GCMS-TQ8040 - Shimadzu · The ion source, incorporating a highly efficient collision cell, enables high-sensitivity and long-term stable analyses. In addition, with high-speed scan

C146-E251FGC

MS-TQ

8040

Gas Chromatograph Mass Spectrometer

GCMS-TQ8040

© Shimadzu Corporation, 2017

www.shimadzu.com/an/

For Research Use Only. Not for use in diagnostic procedures. This publication may contain references to products that are not available in your country. Please contact us to check the availability of these products in your country.Company names, products/service names and logos used in this publication are trademarks and trade names of Shimadzu Corporation, its subsidiaries or its affiliates, whether or not they are used with trademark symbol “TM” or “®”.Third-party trademarks and trade names may be used in this publication to refer to either the entities or their products/services, whether or not they are used with trademark symbol “TM” or “®”.Shimadzu disclaims any proprietary interest in trademarks and trade names other than its own.

The contents of this publication are provided to you “as is” without warranty of any kind, and are subject to change without notice. Shimadzu does not assume any responsibility or liability for any damage, whether direct or indirect, relating to the use of this publication.

First Edition: May 2014, Printed in Japan 3655-04708-30ANS

Smart Performance, Smart Productivity, Smart Operation

Finally, a triple quadrupole GCMS Smart enough for everyday use in your laboratory.

with Smart Technologies

Smart Performance, Smart Productivity, Smart Operation

Finally, a triple quadrupole GCMS Smart enough for everyday use in your laboratory.

with Smart Technologies

The Shimadzu GCMS-TQ8040 is the first triple quadrupole with Smart Performance

for low detection limits and Scan/MRM, Smart Productivity for high efficiency sample throughput,

and Smart Operation for quick and easy method development.

These three smart technologies contribute to Smart MRM, and provide the most accurate,

cost-effective, and easy-to-use triple quadrupole GCMS you have ever imagined.

Simultaneous multi-component analysis is now possible for

hundreds of target compounds, dramatically improving

productivity. Smart MRM produces GC-MS/MS methods with

up to 32,768 transitions in a single run.

P. 8 to Smart Productivity

GC-MS/MS analysis requires multiple settings that can be confusing to the average operator. With Smart MRM, the GCMS-TQ8040

software sets the analytical conditions automatically, making method development painless, fast, and easy.

P. 10 to Smart Operation

MRM Optimization Tool

Smart Database

The ion source, incorporating a highly efficient collision cell, enables high-sensitivity and long-term stable analyses. In

addition, with high-speed scan control technology called Advanced Scanning Speed Protocol (ASSP), multiple analysis

modes can be measured simultaneously, enabling a great deal of information to be obtained in a single analysis.

P. 6 to High Sensitivity and Long-Term Stability

Gas Chromatograph Mass Spectrometer4 5

The Shimadzu GCMS-TQ8040 is the first triple quadrupole with Smart Performance

for low detection limits and Scan/MRM, Smart Productivity for high efficiency sample throughput,

and Smart Operation for quick and easy method development.

These three smart technologies contribute to Smart MRM, and provide the most accurate,

cost-effective, and easy-to-use triple quadrupole GCMS you have ever imagined.

Simultaneous multi-component analysis is now possible for

hundreds of target compounds, dramatically improving

productivity. Smart MRM produces GC-MS/MS methods with

up to 32,768 transitions in a single run.

P. 8 to Smart Productivity

GC-MS/MS analysis requires multiple settings that can be confusing to the average operator. With Smart MRM, the GCMS-TQ8040

software sets the analytical conditions automatically, making method development painless, fast, and easy.

P. 10 to Smart Operation


Smart Database

The ion source, incorporating a highly efficient collision cell, enables high-sensitivity and long-term stable analyses. In

addition, with high-speed scan control technology called Advanced Scanning Speed Protocol (ASSP), multiple analysis

modes can be measured simultaneously, enabling a great deal of information to be obtained in a single analysis.

P. 6 to High Sensitivity and Long-Term Stability


High Sensitivity and Long-Term Stability

Ion Source Featuring High Sensitivity and Long-Term Stability

The filament and the ion source box have been separated, which

reduces the impact of the filament potential on the interior of the ion

source. In addition, a shield is provided to block radiant heat

generated by the filament, achieving a uniform temperature inside

the ion source box. Thus, active spots inside the ion source are not

prone to occur, enabling high-sensitivity analysis with long-term

stability. (Patent: US7939810)

: Filament

Temperature

Low High

: Electric field

: Heat rays

Shield

Shield

High-PerformanceQuadrupole Mass Filter

A high-accuracy mass filter equipped with a pre-rod, as well as

patented electric field control technology, result in

high-accuracy mass separation performance. The pre-rods also

minimize contamination of the quadrupole, eliminating the

need for quadrupole maintenance.

beta-Endosulfan

240.90 > 205.90238.90 > 203.90

23.25 23.50 23.75 24.00

Iprodione

314.10 > 244.90314.10 > 56.10

26.50 26.75 27.00 27.25

MRM Mass Chromatograms (Pesticides, 1 pg/µL)

Ethyl methanesulfonate

109.0 > 79.0109.0 > 97.0

5.04.5

Butyl benzenesulfonate

141.0 > 77.0159.0 > 77.0141.0 > 51.0

18.017.5

MRM Chromatograms of Genotoxic Impurities (10 pg/L) in Pharmaceuticals

Response of a Pesticide (Fenitrothion) in a Sesame Extract

0 20 40 60 8010 30 50 70 90 1000.0

0.2

0.4

0.6

0.8

1.0

1.2

1.4

1.6

2.0

1.8

Are

a ra

tio

wit

h th

e 1s

t cy

cle

resu

lt a

s 1

Number of measurement cycles

OFF-AXIS Ion Optics

Lower detection limits are achieved by OFF-AXIS Ion Optics (Patent Pending). Meta-stable and neutral ions are removed without

sacrificing sensitivity. Helium buffer gas is not required in the CID cell.

High-Efficiency Collision Cell UFsweeper

Shimadzu's proprietary UFsweeper technology

achieves high-speed MRM analysis at speeds up to

800 transitions per second. It sweeps residual ions

from the collision cell to provide high-efficiency CID

and fast ion transport. Rapid ion removal minimizes

cross-talk and enables trace analysis (patent pending).

SIM290.00

15.1 15.2 15.3

MRM290.00 > 204.00290.00 > 118.00

15.115.0 15.2 15.3

Analysis of Residual Pesticides (Isoprothiolane 1 pg/µL)

Sensitivity and Repeatability in Single GC/MS Mode

The high-efficiency ion source provides the foundation of an ion

generation and transmission system, which creates and then

delivers ions to the detector, resulting in a GC/MS with the

maximum possible sensitivity and repeatability. These features

are not realized just for MRM measurements by GC-MS/MS, but

also for scan and SIM measurements in single quadrupole modes,

even with the most reactive compounds.

