rateSodium1123Injection,1.0mCi High @RateHighDetectorEfficiency

lodohippurateSodium1131Injection,0.15mCi LowCountRateLowDetectorEfficiency

‘Reference:Dataonfile,Medi-Physics,Inc.,Richmond,CA

Introducing

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I000HIPPURATESODIUM1123INJECTION

NormalTransplantRenogram1

NEPHROFLOW provides better counting statistics and higher data density.

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--.-----,- Radiopharmaceuticals should be used only by physicians who are qualified by training

andexperienceinthesafeuseandhanduin@ofraciiOnuClidesandwhoseexperienceandtraining havebeen approvedbythe appropnategovemmentagencyauthorizedto licensethe use of radionuclides.

Carcinogenesis.Mutagenesls,ImpairmentofFertilityNo long term animal studies have been performed to evaluate carcinogenic potential,;::@:@ucitY potential, orwhether lodohippurate Sodium I 123affectsfertility in malesor

PregnancyCategoryCAnimalreporductionstudieshavenotbeenconductedwiththisdrug.Itis alsonotknownwhether lodohippurateSodium I 123 can cause fetal harm when administeredto apregnantwoman, orcan affect reproductivecapacity. lodohippurate Sodium I 123shouldbegiventoa pregnantwomanonlyifclearlyneeded.ideally,examinationsusingradiopharmaceuticels.especiallythoseelectiveinnature,inwomenofchildbearingcapabilftyshouldbeperformedduringthefirstfew(approximatelyten)daysfollowing the onset of menses.

NursingMothersSincelodine-123is excretedin humanmilk,formula-feedingshouldbe substitutedforbreast feeding if the agent must be administered to the motherduring lactation.

Pediatric UseSafety and effectiveness in children have notbeen established.ADVERSEREACTSONS:Aswlthallorganiciodlnecontainingcompounds,thepossibilityof allergic reactionsmustbe kept in mind. Nausea, vomiting,and faintinghave beenreported in conjunction with the administration oflodohippurate Sodium I 123.HOWSUPPUED: lodohippurateSodiumI 123InjectIonissuppliedinnominal3,5ml vialsas a sterile, nonpyrogenic, aqueous, isotonic saline solution for intravenous injection.Eachmillilitercontains37megabecquerels(1millicurie)oflodohippurateSodiumI 123atcalibration time.It isavailable,in individualvials,inthefoilowingsizes:

MPI CatalogNo.2041;1 mland37 megabecquerels(1mCi)pervialMPI CatalogNo.2042; 2 mland74megabecquerels(2mCi)pervial

Vialsare packagedinindividualleadshieldswithplasticoutercontalner.

@--@@

solution contains 37 msgabecqurels (1 milIlcune) lodohippurate Sodium I 123 atcalIbratIOn time, 2 mIlligrams lodohippurate Sodium, 1 percent benzyl alcohol (as apreservative).9 mIlligramsper milblftersodiumchloridefor isotonicity,and up to 0.1percentethanol.ThesolutionisbufferedwithsodiumphosphateandthepHisadjustedto 7.0-8.5wIthsodiumhydroxideor hydrOChlOriCacid.Theradlonuclldiccompositionatcalibration time is not Iesa than 94.7 percent I 123, not more than 4.8 percent I 124, andnotmorethan0.5percentallothers(I 125,I 126,I 130,Na24,Ic 121).Theradlonuclidiccompositionat expirationtime Is not lessthan85.5percentI 123,notmorethan 12.9percentl 124,and not more than I .6 percent all others.INDICATIONS AND USAGE: lodohippurat. Sodium I 123 Injection is a diagnostic aid indetermIning renal function, renal blood flow, and urinary tract obstruction, and as a renallma@ngagent

@ONTRAlNDlCATlONS:None Known.WARNINGS: None Known.PRECAUTIONS:

GeneralThe contents of the vial are radIoactive. Adequate shielding of the preparation must bemaintained Stall times.Donot use afterthe expiration tlmeanddate(24 hours aftercallbrationtime)stated on the

@beiThe prescribedlodohippurateSodiumI 123 dose shouldbe administeredas soonaspractical from the time of receipt of the product (i.e., as close to calibration time asposslble)inordertominimizethefractionofradiationexposureduetorelativeincreaseofradionudkiic contaminants wIth time.lodohippurate Sodium I 123,aswell asotherradioactlvedruge, muetbe handledwithcareand appropriate safety measures should be used to minimize radiation exposure tocllnicatpersor@. Care should alsobetakentomlminizeradiationexposuretothepatient

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¼―Nal (TI ) crystal

1123Electroncapture13.2hours15984%0.037

74.5%

1131Beta193hours36482%0.24

22.5%

NEPHROFLOW@IODOHIPPURATESODIUMI123 INJECTION

FrcompI.t.FescfIbing Informatlonconsult package Insert, a brief summary of which follows:

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SCIENTIFIC PAPERS

This year's presentation ofover 600 scientific papers includes a distillationofthe latest advancements and finest work achieved by outstanding scientistsand physicians in the field of nuclear medicine. These papers, presented bythe original authors, with over 30 subjects to choose from, will provide a uniqueopportunity for enhancing your knowledge or exploring new avenues incorrelative areas of nuclear medicine. Ample time is allotted at thesepresentations for questions and discussions.

An extensive display of scientific posters and exhibits will augment thepresentations.

