effects Athletes would get a huge increase in lactic acid Theres also a molecular mutation in the heart that can lead to sudden death Certainly theres a
possibility that drugs could be developed to increase endurance But I dont believe AICAR would improve performance in humans raquo L Goodyear Harvard Medical School Joslin Diabetes Center N Engl J Med 2008 The exercise pill--too good to be true
It might actually have zero effect on athletic performance My 2007 study in the journal Diabetes found it doesnt activate AMPK and only marginally increases glucose uptake in muscles and you would have to take
bucket-loads There is a lot of unjustified hype about AICAR on the Internet and if I was an athlete planning to cheat he definitely wouldnt bother
Dan Cuthbertson a professor at Liverpool University in England
JTV-519 S-107
Modulateurs des canaux calciques stabilisateurs du
complexe Calstabin-Recepteurs de la Ryanodine
(RYCALs)
Heart failure Cardiac arrhythmias Skeletal muscle disorders Cognitive function
deacuteriveacutes de benzothiazeacutepines
Produits creacutees pour eacutechapper
aux controcircles anti-dopage
- laquo designer testosterone raquo
- laquo designer epoetins raquo
- laquo designers steroids raquo
Jusqursquoagrave preacutesenthellipdes meacutedicaments deacutetourneacutes de leur usage theacuterapeutique Aujourdrsquohui helliphellipune industrie speacutecifique au dopage capable - de mettre agrave disposition des sportifs des moleacutecules encore
en eacutetude clinique - de fabriquer des substances conccedilues pour eacutechapper aux controcircles antidopage
CONCLUSION
GH IGF-1 insuline SARMs corticoiumldes
hormones thyroiumldiennes
autre substances actives sur lrsquoeacuterythropoiumlegravese
- SAA
Transport de lrsquooxygegravene
EPO
croissance
musculaire
IGF-1
Myostatine
Meacutetabolisme eacutenergeacutetique
surexpression de
PPAR-δβ
PEPCK-C
repression de NCoR1
helliphelliphelliphelliphelliphelliphelliphelliphelliphellip
Dopage geacuteneacutetique
Gegravene theacuterapie et modification du meacutetabolisme eacutenergeacutetique
Surexpression de PPAR βδ chez la souris transgeacutenique - augmentation des fibres de type 1 - augmentation de lrsquoendurance Wang et al 2004
exercice physique activation PPAR-δ AMPK oxydation des acides gras inhibition lipogenegravese neacuteoglucogenegravese
= + ATP = + performance
agonistes du PPAR- et AMPK
AICAR GW 1516 (GW510516X)
GW 0742
re programment le meacutetabolisme musculaire (meacutetabolisme oxydatif angiogeacutenegravese reacuteserve en glucose) drsquoougrave augmentation de lrsquoendurance
Mice that hadnt done any exercise but were given AICAR could run 23 percent longer and 44 percent farther than sedentary mice that didnt get the drug (Evans)
Trafficking of drug candidates relevant for sports drug testing detection of non-approved therapeutics categorized as anabolic and gene doping agents in products
distributed via the Internet Thevis et alDrug Test Anal 2011
The big problem with AICAR is the side effects Athletes would get a huge increase in lactic acid Theres also a molecular mutation in the heart that can lead to sudden death Certainly theres a
possibility that drugs could be developed to increase endurance But I dont believe AICAR would improve performance in humans raquo L Goodyear Harvard Medical School Joslin Diabetes Center N Engl J Med 2008 The exercise pill--too good to be true
It might actually have zero effect on athletic performance My 2007 study in the journal Diabetes found it doesnt activate AMPK and only marginally increases glucose uptake in muscles and you would have to take
bucket-loads There is a lot of unjustified hype about AICAR on the Internet and if I was an athlete planning to cheat he definitely wouldnt bother
Dan Cuthbertson a professor at Liverpool University in England
JTV-519 S-107
Modulateurs des canaux calciques stabilisateurs du
complexe Calstabin-Recepteurs de la Ryanodine
(RYCALs)
Heart failure Cardiac arrhythmias Skeletal muscle disorders Cognitive function
deacuteriveacutes de benzothiazeacutepines
Produits creacutees pour eacutechapper
aux controcircles anti-dopage
- laquo designer testosterone raquo
- laquo designer epoetins raquo
- laquo designers steroids raquo
Jusqursquoagrave preacutesenthellipdes meacutedicaments deacutetourneacutes de leur usage theacuterapeutique Aujourdrsquohui helliphellipune industrie speacutecifique au dopage capable - de mettre agrave disposition des sportifs des moleacutecules encore