Q1 with post-rod achieves outstanding ion transfer efficiency

UFsweeper provides high ion transfer efficiency

100.0072.00

12.75 13.00 13.25 13.50

%RSD = 1.76 %

100.0072.00

12.75 13.00 13.25 13.50

%RSD = 1.44 %

Thiobencarb 5 pg/µLLeft: GCMS-QP2010 Ultra, Right: GCMS-TQ8040

(for RSD determination, n = 5)277.00

12.25 12.50 12.75 13.00

277260

247214169150

125

9379

63

0 50 100 150 200 250 300 350

Scan Mass Spectrum of Fenitrothion

277260

247214169150

125

9379

63

N

O

O

S

OP

OO

0 50 100 150 200 250 300 350

Mass Spectrum Registered in NIST Library


High Sensitivity and Long-Term Stability

Ion Source Featuring High Sensitivity and Long-Term Stability

The filament and the ion source box have been separated, which

reduces the impact of the filament potential on the interior of the ion

source. In addition, a shield is provided to block radiant heat

generated by the filament, achieving a uniform temperature inside

the ion source box. Thus, active spots inside the ion source are not

prone to occur, enabling high-sensitivity analysis with long-term

stability. (Patent: US7939810)

: Filament

Temperature

Low High

: Electric field

: Heat rays

Shield

Shield

High-PerformanceQuadrupole Mass Filter

A high-accuracy mass filter equipped with a pre-rod, as well as

patented electric field control technology, result in

high-accuracy mass separation performance. The pre-rods also

minimize contamination of the quadrupole, eliminating the

need for quadrupole maintenance.

beta-Endosulfan

240.90 > 205.90238.90 > 203.90

23.25 23.50 23.75 24.00

Iprodione

314.10 > 244.90314.10 > 56.10

26.50 26.75 27.00 27.25

MRM Mass Chromatograms (Pesticides, 1 pg/µL)

Ethyl methanesulfonate

109.0 > 79.0109.0 > 97.0

5.04.5

Butyl benzenesulfonate

141.0 > 77.0159.0 > 77.0141.0 > 51.0

18.017.5

MRM Chromatograms of Genotoxic Impurities (10 pg/L) in Pharmaceuticals

Response of a Pesticide (Fenitrothion) in a Sesame Extract

0 20 40 60 8010 30 50 70 90 1000.0

0.2

0.4

0.6

0.8

1.0

1.2

1.4

1.6

2.0

1.8

Are

a ra

tio

wit

h th

e 1s

t cy

cle

resu

lt a

s 1

Number of measurement cycles

OFF-AXIS Ion Optics

Lower detection limits are achieved by OFF-AXIS Ion Optics (Patent Pending). Meta-stable and neutral ions are removed without

sacrificing sensitivity. Helium buffer gas is not required in the CID cell.

High-Efficiency Collision Cell UFsweeper

Shimadzu's proprietary UFsweeper technology

achieves high-speed MRM analysis at speeds up to

800 transitions per second. It sweeps residual ions

from the collision cell to provide high-efficiency CID

and fast ion transport. Rapid ion removal minimizes

cross-talk and enables trace analysis (patent pending).

SIM290.00

15.1 15.2 15.3

MRM290.00 > 204.00290.00 > 118.00

15.115.0 15.2 15.3

Analysis of Residual Pesticides (Isoprothiolane 1 pg/µL)

Sensitivity and Repeatability in Single GC/MS Mode

The high-efficiency ion source provides the foundation of an ion

generation and transmission system, which creates and then

delivers ions to the detector, resulting in a GC/MS with the

maximum possible sensitivity and repeatability. These features

are not realized just for MRM measurements by GC-MS/MS, but

also for scan and SIM measurements in single quadrupole modes,

even with the most reactive compounds.

Q1 with post-rod achieves outstanding ion transfer efficiency

UFsweeper provides high ion transfer efficiency

100.0072.00

12.75 13.00 13.25 13.50

%RSD = 1.76 %

100.0072.00

12.75 13.00 13.25 13.50

%RSD = 1.44 %

Thiobencarb 5 pg/µLLeft: GCMS-QP2010 Ultra, Right: GCMS-TQ8040

(for RSD determination, n = 5)277.00

12.25 12.50 12.75 13.00

277260

247214169150

125

9379

63

0 50 100 150 200 250 300 350

Scan Mass Spectrum of Fenitrothion

277260

247214169150

125

9379

63

N

O

O

S

OP

OO

0 50 100 150 200 250 300 350

Mass Spectrum Registered in NIST Library


Innovative Technologies that Improve Accuracy and Throughput

UFMS in the Multiple Reaction Mode can acquire over 800 transitions

per second and over 32,000 transitions in a single analysis. The

Smart MRM technology automatically adjusts the analytical dwell

time for each transition, only acquiring data during peak elution, to

fully optimize sensitivity. For example, analysis of more than 400

pesticides that used to require two or three methods can now be

accomplished in a single acquisition method created by Smart MRM,

significantly increasing laboratory throughput.

The UFMS technology guarantees a minimum of ten data points

across each peak for optimum sensitivity and repeatability. Highly

accurate, low-level detection of multiple components in complex

matrices is finally possible by UFMS and Smart MRM.

P. 11 to Smart MRM

5.0 7.5 10.0 12.5 15.0 17.5 20.0 22.5

1.0

2.0

3.0

4.0

5.0

6.0

7.0

(×1,000,000)

Simultaneous Analysis of 439 Pesticides Using UFMS and Smart MRM

(×1,000)8.0

7.0

6.0

5.0

4.0

3.0

2.0

1.0

278.00 > 109.00278.00 > 125.00278.00 > 169.00

12.75 13.00 13.25 13.50

Fenthion %RSD = 4.16%

0.5

1.0

1.5

2.0

2.5

3.0 165.10 > 108.10165.10 > 93.00165.10 > 65.00

16.75 17.00 17.25 17.50

(×10,000)

Pyributicarb %RSD = 2.39%

(×1,000)2.5

2.0

1.5

1.0

0.5

314.00 > 245.00314.00 > 56.00314.00 > 271.00

17.00 17.25 17.50 17.75

Iprodione %RSD = 4.54%

2.5

5.0

7.5

264.00 > 176.00264.00 > 232.00264.00 > 148.00

21.25 21.50 21.75 22.00

(×100)

Indoxacarb %RSD = 4.03%

Mass Chromatogram and %RSD (5 pg/µL)

Normal Analysis 120min

40min 80min 120min

MRM method 1 Analysis of100–150 components

Simultaneous analysisMRM methodSimultaneous analysisof more than 400components



40min

Reduce Analysis Costs and Minimize Downtime

If simultaneous, multi-component analysis can be performed in 1⁄2 to 1⁄3 the time of existing

systems, then two to three times the number of samples can be analyzed in the same period

of time, and return on investment is improved. In addition, the frequency of maintenance,

such as replacing glass liners and columns, is reduced, thereby minimizing downtime.