CONTINUING EDUCATION COURSESRefresher and state-of-the-art continuing education courses in chemistry,

physics, quality assurance, cardiovascular nuclear medicine, PET, SPECT,and NMR will supply up-to-the-minute approaches and procedures for allclinical settings.

TECHNOLOGIST PROGRAMThe ever-increasing importance of the role of the nuclear medicine

technologist will be explored in our Technologist Program, and over 70 hoursof clinical updates will provide chief and staff technologists with the latestin basic, intermediate, and advanced studies. This program will broadenexpertise and enhance the technologist's contributions to nuclear medicine.

EXPOSITIONMore than 1,800 exhibitors from over 90 pharmaceutical and equipment

manufacturers will display their latest products in a lively atmosphere. Theseknowledgeable commercial representatives offer the technical depth our fielddemands, and they are valuable sources oftimely and pertinent information.

AUDIOVISUALS, BOOKS, JOURNALSThe Society of Nuclear Medicine is continually adding to its library of

audiovisuals, books, and other publications. A stop at the publications boothis well worth the time. Here you will find on display what the society has

to offer for year-round educational advancement.Networking opportunities and job referral boards are available at special

locations throughout the meeting as well as membership information at ourmembership booth.Registration: $120 SNM members; $215 nonmembersHotels: $89 average rate/nightIfyou needfurther information, please contact:

The Society of Nuclear MedicineEducation and Meetings Department

136 Madison AvenueNew York, N.Y. 10016

(212)889-0717 Telex: 510-100-5285Circle Reader Service No. 10

14A The Journal of Nuclear Medicine

INTENSIVE LEARNING OPPORTUNITIESFOR ALL NUCLEAR SPECIALISTS

Washington, D.C., will be the backdrop ofour thirty-third Annual Meeting.

The meeting includes four days of intensive learning opportunititesinterspersed with exciting social events. Sites that are uniquely Washington,D.C., will house our get-togethers.

With our commitment to offering only the very best educational resourcesavailable in nuclear medicine, we feel that this meeting will be our finest to

The

Society of

Nudear

Medicine

33rd

Annual

Meeting

June 22—25,1986(Sunday-Wednesday)Washington, D.C.

CENTOCOR ANTI MYOSI N

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CARDIAC AGENT

Imaging techniquescurrently used toevaluatemyocardialinfarction(MI)havea majordrawback:Theydo notpermit differentiation betweenmyocardial necrosis and ischemia inthe earlyhoursfollowinginfarction.Thallium-201,for example,concentratesonlyinnormalmyocardialcells.The bone scanningagenttechnetium-99mpyrophosphateis takenup by necrotic,as wellas by somereversiblydamagedcells,andalsobyoverlappingribs.Theseagentsare of limiteduse fordifferentiatingbetween irreversiblenecrosisandsevereischemia.Yettheabilityto makethatdistinction—andmake it quickly—couldsignificantlyimprove management of cardiacpatients.Mycscint@an imagingagentbasedona monoclonalantibodyspecifictocardiacmyosin,may fillthisvoidincardiac imagingtechnology.BecausethisMAbbindssolelytotheintracellularmyosinthat is exposedoncelldeath,Myoscintconcentratesonlyin necroticcells.Itthereforepermitspreciselocalizationof unsalvageable tissue.

Improved MI diagnosismay ,esuftMyoscintmay permit Ml detectionandlocalizationinsituationsthatmayotherwisebe difficultto interpret.A recent study demonstratesthiscapability.A 62-year-oldmanwithnohistoryofcoronaryarterydiseasewasadmittedto the coronarycare unitafter a brief episode of chest pain andlightheadedness.Hehadevidenceof

imageswereobtainedthereafterat24 arid 48 hours. Planar imagingdemonstratedintenseuptakeofradiotracer in the inferiorwall,extendingintothe posterobasalregion.Thallium-20l imaging also was performed immediately prior to theMyoscintstudy.Therewasevidenceof an inferiorperfusiondefect correspondingtoapproximatelytheareaofincreasedindium-illMyoscintuptake(seeimages).Thisstudy demonstratesthe ability ofindium-ill labeled Myoscintto detectand localizean areaof acutemyocardial necrosisin a patientwhoseelectrocardiogram only demonstrateda nontransmuralMl.

Ongoing Myoscint researchMyoscintis being evaluatedextensivelyin conjunctionwith traditionalimagingtechniques,includingearlythallium-20l imaging,contrastyentriculography,andgatedradionuclideangiocardiography(wallmotionstudies).ThisresearchcontinuestoverifyMyoscint'sefficacy for identifyingzonesof acutemyocardialnecrosis.

Availableforinvestigational useMyoscint is now available for investigational use only. If you wouldlikemore informationon this product,or other biotechnological productsunder development at Centocor,pleasecall us, toll free.