en eacutetude clinique - de fabriquer des substances conccedilues pour eacutechapper aux controcircles antidopage
CONCLUSION
Transport de lrsquooxygegravene
EPO
croissance
musculaire
IGF-1
Myostatine
Meacutetabolisme eacutenergeacutetique
surexpression de
PPAR-δβ
PEPCK-C
repression de NCoR1
helliphelliphelliphelliphelliphelliphelliphelliphelliphellip
Dopage geacuteneacutetique
Gegravene theacuterapie et modification du meacutetabolisme eacutenergeacutetique
Surexpression de PPAR βδ chez la souris transgeacutenique - augmentation des fibres de type 1 - augmentation de lrsquoendurance Wang et al 2004
exercice physique activation PPAR-δ AMPK oxydation des acides gras inhibition lipogenegravese neacuteoglucogenegravese
= + ATP = + performance
agonistes du PPAR- et AMPK
AICAR GW 1516 (GW510516X)
GW 0742
re programment le meacutetabolisme musculaire (meacutetabolisme oxydatif angiogeacutenegravese reacuteserve en glucose) drsquoougrave augmentation de lrsquoendurance
Mice that hadnt done any exercise but were given AICAR could run 23 percent longer and 44 percent farther than sedentary mice that didnt get the drug (Evans)
Trafficking of drug candidates relevant for sports drug testing detection of non-approved therapeutics categorized as anabolic and gene doping agents in products
distributed via the Internet Thevis et alDrug Test Anal 2011
The big problem with AICAR is the side effects Athletes would get a huge increase in lactic acid Theres also a molecular mutation in the heart that can lead to sudden death Certainly theres a
possibility that drugs could be developed to increase endurance But I dont believe AICAR would improve performance in humans raquo L Goodyear Harvard Medical School Joslin Diabetes Center N Engl J Med 2008 The exercise pill--too good to be true
It might actually have zero effect on athletic performance My 2007 study in the journal Diabetes found it doesnt activate AMPK and only marginally increases glucose uptake in muscles and you would have to take
bucket-loads There is a lot of unjustified hype about AICAR on the Internet and if I was an athlete planning to cheat he definitely wouldnt bother
Dan Cuthbertson a professor at Liverpool University in England
JTV-519 S-107
Modulateurs des canaux calciques stabilisateurs du
complexe Calstabin-Recepteurs de la Ryanodine
(RYCALs)
Heart failure Cardiac arrhythmias Skeletal muscle disorders Cognitive function
deacuteriveacutes de benzothiazeacutepines
Produits creacutees pour eacutechapper
aux controcircles anti-dopage
- laquo designer testosterone raquo
- laquo designer epoetins raquo
- laquo designers steroids raquo
Jusqursquoagrave preacutesenthellipdes meacutedicaments deacutetourneacutes de leur usage theacuterapeutique Aujourdrsquohui helliphellipune industrie speacutecifique au dopage capable - de mettre agrave disposition des sportifs des moleacutecules encore
en eacutetude clinique - de fabriquer des substances conccedilues pour eacutechapper aux controcircles antidopage
CONCLUSION
Gegravene theacuterapie et modification du meacutetabolisme eacutenergeacutetique
Surexpression de PPAR βδ chez la souris transgeacutenique - augmentation des fibres de type 1 - augmentation de lrsquoendurance Wang et al 2004
exercice physique activation PPAR-δ AMPK oxydation des acides gras inhibition lipogenegravese neacuteoglucogenegravese
= + ATP = + performance
agonistes du PPAR- et AMPK
AICAR GW 1516 (GW510516X)
GW 0742
re programment le meacutetabolisme musculaire (meacutetabolisme oxydatif angiogeacutenegravese reacuteserve en glucose) drsquoougrave augmentation de lrsquoendurance
Mice that hadnt done any exercise but were given AICAR could run 23 percent longer and 44 percent farther than sedentary mice that didnt get the drug (Evans)
Trafficking of drug candidates relevant for sports drug testing detection of non-approved therapeutics categorized as anabolic and gene doping agents in products
distributed via the Internet Thevis et alDrug Test Anal 2011
The big problem with AICAR is the side effects Athletes would get a huge increase in lactic acid Theres also a molecular mutation in the heart that can lead to sudden death Certainly theres a
possibility that drugs could be developed to increase endurance But I dont believe AICAR would improve performance in humans raquo L Goodyear Harvard Medical School Joslin Diabetes Center N Engl J Med 2008 The exercise pill--too good to be true
