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Alterna(velicensingmodelstos(mulate

innova(on

ThomasKrohn,RPh,MBADirector,ClinicalOpenInnova(on

EliLillyandCompany

WorldDrugReposi(oningCongressWashington,DC

5December2012Pleasenotethatsomeoftheviewspresented

donotnecessarilyreflectthoseofEliLillyand

Company

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3GoalsToday

Caseforalterna(velicensing/businessmodel Lessonsfromotherindustries Examplealterna(vemodel

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DrugDevelopmentToday

TargetedConfirma.on

Closed

Exploratory

Collabora.ve

patent

Innova(on Process

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4/23

LicensingToday

patent

PorNolioAri(on

BusinessDevelopmentDeal

PorNolioGaps

Patentclock(cking

Asymmetricinforma(onInconsistentRepresenta(on

CustomDeals

Effortand(me

Priori(za(on/OppCost

7/30/2019 Drug Repositioning Conf - Krohn Dec 2102

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BackupCompounds:LicensingConcerns

Cannibaliza(onofleadcompound Class-effectsafetyconcerns Partnerdoesbadscience Lossofownershipandcontrol Intellectualpropertyissues

RedHerringsorMi(gableRisks

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IncrementalImprovement

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Weneedabolderalterna(ve

to S1'

to S2

S1

Time

Performance

Disruptive

Change

SimplerFaster Cheaper

SustainingInnova?onEfficiencyInnova?onEmpoweringInnova/on

ClaytonChris(ansenYT,11/4/12

7/30/2019 Drug Repositioning Conf - Krohn Dec 2102

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Learningfromotherindustries

Accesstoop(ons-buy&sell Standardcontentrepresenta(on Streamlinedtransac(ons Licensingtoenableexternalinnova(on

7/30/2019 Drug Repositioning Conf - Krohn Dec 2102

10/23

Accesstoop(ons-buy&sell

MusicIndustry

PhysicalPurchase

MP3Download

Subscrip(onAnymusic,any(me,anywhere

Collec(bles

7/30/2019 Drug Repositioning Conf - Krohn Dec 2102

11/23

Standardcontentrepresenta(on

AmazonSearch

ClinicalCollec(ons

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Streamlinedtransac(ons

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Enablingexternalinnova(on

Opensourceso^wareLicensing

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Crea(veCommonsLicenses

Exclusivity

Permissionrequired

Crea(vity

Predefinedpermission

Absolute Flavors

Copyright Copyle^

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Enablingexternalinnova(on

Opensourceso^ware

Copyle^Licensing

Collabora(veDevelopment

Fulltransparency

LinuxForks

$1B

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Learningfromotherindustries

Accesstoop(ons-buy&sell StandardRepresenta(on Streamlinedtransac(ons Enablingexternalinnova(on

RemovedBarrierstoMarketInnova(on

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LicensingToday

patent

PorNolioAri(on

BusinessDevelopmentDeal

PorNolioGaps

Patentclock(cking

Asymmetricinforma(onInconsistentRepresenta(on

CustomDeals

Effortand(me

Priori(za(on/OppCost

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Whatif?

patent

PorNolioAri(on

BusinessDevelopmentDeal

PorNolioGaps

Patentclock(cking

Access/ClearingHouseSymmetricinforma(on

StandardizedRepresenta(on

StandardizedDeals

Innova(onEnablingLicensing

7/30/2019 Drug Repositioning Conf - Krohn Dec 2102

19/23

7/30/2019 Drug Repositioning Conf - Krohn Dec 2102

20/23

CommonsDrugDevelopment

Pharma Biotechs Academics Foundations Individuals

standardrulesofentry standardlegaltools standarddataformats mustcontributedatatoaccessdata voluntarycommitment

selectedcrea(onof

precompe((vedataspaces

preferredstrategicpartners samerulesandformats:interoperability crea(onofadatacommonsover(me2

decayofdataintopublicdomain founda(onfundingandcrowdtalent encouragetooldevelopmentbycrowd

3

1

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EmpoweringInnova(on

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MoreInforma(on

www.crea(vecommons.org www.lillycoi.com

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