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1HALL!U@ 201

LEFT LATERAL

Comparison of planar thallium-201imagewithindium-illlabeledMyoscintimage shown in the left lateral position.A regionof interestcorrespondingtotheouter margin of the left ventricle on thethallium-201study is supenmposed overboth images. This study demonstratesthe ability of the monoclonal antibodyimaging agent to localize the area ofacute myocardialnecrosis. A large areaof abnormal uptake is noted in the inferior wall on the Myoscint study.

hyperacuteTwavechangesin leads2, 3,andaVF,aswellasSTsegmentdepressioninleadsV2throughV6.Multipleepisodesof ventriculartachycardiaweretreatedwithintravenouslidocaine.He also developedheartblockwithAVdissociationandasystole. A temporary pacemakerwasplacedsoon afteradmissionto thecoronarycareunit.SubsequentelectrocardiogramsdemonstratedSTandT wave changes in the inferolateralleads,but no 0 waves.Thecreatinekinase level rose to 2098 with apositiveMB fraction.Indium-ill labeledMyoscintwasinjectedwithoutincidentapproximately 24 hours after admission. Serial

CENTOCOR

C@de Reader SeMce No.11

IMAGING

INDIUM 111ANTIPIYOSIP4

,@

Forinvestigationof trabecularbone in the axialskeleton

The ND2100 Dual Photon Bone Densitometer is the idealclinical instrument for precise, cost-effective measurementof bone mineral content for assessment and management ofpatients with osteoporosis and other metabolic bone diseases and disorders.The dual photon method is especially useful in assessinglongitudinal bone loss or gain without subjecting patients toexcessive radiation levels. In addition, the ND2100 producesremarkably clear, high resolution images of the axial skeleton. Measurements are:

•Direct and Precise•Highly Reproducible•Cost Effective•Easy and Convenient

The ND2100System includes the scanner unit in which theradioactive substance is maintained, a translucent table,sodium iodide detectors, and computer for operational con

ND2100features include:•Microprocessor Control•High Resolution Video Display•Clear, well defined graphics/printouts•Large scanning area (50cm by 60cm)•Scanning area can be repositioned without moving

patient

For detailed information on the ND2100 Bone DensityScanner, contact:

@ Nuclear Data Inc. ND Medical Products

GolfandMeachamRoadsSchaumburg,Illinois60196Phone:312-884-3636trol, data processing, and file storage. cwcie @ea@erserve@No.12

16A The Journal of Nuclear Medicine

Direct, Precise Bone Mass MeasurementsWith Dual Photon Bone Densitometry

—.,----@----@—@ ...

;L@

; S

208 pp; 6 x 9 “softcoverPublication Date: June 1984

$12.00 per copy

Abbreviated ContentsRadiation in Perspective 8. Genitourinary Tract

1. Basic Science of Nuclear Medicine. . 9. Skeletal System

Radiation and DoseRadiation EffectsImaging of Radiation

2. The Diagnostic Processand Nuclear MedicineSensitivity, Specificity, and Prior Probability

Organ Imaging With Radionuclides3. Thyroid Uptake and Imaging

4. Cardiovascular System

5. Pulmonary Systemand Thromboembolism

6. Liver and Gastrointestinal Tract

7. Biliary Tract

OrderingInformationAdd $2.50 postage and handling for each book ordered. Prepayment required in U.S.funds drawn on U.S banks only. For payments made in U.& dollars, but drawn on a foreignbank, add a bank processing fee of $4.50 for Canadian bank drafts or $40.00 for all otherforeign bank drafts. Check or purchase order must accompany all orders. Make checks

payable to: The Society of Nuclear Medicine. Prices are in US. dollars and are subject to changewithout notice.

The Society of Nuclear Medicine136 Madison Avenue, New York, NY 10016 (212)889-0717

. . . a basic introductory guide to acquaint medical students

and physicians with the most useful nuclear medicine techniques for detecting and evaluating common disorders.

10. Central Nervous System

Imaging Disease Processes11. Trauma

12 . Inflammatory and Infectious Processes

13. Cancer

Nonimaging Diagnostic Techniques14. Nonimaging Procedures

Appendix

Glossaty

Index

CircleReader Service No.1322A

Fundamentals ofNuclear MedicineEditedbyNaomi P. Alazraki, MD,and FredS.Mishkin, MDOtherContributors:Manuel L. Brown, MD, FrederickL. Datz, MD,Leon S Malmud, MD, Isaac C. Reese, PhD, Barry A. Siegel, MD,JamesA.Sorenson,PhD,LeroyA.&igarman,MD,AndrewT.Taylor,Jr., MD, Heidi S Weissmann, MD, Henry N. Weilman, MD

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In 1984Franceissueda commemorativecoinhonoringone of thetruly great sdentists and women of the 20th century, Madame MarieCurie.MadameCurie,a NobelPrizewinner and thediscoverer of the radioactive element radium, is portrayed asa maturewomanon this 100franc .900 fInesilver coin. Aroundher portrait are the words “MarieCurie―and the dates of her birth anddeath “1867-1934―.Under her portrait is the name of the designer“Corbin―.On the centralportionofthe reverseare twosprigsofleaves with the word “Physique―(Physics)and “Chimie―(Chemistry)interspersed between them, an allusion to her two lifetimepursuits.The legend around the sprigs read “Liberte-Egailte-Fraternite―,andabove and below the sprigs are “RepubliqueFrancaise 1984―and “100F―,respectively.Thecoinmeasures31mm in diameter,with a grossweight of 15 grams, and a PURE SILVERweight of 13.49grams or.4340oz.

The depiction of Madame Curie is exquisite showing finelychiseledhair detail and well defined facial features. This classicalbust portraitofa MadameCurieby the artist/engraverCorbin,in the preciousmetalsilver,memorializesthe greatestofFrenchwomenscientists.