Twin Line MS System Eliminates the Need to Vent the MS

The GCMS-TQ8040 is capable of accepting installation of two narrow-bore capillary columns into the MS simultaneously. This allows you to

switch applications without venting the MS.

Simply decide which column is best for your analysis and choose the associated injection port.

Twin Line MS System

5.25 5.50 5.75 6.00

141.00>95.00141.00>79.00

Column 1 (SH-Rxi-5Sil MS)

141.00>95.00141.00>79.00

5.75 6.00 6.25 6.50

Column 2 (SH-Rtx-200 MS)

Methamidophos in Ginger (10 pg/µL), Analyzed on Two Dissimilar Columns Using Smart MRM

CID gas control is a method parameter, allowing acquisition of GC-MS and GC-MS/MS data in the same batch. By coupling this with the Twin Line

MS System, analysis of phenols by SIM and analysis of pesticides by MRM are possible in a single batch without venting the MS.

SIMGC-MS (CID gas– Off)

MRM GC-MS/MS (CID gas– On)

Run SQ and TQ Methods in a Single Sequence

*) The Twin Line MS System requires an optional installation kit and is limited to certain column dimensions.


Innovative Technologies that Improve Accuracy and Throughput

UFMS in the Multiple Reaction Mode can acquire over 800 transitions

per second and over 32,000 transitions in a single analysis. The

Smart MRM technology automatically adjusts the analytical dwell

time for each transition, only acquiring data during peak elution, to

fully optimize sensitivity. For example, analysis of more than 400

pesticides that used to require two or three methods can now be

accomplished in a single acquisition method created by Smart MRM,

significantly increasing laboratory throughput.

The UFMS technology guarantees a minimum of ten data points

across each peak for optimum sensitivity and repeatability. Highly

accurate, low-level detection of multiple components in complex

matrices is finally possible by UFMS and Smart MRM.

P. 11 to Smart MRM

5.0 7.5 10.0 12.5 15.0 17.5 20.0 22.5

1.0

2.0

3.0

4.0

5.0

6.0

7.0

(×1,000,000)

Simultaneous Analysis of 439 Pesticides Using UFMS and Smart MRM

(×1,000)8.0

7.0

6.0

5.0

4.0

3.0

2.0

1.0

278.00 > 109.00278.00 > 125.00278.00 > 169.00

12.75 13.00 13.25 13.50

Fenthion %RSD = 4.16%

0.5

1.0

1.5

2.0

2.5

3.0 165.10 > 108.10165.10 > 93.00165.10 > 65.00

16.75 17.00 17.25 17.50

(×10,000)

Pyributicarb %RSD = 2.39%

(×1,000)2.5

2.0

1.5

1.0

0.5

314.00 > 245.00314.00 > 56.00314.00 > 271.00

17.00 17.25 17.50 17.75

Iprodione %RSD = 4.54%

2.5

5.0

7.5

264.00 > 176.00264.00 > 232.00264.00 > 148.00

21.25 21.50 21.75 22.00

(×100)

Indoxacarb %RSD = 4.03%

Mass Chromatogram and %RSD (5 pg/µL)

Normal Analysis 120min

40min 80min 120min


Simultaneous analysisMRM methodSimultaneous analysisof more than 400components



40min

Reduce Analysis Costs and Minimize Downtime

If simultaneous, multi-component analysis can be performed in 1⁄2 to 1⁄3 the time of existing

systems, then two to three times the number of samples can be analyzed in the same period

of time, and return on investment is improved. In addition, the frequency of maintenance,

such as replacing glass liners and columns, is reduced, thereby minimizing downtime.

Twin Line MS System Eliminates the Need to Vent the MS

The GCMS-TQ8040 is capable of accepting installation of two narrow-bore capillary columns into the MS simultaneously. This allows you to

switch applications without venting the MS.

Simply decide which column is best for your analysis and choose the associated injection port.

Twin Line MS System

5.25 5.50 5.75 6.00

141.00>95.00141.00>79.00

Column 1 (SH-Rxi-5Sil MS)

141.00>95.00141.00>79.00

5.75 6.00 6.25 6.50

Column 2 (SH-Rtx-200 MS)

Methamidophos in Ginger (10 pg/µL), Analyzed on Two Dissimilar Columns Using Smart MRM

CID gas control is a method parameter, allowing acquisition of GC-MS and GC-MS/MS data in the same batch. By coupling this with the Twin Line

MS System, analysis of phenols by SIM and analysis of pesticides by MRM are possible in a single batch without venting the MS.

SIMGC-MS (CID gas– Off)

MRM GC-MS/MS (CID gas– On)

Run SQ and TQ Methods in a Single Sequence

*) The Twin Line MS System requires an optional installation kit and is limited to certain column dimensions.


Simplified GC-MS/MS method development

In order to create an MRM analysis method, complex parameter settings are required,

such as for the optimum transitions and collision energies.

Smart MRM makes method development quick and easy.

Whether starting from scratch to optimize transitions and collision energies for new compounds,

or starting from an MRM database of known target analytes to build a custom MRM method,

Smart MRM takes the stress and difficulty out of method development.


Dichlorvos

0.000

0.200

0.400

0.600

0.800

1.000

1.200

3 6 9 12 15 18 21 24 27 30 33 36 39 42 45

109.00 > 79.00

185.00 > 93.00

185.00 > 109.00

Fenobucarb

0.000

0.200

0.400

0.600

0.800

1.000

1.200

3 6 9 12 15 18 21 24 27 30 33 36 39 42 45

121.00 > 77.10

150.00 > 121.10

121.00 > 103.10

Optimize MRM Transitions Automatically

Determining and optimizing MRM transitions for new compounds

can require significant development time. The “MRM Optimization

Tool“ automates the process by collecting product ion scan data and

finding the optimum collision energy for each transition.

Once established, the transitions are registered to one of the

Shimadzu “Smart Database” files, and the MRM or Scan/MRM

methods are created using Smart MRM.

Compounds and Optimized Transitions

The Shimadzu “Smart Database” is a database of related compounds

(e.g. pesticides, drugs, metabolites, etc.) with optimized transitions

and collision energies, CAS registry numbers, and Retention Indices

(RI) . The user can select from hundreds of pre-registered compounds

in one of the “Smart Database” files, or add their own optimized

transitions. The user selects the compounds to be analyzed, and

Smart MRM builds the MRM or Scan/MRM acquisition method from

the “Smart Database” with the push of a button.

In addition to MRM information, the database file can contain Scan

and SIM ion information, mass spectra and calibration curve

information from the internal standard method. This allows users to

easily create their own database.

Automatic Method Creation

Smart MRM

Smart Database

C17 C18 C19

1700 1735

1735

1800

C17 C18 C19

1700 1800

Automatic adjustment

Identificationwindow

Analyte

20 21 2221.1 min

(Calculated RT)21.5 min(Originally registered RT)

Retention index

Retention index

Retention index

Originally registered method information

Customer's instrument

The AART function adjusts the retention times of target components

based on linear retention indices (LRI) and the retention times of

n-alkanes. The AART function easily adjusts acquisition and

processing method parameters simultaneously.

