Embed Size (px)
Citation preview
D
D
The added Dimensionin Drug Discovery
Delivering
Detail
Diligence
Dedication
in
with
and
www.jubilantbiosys.com
Focus on: Complex Chemistry Capabilities
D
D
D
D
D
D
D
Discovery Chemistry to Preclinical Development Under One Roof
Support Fast track IND filing by our customers through effective Route scouting and Objective CMC support for Tox and 1st GMP batch…Objective
D
D
D
D
D
D
D
Broad Range of Complex Chemistry Capabilities
● Contemporary technological and scientific capabilities
● Experience on asymmetric synthesis with relevant analytical instruments (SFC, UPC2 and HPLC)
● Demonstrated RS, PRD and GMP capabilities
● Library Synthesis: 100-4,000 compounds
● Speciality Chemistry – Sugar, Nucleoside, Steroid, Peptide and others
● Efficient analytical services with low turnaround time
● High-end purification system (PDA, ELSD and MS directed Auto-prep)
● Focus on Green Chemistry
D
D
D
D
D
D
D
Enabling Technologies to Speed Up Discovery
SFC (Waters)
APMS (Waters)
HPLC (Waters-PDA)
Corning Flow Reactor
Multiple Photoreactors
Parallel Reactors
Purification Reactors
● Electronic Lab Notebook
CDD Vault
Signal’s Note Book (PE)
● Reaxys
ACS, Wiley, Elsevier, Thieme etc. (Journals)
● Chemical Tracker (CTS)
● eAnalytics
Tools
D
D
D
D
D
D
D
Case Study-1: Route Design to Maximize Efficiency
D
D
D
D
D
D
D
Case Study 2: Determination of Absolute Stereochemistry
Determination of Absolute Stereochemistry by multiple methods; Based on Expertise in methodologies to control Stereochemistry
D
D
D
D
D
D
D
Case Study 3: Swift Development of IND Fit Synthesis Routes
D
D
D
D
D
D
D
Case Study 4: Optimization to Robust, Scalable Reactions
D
D
D
D
D
D
D
Case Study 5: Med Chem Route to Robust Scale-up Route
D
D
D
D
D
D
D
Case Study 6: Few Examples of Challenging Chemistry
D
D
D
D
D
D
D
Case Study 7: Nucleosides: Synthesis and Analysis of Isomers
D
D
D
D
D
D
D
Key Support Functions Provide For An Overall Productive Experience
A Centralized PM Team for
● Coordination of:
Project course
Resources
Facilitation of logistics
● Ensuring delivery through:
Initiation of the projects
Intervention on any bottle necks encountered for delivery
Process implementations for the successful execution
Project Management
Robust IP process of safeguarding and maintaining client’s IP through a technically skilled dedicated team
SOP driven IP and LNB audit procedures
Initiative in progress for going paperless by transitioning to a digital-based eLN system there by enhancing productivity, Usability, Compliance & IP
Client eLNs used in several cases, where user access provided
IP Management
Lean procurement process for quick delivery of starting materials (SM) from local & international sources
58% SM procured from domestic/local suppliers. With constant effort on adding more YoY
Supply Chain
Import Region
Delhi
Domestic
USA
UK
China
Avg. TAT
3.53
4.93
5.92
5.61
10.19
% Sourcing
33%
26%
29%
3%
10%
Logisticstimeline
24-48 h
48-72 h
72 h
D
D
D
D
D
D
D
Purushotham Vandanapu - Director, Scale-Up Chemistry Operations
MSc. Chemistry (Industrial oriented), Regional Engineering College (NIT), Warangal, Affiliated to Kakatiya University, Andhra Pradesh, India and BSc. Maths, Physics, Chemistry, Andhra Loyola College, Vijayawada, Affiliated to Nagarjuna University; Experience: 26+ years, Process Development of New Chemical entity and Active Pharmaceutical Ingredients.
Diverse & Talented Leadership Team with Global Experience
Vikas Shirsath - Ph.D., SVP,Operations
Ph.D. Medicinal Chemistry, LM College of Pharmacy, Gujarat University; Senior Research Fellowship CSIR Experience: 15+ years, Medicinal and Synthetic Organic Chemistry; Poster, Presentations and Publications- 41, 70+ patents.
Prasant K Deb - Ph.D., AVP, Synthesis and Analytical Chemistry
Ph.D. Organic Chemistry, Guru Nanak Dev University, Amritsar, , INDIA, 2001; Post-Doc: 1. University of Pennsylvania, Philadelphia, PA, USA, 2004-06; Furman University, Greenville, SC, USA, 2002-04; University St. Jerome, Marseille, France, 2001-02; Experience: 10+ years, Chemical Synthesis and Analytical Chemistry, 14 Papers, Multiple research papers at international conferences.
Arunendra Pathak - Ph.D., Associate Director, Chemistry
Ph.D., Central Drug Research Institute, Lucknow , India; PDF University of Joseph Fourier, Grenoble, France; Experience: 15+ years, Organic Synthesis and Medicinal Chemistry; 12 Paper, Number of invited lecture and paper presented in Conferences.
D
D
D
D
D
D
D
Diverse & Talented Leadership Team with Global Experience
Anil Srivastava - Ph.D, Director, Chemistry
Ph.D. (Central Institute of Medicinal & Aromatic Plants, CIMAP Lucknow), PDF: Visiting Research Scientist at P&G, Cincinnati, Ohio (USA); Experience: 18+ years, Library Synthesis, custom synthesis, handling chemistry from mg to multi gram and extending it to kg scale addressing to both med-chem and crop science programs; 1 Patent and 28 papers.
Dipal Ranjan Bhowmik - Ph.D., Associate Director, Chemical Development
Ph.D. Organic Chemistry; Indian Association For The Cultivation Of Science, Jadavpur University, Kolkata, India, 1999; PDF: American Heart Association Postdoctoral Research Fellow; Department of Medicinal Chemistry, School of Pharmacy; Medical College of Virginia, Virginia, Commonwealth University, Richmond, VA, USA, 2000-2002; Postdoctoral Research Fellow, National Science Foundation, Department of Chemistry, Syracuse University, NY, U.S.A, 2002-2003; Experience: 16+ years, Chemical Process Development of New Chemical Entities & Active Pharmaceutical Ingredients; 3 patents, 10 Papers in per reviewed journals.
Vamsi Krishna - Manager, GMP
B.Tech (Chemical Engg) from Adhiyamaan Engineering College; Experience: 16+ years, Development,Scale-up & Technology Transfer.
D
D
D
D
D
D
D
Takeshi Yura - Ph.D., Vice President - Medicinal Chemistry
Ph.D. in Chemistry (Organic Synthesis); University of Tokyo, Department of Chemistry; M.B.A. from Temple University Tokyo, 30 years of experience in medicinal chemistry/drug discovery, numerous publications and patents.
Diverse & Talented Leadership Team with Global Experience
SK Dhakshinamoorthy - Vice President, Discovery Biology & Pharmacology
Ph.D (Anna Univ, India); Postdoc (Baylor College of Medicine, USA); Research Fellow (IMCB, ASTAR, Singapore); Associate Director (Aurigene, India); Director (AMRI, Singapore); Experience: 20+ years, Expertise: Metabolic Dis, Oncology & Inflammation; 25+ Publications.
Ramesh Mullangi - Ph.D., Vice President, DMPK
PhD: Pharmacy (1995). Kakaitya University, Waranagal, India. Post graduation: M. Pharm (1988). Kakaitya University, Waranagal, India. Publications: 225 Publications in peer reviewed international journals.
Jeyaraj D A - Ph.D., Associate Vice President, Medicinal Chemistry
Postdoctoral, Tohoku University, Sendai, Japan (May 2003-Aug 2003) Postdoctoral , Max-Planck Institute für molekulare Physiologie (MPI), Dortmund, Germany (1999-2001) – Alexander von Humboldt (AvH) Fellow Ph.D. (Organic Chemistry), Indian Institute of Technology (IIT), Kanpur (1993-1998) Publications: 10 PCTs and 1 filed; 33 International publications.
D
D
D
D
D
D
D
Diverse & Talented Leadership Team with Global Experience
Ishtiyaque Ahmad - Associate Vice President, Discovery Biology
Ph.D (IISc, India); Postdoc (Lawrence Berkeley Lab, USA); Senior Scientist (Nicolas Piramal, India); Principal Scientist (Matrix lab, India); General Manager (Suven Life, India); Associate VP (GVK Bio, India). Experience: 20+ years, Expertise: CNS, Pain, Mol & Cell Biol.; 10 Patents; 8 International publications
Srividya Swaminathan - Assistant Director, Discovery Biology
Ph.D (JNU, India); Postdoc (NCI-Frederick, USA); Senior Scientist/ Asst. Prof. (NUS, Singapore); Senior Scientist II (AMRI, Singapore); Experience: 20+ years, Expertise: Oncology, CNS, Pain, Metabolic Disorder; Inflammation; 30+ Publications
Santosh Vishwakarma - Assistant Director, Pharmacology
M.Pharm, Ph.D (LM College of Pharmacy, India); Industrial Experience (Suven Life, Orchid, Hetero Lab, India)Key contributor for 2 NCE’s under Phase II evaluation for Alzheimer’s (SUVN-502) & COPD (OCID 2987). Experience: 15+ years, Metabolic Disorder, CNS, Pain, Inflammation; 10 Patents; 8 International publications
Mohd Zainuddin - Ph.D., Assistant Director, DMPK
PhD: Biochemistry (2000-2004), Faculty of Medicine, AMU, Aligarh Publications: 30 publications in peer reviewed international journals Experience: 12 years at Jubilant Biosys Expertise: ADME-preclinical.
D
D
D
D
D
D
D
Diverse & Talented Leadership Team with Global Experience
Ram Gosu - Assistant Director, Structural Biology
Ph.D (IISc, India); Postdoc (University of Minnesota, USA); Expertise: Gene-to-Structure, Protein Engineering & Macromolecular X-ray Crystallography. Experience: 15+ years, 8 International publications
Pratima Deshpande - Group Leader, Immunology
Ph.D (University of Rochester, USA); Postdoc (Emory and Stanford , USA); Experience: 10+ years, Expertise: autoimmunity, infectious immunity and tumor immunity; 6 Publications Group Leader I (Aurigene, India)
D
DD
D The added Dimensionin Drug Discovery
Jubilant Biosys Limited
Bengaluru Research Site:
#96, Industrial Suburb 2nd Stage, Yeshwantpur Bangalore - 560 022 Karnataka India.
Tel: +91 80 66628400
Noida Research Site:
B-34, Sector 58, Noida, Uttar Pradesh 201301
Tel: +91 120 409 3300
For more information:[email protected]
Thank you for your time