It might actually have zero effect on athletic performance My 2007 study in the journal Diabetes found it doesnt activate AMPK and only marginally increases glucose uptake in muscles and you would have to take
bucket-loads There is a lot of unjustified hype about AICAR on the Internet and if I was an athlete planning to cheat he definitely wouldnt bother
Dan Cuthbertson a professor at Liverpool University in England
JTV-519 S-107
Modulateurs des canaux calciques stabilisateurs du
complexe Calstabin-Recepteurs de la Ryanodine
(RYCALs)
Heart failure Cardiac arrhythmias Skeletal muscle disorders Cognitive function
deacuteriveacutes de benzothiazeacutepines
Produits creacutees pour eacutechapper
aux controcircles anti-dopage
- laquo designer testosterone raquo
- laquo designer epoetins raquo
- laquo designers steroids raquo
Jusqursquoagrave preacutesenthellipdes meacutedicaments deacutetourneacutes de leur usage theacuterapeutique Aujourdrsquohui helliphellipune industrie speacutecifique au dopage capable - de mettre agrave disposition des sportifs des moleacutecules encore
en eacutetude clinique - de fabriquer des substances conccedilues pour eacutechapper aux controcircles antidopage
CONCLUSION
agonistes du PPAR- et AMPK
AICAR GW 1516 (GW510516X)
GW 0742
re programment le meacutetabolisme musculaire (meacutetabolisme oxydatif angiogeacutenegravese reacuteserve en glucose) drsquoougrave augmentation de lrsquoendurance
Mice that hadnt done any exercise but were given AICAR could run 23 percent longer and 44 percent farther than sedentary mice that didnt get the drug (Evans)
Trafficking of drug candidates relevant for sports drug testing detection of non-approved therapeutics categorized as anabolic and gene doping agents in products
distributed via the Internet Thevis et alDrug Test Anal 2011
The big problem with AICAR is the side effects Athletes would get a huge increase in lactic acid Theres also a molecular mutation in the heart that can lead to sudden death Certainly theres a
possibility that drugs could be developed to increase endurance But I dont believe AICAR would improve performance in humans raquo L Goodyear Harvard Medical School Joslin Diabetes Center N Engl J Med 2008 The exercise pill--too good to be true
It might actually have zero effect on athletic performance My 2007 study in the journal Diabetes found it doesnt activate AMPK and only marginally increases glucose uptake in muscles and you would have to take
bucket-loads There is a lot of unjustified hype about AICAR on the Internet and if I was an athlete planning to cheat he definitely wouldnt bother
Dan Cuthbertson a professor at Liverpool University in England
JTV-519 S-107
Modulateurs des canaux calciques stabilisateurs du
complexe Calstabin-Recepteurs de la Ryanodine
(RYCALs)
Heart failure Cardiac arrhythmias Skeletal muscle disorders Cognitive function
deacuteriveacutes de benzothiazeacutepines
Produits creacutees pour eacutechapper
aux controcircles anti-dopage
- laquo designer testosterone raquo
- laquo designer epoetins raquo
- laquo designers steroids raquo
Jusqursquoagrave preacutesenthellipdes meacutedicaments deacutetourneacutes de leur usage theacuterapeutique Aujourdrsquohui helliphellipune industrie speacutecifique au dopage capable - de mettre agrave disposition des sportifs des moleacutecules encore
en eacutetude clinique - de fabriquer des substances conccedilues pour eacutechapper aux controcircles antidopage
CONCLUSION
Trafficking of drug candidates relevant for sports drug testing detection of non-approved therapeutics categorized as anabolic and gene doping agents in products
distributed via the Internet Thevis et alDrug Test Anal 2011
The big problem with AICAR is the side effects Athletes would get a huge increase in lactic acid Theres also a molecular mutation in the heart that can lead to sudden death Certainly theres a
possibility that drugs could be developed to increase endurance But I dont believe AICAR would improve performance in humans raquo L Goodyear Harvard Medical School Joslin Diabetes Center N Engl J Med 2008 The exercise pill--too good to be true
It might actually have zero effect on athletic performance My 2007 study in the journal Diabetes found it doesnt activate AMPK and only marginally increases glucose uptake in muscles and you would have to take