EXCELLENT NUMISMATIC INVESTMENTPOTENTIALOnly 100,000 of these Marie Curie commemorative coins werestruck, making this the lowest inintage Frenchcommemorative coin ever, and the lowest mintage French 100franc coin since 1934! The potential of this low mintagecommemorative coin from a country as large and important as Franceseems to be excellent, and should France continue strikingcommemorative coins in the future, there seems littlechance thatmintages willever be this low again.

CWc$eReader Service No.14

MOThER OF MODERN NUCLEAR PHYSICSHONORED ON ThE

1984 FRENCH 100 FRANC

CURIECOMMEMORATIVECOIN

CLASSIC FOREIGN EXCHANGE HEDGEWiththe FrenchFranccurrentlyat 7.58francsto the dollar,a francisworth $.l320 or approximately thirteen and a quarter U.S.Cents (youcan actually take this 100 Franc coin out of Its case and use Itin Parisfor $13.20.).Historically,thebenchmarkexchangeratehasbeen 5 francs to the dollar.If the franc reaches 5 francs to thedollar again, this coin willbe worth U.S.$20.00 INFACEVALUE.

MTh IS PROUD 10 OFFER THE 1984 100FRANC MARIE CURIE COMMEMORATIVECOIN IN LOTS OF 50 COINS EACH FORONLY $18.00 PER COIN ($900 per lot)Allcoins come packaged in the original plasticdisplay cases, and aresealed by the French mint to insure that each coin remains in originalGEM UNCIRCULATEDcondition. A numbered certificate ofauthenticity detailing specificsof the coin accompanies each specimen.

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CircleReaderServiceNo. 15

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nations.. Elimination of backlogs.Your situation might not be listed here, but that doesnot diminish its importance. Please feel free to contact Scans On-Call . . . an exemplary human resource specialist since 1977.

An Equal Opportunity Employer

PolIcy—TheJournalofNuclearMedicineacceptsclassified advertisements from medical institutions,groups, suppliers, and qualified specialists in nuclearmedicine. Acceptance is limited to Positions Open,Pbsitions Wanted, Equipment Available, and Seminars. We reserve the right to decline, withdraw, ormodify advertisements that are not relevant to ourreadership.

Rates forClasslfled Llstlngs—$1O.OOperlineorfraction of line (approx. 50 characters per line. including spaces). Please allow 28 characters for thefirst line which will appear in capital letters. Specialrates for SNM members on Positions Wanted: $9.50perline. Note: Box numbers are availableforthe costofthe 2 lines required.

Rates for DIsplayMs—Agencycommissionsareoffered on display ads only.Full page $920 Quarter page $345Half page 530 Eighth page 295

Terms—Paymentmustaccompanyorder.Makechecks payable, in U.S. dollars on U.S. banks only,to: The Society of Nuclear Medicine.

DeadlIne—firstofthemonthprecedingthepublication date (January 1 for February issue). Please submit classifed listings typed double spaced. No telephone orders are accepted.

Send copy to:Amy KolodnyClassified Advertising CoordinatorThe Society of Nuclear Medicine136 Madison AvenueNew York, NY 10016(212)889-0717

PhysicIan

from the Children's Hospital at Stanford are alsostudied at the University Hospital. The program isapproved by the AMA and satisfies the requirementsofthe American Board ofNuclear Medicine. Prerequisite for entry into programs: 2 years prior training in AMA-approved program in internal medicine,radiology, pathology or pediatrics. Requests for further information (include CV and reference list)should be directed to: I. Ross McDougall, MB, ChB,PhD, Professor of Radiology and Medicine, Stanford University Medical Center, Stanford, CA94305. Stanford is an Equal Opportunity AffirmativeAction Employer.

RESIDENCY IN NUCLEAR MEDICINE. Twoyear ACGME approved program offering very broadclinical and basic science experience. The programis an integrated program involving tertiary care, specialized care, and community hospitals in a balancedprogram. The program also includes oncology andped iatric exposure, strong basic science teaching.radiation safety, radiopharmaceutical services, RIA,and research opportunities. Opportunities for exposure to MRI, CT, and ultrasound are available during the course of the 2-year training program. Forqualified individuals, an advanced I-year fellowshipis available with emphasis in nuclear cardiology ornuclear oncology. This program is an integrated program of the State University of New York at Buffalo School ofMedicine. Positions available July 1,1986. Contact: J.A. Prezio, MD, Chairman and Program Director, SUNY!Buffalo Nuclear Medicine,VAMC, Building 5, 3495 Bailey Ave. , Buffalo, NY14215. EOE.

Technologist

LEAD NUCLEAR MEDICINE TECHNOLOGIST. Lead position available in a progressive, well-equipped department for certifiednuclear medicine technologist with at least 3 yearsofexperience. Excellent opportunity for professionalgrowth with exceptional cultural and recreational opportunities in America's most liveable city. Interestedcandidates are invited to submit a resume to: Personnel Department, Providence Medical Center, 50017th Ave., Seattle, WA 98124; (206)326-5651.EOE.

NUCLEAR MEDICINE TECH. Excellent fulltime opportunity for qualified individual tojoin progressive fast-paced radiology department. State-ofthe-art equipment. BS in nuclear medicine andNMTCB certification required. Day hours, excellentsalary and benefits. Submit resume to: PersonnelDepartment, Mercy Hospital Medical Center, 6th &University, Des Moines, IA 50314. Equal Opportunity Employer.