The Smart MRM technology automatically creates methods with

measurement times optimized for each component based on the

Smart database. The Automatic Adjustment of Retention Time

(AART) function incorporated in the system estimates retention times

with high accuracy. When creating methods for simultaneous

multicomponent analysis, the complicated process of configuring

measurement parameters made it difficult to prepare appropriate

methods. By using the Smart MRM function, however, it is possible to

automatically create methods in which data are acquired with high

sensitivity only during the elution time of the target components. In

addition to MRM methods, SIM methods can be created.

Dwell Time OptimizationAutomatic Estimationof Retention Times

Automatic Creationof Analysis Methods

Parameter Setting

Automatic Adjustment of Compound Retention Time (AART)(Automatic Adjustment of Retention Time)


Simplified GC-MS/MS method development

In order to create an MRM analysis method, complex parameter settings are required,

such as for the optimum transitions and collision energies.

Smart MRM makes method development quick and easy.

Whether starting from scratch to optimize transitions and collision energies for new compounds,

or starting from an MRM database of known target analytes to build a custom MRM method,

Smart MRM takes the stress and difficulty out of method development.


Dichlorvos

0.000

0.200

0.400

0.600

0.800

1.000

1.200

3 6 9 12 15 18 21 24 27 30 33 36 39 42 45

109.00 > 79.00

185.00 > 93.00

185.00 > 109.00

Fenobucarb

0.000

0.200

0.400

0.600

0.800

1.000

1.200

3 6 9 12 15 18 21 24 27 30 33 36 39 42 45

121.00 > 77.10

150.00 > 121.10

121.00 > 103.10

Optimize MRM Transitions Automatically

Determining and optimizing MRM transitions for new compounds

can require significant development time. The “MRM Optimization

Tool“ automates the process by collecting product ion scan data and

finding the optimum collision energy for each transition.

Once established, the transitions are registered to one of the

Shimadzu “Smart Database” files, and the MRM or Scan/MRM

methods are created using Smart MRM.

Compounds and Optimized Transitions

The Shimadzu “Smart Database” is a database of related compounds

(e.g. pesticides, drugs, metabolites, etc.) with optimized transitions

and collision energies, CAS registry numbers, and Retention Indices

(RI) . The user can select from hundreds of pre-registered compounds

in one of the “Smart Database” files, or add their own optimized

transitions. The user selects the compounds to be analyzed, and

Smart MRM builds the MRM or Scan/MRM acquisition method from

the “Smart Database” with the push of a button.

In addition to MRM information, the database file can contain Scan

and SIM ion information, mass spectra and calibration curve

information from the internal standard method. This allows users to

easily create their own database.

Automatic Method Creation

Smart MRM

Smart Database

C17 C18 C19

1700 1735

1735

1800

C17 C18 C19

1700 1800

Automatic adjustment

Identificationwindow

Analyte

20 21 2221.1 min

(Calculated RT)21.5 min(Originally registered RT)

Retention index

Retention index

Retention index

Originally registered method information

Customer's instrument

The AART function adjusts the retention times of target components

based on linear retention indices (LRI) and the retention times of

n-alkanes. The AART function easily adjusts acquisition and

processing method parameters simultaneously.

The Smart MRM technology automatically creates methods with

measurement times optimized for each component based on the

Smart database. The Automatic Adjustment of Retention Time

(AART) function incorporated in the system estimates retention times

with high accuracy. When creating methods for simultaneous

multicomponent analysis, the complicated process of configuring

measurement parameters made it difficult to prepare appropriate

methods. By using the Smart MRM function, however, it is possible to

automatically create methods in which data are acquired with high

sensitivity only during the elution time of the target components. In

addition to MRM methods, SIM methods can be created.

Dwell Time OptimizationAutomatic Estimationof Retention Times

Automatic Creationof Analysis Methods

Parameter Setting

Automatic Adjustment of Compound Retention Time (AART)(Automatic Adjustment of Retention Time)


12 13

Accuracy control results, such as retention time differences, calibration curve linearity and peak shapes (tailing), can be assessed visually.

In addition, the QC chart function in LabSolutions Insight allows visual confirmation of variations in target compounds across multiple data sets.

This is useful when evaluating variations in internal standard substances between samples, for example.

With LabSolutions Insight software, quantitative results for a complete series of data files can be displayed side-by-side for comparison and QC

review. All of the chromatograms for a selected target compound can be displayed simultaneously, making it easy to review the detected peaks

and confirm the quantitative results. Color-coded QA/QC flags quickly identify any outliers that require further examination.

Data acquired from multiple systems can be reviewed or confirmed using client computers connected via a LAN or other network. If multiple

systems are used, data obtained from each system can be reviewed from any client computer. Even in the case of multiple analysts using the

same system, the ability to separate analytical work from measurement work improves work efficiency.

Laboratory

GC/MS analysis

Data review

Client PC

File Server

Analysis administratorClient PCClient PCClient PC

Office

Data confirmation

LC/MS analysis

OperatorOperatorOperator

Operator Operator

File management on a file server is recommended for systems with more than five users.


In LabSolutions Insight, quantitative results can be compared to established criteria, and any outliers are color-coded for easy identification and

further review. Five color-coded criteria levels can be defined, making it easy to determine which data points are outliers, and which specific QC

criteria were not met. Any changes made to calibration curves or manual peak integration are immediately reflected in the color-coded flags.

This function can be used to specify the status of all compounds and samples for their management. By specifying a status, the progress of data

analysis work can be accurately recorded and reported.

Rerun

Pending Accept

Status Review Function

LabSolutions Insight Heightening the Efficiency of Multi-Analyte Data Analysis

Enhanced Accuracy Controls

Color-coded Quantitative Flags

System Configurations Using Multiple Client Computers

12 13

Accuracy control results, such as retention time differences, calibration curve linearity and peak shapes (tailing), can be assessed visually.

In addition, the QC chart function in LabSolutions Insight allows visual confirmation of variations in target compounds across multiple data sets.

This is useful when evaluating variations in internal standard substances between samples, for example.

With LabSolutions Insight software, quantitative results for a complete series of data files can be displayed side-by-side for comparison and QC

review. All of the chromatograms for a selected target compound can be displayed simultaneously, making it easy to review the detected peaks

and confirm the quantitative results. Color-coded QA/QC flags quickly identify any outliers that require further examination.

Data acquired from multiple systems can be reviewed or confirmed using client computers connected via a LAN or other network. If multiple

systems are used, data obtained from each system can be reviewed from any client computer. Even in the case of multiple analysts using the

same system, the ability to separate analytical work from measurement work improves work efficiency.

Laboratory

GC/MS analysis

Data review

Client PC

File Server

Analysis administratorClient PCClient PCClient PC

Office

Data confirmation

LC/MS analysis

OperatorOperatorOperator

Operator Operator

File management on a file server is recommended for systems with more than five users.


In LabSolutions Insight, quantitative results can be compared to established criteria, and any outliers are color-coded for easy identification and

further review. Five color-coded criteria levels can be defined, making it easy to determine which data points are outliers, and which specific QC

criteria were not met. Any changes made to calibration curves or manual peak integration are immediately reflected in the color-coded flags.

This function can be used to specify the status of all compounds and samples for their management. By specifying a status, the progress of data

analysis work can be accurately recorded and reported.

Rerun

Pending Accept

Status Review Function

LabSolutions Insight Heightening the Efficiency of Multi-Analyte Data Analysis

Enhanced Accuracy Controls

Color-coded Quantitative Flags

System Configurations Using Multiple Client Computers

GC-MS/MS Databases Allow Users to Start Analysis ImmediatelyOffering both quantitative and screening applications, these databases contain pre-optimized MRM transitions and collision energies

required for GC-MS/MS analysis, allowing users to start an analysis immediately just by using the AART function to automatically modify

the retention times.

Smart Database Series Supporting Accurate Quantitative Determinations in MRM Analysis

The series contains optimized analysis conditions, so users can start an analysis immediately without investigating the conditions. This database

is for accurate quantitative determinations using standard samples.

Smart Pesticides DatabaseIt covers the pesticides (530 compounds) subject to GC-MS analysis and used inside and outside Japan. The database also contains information on compounds that can be used as internal standards. Therefore, it also supports analysis with the internal standard method.

Smart Environmental DatabaseThe database contains information on 527 compounds including polychlorinated biphenyl, brominated flame retardants, dioxins, polycyclic aromatic hydrocarbons, and organochlorine pesticides, as well as their stable isotope labeled compounds.

Smart Metabolites DatabaseThe database contains 525 compounds including metabolites contained in blood, urine, cells and other biological samples. It also contains information on the stable isotopes of 22 major metabolites, which can be used as internal standards.

Smart Forensic DatabaseThe database is registered with 201 forensic toxicological substances often involved in poisonings, such as drugs of abuse, psychotropic drugs, pharmaceuticals, and pesticides.

Quick-DB Series Enables Quick Screening Without Using StandardsPreregistered with calibration curve information from the internal standard methods, this database allows users to calculate quantitative values

without analyzing standard samples. It can be used for screening when quick confirmation of quantitative results is required.

Quick-DB GC/MS Residual Pesticides DatabaseThe database contains information on calibration curves created using pesticide surrogates as the internal standards, thus enabling the simultaneous screening of 491 residual pesticides without using standard samples. The registered calibration curves have been created by grouping target pesticides based on similar behavioral and physical properties, and allocating pesticide surrogates with similar physical properties to each group as internal standard substances. This allows highly accurate quantitative values to be calculated.

Allocation of Pesticide Surrogates Based on Physical Properties of Target Pesticides

Target pesticides

Analyticalbehavior

Boilingpoint

Others

Hydrophobicity

Recoveryrate

Malathion

Polarity

Pesticide surrogates

Group 1Dichlorvos-d

Group 2Acephate-d

Group 4Iprobenfos-d

Allocation

Sensitivity Variation Adjustments Using Pesticide Surrogates

Database Calibration Curve

PesticideIS(Pesticide-d)

Customer's GC-MS

Pesticide surrogates can also be used to adjust differences in target pesticide responses observed in calibration curves and a customer's instrument due to variations in GC-MS(/MS) sensitivity.

Quick-DB Forensic Toxicology DatabaseThis database contains information on sample preparation, data acquisition, and analysis of 68 compounds often involved in poisonings. Due to the simple QuEChERS method used for the sample preparation, even first-time users can pretreat samples easily. The performance control function, which automatically assesses the system status, quickly determines problematic areas. As a result, users can analyze toxicological substances while consistently maintaining the highest status level.

Using a Calibration Curve for a Pretreated Sample to Correct for Recovery Rates

By using the calibration curve information from a pretreated sample, accurate quantitative values can be obtained. The calibration curve information is used to correct differences in recovery rates for each target compound or correct for effects caused by adsorption, which occurs when creating calibration curves using standards.

If specific control parameter criteria are not satisfied, the optimal steps for restoring the system status are displayed in a message box.

Calibration curve forwhole blood samplespiked with standardand pretreated

Effect ofpretreatmentrecovery rate

Less affected by adsorptioncaused by matrix effects

Quick-DB Forensic Launcher Screen

Off-Flavor Analyzer

Primary odorcomponents

GC/MS analyticalconditions

Sensoryinformation

This analysis system contains information on the major odor-causing substances identified from previous problems and associated sensory information, thus enabling the reliable identification of odor-causing substances. It allows users to calculate quantitative values easily without using standard samples, and to identify odor-causing substances through comparison with registered odor thresholds. The system also supports the use of a sniffer, enabling the efficient confirmation of odors using the predicted retention time display function.In addition, support is provided for a total system, including pretreatment units such as HS, SPME, and thermal desorption units using MonoTrap.

Comparison of Concentration to Odor Threshold Values

Odor-causing substances can be identified through comparisons of odor thresholds with the concentrations of off-flavor components identified in a chromatogram.

Under Threshold Value

Odor thresholdvalue:

10.000 pg/mgConcentration:2.543 pg/mg

Benzophenone

Over Threshold Value


100.000 pg/mg

2,4,6-Tribromophenol

Concentration:2241.933 pg/mg

Since some odor components have a low odor threshold, low concentration levels need to be detected to identify the causative substances. High-sensitivity MRM/SIM analysis by GC-MS(/MS) can reliably detect even trace components near the odor threshold (a few pg/g).

195.0210.0167.0

4.0

3.0

2.0

1.0

0.017.50 17.75 18.00 18.25

0.5

1.0

1.5

210.0 > 167.0210.0 > 195.0195.0 > 167.0

17.50 17.75 18.00 18.25

Mass Chromatograms of 2,4,6-Trichloroanisole(estimated concentration of 18.166 pg/g) in Food with an Odd Odor

(Left: Scan analysis, Right: MRM analysis)


GC-MS/MS Databases Allow Users to Start Analysis ImmediatelyOffering both quantitative and screening applications, these databases contain pre-optimized MRM transitions and collision energies

required for GC-MS/MS analysis, allowing users to start an analysis immediately just by using the AART function to automatically modify

the retention times.

Smart Database Series Supporting Accurate Quantitative Determinations in MRM Analysis

The series contains optimized analysis conditions, so users can start an analysis immediately without investigating the conditions. This database

is for accurate quantitative determinations using standard samples.

Smart Pesticides DatabaseIt covers the pesticides (530 compounds) subject to GC-MS analysis and used inside and outside Japan. The database also contains information on compounds that can be used as internal standards. Therefore, it also supports analysis with the internal standard method.

Smart Environmental DatabaseThe database contains information on 527 compounds including polychlorinated biphenyl, brominated flame retardants, dioxins, polycyclic aromatic hydrocarbons, and organochlorine pesticides, as well as their stable isotope labeled compounds.

Smart Metabolites DatabaseThe database contains 525 compounds including metabolites contained in blood, urine, cells and other biological samples. It also contains information on the stable isotopes of 22 major metabolites, which can be used as internal standards.

Smart Forensic DatabaseThe database is registered with 201 forensic toxicological substances often involved in poisonings, such as drugs of abuse, psychotropic drugs, pharmaceuticals, and pesticides.

Quick-DB Series Enables Quick Screening Without Using StandardsPreregistered with calibration curve information from the internal standard methods, this database allows users to calculate quantitative values

without analyzing standard samples. It can be used for screening when quick confirmation of quantitative results is required.

Quick-DB GC/MS Residual Pesticides DatabaseThe database contains information on calibration curves created using pesticide surrogates as the internal standards, thus enabling the simultaneous screening of 491 residual pesticides without using standard samples. The registered calibration curves have been created by grouping target pesticides based on similar behavioral and physical properties, and allocating pesticide surrogates with similar physical properties to each group as internal standard substances. This allows highly accurate quantitative values to be calculated.

Allocation of Pesticide Surrogates Based on Physical Properties of Target Pesticides

Target pesticides

Analyticalbehavior

Boilingpoint

Others

Hydrophobicity

Recoveryrate

Malathion

Polarity

Pesticide surrogates

Group 1Dichlorvos-d

Group 2Acephate-d

Group 4Iprobenfos-d

Allocation

Sensitivity Variation Adjustments Using Pesticide Surrogates

Database Calibration Curve

PesticideIS(Pesticide-d)

Customer's GC-MS

Pesticide surrogates can also be used to adjust differences in target pesticide responses observed in calibration curves and a customer's instrument due to variations in GC-MS(/MS) sensitivity.

Quick-DB Forensic Toxicology DatabaseThis database contains information on sample preparation, data acquisition, and analysis of 68 compounds often involved in poisonings. Due to the simple QuEChERS method used for the sample preparation, even first-time users can pretreat samples easily. The performance control function, which automatically assesses the system status, quickly determines problematic areas. As a result, users can analyze toxicological substances while consistently maintaining the highest status level.

Using a Calibration Curve for a Pretreated Sample to Correct for Recovery Rates

By using the calibration curve information from a pretreated sample, accurate quantitative values can be obtained. The calibration curve information is used to correct differences in recovery rates for each target compound or correct for effects caused by adsorption, which occurs when creating calibration curves using standards.

If specific control parameter criteria are not satisfied, the optimal steps for restoring the system status are displayed in a message box.

Calibration curve forwhole blood samplespiked with standardand pretreated

Effect ofpretreatmentrecovery rate

Less affected by adsorptioncaused by matrix effects

Quick-DB Forensic Launcher Screen

Off-Flavor Analyzer

Primary odorcomponents

GC/MS analyticalconditions

Sensoryinformation

This analysis system contains information on the major odor-causing substances identified from previous problems and associated sensory information, thus enabling the reliable identification of odor-causing substances. It allows users to calculate quantitative values easily without using standard samples, and to identify odor-causing substances through comparison with registered odor thresholds. The system also supports the use of a sniffer, enabling the efficient confirmation of odors using the predicted retention time display function.In addition, support is provided for a total system, including pretreatment units such as HS, SPME, and thermal desorption units using MonoTrap.

Comparison of Concentration to Odor Threshold Values

Odor-causing substances can be identified through comparisons of odor thresholds with the concentrations of off-flavor components identified in a chromatogram.

Under Threshold Value


10.000 pg/mgConcentration:2.543 pg/mg

Benzophenone

Over Threshold Value


100.000 pg/mg

2,4,6-Tribromophenol

Concentration:2241.933 pg/mg

Since some odor components have a low odor threshold, low concentration levels need to be detected to identify the causative substances. High-sensitivity MRM/SIM analysis by GC-MS(/MS) can reliably detect even trace components near the odor threshold (a few pg/g).

195.0210.0167.0

4.0

3.0

2.0

1.0

0.017.50 17.75 18.00 18.25

0.5

1.0

1.5

210.0 > 167.0210.0 > 195.0195.0 > 167.0

17.50 17.75 18.00 18.25

Mass Chromatograms of 2,4,6-Trichloroanisole(estimated concentration of 18.166 pg/g) in Food with an Odd Odor

(Left: Scan analysis, Right: MRM analysis)


Qualitative Analysis Using GC-MS/MS

GC-MS/MS allows users to freely select ions cleaved by electron ionization (EI), and then cleave precursor ions via collision induced dissociation

(CID), thus enabling the detailed analysis of partial structures. A product ion scan can be used to easily discriminate structural isomers and

regioisomers, which are hard to identify with an EI mass spectrum obtained via GC/MS. This mode is optimal for predicting partial structures.

Example of Structural Isomers EI-ScanEI-Product Ion Scan(Precursor m/z 126)

α-PVP

%

0

25

50

75

100 126

847755 986943

25 50 75 100 125 150

%

0

25

50

75

100 126

9784

695542

30

25 50 75 100 125 150

α-PBP Piperidine analog 25 50 75 100 125 1500

25

50

75

100

%126

69 77 8455 10543

25 50 75 100 125 150 0

25

50

75

100

% 126

41

69 55 84 96 30

Example of Regioisomers EI-ScanEI-Product Ion Scan(Precursor m/z 149)

Methylone (bk-MDMA)

50 100 150 200 0

25

50

75

100

% 58

65 121 149 91 135

50 100 150 200 0

25

50

75

100

% 121

149

65

91

2,3-Methylenedioxy-methcathinone 50 100 150 200

0

25

50

75

100

% 58

65 149 121 91 135

50 100 150 200 0

25

50

75

100

%

65

149

121

93 77

Inert Flow Path Achieves High-Sensitivity GC/MS Flow Path

Minimizing adsorption and other losses in the flow path from sample injection to the detector is important for stable, high-sensitivity

measurements using GC/MS. The flow lines in the GCMS-QP series and the TQ series consist of high-quality, highly reliable consumable parts,

so even trace concentrations of components can be detected with high sensitivity and favorable repeatability.

Equipped with a function to automatically optimize the rod bias voltage during high-speed data

acquisition, the system can collect data stably through scans as well as product ion scans at 20,000 u/sec

(patent: US6610979).

With the GCMS-TQ8040, ten or more product ion scans can be configured for a single measurement,

and three or more user-specified analysis modes (Scan, MRM, product ion scan) can be combined.

Black: 1,111 u/secRed: 5,000 u/secBlue: 10,000 u/sec

Newly Patented Technology (ASSP)

DiazinonPropyzamide

High-Speed Scanning Control (Advanced Scanning Speed Protocol, ASSP)

Glass linerThe Restek glass liner recommended for GCMS analysis uses a proprietary inactivation technology to dramatically suppress active sites. After packing into the insert, the wool is subjected to a complete inactivation treatment. This product is controlled throughout from production to final inspection to provide 100 % satisfaction.

17

16.5

16

15.5

15

14.5

14

13.5

137.8 8 8.2 8.4 8.6 8.8 min

Blue: Sky liner (with wool)Red: A liner other than Sky liner (with wool)

Micro-syringeAutosampler syringes feature improved durability, clarity, and accuracy, achieving reliable injection accuracy.

GC septumOur lineup now includes low bleed septa, which maintain optimal seal performance even when the injection cycles are increased, and can be used even at high temperatures. This reduces sensitivity variations due to leaks.

Ferrules and gold gasketThe high-quality Vespel ferrule is easily attached and designed to resist leaking. The gold gasket is inactive, and adsorption does not occur.

Ion sourceDesigned with a shield that blocks radiant heat generated by the filament, and an ion source treated with an oxide coating, active spots inside the ion source are not prone to occur, which enables high-sensitivity analysis with long-term stability.

Capillary columnsFor the SH-Rxi series, a high-quality fused silica like no other is used as the raw material. Our proprietary surface inactivation technology and optimal process to mask silanol groups result in a low-bleed column with very impressive inactivation performance, even with respect to polar compounds comparable to acidic and basic substances.


Qualitative Analysis Using GC-MS/MS

GC-MS/MS allows users to freely select ions cleaved by electron ionization (EI), and then cleave precursor ions via collision induced dissociation

(CID), thus enabling the detailed analysis of partial structures. A product ion scan can be used to easily discriminate structural isomers and

regioisomers, which are hard to identify with an EI mass spectrum obtained via GC/MS. This mode is optimal for predicting partial structures.

Example of Structural Isomers EI-ScanEI-Product Ion Scan(Precursor m/z 126)

α-PVP

%

0

25

50

75

100 126

847755 986943

25 50 75 100 125 150

%

0

25

50

75

100 126

9784

695542

30

25 50 75 100 125 150

α-PBP Piperidine analog 25 50 75 100 125 1500

25

50

75

100

%126

69 77 8455 10543

25 50 75 100 125 150 0

25

50

75

100

% 126

41

69 55 84 96 30

Example of Regioisomers EI-ScanEI-Product Ion Scan(Precursor m/z 149)

Methylone (bk-MDMA)

50 100 150 200 0

25

50

75

100

% 58

65 121 149 91 135

50 100 150 200 0

25

50

75

100

% 121

149

65

91

2,3-Methylenedioxy-methcathinone 50 100 150 200

0

25

50

75

100

% 58

65 149 121 91 135

50 100 150 200 0

25

50

75

100

%

65

149

121

93 77

Inert Flow Path Achieves High-Sensitivity GC/MS Flow Path

Minimizing adsorption and other losses in the flow path from sample injection to the detector is important for stable, high-sensitivity

measurements using GC/MS. The flow lines in the GCMS-QP series and the TQ series consist of high-quality, highly reliable consumable parts,

so even trace concentrations of components can be detected with high sensitivity and favorable repeatability.

Equipped with a function to automatically optimize the rod bias voltage during high-speed data

acquisition, the system can collect data stably through scans as well as product ion scans at 20,000 u/sec

(patent: US6610979).

With the GCMS-TQ8040, ten or more product ion scans can be configured for a single measurement,

and three or more user-specified analysis modes (Scan, MRM, product ion scan) can be combined.

Black: 1,111 u/secRed: 5,000 u/secBlue: 10,000 u/sec

Newly Patented Technology (ASSP)

DiazinonPropyzamide

High-Speed Scanning Control (Advanced Scanning Speed Protocol, ASSP)

Glass linerThe Restek glass liner recommended for GCMS analysis uses a proprietary inactivation technology to dramatically suppress active sites. After packing into the insert, the wool is subjected to a complete inactivation treatment. This product is controlled throughout from production to final inspection to provide 100 % satisfaction.

17

16.5

16

15.5

15

14.5

14

13.5

137.8 8 8.2 8.4 8.6 8.8 min

Blue: Sky liner (with wool)Red: A liner other than Sky liner (with wool)

Micro-syringeAutosampler syringes feature improved durability, clarity, and accuracy, achieving reliable injection accuracy.

GC septumOur lineup now includes low bleed septa, which maintain optimal seal performance even when the injection cycles are increased, and can be used even at high temperatures. This reduces sensitivity variations due to leaks.

Ferrules and gold gasketThe high-quality Vespel ferrule is easily attached and designed to resist leaking. The gold gasket is inactive, and adsorption does not occur.

Ion sourceDesigned with a shield that blocks radiant heat generated by the filament, and an ion source treated with an oxide coating, active spots inside the ion source are not prone to occur, which enables high-sensitivity analysis with long-term stability.

Capillary columnsFor the SH-Rxi series, a high-quality fused silica like no other is used as the raw material. Our proprietary surface inactivation technology and optimal process to mask silanol groups result in a low-bleed column with very impressive inactivation performance, even with respect to polar compounds comparable to acidic and basic substances.


Optional Units Enable a Variety of System Configurations

Various System Configurations

For GC-MS/MS analysis, different system configurations may be required depending on the application and sample-introduction needs. The

GCMS-TQ8040 offers a wide variety of system configurations and sample-introduction devices to enable an expanded range of applications.

HS-20

OPTIC-4EGA/PY-3030D AOC-6000

GC×GC

MDGC

Chemical Ionization and Negative Chemical Ionization

In addition to electron ionization (EI), chemical ionization (CI) and negative

ion chemical ionization (NCI) are available for the GCMS-TQ8040. The CI

method softly ionizes sample molecules and is effective for confirming

molecular weights, while the NCI method enables selective,

high-sensitivity detection of compounds with functional groups that have

a large electron affinity such as halogens.

The Quick-CI function allows users to switch between the EI and CI modes

with the same ion source, so EI and CI data can be obtained from the

same sample. If confirmation of molecular ions is difficult with the EI

mode, molecular information can be collected from the CI mode data.

50 100 150 200 250

0

50

10086

4414912165

EI

%

50 100 150 200 250

0

50

100

%

236

86

218149 188

CI

EI Mass Spectrum (Top) and CI Mass Spectrum (Bottom) ofPentylone (MW: 235), a Kind of Cathinone

DI-2010 Direct Sample Inlet DeviceDirect sample injection (DI)

is a method in which a

sample is injected directly

into the ion source without

passing through the gas

chromatograph (GC). This is

an effective method for

measuring the mass spectra

of synthetic compounds,

and can be used easily for

the usual GC-MS

configuration. By using this in combination with Quick-CI, EI and CI mass

spectra can easily be collected.

Components that are thermally degradable or difficult to vaporize arenot suited to GC analysis. Their mass spectra can be obtained easily using the DI probe.

250 500 750

5998116

158

216 398 520 662 763

EI100

75

50

25

0

%

250 500 750

%158

116

174254 398

558

679

662 731

838CI M+H+100

75

50

25

0

Mass Spectrum for Antibiotic Roxithromycin

AOC-6000 Multifunctional Autosampler

The AOC-6000 supports three sample injection methods:

liquid sample injection, headspace (HS) injection, and solid

phase micro extraction (SPME) injection, so samples in a

variety of forms can be analyzed. It allows the sample

injection method to be switched automatically, enabling

different sample injection methods to be combined in a

continuous operation.

With the automatic syringe exchange and stirring

function, standard samples can be prepared automatically

with a variety of dilution levels, and everything from the

creation of calibration curves to the quantitative

determination of unknown samples can be fully

automated.

SPME Injection

2-Methylisoborneol(Concentration: 1 ng/L)

HS-20 Headspace Sampler

The HS-20 headspace sampler provides strong backup for

the analysis of volatile components at every stage from

research to quality control departments. The high-sensitivity

electronic cooling trap enables quantitative and qualitative

determination of trace components that cannot be detected

with a conventional headspace sampler.

The HS-20 transfer line is built into the GC unit, which

makes it easy to combine the HS-20 with the AOC-20 liquid

sample injector, as well as to switch between these units.

OPTIC-4 Multimode Sample Inlet

The OPTIC-4 multimode sample inlet is a GC injection port

that enables a variety of sample injection modes for

GC-MS, including large-quantity injection, inlet

derivatization, thermal desorption, and DMI (difficult

matrix introduction).

Combining this with an autosampler enables automatic

replacement of inserts, improving productivity in

multisample analyses.

Sample in microvial

LinerNeck

Carry InSplit Flow

Column Flow

DMI (Difficult Matrix Introduction) Mode Simplifies Pretreatment

3.5

3.0

2.5

2.0

1.5

1.0

0.5

20.0 25.0 30.0 35.0 40.0 45.0 50.0

(×1,000,000)

1

2

3 4

5

1. Linalool

3. Ionone

5. Tetradecanoate

2. Citronellol

4. Lillial

TIC

An undiluted shampoo solution was placed directly in a microvial and measured in DMI mode, enabling the selective analysis of volatile components.


Optional Units Enable a Variety of System Configurations

Various System Configurations

For GC-MS/MS analysis, different system configurations may be required depending on the application and sample-introduction needs. The

GCMS-TQ8040 offers a wide variety of system configurations and sample-introduction devices to enable an expanded range of applications.

HS-20

OPTIC-4EGA/PY-3030D AOC-6000

GC×GC

MDGC

Chemical Ionization and Negative Chemical Ionization

In addition to electron ionization (EI), chemical ionization (CI) and negative

ion chemical ionization (NCI) are available for the GCMS-TQ8040. The CI

method softly ionizes sample molecules and is effective for confirming

molecular weights, while the NCI method enables selective,

high-sensitivity detection of compounds with functional groups that have

a large electron affinity such as halogens.

The Quick-CI function allows users to switch between the EI and CI modes

with the same ion source, so EI and CI data can be obtained from the

same sample. If confirmation of molecular ions is difficult with the EI

mode, molecular information can be collected from the CI mode data.

50 100 150 200 250

0

50

10086

4414912165

EI

%

50 100 150 200 250

0

50

100

%

236

86

218149 188

CI

EI Mass Spectrum (Top) and CI Mass Spectrum (Bottom) ofPentylone (MW: 235), a Kind of Cathinone

DI-2010 Direct Sample Inlet DeviceDirect sample injection (DI)

is a method in which a

sample is injected directly

into the ion source without

passing through the gas

chromatograph (GC). This is

an effective method for

measuring the mass spectra

of synthetic compounds,

and can be used easily for

the usual GC-MS

configuration. By using this in combination with Quick-CI, EI and CI mass

spectra can easily be collected.

Components that are thermally degradable or difficult to vaporize arenot suited to GC analysis. Their mass spectra can be obtained easily using the DI probe.

250 500 750

5998116

158

216 398 520 662 763

EI100

75

50

25

0

%

250 500 750

%158

116

174254 398

558

679

662 731

838CI M+H+100

75

50

25

0

Mass Spectrum for Antibiotic Roxithromycin

AOC-6000 Multifunctional Autosampler

The AOC-6000 supports three sample injection methods:

liquid sample injection, headspace (HS) injection, and solid

phase micro extraction (SPME) injection, so samples in a

variety of forms can be analyzed. It allows the sample

injection method to be switched automatically, enabling

different sample injection methods to be combined in a

continuous operation.

With the automatic syringe exchange and stirring

function, standard samples can be prepared automatically

with a variety of dilution levels, and everything from the

creation of calibration curves to the quantitative

determination of unknown samples can be fully

automated.

SPME Injection

2-Methylisoborneol(Concentration: 1 ng/L)

HS-20 Headspace Sampler

The HS-20 headspace sampler provides strong backup for

the analysis of volatile components at every stage from

research to quality control departments. The high-sensitivity

electronic cooling trap enables quantitative and qualitative

determination of trace components that cannot be detected

with a conventional headspace sampler.

The HS-20 transfer line is built into the GC unit, which

makes it easy to combine the HS-20 with the AOC-20 liquid

sample injector, as well as to switch between these units.

OPTIC-4 Multimode Sample Inlet

The OPTIC-4 multimode sample inlet is a GC injection port

that enables a variety of sample injection modes for

GC-MS, including large-quantity injection, inlet

derivatization, thermal desorption, and DMI (difficult

matrix introduction).

Combining this with an autosampler enables automatic

replacement of inserts, improving productivity in

multisample analyses.

Sample in microvial

LinerNeck

Carry InSplit Flow

Column Flow

DMI (Difficult Matrix Introduction) Mode Simplifies Pretreatment

3.5

3.0

2.5

2.0

1.5

1.0

0.5

20.0 25.0 30.0 35.0 40.0 45.0 50.0

(×1,000,000)

1

2

3 4

5

1. Linalool

3. Ionone

5. Tetradecanoate

2. Citronellol

4. Lillial

TIC

An undiluted shampoo solution was placed directly in a microvial and measured in DMI mode, enabling the selective analysis of volatile components.


C146-E251FGC

MS-TQ

8040


GCMS-TQ8040

© Shimadzu Corporation, 2017

www.shimadzu.com/an/

For Research Use Only. Not for use in diagnostic procedures. This publication may contain references to products that are not available in your country. Please contact us to check the availability of these products in your country.Company names, products/service names and logos used in this publication are trademarks and trade names of Shimadzu Corporation, its subsidiaries or its affiliates, whether or not they are used with trademark symbol “TM” or “®”.Third-party trademarks and trade names may be used in this publication to refer to either the entities or their products/services, whether or not they are used with trademark symbol “TM” or “®”.Shimadzu disclaims any proprietary interest in trademarks and trade names other than its own.

The contents of this publication are provided to you “as is” without warranty of any kind, and are subject to change without notice. Shimadzu does not assume any responsibility or liability for any damage, whether direct or indirect, relating to the use of this publication.

First Edition: May 2014, Printed in Japan 3655-04708-30ANS

Documents

GCMS-TQ8040 - Shimadzu · The ion source, incorporating a highly efficient collision cell, enables high-sensitivity and long-term stable analyses. In addition, with high-speed scan