bucket-loads There is a lot of unjustified hype about AICAR on the Internet and if I was an athlete planning to cheat he definitely wouldnt bother
Dan Cuthbertson a professor at Liverpool University in England
JTV-519 S-107
Modulateurs des canaux calciques stabilisateurs du
complexe Calstabin-Recepteurs de la Ryanodine
(RYCALs)
Heart failure Cardiac arrhythmias Skeletal muscle disorders Cognitive function
deacuteriveacutes de benzothiazeacutepines
Produits creacutees pour eacutechapper
aux controcircles anti-dopage
- laquo designer testosterone raquo
- laquo designer epoetins raquo
- laquo designers steroids raquo
Jusqursquoagrave preacutesenthellipdes meacutedicaments deacutetourneacutes de leur usage theacuterapeutique Aujourdrsquohui helliphellipune industrie speacutecifique au dopage capable - de mettre agrave disposition des sportifs des moleacutecules encore
en eacutetude clinique - de fabriquer des substances conccedilues pour eacutechapper aux controcircles antidopage
CONCLUSION
The big problem with AICAR is the side effects Athletes would get a huge increase in lactic acid Theres also a molecular mutation in the heart that can lead to sudden death Certainly theres a
possibility that drugs could be developed to increase endurance But I dont believe AICAR would improve performance in humans raquo L Goodyear Harvard Medical School Joslin Diabetes Center N Engl J Med 2008 The exercise pill--too good to be true
It might actually have zero effect on athletic performance My 2007 study in the journal Diabetes found it doesnt activate AMPK and only marginally increases glucose uptake in muscles and you would have to take
bucket-loads There is a lot of unjustified hype about AICAR on the Internet and if I was an athlete planning to cheat he definitely wouldnt bother
Dan Cuthbertson a professor at Liverpool University in England
JTV-519 S-107
Modulateurs des canaux calciques stabilisateurs du
complexe Calstabin-Recepteurs de la Ryanodine
(RYCALs)
Heart failure Cardiac arrhythmias Skeletal muscle disorders Cognitive function
deacuteriveacutes de benzothiazeacutepines
Produits creacutees pour eacutechapper
aux controcircles anti-dopage
- laquo designer testosterone raquo
- laquo designer epoetins raquo
- laquo designers steroids raquo
Jusqursquoagrave preacutesenthellipdes meacutedicaments deacutetourneacutes de leur usage theacuterapeutique Aujourdrsquohui helliphellipune industrie speacutecifique au dopage capable - de mettre agrave disposition des sportifs des moleacutecules encore
en eacutetude clinique - de fabriquer des substances conccedilues pour eacutechapper aux controcircles antidopage
CONCLUSION
JTV-519 S-107
Modulateurs des canaux calciques stabilisateurs du
complexe Calstabin-Recepteurs de la Ryanodine
(RYCALs)
Heart failure Cardiac arrhythmias Skeletal muscle disorders Cognitive function
deacuteriveacutes de benzothiazeacutepines
Produits creacutees pour eacutechapper
aux controcircles anti-dopage
- laquo designer testosterone raquo
- laquo designer epoetins raquo
- laquo designers steroids raquo
Jusqursquoagrave preacutesenthellipdes meacutedicaments deacutetourneacutes de leur usage theacuterapeutique Aujourdrsquohui helliphellipune industrie speacutecifique au dopage capable - de mettre agrave disposition des sportifs des moleacutecules encore
en eacutetude clinique - de fabriquer des substances conccedilues pour eacutechapper aux controcircles antidopage
CONCLUSION
Produits creacutees pour eacutechapper
aux controcircles anti-dopage
- laquo designer testosterone raquo
- laquo designer epoetins raquo
- laquo designers steroids raquo
Jusqursquoagrave preacutesenthellipdes meacutedicaments deacutetourneacutes de leur usage theacuterapeutique Aujourdrsquohui helliphellipune industrie speacutecifique au dopage capable - de mettre agrave disposition des sportifs des moleacutecules encore
en eacutetude clinique - de fabriquer des substances conccedilues pour eacutechapper aux controcircles antidopage
CONCLUSION
Jusqursquoagrave preacutesenthellipdes meacutedicaments deacutetourneacutes de leur usage theacuterapeutique Aujourdrsquohui helliphellipune industrie speacutecifique au dopage capable - de mettre agrave disposition des sportifs des moleacutecules encore
en eacutetude clinique - de fabriquer des substances conccedilues pour eacutechapper aux controcircles antidopage
CONCLUSION