NUCLEAR MEDICINE TECHNOLOGY INSTRUCTOR. Full-time, line item position beginningMay 7. 1986. Coordinate and evaluate clinical education with multiple affiliate hospitals. Duties includethe preparation and implementation of educationalmodules, curriculum development, counseling, andcommittee participation. NMTCB or ARRT registration required. BS preferred. Three years clinical experience essential. Previous experience in nuclearmedicine education and/or clinical supervision preferred. Submit CV and three letters of reference byMarch 15, 1986 to: Director of Personnel. Santa FeCommunity College. P.O. Box 1530. Gainesville.FL 32602. EOE.

Physician

(asst. prof.). Strong interest in advanced technologyand computers. Available immediately. Reply to:Box 301, Society ofNuclear Medicine, 136 MadisonAve. , New York, NY lOOl6.

For Sale

FOR SALE Technicare 410 Gamma Camera withLEAP, medium energy, RSH, and pinhole collimators. Includes area-scan, whole-body imagingtable. Technicare 560 Computer with VI-4 multiformatter; (414)567-0371, ext. 247.

This publication isavailable in microform

from UniversityMicrofilms

.@ International.

E Pleasesendinformationaboutthesetitles:

Name

City

State _______________ Zip

Phonel I

Call toll-free 800-521-3044. In Michigan.Alaska and Hawaii call collect 313-761-4700.Ormail inquiry to: University Microfilms International.300 North Zeeb Road. Ann Arbor. MI 48106.

25A

Classified Advertising

T@ cOSTOF

GIVE TO THEAMERICAN CANCERSOCIETY.

Thissp@soa*@iMdapubkcNrves.

PositionsOpen

NUCLEAR MEDICINE PHYSICIAN. The University of Miami/Jackson Memorial Medical Centeris seeking a nuclear medicine physician, ABNM certified oreligible, withclinical, teaching, and researchexperience. Rank and salaiy will depend on qualifications and experience. Send CV to: Aldo N. Serafini,MD, Director, Nuclear Medicine Division, University ofMiami School ofMedicine (D-57), P.O. Box016960, Miami, FL 33101 . An Equal Opportunity!Affirmative Action Employer.

NUCLEAR MEDICINE PHYSICIAN-PATHOLOGIST. BC/BE in both pathology and nuclearmedicine for 1,000-bed Central Florida hospital.Contact: Ben Willard, Jr. , MD. 1414 South KuhIAve. , Orlando, FL 32806. EOE.

Scientist

RADIOPHARMACIST. Loma Linda UniversityMedical Center seeks qualified PhD in clinical andresearch nuclear radiopharmacy. Send CV to: GeraldA. Kirk, MD, Director ofNuclear Radiology, LomaLinda University Medical Center, Loma Linda, CA92354.EOE.

Resident

NUCLEAR MEDICINE RESIDENT. Unexpected opening in nuclear medicine residency forI-year special competency or 2-year residency.Fellowship includes research opportunities in GInuclear medicine, magnetic resonance. and labeledantibiotics. Contact: Alan H. Maurer, MD, DirectorofNuclear Medicine, Dept. ofDiagnostic Imaging, Temple University School of Medicine andHospital, Philadelphia, PA 19140. An Equal Opportunity Employer.

STANFORD UNIVERSITY SCHOOL OFMEDICINE. NUCLEAR MEDICINE RESIDENCY PROGRAM. Unexpected resident position isavailable beginning July 1, 1986, for a 2-year program at Stanford University Medical Center and affiliated Veterans Adm. Medical Center. Patients

Positions Wanted

NUCLEAR RADIOLOGIST. Experiencedgeneral diagnostic radiologist completing fellowshipin nuclear radiology July 1986. Desire nuclearradiologist position or one requiring general andnuclear radiologic capabilities, preferably inMetropolitan NYC area. Reply to: Box 300, Society of Nuclear Medicine, 136 Madison Ave. , New

York, NY 10016.

PHYSICIAN, CERTIFIED ABNM and ABR. Extensive experience managing a full service nuclearmedicine division in a 500-bed teaching hospital

Volume 27 •Number 3 •March 1986

TEXASc__-@ Operator #596

@ FLORIDA@&l@@ Operator #37

NATIONWIDEOperator #3

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NURSING& HOSPITALJOBGUIDESproadecomprehensiwmedic@opporluniy Iiuingsforadminstrative and staff positions in Florid. and T.xu In additionto salary programs. benefit packagesand detailed information about top medical institutions, the Guides give specifics about variousregionswithineachstate,withclimate,population.housing.culturalandrecreationalactivities.

(In Florida Call 1-904-373-2200)

CornputerScientistWeare recruiting for a computer scientist,preferablywith

experience in image processing, for an expanding NuclearCardiology Laboratory at The Long Island College Hospital—amajor teaching affiliate of DownstateMedical Centerin NewYorkCity.Responsibilitiesincludeteachingof residents and technologists, supervision of clinical computerapplications and a major effort in the development of newquantitative programs for both planar and SPECT imagingmodalities.

Send CVwith salary historyand requirementsto: StevenReisman, MD, Director, Nuclear Cardiology.

UJL•THE LONG ISLAND COLLEGE HOSPITALBrooklyn, NY11201:;‘tr—AnEqualOpportunityEmployerMIFIH

lic@

DireCtOrRadiochemistryResearchGroup

The worlc@sleading independent monoclonal healthcare products company Isseeking innovative and experienced Ph.D.chemist to assume senior posItionassembling,organizing,anddirecting radiochemistryresearch team. Major scientific thrust Is to developoptimaltechniquestolabelmonoclonalantibodiesandother biological compounds for diagnostic imagingand radioimmunotherapy. Extensive stateof -the-artfacilitiesavallablaAmpleopportunityfor collaborationwith academic research centers and significant professionalgrowth. Expertisein technetium metallochemistryand/orinorganicligandsynthesisdesirable.Positionavailableimmediately.

Pleasereply with curriculum vitae to:Harvey J. Berger, MDSeniorvice President

Centocor@Inc.244 Great valley Parkway

Malvem, PA19355leiephone (215)296-4488

CENTOCOREqual Opportunity Employer

TheUniversityofTexasHealthScienceCenterat Houston

TheHeartInstituteofJapanand

KyotoUniversitySchoolofMedicineannounce

U.S.-jAPANCARDIOLOGYUPDATENEWAPPROACHESTOCORONARYARTERYDISEASE,PTCA,ANDPET

In memoryof Dr. AndreasGruentzig

jUNE5-6, 1986 JUNE9-10, 1986‘IOKYO,JAPAN KYOTO,JAPAN

For information contact:OfficeofContinutingEducation

Universityof TexasMedical School(713)792-5346 (Texas only)/l-800-23l-9481 (outside Texas)

For travel information contact:DananInternationalTravel

(713)446-8228(Texasonly)/l-800-472-0099(outsideTexas)

26A The Journal of Nuclear Medicine

NUCLEAR MEDICINEPHYSICIAN

The general hospital, St. John's, Newfoundlandis recruiting a physician to direct the Departmentof Nuclear Medicine. The hospital is a referral center for the province and is located within the healthsciences centre which also houses the memorialuniversity faculty of medicine.

In addition to directing the department, the appointee will be expected to participate in undergraduate and post graduate teaching. Research activities will be encouraged, an appropriate jointappointment to the faculty of medicine will beoffered.

Candidates should possess (or be eligible for)appropriate certification by the Royal College ofPhysicians and Surgeons of Canada.

All qualified individuals are encouraged to applybut in accordance with Canadian immigration requirements, priority will be given to Canadian ciiizens and permanent residents of Canada.

Enquiries, along with a curruculum vitae andthe names ofthree referees, should be forwarded to:

Dr. G. B. AdamsChairman, Nuclear Medicine Search CommitteeThe General Hospital Health Sciences Centre

Prince Philip Drive, St. John's, Newfoundland,Canada A1B 3V6

ComputerCouncilTheCOMPUTERCOUNCILismadeupofSocietymemberswhohavean interestin computersandtheirapplicationinthediagnostic,therapeutic,andinvestigativeareasofnuclearmedicine.Itprovidesa sourceof informationrelatingto computerscience to the Society membership through itsmeetingsand publications.

CorrelativeImagingCouncilTheCORRELATIVEIMAGINGCOUNCILprovidesa structureinwhichcliniciansandscientistscandevelop and disseminate information on themedicalandphysiologicalapplicationsof variousimaging modalitiesas they correlateto nuclearmedicine.

RadioassayCouncilTheRADIOASSAYCOUNCILmaintainsthescientific,economic,andhistoricelementsofthe radioassaydisciplinewithinthe Society.

RadiopharmaceuticalScienceCouncilThe RADIOPHARMACEUTICAL SCIENCECOUNCILprovidesa forumfor discussionanddissemination of information relating to the radiopharmaceuticalsciencesand promotesand encourages basic radiopharmaceutical research anddevelopmentwithin the Society. It publishes anewsletterandholdsperiodicmeetingsonspecialsubjects.

If you are interested in joining any or all of the Councils, please contact the Membership Department. The costfor 1986 Council membership is only $5.00 per council.

TheSocietyof NuclearMedicineMembershipDepartment 136MadisonAvenue,NewYork,NY10016,(212)889-0717.

CircleReader Service No.18

Volume27 •Number3 •March1986 27A

SNMc0uNCILSToSatiSfythe needsof those individual disciplines within nuclear medicine,TheSociety of Nuclear Medicine has established special interest Councils that function autonomouslywithin the Society and are open to all interested members.

AcademicCouncilTheACADEMICCOUNCILiscomposedoffacultymembersof nuclearmedicinedepartments,divisions,or sectionsin accreditednuclearmedicineschools,or inthoseinAMAapprovednuclearmedicine residencyprogramsin the U.S.or canada.

Theobjectivesofthe Councilare:(1)to promotemedical education, research, and patient carerelatedto nuclearmedicine;(2)to developbettermethodsof undergraduateandgraduateteachingofnuclearmedicine;and(3)to provideaforumfordiscussionof problemsofmutualinterestandconcern,aswellasaninformalexchangeof ideasandprograms.Withinthe Councilthereisa subgroupofdirectorsof nuclearmedicineresidencytrainingprogramswho confer at least annuallywith theABNMon areasof mutual interest.

CardiovascularCouncilThe CARDIOVASCULARCOUNClLconsists ofSocietymembersinterestedin th@@performanceandapplicationofcardiovascularnuclearmedicineprocedures.Itseeksto providea forumfordiscussion and developmentof cardiac scintigraphicmethodsin aneffortto realizethe mostbeneficialapplications.TheCouncilactivelyseeksindividuals who sharethis goal.

Instrumentation CouncilTheINSTRUMENTATIONCOUNCILpromotestheadvancementanddisseminationof knowledgeofinstrumentationutilizedin nuclearmedicineandserves as a resource center in instrumentation forthe Society.

A Patient's Guideto Nuclear Medicine

Educate your patients with SNMPatient Information Pamphlets

A Patient'sGuideto Nuclear Medicine

Well illustrated, this 16-page pamphlet explains what nuclear medicineis, how the procedures are performed, and how they can help in the

early detection of disease.Divided into 3 sections, the guide opens with a general overview of

nuclear medicine. A question-and-answer section follows, addressing

such topics as safety, the benefits of nuclear medicine procedures, preand post-instructions, and testing of pregnant women and children.The third section explains some of the more commonly performed

procedures such as bone, liver, lung, heart, and thyroid uptake scans.

16 pp 5@/2X 8@/2;in 2 colors;2O@per pamphlet;minimum order: 100copies

Guidelines forPatients ReceivingRadioiodine TreatmentPrepared in collaboration with the U.S. Nuclear Regulatory Commis

sion, this 8-page pamphlet answers patients' questions about homecare after receiving radioiodine treatment for thyroid conditions.

Easy-to-read language outlines important precautions patients canfollow to help reduce radiation exposure to others. It also contains a

checklist that physicians can review with their patients to determine

which guidelines are appropriate for them and how they should be

followed.8 pp 5@/2X 8@/2;in 2 colors;

___________________ 30Cper pamphlet;minimum order:25 copies

Healthcare professionals in private practice, hospitals, and clinics will find

that these pamphlets provide a brief, attractive, and inexpensive way to educate patients and their families about the importance of proper health care.

ORDERING INFORMATIONSingle copies are available for review at $1.50 each. All prices include postage and handling. Prepayment

required in U.S. funds drawn on U.S. banks only. Make checks payable to: The Society of Nuclear Medicine.

Prices are in US. dollars and subject to change without notice.

THE SOCIETY OF NUCLEAR MEDICINEBook Order Department, 136 Madison Avenue, New York, NY 10016

CircleReader service No. 19

Guidelines forPatients ReceivingRadioiodine Treatment

28A TheJournalof NuclearMedicine

broad overview of each topic and additionalreferences deal with subjects in greater depthor provide historical insight.

The new edition addresses exciting newareas in the field such as emission computedtomography and nuclear magnetic resonance.Expanded sections include chapters dealingwith clinical imaging and nonimagingprocedures.

This book provides a valuable referencesource for radiopharmacists, radiochemists,physicists, health physicists, clinicians,electronic engineers, computer engineers, andlaboratory specialists working or studying inthe field.

Book Reviews of the First Edition

“Thebook is stronglyrecommendedto all engagedintraining personnel for work in nuclear medicine,whether the course concerned is aimed at medical,scientific, or radiography staff.―—The British Journalof Radiology

“Thisbook attempts to catalog and categorize inoutline form the more pertinent journal articles andbook chapters relating to the extensive field of nuclearmedicine science. The result is surprisingly detailed,complete , well-organized , and clear. “—MedicalUltrasound

“TheSyllabus appears to be a sound investment forany nuclear medicine department actively involved inthe teaching of students.―—American Journal ofRoe ntgenology

81/i x 11―hardcover; 280 pagesISBN 0-932004-15-6; $30.50

This enlarged and updated edition presents acomprehensive, but carefully screened,bibliography of the current literature availablein the field of nuclear medicine science.

Arranged in outline form, the bookcontains references chosen for clarity, depth,and availability. General references provide a

Ordering Information: $30.50 plus $2.50 postage and handlingfor each book ordered. Prepaymentrequiredin U.S. fundsdrawn on U.S. banks only. No foreign funds accepted. For payments made in U.S. dollars, but drawn on a foreign bank,add a bank processing fee of $4.50 for Canadian bank drafts or $40.00 for all other foreign bank drafts. Check or purchaseorder must accompany all orders. Make checks payable to: The Society of Nuclear Medicine. Prices are in U.S. dollars andsubject to change without notice.

Society of Nuclear Medicine136 Madison Avenue, New York, NY 10016

Volume27 •Number3 •March1986 29A

NUCELI@i MEDICINESCIENCE S@@W@13USSecond Edition

Ifyou'relookingforthebestuptakesystem, designed for patient comfortand easy operation, take a look at theThyroid Uptake System II from AtomicProducts.

It sets new performance standardsbecause it is “trulydedicated― to thyroiduptake activity studies.

Operation is simple, and straightforward, thanks to the user friendlymenu selection and logical control paneldesign. All operations and calculationsare handled by a high-speed microprocessor with data displayed on the built-invideo monitor. An optional printer isavailable for hard copy.

The isotopemenuis preselected for7isotopes(1-123;1-125;1-131;Co-57;Cr-51; Tc-99m; Cs-137), with a manualoverride.

Patient measurements are automatically decay corrected, and it calculatesthe final uptake percentage. It has amemory capacity for 8 separate patients,3measurementsperpatient.

The system can be configuredas afree-standing unit, or used in a table topsetting, depending on your needs and

patient requirements.The Thyroid Uptake System II. It

sets new standards for uptake studies.From your Nuclear Medicine Source...Atomic Products Corporation.

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DESCRIPTION: Each kit contains10 multidosereactionvials. each containing10 mg ofmedronic acid, 0.17 mg (minimum) stannous chloride (maximum stannous and stannicchloride 0.29 mg). and 2 mg ascorbic acid. Thecontents ofthe vial are sterile, pyrogen-free,lyophitized and sealed under nitrogen. The pH has been adjusted to 4-8 with hydrochloricacid and sodium hydroxide.Administration is by intravenous injection for diagnostic use, after reconstitution with oxidant-free Sodium Pertechnetate Tc 99m Injection. The product as supplied is sterile andpyrogen-free.The precise structure of stannous Technetium Tc 99m medronate complex is unknown atthis time.INDICATiONS AND USAGE: TechnetiumTc 99m MedronateInjectionmay be usedas abone imaging agent to delineate areas of altered osteogenesis.CONTRAINDICATIONS:Noneknown.WARNINGS: Thisclassofcompoundisknowntocomplexcationssuchascalcium.Particular caution shouldbe used with patientswho have, or who may be predisposedto,hypocalcemia (i.e., alkalosis).Preliminary reports indicate impairment ofbrain scans using Sodium PertechnetateTc 99mInfection which have been preceded by a bone scan using an agent containing stannousions. This impairment may result in false-positive or false-negative brain scans. It is recommended,wherefeasible,thatbrainscansprecedeboneimagingprocedures.Aiternately,abrain-imagiog agent such as TechnetiumTc 99m Pentetate Injection may be employed.PRECAUTiONS:

GeneralThe contentsof the kitbeforepreparationare not radioactive.However,after the SodiumPertechnetateTc 99m Injectionis added,adequateshieldingof the finalpreparationmustbe maintained.Contents of the vial are intended only for use in the preparation of Technetium Tp 99mMedronateInjectionandare NOTto beadministereddirectlytothepatient.TechnetiumTc99m Medronatelnjection, aswellasother radioactivedrugs, mustbehandledwith care. Once Sodium Pertechnetate Tc 99m Injection is added to the vial, appropriatesafety measures shouldbe used to minimizeexternal radiationto clinicaloccupationalpersonnel. Care should also betaken to minimize radiation exposureto patients in a mannerconsistent with proper patient management.To minimize radiation dose to the bladder, the patient should be encouraged to drink fluidsandtovoidimmediatelybeforethe examinationandas oftenthereafteras possibleforthenext4—6hours.Technetium Tc 99m Medronate Injection should be formulated within six (6) hours prior toclinicaluse. Optimal imaging results are obtained onetofourhours afteradministration. The

solution should not be used if cloudy.The vialsshouldnotbe usedaftertheexpirationdateshownonthelabel.Radiopharmaceuticalsshouldbe usedonlybyphysicianswhoare qualifiedbytrainingandexperienceinthesafeuseandhandlingofradionuclidesandwhoseexperie.iceandtraininghavebeenapprovedbytheappropriategovernmentagencyauthorizedtoticensetheuseofradionuclides.

Carcinogenesis, Mutagenesis, Impairment of FertilityNo long-termanimal studieshave been performedto evaluate carcinogenicpotential,mutagenic potential, or whether TechnetiumTc 99m Medronate Injection affects fertility inmalesorfemales.

PregnancyCategoryCAnimal reproductive studies have not been conducted with TechnetiumTc 99m MedronateInjection.It isalso notknownwhetherTechnetiumTc 99m MedronateInjectioncan causefetal harm when administeredto a pregnantwomanor can affect reproductivecapacity.TechnetiumTc 99m Medronate Injection should begivento a pregnant womanonly if clearlyneeded.Ideally,examinationsusingradiopharmaceuticals.especiallythoseelectiveinnature,ofawoman of childbearing capability, should be performed during the first few (approximately10) days following the onset of menses.

Nursing MothersTechnetiumTc 99m is excreted in human milk during lactation. Therefore, formula feedingsshouldbesubstitutedforbreastfeedings.

Pediatric UseSafetyandeffectivenessinchildrenhavenotbeenestablished.ADVERSEREACTiONS:Althoughadversereactionshavenotbeenreportedthatarespecifically attributable to the use of Technetium Tc 99m Medronate Injection, allergicdermatological manifestations (erythema and other allergic reactions) have been reportedwith similar agents.HOW SUPPLIED:

KitContents10 STERILE REACTION VIALS(10 cc, silver aluminum overseal), each containing,

in Iyophilized form and under nitrogen atmosphere, 10mg ofmedronic acid, 0.17mg (minimum) stannous chloride (maximum stannous and stannic chloride 0.29mg), and 2 mg ascorbic acid. Hydrochloric acid and sodium hydroxide have beenaddedfor pH adjustment priorto lyophilization.

20 PRESSURE-SENSITIVE LABELS for final preparation of Technetium Tc 99mMedronateInjection.

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KitforthePreparationofTechnetiumTc99mMedronateInjectionHighbonetosofttissueratios:Usually40%to50%uptake within 3 hours. Up to 50% is usually clearedby urinaryexcretionwithinthefirst3—6hours.

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MPIMDPKITMultidoseKitforthePreparationofTechnetiumIc 99mMedronateInjectionForcompleteprescribinginformationconsuftpackageInsert,a briefsummaryofwhichfollows: