International Society for Clinical News Biostatistics - ISCB · International Society for Clinical Biostatistics News Number 51 June 2011 Editor: David W. Warne Executive Committee

International Society for Clinical Biostatistics

News

Number 51 June 2011 Editor: David W. Warne

Executive Committee 2011 Editorial

Officers

President: Harbajan Chadha-Boreham (CH)

Vice-President: Koos Zwinderman (NL)

Secretary & News Editor:

David W. Warne (CH)

Treasurer: KyungMann Kim (US)

Members

Past-President 2011: Norbert Victor (DE) Deceased 18Apr2011

Webmaster: Ingrid Sofie Harbo (DK)

Michal Abrahamowicz (CA)

Lucinda Billingham (GB)

Krisztina Boda (HU)

Tomasz Burzykowski (BE)

Lutz Edler (DE)

Catherine Legrand (BE)

Saskia Le Cessie (NL)

Zdenek Valenta (CZ)

ISCB 32 is fast approaching and you can find the draft programme in the middle of this news. For only the second time, the conference will be outside Europe,

this year in Ottawa, Canada. Please see www.iscb2011.info for the latest details.

Work continues on the future conferences in Bergen, Munich and Vienna and we have received

proposals for 2015. It’s never too early to start planning a conference in your city – if you have an idea, please contact the Officers and we’ll be happy to help.

In the middle of April, we learned that our Past-

President, Norbert Victor, had passed away after a long battle against cancer. The Officers who had worked with him over the last few years were very saddened by the news, and messages of condolence were received from

various members of the Society. Norbert continued work for ISCB even when his prognosis wasn’t good and we all benefitted from his great experience and guidance. A full tribute will appear in the December News.

Thanks to the contributors to this News: Harbajan Chadha-Boreham, KyungMann Kim, Koos Zwinderman, Julia Singer and Ulrich Mansmann, Tim Ramsay and KyungMann Kim, Anca Vitcu, Julia

Singer, Sylvain Larroque and the book reviewers, and Rita Schou of the ISCB Office (which has moved recently – please note the new address and numbers).

WWW and Email Addresses Correspondence Address

www: www.iscb.info

Permanent Office: office@ iscb.info

Book Review Editor: slarroque.iscbbooks@ yahoo.fr

ISCB News Editor David W. Warne

Home: Chemin du Petit-Bel-Air 115,

CH-1226 Thônex, Switzerland.

david_w_warne@ bluewin.ch

National Group Representatives, Deputies Subcommittee Chairs/Secretaries 2011

Czech Rep.:

Zdenek Valenta [zdenek.valenta@ fulbrightmail.org]

Marek Maly [mmaly@ szu.cz]

Poland: Ewa Kawalec [mxkawale@ cyf-kr.edu.pl]

Krystyna Szafraniec [mygomola@ cyf-kr.edu.pl]

Walerian Piotrowski [walekpio@ ikard.waw.pl]

Hungary: Jeno Reiczigel [reiczigel.jeno@ gmail.com]

Krisztina Boda [boda@ dmi.u-szeged.hu]

Serbia Zorana Bizetic [zorana@ ncrc.ac.rs]

Romania Anca Vitcu [avitcu@ yahoo.com]

Conf. Organising: David W. Warne (CH), Lutz Edler (DE)

Education: Catherine Quantin (FR), Jeno Reiczigel (HU)

Epidemiology: Vana Sypsa (GR), Marie Reilly (SE)

Membership: Lucinda Billingham (GB),

David W. Warne (CH)

National Groups: Julia Singer (AT),

Stanislav Katina (GB)

Regulatory Affairs: Christoph Gerlinger (DE),

Christos Nakas (GR)

Student Conf. Awards:

Ulrich Mansmann (DE), Nadine Grambauer (DE)

Vaccines: Jos Nauta (NL), Jingyee Kou (US)

Index

ISCB Membership ..................................................... 2 ISCB President’s Mid Year Message ........................... 3 ISCB Treasurer’s Mid-Year Report ............................. 4 Book Review by Melanie Bell (AU) .............................. 6 Book Review by Marek Brabec (CZ) ........................... 7 Books for Review by Sylvain Larroque ....................... 8 Book Review by Jan Kalina (CZ) .............................. 10 ISCB32 Ottawa 2011: Update ................................. 11 ISCB32 Ottawa 2011: Conference Awards for

Scientists (CAS) ............................................. 13 ISCB32 Ottawa 2011: Student Conference Awards

(SCA)............................................................. 13 ISCB32: Ottawa, Canada: AGM Agenda ................... 31

ISCB Short Course in Romania: Report ................... 32 Biostatistics Meeting in Hungary: Call for Abstracts 32 ISCB GENERAL INFORMATION .............................. 33 Advertising Rates .................................................... 33 Society’s Aims ......................................................... 33 Changes of Address or Email .................................. 33 Information on Submitting Articles ......................... 33 ISCB Office & Executive Committee: Contact Details 34 ISCB Membership and Googlegroups Emailing Lists 35 ISCB Subcommittees: Contact Details ..................... 36 ISCB Membership Information ................................ 38 ISCB Membership Subscription .............................. 39 Calendar ................................................................. 40

http://www.iscb2011.info/

http://www.iscb.info/

ISCB News #51 Page 2 June 2011

ISCB Membership

Welcome to the 370 new members who joined ISCB by attending ISCB31 in Montpellier. Please renew your membership using the form sent with this News! If you are attending the Ottawa conference, welcome to ISCB!

end end Dec Dec Dec Dec Dec Dec Dec Nov Nov Dec Nov Nov Nov Nov Nov Dec Nov Jun Dec Jun

*=host of Conference 89 92 93 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08 09 10 10 11

Total 261 596 715 698 725 702 685 729 818 797 837 825 756 758 620 808 800 921 862 437 880 517

# Countries 23 32 32 31 33 34 37 37 41 40 45 41 40 38 39 40 41 42 39 32 42 34

1. Poland [NatGrp] 11 11 24 24 30 21 19 26 34 37 41 41 43 40 49 54 62 66 67 71 73

2. Romania [NatGrp] 2 4 1 1 1 19 21 30 28 30 31 36 1 2 65

3. Hungary [NatGrp] 1 21 17 18 19 25* 27 29 29 33 34 41 48 42 38* 50 44 43 44 42 42 48

4. UK 50 90 176* 120 144 121 128 169* 135 151 153 141 190* 140 109 133 117 114 124 46 114 45

5. USA 18 45 40 39 41 40 79* 66 76 77 89 78 75 57 51 67 62 74 67 34 64 40

6. Germany 30 67 75 84 71 78 72 70 186* 90 87 77 61 57 51 73 48 59 72 36 61 40

7. Czech Rep. [NatGrp] 1 1 1 1 1 1 2 2 1 1 1 1 3 17 36 28 44* 27 30 29

8. Denmark 4 58* 38 31 30 32 26 35 38 39 36 46 41 37 37 40 34 154* 54 33 60 28

9. Netherlands 14* 30 38 33 36 29 31 39 35 33 38 39 33 87* 35 44 41 39 49 18 56 21

10. Belgium 13 22 27 30 30 32 35 29 25 33 36 33 23 27 24 23 32 33 33 18 32 18

11. Switzerland 14 25 22 80* 33 29 24 25 23 18 23 26 22 23 23 55* 28 26 28 11 30 15

12. France 30 52 62 50 73 67 52 52 49 53 37 93* 31 41 30 57 41 49 49 26* 119* 12

13. Australia 6 9 11 6 9 8 11 9 10 12 8 9 14 8 6 11 11 10 13 10 18 10

14. Canada 6 12 14 14 11 13 15 14 9 9 10 14 16 8 12 12 19 22 18 8 18 10*

15. Norway 13 18 25 22 12 18 10 10 11 10 16 16 12 14 12 13 12 19 21 7 15 10

16. Sweden 23 51 53 54 58 64 51 45 38 44 88* 50 36 34 24 23 19 27 19 10 18 9

17. Austria 4 9 11 13 11 16 13 11 15 18 15 13 16 17 15 14 16 17 15 7 15 7

18. Japan 2 6 7 5 7 4 10 13 20 12 11 10 10 10 17 17 27 20 26 4 24 6

19. Italy 16 33 37 32 32 33 26 33 26 63* 29 25 15 25 15 23 24 20 10 6 15 4

20. Finland 2 7 7 9 9 9 7 5 10 9 18 11 7 11 10 6 8 8 9 6 8 4

21. Slovenia 1 2 3 2 1 1 3 2 1 2 1 2 3 3 4 5 5 4 3 3 4

22. Serbia [NatGrp] 1 2 3

23. Spain 10 12 18 12 46* 23 14 16 12 11 11 8 7 15 5 9 8 5 14 2 14 2

24. India 1 1 1 1 1 1 1 1 2 1 2 2 3 2 2 3 4 4 2 3 2

25. Malaysia 2 1 2 2 1 1 1 1 1 3 3 2 1 1 2 1 3 2

26. Israel 1 3 4 4 4 4 3 3 4 10 13 10 7 8 3 4 2 2 1 1 2 2

27. Greece 1 1 1 1 1 3 1 6 1 2 2 3 50* 5 7 4 7 1

28. Portugal 1 3 5 2 2 2 2 5 5 3 4 3 3 1 1 1 2 6 2 7 1

29. Taiwan 1 1 1 1 1 1 3 7 4 1

30. South Africa 1 4 1 3 2 2 2 2 2 3 3 3 2 3 3 3 2 5 2 2 1

31. Slovakia 1 1 2 2 2 2 1 1 1

32. New Zealand 1 1 2 1 2 2 2 3 3 3 1 2 2 2 5 2 1 1 1

33. Brazil 2 1 1 1 1 1 1

34. Singapore 3 6 4 5 8 5 7 2 4 6 2 4 1 1

35. South Korea 3 1 1 1 6 6 6

36. Turkey 1 1 1 1 2 2 3 4 7 2 1 3

37. China 1 1 2 3 3 3 3 3 3 3 2 2

38. Algeria 2

39. Iran 1 1 1 1 4 1 3 5 1 2 1

40. Mexico 1 1 1 1 1 1 2 2 2 1 1 1 1

41. Estonia 2 1 1 1 1 1

42. Vietnam 1

43. Cuba 2 2 2 2 2 2 1 1 1 1

44. Indonesia 1 1 1

45. Pakistan 1 1 1 1

46. Kenya 1 1 1

47. Ireland 1 2 3 4 3 4 4 2 3 2 3 1 1 2

48. Russia 1 3 3 3 2 2 1 4 3 2 1 1 1 1

49. Sri Lanka 1 1 1

50. Bangladesh 1

51. Luxembourg 1

52. United Arab Emirates 1 1

53. Chile 1

54. Thailand 1 1 1 1 2 1 1 2 2 2 3

55. Saudi Arabia 1 1

56. Malawi 1 1 1

57. Colombia 1 1 1 1

58. Croatia 1 1 1

59. Gambia 1

60. Lithuania 2

61. Argentina 1

62. Kuwait 1 1

63. Sudan 1

64. Ukraine 1 1

65. Egypt 1

66. Philippines 1

67. Zimbabwe 1

68. Oman 1


ISCB President’s Mid Year Message

From Harbajan Chadha-Boreham

I am honoured to be the ISCB President during the term 2011-2012 and look forward to serving the ISCB in this

role. Having been on the ISCB Executive Committee since 2001 (4 years as ordinary member, 4 years as Secretary and 2 years as Vice-President), I am collaborating closely with the Officers and members who are active in the ISCB.

The second quarter of this year started with the sad news about our Past-President, Norbert Victor, who passed away on 18 April 2011. Norbert served on the ISCB Executive Committee for ten years and admirably

continued with his Presidential duties during 2009-2010, even though he was undergoing treatment for cancer. My initial memories of Norbert go back to the Heidelberg ISCB Conference in 1999, when he was

Chair of the Local Organising Committee. Norbert played a significant role as ISCB Treasurer during early half of the last decade when ISCB was at risk of running into financial problems. We are grateful for Norbert’s dedicated contributions to the ISCB in several ways, which will be recounted in a tribute to him by our current Vice-President Koos Zwinderman.

Substantial changes have occurred in the composition of the Executive Committee following last year’s elections. Regarding the Officers, Koos became the Vice-President after proving to be an efficient Treasurer for four years when we have seen continued steady growth in our financial equity, due to large profits from the conferences. David Warne was re-elected as Secretary, having served the ISCB in this role for two years. He continues to devote considerable time to ISCB in numerous ways, including Editorship of the Newsletter and chairing the Conference Organising Subcommittee since my stepping down from the chair position last year. KyungMann Kim was elected as the Treasurer this year after terminating his long held positions: Chair of Student Awards Subcommittee and Secretary of the Membership Subcommittee. KyungMann continues to be active in other aspects, as he is also chairing the Scientific Programme Committee of the Ottawa Conference to be held this August.

I warmly welcome eight ordinary members who were elected to the Executive Committee in November 2010: Michal Abrahamowicz (Canada), Lucinda Billingham

(UK), Krisztina Boda (Hungary), Tomasz Burzykowski (Belgium), Lutz Edler (Germany), Saskia le Cessie (Netherlands), Catherine Legrand (Belgium) and Zdenek Valenta (Czech Republic). The new members bring along with them fresh zeal that will help to stimulate our society to venture into unexplored areas. I look forward to collaborating with the newly elected and re-elected members, some of whom have already been active in the society for many years.

My deep gratitude goes to the outgoing members of the Executive Committee: Adriano Decarli, Giota Touloumi, Jean-Christophe Thalabard and Ulrich Mansmann, who have made important contributions to our society, notably as key members of conference organising committees in their countries and their commitment to the society is valuable. Ulrich Mansmann is active as Chair of the Student Conference Awards Committee, as well as Chair of the Local Organising Committee for the ISCB conference in Munich (2013).

My sincere thanks go to Chairs (Emmanuel Lesaffre and Rumana Omar) and Secretaries (KyungMann Kim) of the Subcommittees, who stepped down from their positions after several years of dedicated work for the

society. Emmanuel Lesaffre initiated and chaired the Membership Subcommittee since 2005 and has been

instrumental in promoting the ISCB via support to students, establishing links with sister societies and reaching out to far off countries, the latter being supported by KyungMann Kim: Rumana Omar has revived the Education Subcommittee since 2006 and has helped many target countries to benefit from statistical courses, as well as supporting the pilot “Prognostic Modelling” workshop in Dijon (2009). Rumana’s continued involvement in the Education Subcommittee is much appreciated. I wish the incoming subcommittees’ chairs and secretaries great success in achieving their aims.

The Officers’ quarterly teleconferences are key events

for in-depth discussions and decision making, supplemented with many emails and other teleconferences. Hereafter I report briefly on the main activities:

We were stirred up soon after Christmas by the news

that it was no longer viable for the ISCB permanent office to continue at Cyncron. Thanks to the impressive negotiations led by Koos, we were able to transfer quickly to Biostata at the beginning of February to coincide with Rita Schou’s (ISCB Permanent Office Secretary) move to work at Biostata with Bjarne Bodin (ex-webmaster of ISCB).

The accounts from last year have been finalised and we continue to achieve a healthy equity, thanks to the

substantial profits produced from the conference led by Jean-Pierre Daurès and his collaborators in Montpellier last year.

The Romanian National Group and the Serbian National Group were approved last year and various exchanges regarding setting-up of the new groups took place.

We are following up with organisers of future ISCB conferences: Bergen 2012 (Geir Egil Eide), Munich 2013 (Ulrich Mansmann) and Vienna 2014 (Michael Schemper) and we have initial proposals for 2015/16 conferences.

The ISCB website is planned to undergo some modernisation in order to incorporate enhanced features. Ingrid Sofie Harbo (newly chosen ISCB

webmaster) is taking care of this: The Officers had a teleconference with Ingrid regarding user specifications for updating the website. I thank Bjarne Bodin who stepped down from the Webmaster position having made vital contributions as a former webmaster, amongst his many other services to ISCB (including the ISCB conference in Copenhagen).

All the ISCB Subcommittees are active and we shall get their full reports for this year’s Executive Committee and Annual General meetings in August.

This year’s ISCB conference in Ottawa (21 - 25 August) is an exciting and unusual out-of-Europe experience not to be missed. We can see that the arrangements are going well with a varied and stimulating scientific and social programme, as outlined in this Newsletter. The website is open for registrations and if you have not registered yet, I would like to encourage you to do so.

I look forward to meeting you all in Ottawa. Dans l’attente de vous rencontrer à Ottawa.


ISCB Treasurer’s Mid-Year Report

From KyungMann Kim and Koos Zwinderman

A summary of the financial position of the ISCB

is given below; it will be discussed at the ExCom meeting and the Annual General Meeting in Aug

2011 in Ottawa.

As the time of writing, the Society's accounts are

being audited by Ernst & Young,

Statsautoriseret Revisionsaktieselskab in

Copenhagen, but their approval is not yet available. Nevertheless, it is clear that the

Society's financial position has further improved

during 2010 with a surplus of €44,567, due to

the success of the 2010 annual conference in

Montpellier, France. The conference had a balance of €47,916. The finances and accounts

of the Montpellier conference were audited and

approved by our member, Christel Castelli, as an

internal reviewer, according to §10.07 of our

Constitution. Both reports were approved by the

Officers of the ISCB. Due to the 2010 surplus, the equity position of the ISCB has improved to

€320,660 as of 31 December 2010.

ISCB Equity 1997-2010:


ISCB Treasurer’s Mid-Year Report (continued)

Euro 2010 2009

Income

Membership fees 24,780.00 24,360.00 Conference surplus 47,916.15 72,796.35 Course surplus 500.00 Advertising 2,100.00 1,850.00 Earned interest 427.38 1,862.99 Currency gains 2.25 103.82

Total income 75,225.78 101,473.16

Expenditure

Permanent Office: Consumables 10.08 8.39 Postage & freight 384.96 217.77 Telecommunication & internet 1,371.83 1,641.14 Ballots 2,729.63 Printing & photocopying 110.26 331.66 Administration 12,826.88 12,811.21

17,433.64 15,010.17 Officers & ExCom: Conference fees Accommodation 1,285.00 Travel expenses 842.40 780.36 Other expenses 253.65 99.10

1,096.05 2,164.46 Awards (Students, Scientists): Conference fees 226.00 Accommodation 105.80 737.00 Travel expenses 489.10 Other expenses 35.00

105.80 1,487.10 President’s Invited Speaker Conference fees Accommodation 595.00 Travel expenses 367.05 Other expenses 60.00

1,033.05 Workshops / Courses: Honorarium 1,042.14 Accommodation 613.88 Travel expenses 543.98

2,200.00 Newsletter: Office expenses 9,122.72 8,621.18 Editorial expenses Travel expenses

9,122.72 8,621.18 Other items: Bank charges 825.71 1,005.26 Audit 1,930.00 1,850.00 Currency loss 145.30 66.23 Outstanding payment, Copenhagen 2008 425.00 Consultants 964.75

2,901.01 4,311.24

Total expenditure 30,659.22 34,816.20

NET INCOME: 44,566.56 66,656.96

Assets

Bank accounts: Barclays Euro account 42,852.44 36,941.19 Nordea DKK account 137,648.54 163,009.12 Nordea Euro account 59,829.18 83,855.88

240,330.16 283,806.19

Others: Accounts receivable 300.00 3,417.03 Seed money, Ottawa 2011 34,776.58 1,248.87 Montpellier, 2010 58,716.15

93,792.73 4,665.90

Total Assets 334,122.89 288,472.09

Liabilities

Owing to Permanent Office 10,679.75 7,966.93 Audit 1,930.00 1,850.00 Prepayment account, members 565.22 200.00 Accounts payable 287.58 2,361.38

Total Liabilities 13,462.55 12,378.31

Assets less Liabilities 320,660.34 276,093.78

EQUITY brought forward 276,093.78 209,436.82

Profit by 31 December 2010 44,566.56

Profit by 31 December 2009 66,656.96

EQUITY carried forward 320,660.34 276,093.78 Conversion rates: 31-12-2010 DKK/EUR 745.44 GBP/EUR 1.2105

31-12-2009 DKK/EUR 744.15 GBP/EUR 1.1441


Book Review by Melanie Bell (AU)

Fairclough, Diane L Design and Analysis of Quality of Life Studies in Clinical Trials (2nd edition) CRC (2010) 978-1-4200-6117-8

Most clinicians and researchers recognize the

importance of measuring and analysing health

related quality of life (QoL) in clinical trials.

There is also a growing recognition that the

analysis of quality of life data cannot be

separated from considerations of missing data, and that these considerations must be rigorous.

Professor Fairclough has succeeded in writing a

book which can be used by trial statisticians for

the valid analysis of quality of life data. It is a

remarkable combination of theory and practical advice.

In the first edition of the text, examples were

given in SAS, and the data were not provided.

The second edition remedies this, by including

examples in R and SPSS as well as SAS, and

gives links to download all the data and much of the code in the book. Other additions are

mediation and moderation models, a short

section on Quality Adjusted Life Years (QALYs)

as well as updates of much of the first edition’s

material.

The intended audience is anyone working in the

area of quality of life, but mainly biostatisticians,

both academic and non-academic. Additionally,

any statistician interested in missing data would

benefit from the very practical nature of this

book. Of the half dozen or so books on missing data, this one probably gives the most code. This

book does not discuss development or

psychometric properties of QoL instruments.

The first chapter provides an introduction to

health related QoL, its measurement, and six studies. These include four cancer trials, a

migraine trial, and an osteoarthritis trial. An

introduction to the study, its QoL measures,

their timing and missing data patterns are

shown. Professor Fairclough’s 30+ years of

clinical trials experience is evident in the second chapter entitled Study Design and Protocol

Development, as it includes a great deal of

practical advice, including three checklists and

several pages on avoiding missing data.

Matching the design, instrument, and assessments timing with the objectives of the

trial is stressed.

The third and fourth chapters discuss

longitudinal models in depth, and the fifth

outlines moderation and mediation. Fairclough

is methodical in her development of this material, discussing various parameterizations

(e.g. cell mean, reference cell), growth curves,

means models, and covariance structures.

Anyone interested in learning about longitudinal

models would benefit from reading it.

The next seven chapters concern missing data:

characterization, introduction to analysis, simple

imputation, multiple imputation; missing not at

random models (MNAR) models including

pattern mixture, random effects dependent

dropout and selection models. This is where the

book shines. While giving enough theory to be

rigorous, but not so much as to overwhelm readers, she goes through the nuts and bolts of

how to actually fit these models. Readers who

want more theory can take advantage of her

thorough referencing. She explains, in detail,

why the commonly used approaches of simple imputation (such as mean substitution or last

value carried forward) and assuming that data

are missing completely at random (such as when

MANOVA is used) are almost always wrong.

Although her treatment of multiple imputation is

mostly complete, one topic she has not discussed is multiple imputation with chained

equations.

Fairclough is honest in her appraisal of methods

for data which are missing not at random. She

states repeatedly that MNAR make strong, un-testable assumptions; that lack of fit of an MNAR

model does not imply that the data are not

MNAR; estimates are not robust to model

misspecification; and that MNAR models are

useful as part of a sensitivity analysis.

Chapter 13 addresses multiple endpoints and issues of multiplicity and how to integrate QoL

outcomes into the trial’s analytic strategy.

Chapter 14 extends this by considering

composite endpoints and summary measures.

The term composite outcome refers to what she called summary statistics in the first edition. The

change in terminology is a bit confusing, as I

think the term composite outcome has a very

different meaning to most statisticians, but I

appreciate that there are a lot of terms for the

same thing that get bandied about. The next chapter is on QALYs and QTWiST as they apply

to clinical trials. This not a complete treatment,

but a good introduction, and one that highlights

issues with missing data.

The final chapter gives a thorough discussion of analysis plans, including sample size estimation,

and reporting of results. Two helpful checklists

are included, and meshing the trial objectives

with the analysis is stressed. She is explicit

about the lack of a one-size-fits-all approach to

analysis, and outlines several possible goals for measuring and analysing QoL data in a clinical

trial.

The graphs are ugly, but this is largely an

indictment of SAS. However, my complaints are

small about this overall excellent book. All in all, this is a useful resource for statisticians working

in the areas of quality of life, clinical trials,

and/or missing data.


Book Review by Marek Brabec (CZ)

Gelfand, Alan E., Diggle, Peter J., Fuentes, Montserrat and Guttorp, Peter (eds.)

Handbook of Spatial Statistics

CRC (2010) 978-1-4200-7287-7

This book is certainly bound to become an

influential classic in the field of Spatial Statistics. Certainly it already became a “must

have” reference work that will serve a wide range

of students and researchers, both from statistics

and from other applied fields, where spatial

modelling is nowadays more and more popular.

Taking into account the names of the editors

and all of the (29!) contributors, it is a priori

expectable that the text will be of high quality in

many respects. Nevertheless, I was greatly

surprised in the most positive sense - reading it

surpassed the expectations. It is a comprehensive piece of work that summarizes

current state of the developments of the spatial

statistics in its multitude. The range of topics

covered is impressive itself, ranging from

classical methods like kriging to modern point process theory or special, but commonly used

applications in fields like climatology or

epidemiology.

The book has 31 chapters dealing with different

problems in Spatial Statistics. They are divided

into six, naturally defined, parts devoted to Historical introduction (an interesting

chronology written by P.J. Diggle), Continuous

spatial variation, Discrete spatial variation,

Spatial point patterns, Spatio-temporal

processes and Additional topics.

Generally, the Handbook is written in a

surprisingly friendly style, with a lot of

mastership not only on the statistical, but also

on the pedagogical side. Obviously, the

readability varies a bit among the entries written

by different authors (some chapters are a bit harder to read than the rest), but generally, the

text is exceptionally accessible and self-

containing. Almost all chapters cover their

material in such a way that reading them will be

useful and enlightening for a wide scope of readers – from beginners to rather specialized

researchers, exposing them to terminology,

conceptual framework, current state of the art of

spatial modeling, necessary background theory,

fresh ideas, interesting and novel thoughts as

well as to a lot of useful references.

Individual authors present classical approaches

(traditional geostatistics), model based

(likelihood) approaches as well as Bayesian

treatments. Many parallels are made to the

analysis of time series (including some spectral theory, Bochner’s theorem implications for

modeling, etc.) so that readers with a traditional

statistical education get a lot of motivation for

the spatial concepts, and then he/she can

smoothly continue to the spatio-temporal

extensions.

The attention is carefully and proportionally

divided between the “mainstream” and not-so-

standard or “additional” topics. Even those off-

standard themes are selected so that they

represent areas that are of substantial interest, both in terms of application and theoretical

developments.

Readers with an ISCB background will benefit

from reading this book in many ways. They

reach from the description of the “continuous

spatial variation models” (i.e. classical geostatistics models and their modern

extensions like hierarchical specifications) or

modern spatial point process theory and

methods (now increasingly more popular in

biomedical research), or disease mapping models with clear interest to the clinical biostatistics

community, to the deep discussion of the nature

of “ecological fallacy” (or MAUP, or COSP

problems) that are inherent to many

epidemiological as well as other biomedical

studies.

In my opinion, this book really sets the standard

for the modern spatial statistics as a field for

years to come. Anybody even mildly interested in

the theory or applications of various parts of

spatial statistics should read it, or even better, to have it handy as an authoritative and

remarkably useful reference.


Books for Review by Sylvain Larroque

Books for review:

Author(s) Title Publisher (year) ISBN Reviewer

1. Wellek, Stefan. Testing Statistical Hypotheses of Equivalence and Non-Inferiority,

2nd edition

CRC (2010) 9781439808184

2. Chow, Shein-Chung. Design and Analysis of

Bioavailability and Bioequivalence Studies, Third Edition

CRC (2009) 978-1-58488-668-6

3. Cosmatos, Dennis. Translational Medicine CRC (2009) 978-1-58488-872-7

4. Peace, Karl E. Design and Analysis of Clinical Trials with Time-to-Event Endpoints

CRC (2009) 978-1-4200-6639-5

5. Buonaccorsi, John P. Measurement Error - Models, Methods and Applications

CRC (2010) 978-1-4200-6656-2

6. Karian, Zaven A, Dudewicz, Edward J.

Handbook of Fitting Statistical Distributions with R

CRC (2011) 9781584887119

7. Chang, Mark Monte Carlo Simulation for the Pharmaceutical Industry

CRC (2011) 9781439835920

8. Shoukri, Mohamed M. Measures of Inter-observer Agreement and Reliability

CRC (2010) 9781439810804

9. Dey, Dipak K, Ghosh, Samiran,

Mallick, Bani K.

Bayesian Modeling in Bioinformatics

CRC (2010) 9781420070170

10. Martinez, Wendy L,

Martinez, Angel R, Solka, Jeffrey L.

Exploratory Data Analysis with

MATLAB

CRC (2011) 9781439812204

11. Pong, Annpey, Chow, Shein-Chung (eds.)

Handbook of Adaptive Designs in Pharmaceutical and Clinical Development

CRC (2011) 9781439810163

12. Hanagal, David D. Modeling Survival Data Using Frailty

CRC (2011) 9781439836675

13. Cheung, Ying Kuen Dose Finding by the Continual Reassessment Method

CRC (2011) 978-1420091519

14. Chen, Din, Peace, Karl E.

Clinical Trial Data Analysis Using R

CRC (2011) 978-1439840207

Important note to potential reviewers:

We regularly receive books from publishers for review in the

Newsletter. We are most grateful for these “donations”, the reviews of which we regard as a service to you, our members. Regretfully, some individuals, despite repeated reminders, neither return a review, nor the book to ISCB... When

requesting a book, please remember that you’re making a commitment to the Society to do a little work in return for keeping the book.

Sylvain Larroque: slarroque.iscbbooks@ yahoo.fr

Please do a little work in return for keeping the book and

your name will be published in the News!

For the format and length, please see recent issues of ISCB News. You can send the review in a variety of formats but plain text email, html, RTF or Word are preferred. The

reviews may be edited for clarity (English grammar and spelling, punctuation etc.).

Book publishers’ webpages:

Hodder Arnold www.hoddereducation.co.uk/RVE99a510f93213434c8b6939f2cb4789e5,,.aspx

Blackwell www.blackwellpublishing.com/subjects/PB/

Cambridge University Press www.cambridge.org/uk/browse/default.asp?subjectid=1007745

CRC (Taylor and Francis) www.crcpress.com/shopping_cart/categories/categories_products.asp?parent_id=104

Oxford University Press www.oup.co.uk/academic/science/maths/

Springer www.springer.com/east/home/statistics?SGWID=5-10128-0-0-0

Wiley www.wiley.com/WileyCDA/Section/id-300665.html

http://www.hoddereducation.co.uk/RVE99a510f93213434c8b6939f2cb4789e5,,.aspx

http://www.blackwellpublishing.com/subjects/PB/

http://www.cambridge.org/uk/browse/default.asp?subjectid=1007745

http://www.crcpress.com/shopping_cart/categories/categories_products.asp?parent_id=104

http://www.oup.co.uk/academic/science/maths/

http://www.springer.com/east/home/statistics?SGWID=5-10128-0-0-0

http://www.wiley.com/WileyCDA/Section/id-300665.html


Books for Review (continued)

Books reviews in this issue:


1. Fairclough, Diane L Design and Analysis of Quality of Life Studies in Clinical Trials (2nd edition)

CRC (2010) 978-1-4200-6117-8 Melanie Bell (AU)

2. Gelfand, Alan E., Diggle, Peter J., Fuentes, Montserrat and Guttorp,

Peter (eds.)

Handbook of Spatial Statistics CRC (2010) 978-1-4200-7287-7 Marek Brabec (CZ)

3. Göhlmann, Hinrich,

Talloen, Willem

Gene Expression Studies Using

Affymetrix Microarrays CRC (2009) 978-1-4200-6515-2 Jan Kalina (CZ)

Books sent out recently:


1. Julious, Steven A. Sample Sizes for Clinical Trials CRC (2009) 978-1584887393 Patrick Richard (FR)

2. Herson, Jay Data and Safety Monitoring

Committees in Clinical Trials CRC (2009) 978-1-4200-7037-8 Theo Stijnen (NL)

3. D. C. Hoaglin, F. Mosteller

and J. W. Tukey

Exploring Data Tables, Trends,

and Shapes Wiley (2006) 0-470-04005-x Gaj Vidmar (SI)

4. Berry, Scott M,

Carlin, Bradley P, Lee, J Jack, Muller, Peter.

Bayesian Adaptive Methods for Clinical Trials

CRC (2010) 9781439825488 Francois Aubin (FR)

5. Kupper, Lawrence L, Neelon, Brian, O'Brien, Sean M.

Exercises and Solutions in Biostatistical Theory

CRC (2010) 978-1-58488-722-5 Rainer Muche (DE)

Books sent for review quite a long time ago

Author(s) Title Publisher (year) Reviewer

1. Bengt D Furberg, Curt D Furberg

Evaluating Clinical Research:

All that Glitters is not Gold (2nd ed.)

Springer (2007) 978-0387728988

Gerd Rosenkranz (CH)

2. J. Edward Jackson A User's Guide to Principle Components

Wiley (2003) 0-471-47134-8 Nicole Close (US)

3. J M Bernardo et al (eds.) Bayesian Statistics 7 Oxford University Press (2003)

0-19-852615-6 Stefan Tigan (RO)

4. John Verzani Using R for Introductory Statistics

Chapman & Hall/CRC (2005) 1-58488-450-9

Justin Clayton (US)

5. J. Rick Turner New Drug Development: Design, Methodology, and Analysis

Wiley (2007) 978-0-470-07373-5 Tim Friede (DE)

6. Frank R. Hampel, Elvezio M. Ronchetti, Peter J. Rousseeuw and Werner A. Stahel

Robust Statistics: The Approach Based on Influence Functions

Wiley (2005) 0-471-73577-9 Lars Krogsgaard Thomsen (DK) LOST TO FOLLOW-UP?

mailto:[email protected]


Book Review by Jan Kalina (CZ)

Göhlmann, Hinrich, Talloen, Willem Gene Expression Studies Using Affymetrix Microarrays CRC (2009) 978-1-4200-6515-2

The book is devoted to theoretical and practical aspects of microarray experiments using the

Affymetrix technology. The book in 9 chapters (xxiii + 327 pp.) combines information in biology, bioinformatics and biostatistics useful for practitioners working in gene expression studies using Affymetrix microarray technology in all possible applications. The book was published by Chapman & Hall/CRC in Mathematical and Computational Biology Series.

The book was written with the aims to "guide molecular biologists through the process of using Affymetrix microarrays for gene expression studies", to show "how to optimize experiments and data analysis

using the Affymetrix GeneChip system as well as other microarray platforms" and to "present and explain various analysis methods via illustrative examples using R and BioConductor".

Chapters 1 to 3 constitute the biological part of the book with detailed explanation of molecular genetic matter, while chapters 4 to 9 contain the data analysis part of gene expression studies. Chapter 1 explains the biological motivation for gene expression studies and their importance. Chapter 2 in a systematic way presents the technology of Affymetrix microarrays and their advantages. Chapter 3 describes the microarray experiments from the technical point of view.

In the statistical chapters the problems are described

systematically and in logical order. Chapter 4 studies the pre-processing, which is typically performed by standard automated procedures including the background correction, normalization and summarization. These methods require a careful attention in practice, as they have a crucial impact on the results.

Chapter 5 as the longest chapter summarizes statistical methods applicable to analysis of microarrays measurements. Here the authors tried to explain many concepts and methods, starting by persuading the readers about the sole importance of statistics and proceeds to the most complex high-dimensional methods of multiple testing and

classification analysis.

Chapter 6 describes the visualization by means of simple graphical output together with its interpretation in a comprehensible way. Chapter 7 mentions application areas in pharmaceutical research. Chapter 8 devoted to R and BioConductor software very briefly presents the software and its philosophy, together with a list of other software packages available for microarray analysis. This

chapter however does not give details sufficient for using the software for an immediate data analysis.

Chapter 9 offers an expert opinion on the future development of microarrays and gene expression studies in general.

The book can be recommended as a valuable self-contained introductory material presenting all aspects of gene expression studies using Affymetrix microarrays. The book is well-arranged. The inserted boxes explaining biological or statistical concepts help to make the book very readable. The technology description is specific for Affymetrix microarrays, just like the data pre-processing methods. The biological principles and the statistical methods for the analysis

of high-dimensional data and data visualization are general and relevant for other microarray platforms, although other platforms are not investigated in the book.

From the statistical point of view the book does not assume any prior knowledge of statistics. It includes statistical aspects as a major theme, which are presented in a simplified and transparent manner. The level of explanation is proper for biologists, avoiding complicated mathematics. The statistical methods are explained on examples with colourful pictures. While the examples are computed in R and BioConductor, the software code is not given. This is not a cook book with methods immediately applicable to solve a particular bioinformatic problem, but a well

written overview over a broad range of problems and solutions with the interpretation. Besides a thorough overview of statistical methods the chapter summarizes the experience of the authors with analyzing real data sets.

The range of topics and methods of the book is truly immense. Thus the book can address readers with a different background. Although Rosa (2010) finds the book confusing for biologists, in my opinion it covers and discusses all aspects of Affymetrix microarray studies important for practitioners. It gives only an introduction to very advanced statistical methods into hands of biologists. Statisticians will appreciate the first three biological chapters, which go into details concerning the microarrays technology and principles

of biological experiments. Nevertheless they may want to learn more information in the references concerning details or computational aspects of the statistical methods and practical tips on software usage.

Reference

Rosa G.J.M. (2010): Göhlmann H. and Talloen W.: Gene expression studies using Affymetrix microarrays. A book review. Biometrics 66 (4), 1314-1315.


ISCB32 Ottawa 2011: Update

From Tim Ramsay, Chair of the Local Organising Committee

From 21-25 August 2011, the 32nd Annual Conference of the International Society for Biostatistics (ISCB) will be held at the new Ottawa Convention Centre. Opened in April 2011, “Canada’s Meeting Place” is the ideal venue to hold this conference. Overlooking Ottawa’s Rideau Canal and surrounded by Ottawa’s national and cultural sites in a relaxed urban vibe, the new Centre will be within easy walking distance of many stores and restaurants in the downtown Ottawa area.

Since 1978, when the 1st Annual Conference was held in Brussels, Belgium, these conferences have provided an important international forum to stimulate research into the principles and methodology used in the design and analysis of clinical research and to increase the relevance of statistical theory to the real world of clinical practice.

The 32nd Annual Conference in Ottawa will provide a forum for the international exchange of theory, methods and

applications of biostatistics in medical research and practice among statisticians, epidemiologists and medical researchers working or interested in the field of clinical biostatistics.

For more information, explore our web site www.iscb2011.info

On behalf of the Organising Committee and those who will be sponsoring and supporting this 32nd International gathering of biostatistical researchers, we extend a warm invitation for you to come to Ottawa, Canada in August 2011.

For more information please contact the Conference Secretariat at:

Marie Lanouette, Conference Manager, 32nd Annual Conference of the International Society for Clinical

Biostatistics, Conference Services Office,

National Research Council Canada, 1200 Montreal Road, Building M-19, Ottawa, Ontario K1A 0R6, Canada

tel: +1 (613) 993-0414 fax: +1 (613) 993-7250

email: [email protected] web: www.iscb2011.info

There are direct flights to Ottawa from many major American cities. Flights from Europe go through either Montreal or Toronto.

The SPC:

KyungMann Kim, Madison, Wisconsin, USA (Chair)

Michal Abrahamowicz, Montreal, Quebec, Canada

Lucinda Billingham, Birmingham, UK

Adriano Decarli, Milan, Italy

Christel Faes, Diepenbeek, Belgium

Jeanine Houwing-Duistermaat, Leiden, Netherlands

Wendy Lou, Toronto, Ontario, Canada

Tim Ramsay, Ottawa, Ontario, Canada (Chair LOC)

Willie Sauerbrei, Freiburg, Germany

Janez Stare, Ljubljana, Slovenia

Toshiro Tango, Tokyo, Japan

Jeremy Taylor, Ann Arbor, Michigan, USA

Jean-Christophe Thalabard, Paris, France

Stephen Walter, Hamilton, Ontario, Canada

The LOC:

Tim Ramsay, Ottawa, Ontario (Chair)

Michal Abrahamowicz, Montreal, Quebec

Lehana Thabane, Hamilton, Ontario

Stephen Walter, Hamilton, Ontario

Wendy Lou, Toronto, Ontario

http://www.iscb2011.info/


ISCB32 Ottawa 2011: Update (continued)

Professor Nan Laird from Harvard School of Public Health will give the ISCB President’s invited keynote lecture*.

The scientific programme consists of:

• Five ordinary invited sessions, covering emerging issues in clinical trials, epidemiology, healthcare economics, pharmacogenomics and comparative effectiveness research.

• A large number of contributed sessions, both oral and poster sessions.

• One parallel stream of session will be devoted to epidemiology, covering both statistical methods and applied problems where methodological advances are needed.

•

Four pre-conference courses will be offered.

• Four mini-symposia on:

Current and Emerging Statistical Issues in Vaccine Research,

Chronobiology and Blood Pressure,

Statistical Challenges in Comparative Effectiveness Research,

Special CANNeCTIN Mini-symposium: Issues in Cardiovascular and Diabetes Trials

Finally, an attractive Social Programme has been set up with various tours being considered e.g. Canada Aviation Museum, Bicycle Tours of Ottawa, Canadian Museum of Civilization, a hike in Gatineau Park.

To register, go to: http://www.iscb2011.info/02-registration_e.shtml Registration Fees:

CAD

ISCB Members $690

ISCB Non-members $750

Student Members $375

Student Non-members $400

Courses - Sunday, August 21 (includes

coffee break and lunch) $450

Students $250

Mini-Symposia ONLY - (included in registration fees above) Thursday, August

25 $350

Students $250

Dinner (not included in registration fees) $100

Students $60

* Title: The Challenges of Finding Genes in the Age of Association

Abstract: In the relatively short time span of less than 10 years, association analysis has become the primary study design for finding new disease genes. In only five years, Genome Wide Association Studies have become common currency. Early successes with association analysis (Macular Degeneration and Diabetes) led to great excitement about the promise of GWAS for understanding the genetic basis of complex disease. Although the number of GWAS have proliferated rapidly, replications are often disappointing and Meta-Analysis has become an essential part of the process of gene discovery. This talk will review some of these features of modern gene mapping, including sample selection, the use of participants in clinical trials, designs on the horizon and integration of genetic, clinical and biologic data.

Nan Laird is a Professor of Biostatistics at the Harvard School of Public Health. Dr. Laird has contributed to methodology in many different fields, including meta-analysis, statistical genetics, and longitudinal data. She is a co-author of the book, Applied Longitudinal Analysis, with Garrett Fitzmaurice and James Ware and is a co-author with Christoph Lange on a forthcoming book on Statistical Genetics. She is the recipient of many awards and prizes, including Fellow of the American Statistical Association, the American Association for the Advancement of Science, the Florence Nightingale Award, and the Janet Norwood Award.

http://www.iscb2011.info/02-registration_e.shtml

http://www.iscb2011.info/02-registration_e.shtml


ISCB32 Ottawa 2011: Conference Awards for Scientists (CAS)

From Julia Singer

This year there were 8 applications from 5 countries (India, Iran, Malaysia, Egypt and Serbia) which arrived before the extended deadline for submission.

Although the terms of references were re-formulated recently in order to indicate clearly the type of applications which are sought (contributions describing new statistical methods and illustrating their implementation in medical research, or presenting the results of medical studies which involve novel and interesting applications of biostatistics), most of the applications did not meet these criteria. Therefore, only 2 awards were granted this year, and this was the unanimous decision of the members of the National Groups SC.

The authors of the award-winner abstracts are (in alphabetic order): Mohammad Reza Maracy (Iran) and Nataša Bogavac-Stanojević (Serbia). The travel support was not granted. Both will present posters.

Nataša Bogavac-Stanojević

Serbia The Bayesian analysis of different models in detection of the coronary artery disease

Mohammad Reza Maracy

Iran Development and Validation of a postpartum depression Risk Score in delivered women, Iran

ISCB32 Ottawa 2011: Student Conference Awards (SCA)

From Ulrich Mansmann This year, there were 20 Student Conference Award (SCA) applications: 8 from UK; 5 from USA; and 1 each from Belgium, Canada, Egypt, France, Germany, Singapore, and South Africa. Three students were selected by the SCA subcommittee based on the submitted abstract and summary of the paper from each applicant. I would like to take this opportunity to thank the Subcommittee members and KyungMann Kim (SPC Chair) for their contribution. This year’s Student Conference Awardees are given below along with their affiliation and the title of presentation:

Josephine Buyze Belgium Gent University An Instrumental Variables Approach for the Performance of Health Care Centers in terms of Survival

Dominik Magirr UK Lancaster University

A Generalized Dunnett Test for Multiarm-Multistage Clinical Studies with Treatment Selection

Siew Wan Hee UK University of Warwick

A Series of Decision-Theoretic Phase II Trials

Please join me in congratulating them. I look forward to seeing their presentations during the Conference and hope to see as many of you at the contributed sessions of their presentations.

ISCB32: Ottawa 2011: Draft Programme


Overview 1: for up-to-date information, please see http://www.iscb2011.info/03-scientific_program_e.shtml Time Sun 21 Aug Mon 22 Aug Tue 23 Aug Wed 24 Aug Thu 25 Aug

07:00 Registration Registration Registration Registration Registration

08:00 Welcome to ISCB32

08:30 Invited Session: I1

Contributed Sessions: C01-C03

Invited Session: I4


Invited Session: I5


Mini-Symposia 1-4

09:00 Pre-Conference Courses 1-4

10:00 Refreshments Refreshments Refreshments Refreshments

10:30 Refreshments Contributed Sessions: C04-C07


Keynote Lecture Mini-Symposia 1-4

11:00 Pre-Conference Courses 1-4

11:30 Annual General Meeting

(with lunch)

12:00

Lunch SC Meetings (with lunch)

Lunch SC Meetings (with lunch)

Lunch Lunch Close

13:30

Pre-Conference Courses 1-4 Invited Session: I2


Conference Excursions Contributed Sessions: C24-C27

15:00 Refreshments Refreshments Refreshments

15:30

Pre-Conference Courses 1-4 Invited Session: I3


Invited Session: I6


17:00 +ExCom: 13:00-18:00

SC Meetings

17:30

18:00

18:30 Welcome Reception

19:00 Conference Dinner and Awards

Breaks Poster Sessions PMA-PMP Poster Sessions PTA Poster Sessions PWA-PWP

Sunday Details: Course 1 (full day) Course 2 (full day) Course 3 (full day) Course 4 (full day)

Proportional Hazards Regression. Based on the Textbook, Proportional Hazards Regression (2008), Springer

Statistics for Curves and Surfaces: The Analysis of Functional Data

Microsimulation Methods in Population Health Using Genetic Markers for Risk Prediction – Potential and Challenges

John O’Quigley, Université Pierre et Marie Curie, Paris, France and Ronghui Xu, University of California San Diego, San Diego, USA

James Ramsay, Professor Emeritus, Psychology, McGill University, Montréal, Canada

William Flanagan, Chief, Health Analysis Section, Statistics Canada, Ottawa, Canada

Celia Greenwood, Centre for Clinical Epidemiology, Lady Davis Research Institute, Jewish General Hospital, Montréal, QC, Canada

This course is based on the book Proportional Hazards Regression (2008), Springer. The topic is survival analysis centered around both proportional and non-proportional hazards models and these cover a very extensive array of possibilities. The morning session is of an introductory/intermediate nature and covers the main theory of survival analysis, its use in describing multi-state transition problems, and how to make use of proportional hazards type formulations. Inference is described via some notions from stochastic processes, in particular martingale theory and the theory of empirical processes. Emphasis is given, via examples, of the ability of PH models and possibly time-dependent covariates, to describe a very broad range of practical situations. The afternoon session is devoted to more advanced topics, in particular the predictive power of models via measures of explained variation, the adequacy of model fit, estimation of the survivorship function on the basis of different prognostic configurations and, if time allows, a closer look at inferential questions such as small sample theory.

Functional data analysis is a branch of statistics that analyzes data providing information about curves, surfaces or anything else varying over a continuum. The continuum is often time, but may also be spatial location, wavelength, probability and etc. The data may be so accurate that error can be ignored, may be subject to substantial measurement error, or even have a complex indirect relationship to the curve that they define. For example, measurements of the heights of children over a wide range of ages have an error level so small as to be ignorable for many purposes, but daily records of precipitation at a weather station are so variable as to require careful and sophisticated analyses in order to extract something like a mean precipitation curve. However these curves are estimated, it is the assumption that they are intrinsically smooth that often defines a functional data analysis. In particular, functional data analyses often make use of the information in the slopes and curvatures of curves, as reflected in their derivatives. Plots of first and second derivatives as functions of t, or plots of second derivative values as functions of first derivative values, may reveal important aspects of the processes generating the data. As a consequence, curve estimation methods designed to yield good derivative estimates can play a critical role in functional data analysis. Models for functional data and methods for their analysis may resemble those for conventional multivariate data, including linear and nonlinear regression models, principal components analysis, and many others. But the possibility of using derivative information greatly extends the power of these methods, and also leads to purely functional models such as those defined by differential equations, often called dynamical systems.

This full day workshop will provide an introduction to microsimulation techniques and will explore how analysis of health data is used to inform and develop population health models. Topics to be covered will include discrete-event simulation, Monte Carlo error, developing risk equations that relate risk factor exposure to incidence and mortality, continuous variables (e.g. body mass index, health utilities index), dynamic risk factor models, calibration and validation, uncertainty analyses. In addition, we will show projections from specific applications for models of some conditions, such as osteoarthritis and acute myocardial infarction. Finally, we will present the Cancer Risk Management Platform, a web-enabled tool designed for use by health researchers and decision makers for comparative evaluations of different intervention strategies. We will highlight the impact of smoking on lung cancer, and various screening modalities for early detection of colorectal cancer.

The session will start with an introduction to genetic markers (primarily SNPs or single nucleotide polymorphisms), and haplotypes, which are the marker values that lie on the same chromosomal strand within an individual. Then we will discuss fairly generally the concept of differences between populations at the genetic level, and how these translate into differences in patterns of genetic markers in candidate genes. Linkage disequilibrium will be defined, and the concept of synthetic associations will be discussed. An overview of genome-wide association studies, and the kind of results normally seen, will be presented. The second major topic that we will cover is the concept of having many different variants within the same gene, some common, some rare, some with small effects, and some potentially with large effects. Even if a gene is known to have influence on a disease process, it may not be straightforward to choose the best way to measure the genetic contribution to risk. We will then talk about predictive models for disease risks, and go over many of the concepts presented in Kraft (2009). Large relative risks or small p-values for a genetic marker may not translate into good predictions; population attributable risks (PAE) are better measures. Many identified genetic variants have small relative risks; there may still be an important impact on PAR if the variant is common. However, even variants with large relative risks may have only small impact on the PAR if they are rare in the population. We will discuss genetic risk scores, how they are constructed and used, and the assumptions inherent in such constructions. A simulation study designed to examine the potential for predictive models in colorectal cancer will be discussed (Hawken 2010), and then several examples of predictive modeling in different disease contexts with genetic predictors will be presented. Kraft et al. (2009) Beyond odds ratios — communicating disease risk based on genetic profiles. Nature Reviews Genetics 10:264-269 Clayton D (2009) Prediction and interaction in complex disease genetics: experience in type 1 diabetes. Plos Genetics 5 (7). Hawken SJ (2010) The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer. Hum Genet 128: 89-101

http://www.iscb2011.info/03-scientific_program_e.shtml



Overview 2:

MON 22 AUG

08:00-08:30 Welcome and Opening Of the Conference

08:30-10:00 I1 - Issues in Systematic Reviews of Epidemiological and Prognostic Studies

C01 - Survival models C02 - Causal inference I C03 - Statistical methods: Multiple imputation

10:30-12:00 C04 - Statistical models C05 - Survival analysis: Recurrent events C06 - Clinical trials: Dose finding/Biosimilar C07 - Statistical methods: Epidemiology studies

13:30-15:00 I2 - Latent Class Analysis in Diagnostic Studies

C08 - Survival analysis: Competing risks C09 - Clinical trials: Optimal designs C10 - Statistical methods: Missing data

15:30-17:00 I3 - Statistical analysis of next-generation sequencing data in epidemiological studies

C11 - Survival analysis: Multi-state/Semi Markov

C12 - Clinical trials: Non-inferiority/Early phase

C13 - Statistical methods: I

TUE 23 AUG

08:30-10:00 I4 - Relative Survival Estimation and Modeling

C14 - Causal inference II C15 - Clinical trials: Flexible designs C16 - Statistical methods: Measurement errors/misclassification

10:30-12:00 C17 - Marker studies C18 - Survival analysis: Frailty/Competing risks

C19 - Cluster randomized trials C20 - Statistical methods: II

WED 24 AUG

08:30-10:00 I5: Innovative Statistical Methods in Drug Development

C21 - Survival analysis in epidemiology I C22 - Prediction models C23 - Statistical methods: III

10:30-12:00 Keynote lecture: Nan Laird

12:00-13:30 Annual General Meeting

13:30-15:00 C24 - Clinical trials: General C25 - Survival analysis in epidemiology II C26 - Meta-analysis I C27 - Statistical methods: Longitudinal models

15:30-17:00 I6: Towards Stratified Medicine – Modeling Interactions between Treatment and Continuous Markers

C28 - Surveillance methods C29 - Meta-analysis II C30 - Statistical methods: Joint modeling

THU 25 AUG

08:30-12:00

Current and Emerging Statistical Issues in Vaccine Research

Chronobiology and Blood Pressure Statistical Challenges in Comparative Effectiveness Research

Special CANNeCTIN Mini-symposium: Issues in Cardiovascular and Diabetes Trials

Organizer: Vaccines Sub-Committee of the International Society for Clinical Biostatistics

Organizer: Douglas Wilson, School of Medicine and Health, Wolfson Research Institute, Durham University

Organizer: Michal Abrahamowicz, McGill & M.A. Brookhart, UNC

Organizer/Chair: Lehana Thabane, McMaster University, Canada



Details:

MON 22 AUG (08:00-10:00): WELCOME AND OPENING OF THE CONFERENCE

I1 - Issues in Systematic Reviews of Epidemiological and Prognostic Studies C01 - Survival models

Willi Sauerbrei Germany Organiser / Chair:

Doug Altman UK The Importance of High Quality Conduct and Reporting of Prognostic Studies

Charles Poole USA Enhancing the Synergy between Meta-Analysis and Observational Epidemiology

Simon Thompson UK Estimating Causal Effects by Meta-analysis of Mendelian Randomisation Studies

Daniela Dunkler Austria An Empirical Comparison of Fixed and Random Effects Models in Survival

Hasinur Khan UK Variable Selection for the AFT Model via Regularized Weighted Least Squares and other Methods

Fanny Leroy France Time to Onset of Adverse Drug Reactions: Parametric Modelling for Spontaneously Reported Cases

Kyle Raymond Denmark Estimating Haplotype Match Effects in BMT Studies

Willy Wynant Canada Flexible Modeling of Survival Functions Conditional on Time-Varying and Non-Linear Effects

C02 - Causal inference I C03 - Statistical methods: Multiple imputation

Vanessa Didelez UK Issues in the Bayesian Analyses of Mendelian Randomisation Studies

Lisa Hampson UK Incorporating Baseline Covariates into Causal Estimators for Survival Data: A Comparison of Methods

Siew Wan Hee UK A Series of Decision-Theoretic Phase II Trials [SCA Award Winner]

Yun Li USA Causal Benefit in Survival among the Treated as a Result of a Time-Dependent Treatment

Liang Li USA Propensity Score Analysis with Matching Weights

Rachael Hughes UK Comparison of Methods of Inference for Imputation Estimators

Dirk Klingbiel Switzerland

Multiple Imputation of Missing Covariates for Multiple Survival Endpoints

Katherine Lee Australia A Comparison of Methods for Imputing Ordinal Variables Using the Multivariate Normal Model in Multiple Imputation

Lynne Moore Canada Multiple Imputation for Multicenter Studies: Implications for Institutional Performance Indicators



MON 22 AUG (10:30-12:00)

C04 - Statistical models C05 - Survival analysis: Recurrent events

Yuli Liang Sweden Combined Permutation Invariant Covariance Matrix and Estimation in Multilevel Models

Elisabeth Svensson Sweden Construction of a Global Score for Multi-item Assessments in Epidemiological Studies

Howard Henry Zappe

Thom UK Structural Uncertainty in Health Economic Models

Xiao-Feng

Wang USA Modeling Time-dependent Behavior of Fractional Anisotropy in Diffusion Tensor Imaging

Yan Zhou Canada Deviance information criterion (DIC) for non-identifiable models: An application to diagnostic test evaluation in the absence of a gold-standard test

Md. Aminul

Hoque Japan A New Nomogram Development for the Prostate Cancer Recurrence after Radical Prostatectomy

Harold Malcolm

Hudson Australia Age-Cohort Models for Recurrent Events in Longitudinal Studies

Yang-Jin Kim Korea South

Statistical Analysis of Bivariate Recurrent Event Data with Incomplete Observation Gaps

Jerome Tanguy France Bayesian Methods for Analysing a Recurrent Event

Y. Xu Singapore Estimation of Protective Efficacy and a Non-susceptible Fraction using Recurrent Event Data

C06 - Clinical trials: Dose finding/Biosimilar C07 - Statistical methods: Epidemiology studies

Alexia Iasonos USA Impact of Priors and Skeletons in Model Based Dose Finding Studies

Tomoyuki Kakizume Japan A Continual Reassessment Method with Adjustable Cohort Size Based on Bayesian Posterior Probabilities in Cancer Phase I Studies

Satoshi Morita Japan Bridging Dose Finding Studies

Melanie Poulin-Costello

Canada Statistics of Biosimilars: An Overview

Fei Wang USA Modeling Multiple Endpoints in a Dose-Finding Study

Michel Hendrik Pieter

Hof Netherlands Methods for Analyzing Data from Probabilistic Linkage Strategies Based on Partially Identifying Variables

Aihua Liu Canada Impact of Mis-modeling Non-linear Exposure-Risk Relationships on Interaction Estimation and Testing: Simulation Study

Malihe Nasiri Iran Discriminant Analysis with Applications to Predicting Pre-eclampsia from Longitudinal Hemoglobin Profiles

Julien Stirnemann France Non-parametric Deconvolution Estimation of Onset of Pregnancy with Replicate Observations

Roula Tsonaka Netherlands Estimation of Genetic Effects from Case-Control and Affected Sibling Pair Studies Using a Marginalized Approach



MON 22 AUG (13:30-15:00)

I2 - Latent Class Analysis in Diagnostic Studies C08 - Survival analysis: Competing risks

Nandini Dendukuri

Canada Organiser / Chair:

Paul Albert USA On Estimating Diagnostic Accuracy from Studies With Multiple Raters and Partial Gold Standard Evaluation

Wes Johnson USA Identifiability of Models for Multiple Diagnostic Testing in the Absence of a Gold Standard

Joris de Groot

Netherlands Adjusting for Differential-verification Bias in Diagnostic accuracy Studies: A Bayesian Approach.

Jean-Marie

Boher France A Test for Proportional Hazards for Competing Risk Data Based on Cumulative Sums of Martingale Residuals

Christian

Boudreau Canada Score Test for Center Effects in Competing Risks

Z.J. Chen Singapore Handling of Tied First Failures in Competing Risks Analysis

Emmanuelle

Deslandes-Boutmy

France A Discrete-Time Hazard Model for ICU Mortality Data

Guoqing Diao USA Time Dependent Covariates in a Competing Risks Setting

C09 - Clinical trials: Optimal designs C10 - Statistical methods: Missing data

Ruud Boessen Netherlands Early Reallocation of Placebo Non-responders in the Sequential Parallel Comparison Design; Consequences on Required Sample Size and Patient Weeks

Tim Friede Germany Designing an Adaptive Clinical Trial with Subgroup Selection Using Early Outcomes

Thomas

Jaki UK Optimal Designs for Multi-arm Multi-stage Clinical Trials

Tony Panzarella

Canada Comparing the Effect of an Inaccurate Control Group Event Rate using Fixed Absolute and Relative Treatment Differences when Re-estimating a Sample Size for a Randomized Clinical Trial with a Dichotomous Outcome Stephe

n Walter Canada Optimal Treatment Allocation in Two-stage Randomised

Clinical Trials

Rolf Groenwold Netherlands Dealing with Missing Outcome Data in Randomized Trials and Observational Studies

Angelo Passalacqua

UK Missing Data Analysis of a Randomised Controlled Trial under Two Scenarios: With and without Provision for Attrition

Matthieu Resche-Rigon

France Systematically Missing Confounders and Complex Missing Data Patterns

Hua Shen Canada Statistical Methods for Dealing with Incomplete Covariates with Left-Truncated Survival Data in Clinical Trials

Elizabeth

Williamson Australia Doubly Robust Estimators of Exposure Effect with Missing Data



MON 22 AUG (15:30-17:00)

I3 - Statistical analysis of next-generation sequencing data in epidemiological studies C11 - Survival analysis: Multi-state/Semi Markov

Jeanine Houwing-Duistermaat

Netherlands Organiser / Chair:

Suzanne Leal USA Collapsing Methods for the Analysis of Sequence Data

Charles Kooperberg USA Tests for Analysis of Next Generation Exome Sequence Data

Robert Elston USA The Analysis of Sequence Data in family versus Case-control Design

Somnath Datta USA A Nonparametric Regression Model for Waiting Times from a Multi-Stage Model

Jinhui Ma Canada Estimating the Minimum Detectable Hazard Ratio for a Population Based Longitudinal Study Using Multi-state Markov Model: A Simulation Study

Tarylee Reddy South Africa

HIV Disease Progression in South Africa using Multistate Markov Models

Mar Rodriguez-Girondo

Spain New Methods for Testing that a Multi-State Model is Markov

Kourosh Sayehmiri Iran Prognostic Factors of Survival Time after Haematopoietic Stem Cell Transplant in Acute Leukemia Patients : A Semi-Markov Multi-State Model

C12 - Clinical trials: Non-inferiority/Early phase C13 - Statistical methods: I

Felix Almendra-Arao

Mexico A New Non inferiority Test for the Difference between Two Proportions

Josephine

Buyze Belgium An Instrumental Variables Approach for the Performance of Health Care Centers in terms of Survival [SCA Award Winner]

Cornelia Ursula

Kunz Germany Estimation for Secondary Endpoints in Two-stage Phase II Oncology Trials

Jen-Pei Liu Taiwan A Pragmatic Approach to Sampling Size Determination for the Equivalence Hypothesis

Charlotte Rietbergen Netherlands Incorporation of Historical Data in the Analysis of Randomized Therapeutic Trials

Christopher

Jackson UK Bayesian Evidence Synthesis to Estimate Progression of Human Papillomavirus

Ian James Australia Use of Visit-time Data in the Analysis of Time to a Threshold Event

Ian Marschner

Australia Relative Risk Regression: Reliable and Flexible New Methods

Chris Fook Sheng

Ng Japan Relative Incidence of Adverse Events in Disseminated Intravascular Coagulation Patients using modified Self-controlled Case Series Method

Yongling Xiao Canada Flexible Modeling of the Cumulative Effects of Time-Dependent Exposure in a Marginal Structural Cox Model



TUE 23 AUG (08:30-10:00)

I4 - Relative Survival Estimation and Modeling C14 - Causal inference II

Janez Stare Slovenia Organiser / Chair:

Jacques Esteve France Historical Overview and Current Challenges

Maja Pohar Perme

Slovenia A Novel Estimator of the Relative Survival Probability

Michal Abrahamowicz

Canada A Flexible Method for Joint Modeling of Baseline Hazard and Time Dependent Effects

Etienne Gayat France Propensity Score and Cluster Effect when Analyzing Survival Data: Empirical Example and Monte Carlo Simulations

Saskia Le Cessie

Netherlands

Comparing Population Effects of Different Intervention Policies, using Inverse Probability Weighting and Regression Methods

Elizabeth McKinnon

Australia Treatment Comparisons with k:m Matching in the Survival or Multi-state Setting

Tom Palmer UK Generalised Method of Moments Estimation of Structural Mean Models

Shiro Tanaka Japan Direct Effect and Energy Adjustment in Nutritional Epidemiology

C15 - Clinical trials: Flexible designs C16 - Statistical methods: Measurement errors/misclassification

Amy Bian USA Evaluating the Utility of ROC Analysis in Blinded Evaluation of an Ongoing Clinical Trial

Eric Derobert France Majesty and Misery of Interim Dose Selection (as conjectured from a 3-doses configuration)

Thomas Dobbins USA Group Sequential Tests of Futility: The Relationship between Type II Error Spending and Conditional Power Approaches

Dominic Magirr UK A Generalized Dunnett Test for Multiarm-Multistage Clinical Studies with Treatment Selection [SCA Award Winner]

Satoshi Teramukai

Japan A Bayesian Adaptive Design with Two-Priors Approach and Predictive Probabilities in Single-Arm Exploratory Clinical Trials

Setcheou Rodrigue

Allodji France Impacts and Correction of Measurement Errors on Estimated Excess Relative Risk in an Occupational Cohort Study

Rebecca Gilbert UK Misclassification of Outcome in Case-Control Studies

Shahadut Hossain United Arab Emirates

Measurement Errors and Misclassifications in Covariates: Impacts on the Main and Interaction effects and the Bayesian Adjustment

Ruth Keogh UK Estimating the Association between Categorized Exposure and Disease Risk in the Presence of Exposure Measurement Error

Loki Natarajan USA Dichotomizing Mismeasured Variables and Disease Diagnosis



TUE 23 AUG (10:30-12:00)

C17 - Marker studies C18 - Survival analysis: Frailty/Competing risks

Andrea Lyn

Jorgensen UK Measuring and Adjusting for Compliance in a Pharmacogenetic Study of Warfarin

Melania Pintilie Canada Comparison of Different Strategies for Finding Clinically Useful Signatures

Zdenek Valenta Czech Republic

Exploiting Shrinkage Approach in Analysing Gene Expression Data

Wiebke Werft Germany Screening and Modelling Treatment-by-Gene Interaction in High-dimensional Data

Manuela Zucknick Germany Integration of Copy Number Variation and Gene Expression Data in Bayesian Models for Prediction and Biomarker Selection

E.Y-C. Chong Singapore A Frailty Model With Conditional Additive Hazards for Semicompeting Risks

Alexander Szubert UK Comparison of Statistical Methods for the Analysis of Skeletal-Related Events with a Competing Risk: Experience from the MRC Myeloma IX Randomized Controlled Trial

Steffen Unkel UK The Relative Frailty Variance and Shared Frailty Models

Bart Van Rompaye

Belgium Event-specific Evaluation of Health-care Providers based on Time-to-competing Risks Data

Jing Xu Australia Cox Proportional Hazard Model Estimation under Dependent Censoring using Copulas and Maximum Penalized Likelihood

C19 - Cluster randomized trials (4) C20 - Statistical methods: II

AgnÞs Caille France Power Impact of Dichotomization of a Continuous Outcome in Cluster Randomized Trials

Esther De Hoop Netherlands Improving Efficiency in Cluster Randomized Trials: A Comparison of an Ancova, Extended Ancova and Stepped Wedge Design with the Posttest Design

ClÚmence Leyrat France Propensity Scores in Cluster Randomized Trials

Anne Presanis UK Influence in Complex Evidence Synthesis

Bendix Carstensen Denmark Method Comparison Studies: The Use of Transformation of Measurements

Raluca Ionescu-Ittu

Canada Detection and Implications of Model Misspecification in Large Database Studies of Drug Effects with Binary Outcomes

Roger John

Marshall New Zealand

Visualizing the Agreement between Clinical Definitions and Associated Outcomes Using Two and Three Dimensional Scaled Rectangle Diagrams: The Case of Metabolic Syndrome and Cardiovascular Disease

Karen Messer USA Data Mining in Vaccine Development: Calling Hits in a High-Throughput Screening Assay

Stephen Senn UK The Ghosts of Departed Quantities: Approaches to Dealing with Observations below the Limit of Quantitation



WED 24 AUG (08:30-10:00)

I5- Innovative Statistical Methods in Drug Development C21 - Survival analysis in epidemiology I

K. K. Gordon Wendy

Lan Lou

USA Canada

Organiser: Chair:

Martin Michael

Posch

Proschan

Austria

USA

Adaptive Methods before Breaking the Blind

H.M. James

Hung USA Adaptive Selection Designs in Drug Development

Inoncent

Richardus

Agueusop Vonk

Germany Biomarker Patient Selection – Effects on Drug Development

Pierre-Jerome

Bergeron Canada Nonparametric Estimation of the Survival Function for Prevalent and Incident Cases under Stationary Incidence

Yu-Jen Cheng Taiwan Analysis of Prevalent Survival Data

Brent Logan USA Long-term Survival Comparisons with Covariate Adjustment using a Registry Database

Elizabeth L.

Turner UK Eliminating Avoidable Blindness Due to Cataract: Incidence Estimation and Surgical Planning Using Cross-Sectional Prevalence Data and Mortality Rates

Min Zhang USA Semiparametric Estimator for Differences in Restricted Mean Lifetimes in Observational Studies

C22 - Prediction models C23 - Statistical methods: III

Thomas Debray Netherlands

Aggregating Published Prediction Models with Individual Patient Data: A Comparison of Approaches

Rachel Jinks UK The Magnitude and Distribution of Royston & SauerbreiÆs Prognostic Discrimination Measure D in Different Disease Areas

Yu Fan Sim Singapore

The Use of Gail Models for Assessing Breast Cancer Risk in Singapore Women Population

Ben Van Calster

Belgium A New Measure to Evaluate Discrimination of Ordinal Risk Prediction Models: Relationships Between Ordinal c-indexes

Hans C. Van Houwelingen

Netherlands

Validation and Calibration of Breast Cancer Models in Swedish Sisters

Jerome Lambert France Volume under ROC Surface for Measuring Predictive Accuracy of Survival Models

Hye-Seung

Lee USA Regression Approach to Examine Sirolimus Effect on the Correlation between FEV1 and VEGF-D: MILES Trial

Ana Subtil Portugal Bayesian Latent Class Models for Estimating Malaria Prevalence and Diagnostic Test Accuracy

Werner Vach Germany Joint Evaluation of Sensitivtiy and Specificity in Analysing a Diagnostic Study

Guangyong

Zou Canada Simultaneous Confidence Intervals for Comparing Multiple Areas under the Receive Operating Characteristic Curves Derived from the Same Cases



WED 24 AUG (10:30-11:30)

Keynote Lecture by the

President’s Invited Speaker

Nan Laird, Harvard School of Public Health

USA

The Challenges of Finding Genes in the Age of Association

Abstract: In the relatively short time span of less than 10 years, association analysis has become the primary study design for finding new disease genes. In only five years, Genome Wide Association Studies have become common currency. Early successes with association analysis (Macular Degeneration and Diabetes) led to great excitement about the promise of GWAS for understanding the genetic basis of complex disease. Although the number of GWAS have proliferated rapidly, replications are often disappointing and Meta-Analysis has become an essential part of the process of gene discovery. This talk will review some of these features of modern gene mapping, including sample selection, the use of participants in clinical trials, designs on the horizon and integration of genetic, clinical and biologic data.

WED 24 AUG (11:30-13:30)

ISCB Officers, ISCB ExCom,

ISCB SC Representatives, Future ISCB Conference Organisers and

All attending the conference are invited to attend the:

ISCB Annual General Meeting

The draft agenda is the following: 1 President's report 2 Treasurer's report 3 Subcommittee reports and motion for continuation: 3.1 Conference Organising 3.2 Education 3.3 Epidemiology 3.4 Membership 3.5 National Groups 3.6 Student Conference Awards 3.7 Statistics in Regulatory Affairs 3.8 Vaccines 4 Update about future ISCB meetings: 2012 Bergen, and news about 2013 and 2014, Munich and Vienna. 5 Any Other Business



WED 24 AUG (13:30-15:00)

C24 - Clinical trials: General C25 - Survival analysis in epidemiology II

James Hanley Canada How Big Are the Mortality Reductions Produced by Cancer Screening? Why Do So Many Trials Say 20%?

Afisi Ismaila Canada Preference-based Estimates of Treatment Efficacy among Compliant Patients in a Randomized Clinical Trial with a Continuous Outcome

Ruediger Paul

Laubender

Germany Estimating Subject-Treatment Interactions in Parallel Group Designs using Covariates

Jorgen Seldrup France Due Diligence and the Probability of Success

Wenle Zhao USA Minimize Controversial Clinical Trials by Ensuring Better Balance of Prognostic Baseline Covariates at Randomization

Coraline Danieli France Comparison of Different Approaches to Estimate Net Survival: A Simulation Study

Roch Giorgi France The Impact of Additional Life Table Variables on Excess Mortality Estimates

Douglas Schaubel USA Modifications of and Alternatives to the Standardized Mortality Ratio (SMR) in Evaluating Center-specific Mortality

Matthew Sperrin UK Correcting for Age at Observation in Epidemiological Survival Analysis

Willem Van Der Wal

Netherlands

Correcting for Informative Censoring of Time-to-Event data in Cost-Effectiveness Analysis

C26 - Meta-analysis I C27 - Statistical methods: Longitudinal models

Jessica Barrett UK The Use of Percentile Ratios in the Individual Patient Data Meta-analysis of Survival Outcomes

Sujit Ghosh USA Bayesian Meta Analysis for Comparative Effectiveness Research

Verena Roloff UK Applying Adaptive Designs in Meta-Analysis

Fotios Siannis Greece Meta-Analysis subject to Misclassification

Yinghui Wei UK Estimating within-Study Correlations in Multivariate Random-Effects Meta-Analysis of Multiple Outcomes from Randomised Trials

Tatiana Benaglia UK Do All Individuals Experience a Change in Age-related Cognitive Decline?

Kathrine Frey

Fr°slie Norway Functional Principal Component Analysis Extract all Observed Variation from Temporal Glucose Curves and Support the use of Area under the Curve

Petra Graham Australia Longitudinal Models for Change in Eye Lens Curvature

Azadeh Shohoudi Canada Variable Selection in Longitudinal Data with Change-point

Ronghui Xu USA Conditional Akaike Information for Clustered Data



WED 24 AUG (15:30-17:00)

I6 - Towards Stratified Medicine – Modeling Interactions between Treatment and Continuous Markers C28 - Surveillance methods

Willi Lisa

Sauerbrei McShane

Germany USA

Organiser / Chair: Chair:

Marco Bonetti Italy Treatment-covariate Interactions In Survival Studies: Modeling, Dichotomizing, and STEPP.

Willi Sauerbrei Germany Make more Use of the Information from Continuous Covariates – Modelling with MFPI to Investigate for Differential Treatment Effects in Large RCTs

William Barlow USA Designing a Randomized Trial to Test an Interaction of Treatment and a Continuous Genomic Assay

Lisa McShane USA Discussion of Issues in Translating Statistical Models into Clinical Tools for Therapy Decisions

Douglas Dover Canada Creating the Funnel in Funnel Plots for Public Health Surveillance

Doyo Gragn

Enki UK Evaluation of Statistical Algorithms for the Detection of Infectious Disease Outbreaks in Large Multiple Surveillance Systems

Angela Noufailzy UK Robust Threshold Estimation in Regression-Based Statistical Surveillance Systems

Toshiro Tango Japan FleXScan with a Restricted Likelihood Ratio: A Spatial Scan Statistic for Irregularly Shaped Clusters

Yongyue Wei China Impact of Under-reporting on the Estimation of Relative Risk in Signal Detection of Intrauterine Device Based on State Contraceptives Adverse Reaction Surveillance Database in China

C29 - Meta-analysis II C30 - Statistical methods: Joint modeling

Mireya Diaz USA Order of Random Effects Influences Numerical Estimates of Meta-Analyses based on Multivariate Mixed Models: Extent of the Problem and Possible Solutions

Juneyoung Lee Korea South

A Data-driven Joint Measures for Asymmetry and Publication Bias in Meta-analysis

Alexander Strawbridge UK Estimating the Shape of Association between a Continuous Exposure and an Outcome, Using 2-stage Meta-analysis of Individual Participant Data

Michael Sweeting UK An IPD Meta-Analysis of Parameters and Predictions from Longitudinal Mixed-Effects Models of Abdominal Aortic Aneurysm Growth

Rebecca Walwyn UK Meta-Analysis of Intraclass Correlation Coefficients (ICCs) from Randomized Trials

Paul Birrell UK Discriminating Between GP Consultations for Pandemic Influenza A/H1N1, and Other Influenza-Like Illness: A Bayesian Joint Modelling Approach

Michael Crowther UK Flexible Joint Modelling of Longitudinal and Time-to-Event Data

Juan Gonzalez-Maffe

UK A Bayesian Approach for the Joint Analysis of Multiple Indicators of Gingivitis Using Generalised Linear Mixed Models (GLMM)

Zebedee Jammbe

Musoro Netherlands Methods for Analyzing Data with Multiple-repeated Events and Immune Markers

Christina Yap UK Joint Modelling of Quality of Life and Survival in a Randomised Cancer Trial Data: Sensitivity of Results to Model Choice



Poster Sessions: Please see final programme for Day and Time of Presentation

Mohd Asrul Affendi Malaysia Modified Score Test for Zero-inflated Poisson Model

Mohd Asrul Affendi Malaysia Zero Inflated Poisson Regression on Mortality Rate Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) Co-Infection Patients in Malaysia

Sanjay Agarwal India Statistical Algorithm for Comparison of Protein Domains

Doug Altman UK Bias in Non-randomised Studies of Healthcare Interventions

AbuBakr Awad Egypt Using Data Mining Techniques to Explore Baseline Predictors of Response to Peg-Interferon Ribavirin in 3720 chronic HCV Egyptian Patients

Tahany Awad Denmark Using Data Mining Techniques to Develop a Prediction Model for Liver Fibrosis in Patients with Chronic Hepatitis C Virus

Tiba Baroukh France Bridging Clinical Practice and Research with the Psychotherapy Practices Based Research's Network Project : First Results

Mathieu Bastard France Latent Trajectory Model in Epidemiology: Application to the CD4 Cells Evolution of Patients on Antiretroviral Treatment

Nural Bekiroglu Turkey Comparison of Inverse Gaussian Distribution with Survival Analysis in Advanced Chronic Heart Failure Patients

John Belcher UK The Advantages of Using Binary States to Assess the Influence of Life-course Socio-economic Position on Pain Interference: Results from the North Staffordshire Osteoarthritis Project (NorStOP)

Tatiana Benaglia UK Effectiveness and Cost Effectiveness of Cytosponge Screening and Management Strategies for BarrettÆs Oesophagus

Andrea Benedetti Canada Modelling Correlated Binary Data Using Alternating Logistic Regressions

Natasa Bogavac-Stanojevic

Serbia The Bayesian Analysis of Different Models in Detection of the Coronary Artery Disease [CAS Award Winner]

Jean-Marie Boher France A New Method for Optimal Cutoff Determination Using Maximally Selected Standardized Logrank Statistic

Daniel Bratton UK When Inferiority Meets Non-inferiority: Implications for Interim Analyses

R. Che USA A Comparison of Genetic Risk Score Methods in a Case-Control Study

Rong Chu Canada Impact of Sample Size on Prognostic Imbalance and Covariate Adjustment in Randomized Controlled Trials (RCTs)

Nandini Dendukuri Canada Bayesian Meta-Analysis of Diagnostic Test Accuracy in the Absence of a Gold-Standard Reference Test

Habib Ollah Esmaily Iran Analysis of Incomplete Longitudinal Ordinal Responses with Bayesian method

Fiona Ewings UK Estimation of Optimal Dynamic Treatment Regimes in HIV-Infected Individuals: Impact of Rate of CD4 Decline, Frequency of CD4 Testing and Grace Periods



Shona Fielding UK Long Term Effects of Smoking on Hospital Admissions and Mortality in the UK

Richard Fox UK Evaluation of Methods to Adjust for Treatment Switching in Clinical Trials

Piers Gaunt UK Quality-Adjusted Survival Analysis using the Integrated Quality Survival Product: Comparison of Utilities and Profile Measures Using a Large Phase III Randomised Clinical Trial in Lung Cancer

Heloise Gauvin Canada Proportional Hazards Models for Estimating the Effect of Occupational Exposures in Case-control Studies

Salah Ghabri France An Optimal Repeated Measure Approach to Minimize Sample Size in Nutritional Human Intervention Studies

Emina Hadzibajramovic Sweden Discriminant Validity of the Stress-Energy Questionnaire (SEQ) Regarding Work and Leisure Time

Kirsten Harrild UK Predictive Capabilities of N-terminal Pro-B Type Natriuretic Peptide Levels and the Logistic EuroSCORE for Long-Term Outcome after Cardiac Surgery

Scott Harris UK Internal and External Validation: ROC Curves for Liver Biomarkers

William Havercroft UK Simulation of Time-Dependent Confounding in Marginal Models

Daniel Hercz Canada Optimal Assessment of Non-Linearity with an Application in Smoking and Lung Function in COPD Patients

Trynke Hoekstra Netherlands Patterns of Diabetes Related Primary Care Utilization and Predicting Factors: An Application of Multilevel Latent Class Analysis

Verena Hoffmann Germany Prediction of Rare Events Like Falls in Hospital Using Ensemble Methods

Mostafa Hosseini Iran Application of Parametric Time Dependent Cure Model in Analysis of Survival of CAPD Patients

Sayed Mohsen

Hosseini Pozveh

Iran Risk Score Model for Predicting Sonographic Non-alcoholic Fatty Liver Disease in Children and Adolescents

Ella Huszti USA Reflections on Analytic Strategies in ROC Chest Compressions Trial

J.S. Hwang Korea South

Mortality Associated with Adding Stereotactic Radiosurgery to Whole Brain Radiotherapy in Brain Metastases Patients with Lung Cancer History; Conventional Logistic and Instrumental Variables Approach

Thomas Jaki UK Using Change in Tumor Size in Oncology Phase II Studies

Yannan Jiang New Zealand

Stepped Wedge Design in Cluster Randomised Trials - A Systematic Review and Case Study

Pierre Joly France Estimation of Prevalence of Dementia in France in 2010 and 2030

Soodabeh Joolaee Iran Nursing FacultiesÆ Knowledge and Attitude Regarding Evidence-Based Practice (EBP)

EsmÞ Jordaan South Africa Latent Class Analysis to Assist in Identifying Schizophrenia Subtypes

Atul Juneja India Role of Tobacco in Development of Cervical Neoplasia

Tatsuo Kagimura Japan Estimation and Inference on Intraclass and Concordance Correlation Coefficients: Similarities and Differences under the ANOVA Model



Tatsuo Kagimura Japan Estimation and Inference on Intraclass and Concordance Correlation Coefficients: Asymptotic Variance of the Variance Component Estimator for Fixed Raters

Brennan Kahan UK Improper Analysis of Trials Randomized using Stratified Blocks or Minimization

Emily Karahalios Australia The Impact of Missing Data on Analyses of Time-dependent Covariates in a Longitudinal Cohort: A Simulation Study

Magdalena Kauczynska Karlsson

Norway Predicting Parkinson's disease by integrating clinical and microarray data with Canonical Partial Least Squares

Fumiaki Kobayashi Japan Statistical Evaluation of Multiple Surrogate Markers using Propensity Score

Fumiaki Kobayashi Japan New Measures of the Proportion of Treatment Effect Explained by Surrogate Markers Using the Effect Decomposition

Maria Kohl Austria Estimation of Nonlinear Interactions in Cox Regression

Michael Lauseker Germany Dependent Left Truncation in Geskus' Model for the Subdistribution Hazard of a Competing Risk - A Simulation Study

JungBok Lee Korea South

Regression Analysis of ROC Curve with Clustered Ordinal Outcomes Using a Grouped-time Survival Model

Jiri Letal Czech Republic

Combining of Logistic Regression and Time-series Analysis Approach in Evidence of Association between the Concentration of Neopterin/creatinine and Toxicity of Radiation in Patients with Head and Neck Cancer

Xiao Li Canada Variable Selection in Cox Proportional Hazards Model Based on Extended Bayes Information Criteria

Jr-Rung Lin Taiwan Statistical Evaluation of Targeted Clinical Trials with Survival Endpoints

Zhihui (Amy) Liu Canada Measuring Performance of Prognostic Models for Survival Data: Some Heuristics

Ronir Raggio Luiz Brazil A New Indicator for the Measurement of Change with Ordinal Scores

Mahasen Mabrouk Egypt Prediction of Fibrosis in Egyptian Patients with Chronic HCV Infection based on the Routine Pre-Treatment Workup

Mohammad Reza

Maracy Iran Development and Validation of a Postpartum Depression Risk Score in Delivered Women, Iran [CAS Award Winner]

A.K. Mathai India Issues Related to Categorization of Continuous Independent Variables in Multiple Logistic Regression Analysis in Epidemiological / Medical Research

Ajit Mathur India An Investigation into Socio-economic Differentials of Hypertensive Men and Women in Selected Cities of India

Reza Ali Mohammadpour Iran Estimating of Gastrointestinal Tract Cancer Mortality Rates in North of Iran by Generalized Poisson Regression Model

Veronica Moroz UK Evaluating the Impact of Differences Between Historical Control Data Used in Power Calculations and the Observed Estimates in Paediatric Oncology

Tim Morris UK An Evaluation of Multiple Imputation by Predictive Mean Matching and Local Residual Draws



Ajit Mukherjee India A Statistical Evaluation of Threshold Value of 25 (OH) D3 (Vitamin D) Below which Parathyroid Hormone (PTH) Levels Start Rising

Parvzi Nasiri Iran Estimation Parameters of Weighted Exponential Distribution

Keramat Nourijelyani Iran A Bayesian Correction for Verification Bias in Diagnostic Tests: A Practical Application

Mavis Pararai USA Modeling Underreported Counts Using the Generalized Poisson Regression Model

Hassan Pazira Iran Bayesian estimations on the minimix distribution using grouped and un-grouped data

Janet Peacock UK The Reporting of Adverse Events in RCTs of Treatment for Neuropathic Pain: Descriptive Study Based on a Systematic Review of Cost-Effectiveness

Leslie Pibouleau France Bayesian Hierarchical Meta-Analysis Model for Medical Device Evaluation

Ruth Pickering UK Questions Asked and Answered in Pilot and Feasibility Randomized Controlled Trials

Romain Pirracchio France Evaluation of the Benefit of Continuous Positive Airway Pressure (CPAP) in Acute Heart Failure: Discrepancies between two Propensity Score Approaches

Athanase Polymenis Greece An Application of Finite Mixtures for Modelling Endothelin-1 Levels in Patients with Congenital Heart Disease and Left to Right Cardiac Shunts

Edwin Amalraj

Raja UK Comparison of the Population Average and Mixed Effect Logistic Model to Examine Maternal BMI and the Risk of Stillbirth and Spontaneous Preterm Birth

Damodar Sahu India Potential Gains in Life Expectancy by Elimination of Major Cause-Specific Deaths in Selected States of India

Amal Saki Iran Survival Tree: A Method for Identifying Prognostic Factors and Subgroups in Iranian Colorectal Cancer Patients

Alexia Savignoni France Effect of a Confounder Event Occurring Over Time: Estimation and Interpretation. A Study Based on Survival Data Simulations with Application on Breast Cancer

Jan C. Schuller Belgium Please do not mix Statistical Hypotheses with Sample Size Considerations

Wolfgang Seewald Switzerland Simulations to Assess the Power of a Randomized Parallel Trial with Binary Outcome and Treatment by Site Interaction

Ali Shadrokh Iran Estimation of the Parameter of the Exponential Geometric Distribution with Presence of Outlier

Mohammad Taghi

Shakeri Iran Survival Analysis for Recurrent Event Data: Comparative Study between 'Anderson & Gill' and 'Shared Frailty' Models

Martin Sill Germany SEURAT: Interactive Visualization Software for the Integrated Analysis of Microarray Data

Ahmad Sohrabi Iran Demographic Information and Personality Profiles of Individuals Attempting Aggressive Behaviors in Public Places

Salvador Alfonso

Sanchez-De La Pena

Mexico Chrono-Pre-Metabolic Syndrome (CPMS) in Mexican Populations

Julien Stirnemann France Individual Predictions Based on Population Nonlinear Mixed Modeling: Application to Prenatal Twin Growth



Brian Tom UK Study of Fatigue in Psoriatic Arthritis Patients - A Bivariate Multi-state Modeling Approach that Allows for Intermittent Observation of Disease Activity and Fatigue

Surena Vahabi Iran Clinical Versus Statistical Significance in Postgraduate Periodontal Theses

Hannu Võhõnikkilõ Finland The Use of Time to Event Methods in Dental Research: Comparison of Five Dental Journals during 11-Year Period

Philippe Wagner Sweden Increasing Validation Efficiency in Large Registers

Kongming Wang USA Interval-censored Analysis of Progression Free Survival

Christopher Weir UK Use of Routinely Collected Data for Identification of Control Groups and Long-term Follow-up in a Case-control Study of Outcome Following Head Injury

Christina Wunder Germany Some Flexible Designs in Cancer Research: Why Needed, What Needed and What Possible?

Ram Janak Yadav India To Assess the Impact of ICDS Food Fortification in the State of Uttar-Pradesh, India

Kazue Yamaoka Japan Sensitivity Analysis for a Cluster Randomized Trial on Effects of Lifestyle Education Program for Type 2 Diabetes in Clinics

Yishen Yang Sweden Comparison of Changes in Ordered Categorical Data between Groups

Ho Ming Yuen UK Are We Relying on More Continuous Treatments for Depression? The Three Rolling 10-year Cohorts from the General Practice Research Database

Jufen Zhang UK Quality of Life and Risk of Mortality in Patients with Suspected Heart Failure

Linghua Zhou China Evaluate the Safety of Combined Vaccine


ISCB32: Ottawa, Canada: AGM Agenda

From David W. Warne

The Annual General Meeting (AGM) will be held on Wed 24 August from 1130-1330 at the ISCB32

Conference Site, Ottawa Congress Centre, Canada. The draft agenda is the following:

1 President's report

2 Treasurer's report

3 Subcommittee reports and motion for continuation:

3.1 Conference Organising

3.2 Education

3.3 Epidemiology

3.4 Membership

3.5 National Groups

3.6 Student Conference Awards

3.7 Statistics in Regulatory Affairs

3.8 Vaccines

4 Update about future ISCB meetings:

2012 Bergen, and news about

2013 Munich and

2014 Vienna.

5 Any Other Business

ALL participants of the Ottawa meeting, including newcomers to ISCB are, by definition, ISCB members

and are most welcome to attend the AGM. Please take part!


ISCB Short Course in Romania: Report

From Anca Vitcu

From 06 - 08 April 2011, the Faculty of Computer Science from “Al. I. Cuza” University of Iasi hosted

the second international ISCB course in Romania (http://thor.info.uaic.ro/~rng/).

The lectures on “Adaptive and Sequential Procedures for Clinical Trials” provided by John Whitehead

and Thomas Jaki from Lancaster University, UK covered a broad and complex sequence of issues from

classical conceptual components to their latest research outcomes. The presentations were

accompanied by attractive discussion sessions enriched with detailed examples and focused

applications. Due to videoconference facilities, the course was also attended on-line by 10 of the 28 participants from Hungary, Germany and Romania. The costs of the course were shared by ISCB

(~54%) and ISCB Romanian National Group (~40% - mainly from membership and participation fees)

with a contribution of the Faculty of Computer Science (~6%).

The cycle of ISCB international short courses in Romania started in autumn 2010 with the

presentations provided by Jenő Reiczigel and Julia Singer on “Re-sampling methods (with R)”, followed

in the spring 2011 by above-mentioned lectures. All brought a charismatic and provocative approach of challenging problems of our living world, invigorated a biostatistics research group hidden in a vibrant

IT community by illuminating ideas and encouraging alternative ways of thinking. I see it as the

beginning of a success story which involves an excellent professional, administrative and financial

collaboration among participants coming from ISCB national groups, invited lecturers, ISCB and the

Faculty of Computer Science of “Al. I. Cuza” University of Iasi.

Biostatistics Meeting in Hungary: Call for Abstracts

From Julia Singer

One of the aims of ISCB is “to promote better understanding of the use and interpretation of

biostatistics by the general public, and by national and international organizations and agencies within

the public and commercial sectors with an interest in, and/or responsibilities for, public health”. Cross-

border regional cooperation programmes may enhance the promotion of this important cause.

The ISCB national groups share the same aims as the global society, having regular internal meetings

to stimulate research on biostatistical methodology in their countries (in particular countries of Central and Eastern Europe). Territorial cooperation between national groups can facilitate solving the specific

problems of these countries which had in the 1990s a considerable handicap in the use of biostatistical

tools in clinical research.

Therefore, the national groups of three neighbouring countries (Hungary, Romania and Serbia) have

decided to organise a two-day joint meeting on 4-5 November 2011, in Szeged (the Hungarian city closest to the Romanian and Serbian border). Members of other national groups are also invited.

Key topics of the conference:

• Teaching biostatistics

• Common biostatistical errors in medical research

• Statistical modelling

• The biostatistics of genomic data

• Round-table on specific problems of national groups

Planned registration fee: no registration fee (15-20 Euros are the estimated costs of a common dinner

on Friday evening – optional)

Abstracts in the key topics are preferred, but other topics are accepted as well. Scientists should submit

the abstract of the poster/oral presentation (with indication of the preference for poster or oral presentation) to:

Julia Singer, Baxter Innovations GmbH, Global Biostatistics, IZD Tower, Wagramer Strasse 17-19,

A-1220 Vienna, AUSTRIA. Tel: +43 1 20100 3587. Fax: +43 1 20100 534.

Email: [email protected]

The closing date for applications will be 15 August 2011.

http://thor.info.uaic.ro/~rng/


ISCB GENERAL INFORMATION

Advertising Rates

The prices are:

Full A4 page: € 500

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Quarter A4 page: € 200

Additionally, we will include loose flyers with the

distribution of the newsletter at an initial handling cost

of € 500. However, if the addition of the flyers increases

the postal charges, the advertiser will also be charged

the difference in distribution costs. For further

information, please contact [email protected].

Publishing dates: Dec 2011

(and deadlines) Jun 2012

early Nov 2011

early May 2012

Adverts sent to the ISCB emailing list of

approximately 900 current and recent members:

€ 750 for 4 emails/year

€ 300 for a single email

ISCB webpage advertising:

€ 750 for one year with link from ISCB's homepage

IMPORTANT NOTE: Email Lists and Personal Information

ISCB has a strict policy not to give out any information concerning its members to any organisation which requests it. If a company wishes to send material to the members, the brochures must be sent to

the Society’s Permanent Office and News Editor for distribution with the News (see above). Alternatively,

small non-commercial announcements can be sent free of charge as an email to most members of ISCB.

Society’s Aims

The Society is organised and shall be operated for educational and scientific purposes with the following

Aims:

to stimulate research on the biostatistical principles and methodology used in clinical research;

to increase the relevance of statistical theory to clinical medicine;

to promote high and harmonised standards of statistical practice;

to work with other societies and organisations in the advancement of biostatistics;

to promote better understanding of the use and interpretation of biostatistics by the general public, and by national and international organisations and agencies within the public and commercial sectors with an interest in, and/or responsibilities for, public health; and

to provide a common forum for clinicians and statisticians through meetings, seminars and publications

Changes of Address or Email

Please inform the Permanent Office that looks after the membership and mailing list databases.

Also, if your email address changes, please inform the Office and the News Editor so that your address

is changed in the ISCB database and emailing list (googlegroup).

Information on Submitting Articles

Articles sent via email (Word, HTML or text) on almost any topic are most welcome. This is an informal

newsletter for you the readers, so please join in and make ISCB News a magazine that’s even more

interesting and fun to read.



ISCB Office & Executive Committee: Contact Details

Who SCs Address Tel: Fax: Email:

ISCB Permanent

Office

Symbion Science Park, Fruebjergvej 3 (Box 67),

DK-2100 Copenhagen Ø, Denmark

+45 2682 7970 +45 7022

1571

office@ iscb.info

Contact email for ISCB emailing list (googlegroup)

iscb@ googlegroups.com

President

Harbajan Chadha-Boreham

Epid,

Memb, SiRA

Actelion Pharmaceuticals Ltd, Department of

Biometry, Gewerbestrasse 16, CH-4123 Allschwil, Switzerland

+41 61 565 66

69

+41 61

565 64 70

Harbajan.Chadha-

Boreham@ Actelion.Com

Director Biostatistics, Department of Biometry, Actelion Pharmaceuticals Ltd., Basel, Switzerland. Main activities relate to clinical

trials and epidemiology studies with statistical methods focusing on rare diseases and evaluation of medical diagnosis tools. I have been an active member of the ISCB since1993; initially on the Statistics in Regulatory Affairs Subcommittee and later as Chair of the Local Organising Committee of ISCB23 Conference (2002), Dijon, France. I founded the ISCB Subcommittee on Conference Organising (2003) in order to help the organisers of future conferences. As member of the ISCB Membership

Subcommittee since 2005, I have been involved in initiatives to promote the ISCB. In recent years I have supported the activities of several Subcommittees, notably the formation of Epidemiology Subcommittee and hosting of the pilot workshop in Dijon by the Education Subcommittee. I have served on the ISCB Executive Committee for ten years: Ordinary Member, Secretary and Vice-

President. As President, I will facilitate exchange of experiences between past and future conference organisers, so that we can continue to offer ISCB annual conferences that have high scientific quality, are socially interesting and financially successful. I will maintain my collaboration with the ISCB Subcommittees to support their regular work and encourage new initiatives, which are important for the good functioning of our society.

Vice-President:

Koos Zwinderman

Conf,

Vacc

Academic Medical Centre, Dept. of Clinical

Epidemiology & Biostatistics, University of Amsterdam, PO Box 22660, NL-1100 DD Amsterdam, Netherlands

+31 20

5665820

+31 20

6912683

a.h.zwinderman@

amc.uva.nl

Professor of biostatistics at the department of Clinical Epidemiology, Biostatistics and Bioinformatics at the Academic Medical Center of the University of Amsterdam in Netherlands. I was trained as a mathematician and psychologist at the university of Groningen (Netherlands) and obtained my PhD at the University of Nijmegen (Netherlands). My thesis concerned consistency of estimators and goodness of fit tests of a variant of the random-effects logistic regression model. My biostatistical interests are-

amongst others-statistical genetics, repeated measures and monitoring, clinical trials, and meta-analysis, and I was involved in numerous clinical trials and epidemiological research projects. I have been a member of ISCB for over 15 years, was member of the organising committee of the Leiden conference in 2004, and was a member of the ExCom for the period 2003-2006, and ISCB treasurer 2006-2008. As treasurer I would like to proceed to monitor the financial situation of the Society and help organizing

successful scientific conferences that are sufficiently profitable to carry on the Society’s work.

Secretary and News Editor: David W. Warne

Conf, Memb

Chemin du Petit-Bel-Air 115, CH-1226 Thônex, Switzerland

+41 22 700 63 80


Associate Director Biostatistics, Merck Serono, Geneva, Switzerland. Over the last 16 years, my main activities in medical statistics involved designing clinical development projects, and the design, conduct, analysis and reporting of clinical trials in infertility. I am especially interested in non-inferiority and equivalence studies and in the practical aspects of clinical trials such as randomisation and use of Bayesian methods. I’ve recently moved into a new role focussing on processes, quality and

outsourcing. I joined ISCB in 1992 as Newsletter Editor and have attended all the annual meetings from 1993 and taken part in most of the Executive Committee meetings over the last 18 years. As well as editing almost 40 issues of the ISCB News, I was chair of the Communications Subcommittee from 1999-2007 and run the Society’s emailing list. I have been a member of the Subcommittees on Conference Organising since 2004 and Membership since 2007. I was the chair of the Local Organising

Committee of ISCB27 in Geneva in 2006. In 2007, I was honoured to be made a Life Member of ISCB. As Secretary, I look forward to continue helping with the organisational aspects of the Society and its annual meetings and, as an Officer of the ExCom, I would like to help ISCB maintain its reputation for providing highly successful annual meetings and courses.

Treasurer: KyungMann Kim

Memb, SCA

Department of Biostatistics and Medical Informatics, University of Wisconsin School of

Medicine and Public Health, 600 Highland Ave, K6/438 CSC, Madison, WI 57392-4675, USA

+1 608 265 6380

+1 608 265 5579

kyungmannkim@ wisc.edu

Professor of Biostatistics and Statistics, University of Wisconsin-Madison and Director of Biostatistics Shared Resource,

University of Wisconsin Carbone Cancer Center. His current area of research includes sequential analysis, clustered data analysis and clinical cancer research. He has been a member of the Society since 1998. He served as an elected member of the ISCB Executive Committee during 2006-2010 and as a member and chair of the Student Conference Award Subcommittee during 2006-2010 and a member of the Membership Subcommittee during 2007-2010. He is very active in professional services to the

U.S. National Institutes of Health (NIH) and as data monitoring committee member on many NIH- and industry-sponsored clinical trials in various diseases.


ISCB Office and Executive Committee: Contact Details (continued)

Who SC Address Tel: Fax: Email:

Past-President 2011: Norbert Victor

Webmaster:

Ingrid Sofie Harbo Memb

H. Lundbeck A/S, Ottiliavej 9, DK-2500 Valby,

Denmark

+45 3643

2004

+45 3643

8263

INSH@

lundbeck.com

Michal Abrahamowicz

Epid, Memb

Division of Clinical Epidemiology, McGill University Health Centre (MUHC), Royal Victoria Hospital, 687 Pine Avenue West, V-Pavilion, Room V2.20A, Montreal, QC H3A 1A1, Canada

+1 514 934 1934, ext. 44712

+1 514 934 8293

michal@ epimgh.mcgill.ca

Lucinda Billingham Conf, Memb

Cancer Research UK Clinical Trials Unit, University of Birmingham, UK

+44 121 414 3790

+44 121 414 3700

L.J.Billingham@ bham.ac.uk

Krisztina Boda Educ

Department of Medical Physics and Informatics,

University of Szeged, H-6720 Szeged, Korányi fasor 9, Hungary

+36 62 545 079

+36 62 544 566

boda@ dmi.u-szeged.hu

Tomasz

Burzykowski

Educ,

SCA

I-BioStat, Hasselt University, Agoralaan D, B-

3590 Diepenbeek, Belgium

+32 11

268243

+32 11

268299

tomasz.burzykowski

@ uhasselt.be

Lutz Edler Conf Am Schafgarten 27, D-67373 Dudenhofen, Germany

+49 6232 289 0991

+49 6232 289 0867

edler@ dkfz-heidelberg.de

Catherine Legrand Vacc

Institute of Statistics, Biostatistics and Actuarial Sciences (ISBA), Université catholique de Louvain, 20 Voie du Roman Pays, B-1348 Louvain-la-Neuve, Belgium

+32 10 478798

+32 10 473032

catherine.legrand@ uclouvain.be

Saskia Le Cessie Vacc Clinical Epidemiology/Medical Statistics and Bioinformatics, LUMC, C-7, Postbus 9600, NL-2300 RC Leiden, Netherlands

+31 71 526 2124

- S.le_Cessie@ lumc.nl

Zdenek Valenta Conf, NG

Institute of Computer Science AS CR, Pod Vodarenskou vezi 2, 182 07 Prague, Czech Republic

+420 266 052 094

+420 286 581 453

zdenek.valenta@ fulbrightmail.org

ISCB Membership and Googlegroups Emailing Lists

From Rita Schou (ISCB Office) and David W. Warne (Googlegroups Administrator)

We try to make sure our membership database (in Denmark)

is kept up to date.

We also have an electronic mailing list called iscb@ googlegroups.com, which allows members from the current and past years to be contacted to discuss statistical

ideas and to receive news about ISCB events.

From time to time we compare the 2 databases and if we find you’ve got 2 email addresses, we’ll ask which you prefer.

If you haven’t done so already, please send us your email

address to allow us to contact you more easily.

If you’ve sent us your email, but haven’t accepted the invitation to join the iscb googlegroup, please accept the next invitation by pressing Reply-Send.

Rest assured that no company will send you any junk email – all emails are checked by the Office or the Googlegroup Administrator.


ISCB Subcommittees: Contact Details

Please contact the chairs/secretaries of these subcommittees for further information. (*=President’s Representative)

Title & Email Terms of Reference Members Email addresses

Conference Organising iscb-conf-org@

googlegroups.com

1. Bring together ISCB conference organisers or ISCB members who have an interest in sharing and passing on their knowledge and experience to help

future ISCB conference organisers. 2. Document processes and systems for assisting ISCB conference organisers. 3. Review and update the documents

whenever necessary and promote their usage for improving the procedures or meetings.

Chair:

1. *David W. Warne (CH) david_w_warne@ bluewin.ch

Secretary:

2. Lutz Edler (DE) edler@ dkfz-heidelberg.de

Members:

3. Lucinda Billingham (GB) L.J.Billingham@ bham.ac.uk

4. Bjarne Bodin (DK) bb@ biostata.com

5. Christel Castelli (FR) christel.castelli@ chu-nimes.fr

6. Geir Egil Eide (NO) geir.egil.eide@ helse-bergen.no

7. Ulrich Mansmann (DE) mansmann@ ibe.med.uni-muenchen.de

8. Tim Ramsay (CA) tramsay@ ohri.ca

9. Michael Schemper (AT) michael.schemper@ meduniwien.ac.at

10. Zdenek Valenta (CZ) zdenek.valenta@

fulbrightmail.org

11. Koos Zwinderman (NL) a.h.zwinderman@ amc.uva.nl

Education iscb-education@ googlegroups.com

To support and organise one or two day courses on contemporary methods in clinical biostatistics in locations represented by the Society. Guidelines

and a list of courses offered in the past are available.

Chair:

1. Catherine Quantin (FR) catherine.quantin@ chu-dijon.fr

Secretary:

2. Jeno Reiczigel (HU) reiczigel.jeno@ gmail.com

Members:

3. *Krisztina Boda (HU) boda@ dmi.u-szeged.hu

4. Tomasz Burzykowski (BE) tomasz.burzykowski@ uhasselt.be

5. Mike Campbell (GB) m.j.campbell@ sheffield.ac.uk

6. Eric Cobo (ES) erik.cobo@ upc.edu

7. Rumana Omar (GB) Rumana@ stats.ucl.ac.uk

8. Elisabeth Svensson (SE) elisabeth.svensson@ oru.se

9. Jean-

Christophe Thalabard (FR)

jean-christophe.thalabard@

mi.parisdescartes.fr

10. Maria Grazia Valsecchi (IT) grazia.valsecchi@ unimib.it

11. Norbert Victor (DE)

Epidemiology

iscb-epidemiology@ googlegroups.com

1. Advise the Scientific Programme Committee of the annual

ISCB meetings, if needed, on relevant topics in epidemiology for establishing invited sessions and choosing invited speakers.

2. Establish connections with Epidemiological Societies and organise mutual sessions, courses or workshops at our conferences or elsewhere.

3. Generate awareness and discussions in the Society of guidelines for conducting, analysing and reporting epidemiological studies.

Chair:

1. Vana Sypsa (GR) vsipsa@ med.uoa.gr

Secretary:

2. Marie Reilly (SE) marie.reilly@ ki.se

Members:

3. *Michal Abrahamowicz (CA)

michal@ epimgh.mcgill.ca

4. *Harbajan Chadha-

Boreham (CH)

Harbajan.Chadha-Boreham@

Actelion.Com

5. Adriano Decarli (IT) adriano.decarli@ unimi.it

6. Geir Egil Eide (NO) geir.egil.eide@ helse-bergen.no

7. Catherine Klersy (IT) Klersy@ smatteo.pv.it

8. Elaine Pascoe (AU) elaine_pascoe@ yahoo.com.au

9. Catherine Quantin (FR) catherine.quantin@ chu-dijon.fr

10. Tim Ramsay (CA) tramsay@ ohri.ca

11. Willi Sauerbrei (DE) wfs@ imbi.uni-freiburg.de

12. Ewout Steyerberg (NL) E.Steyerberg@ erasmusmc.nl

13. Stephen Walter (CA) walter@ mcmaster.ca

Membership Iscb-membership@ googlegroups.com

To explore strategies to increase the ISCB membership by means of:

1. Highlighting the unique position of the ISCB, i.e.

bringing together clinicians, methodologists, epidemiologists and biostatisticians

2. Make strategic links with medical and

epidemiological societies in order to make publicity at

their meetings and bring clinicians/epidemiologists with a methodological/biostatistical interest to our

ISCB meeting

3. Widen the geographical spread of the ISCB members

4. Ensure the regeneration of our current core

membership. 5. Provide guidelines for future conference organisers

on choosing a scientific programme committee that

will help in widening membership 6. To consider the future of the Newsletter, including

ways to support the Editor, procedures for transition

of editorship.

7. To maintain the ISCB homepage on the World Wide Web and facilitate placement of annual meeting

information on the homepage.

8. To consider other communications with members, such as through email or the World Wide Web.

Chair:

1. Lucinda Billingham (GB) L.J.Billingham@ bham.ac.uk

Secretary:

2. David W. Warne (CH) david_w_warne@ bluewin.ch

Members:

3. Michal Abrahamowicz (CA) michal@ epimgh.mcgill.ca

4. Bjarne Bodin (DK) bb@ biostata.com

5. Harbajan Chadha-

Boreham (CH)

Harbajan.Chadha-Boreham@

Actelion.Com

6. *Ingrid Sofie Harbo (DK) INSH@ lundbeck.com

7. KyungMann Kim (US) kyungmannkim@ wisc.edu

8. Emmanuel Lesaffre (BE) e.lesaffre@ erasmusmc.nl

9. Toshiro Tango (JP) tango@ niph.go.jp

10. Maria Grazia Valsecchi (IT) grazia.valsecchi@ unimib.it

11. Giota Touloumi (GR) gtouloum@ med.uoa.gr



How to Contact the ISCB Subcommittees (continued)

Title & Email Terms of Reference Members Email addresses

National Groups

Iscb-national-groups@ googlegroups.com

1. To help those who are interested in

forming a National Group through the approval process. 2. To review the arrangements with the current National Groups, specifically

regarding financial matters. 3. To set rules and standards for funding of ISCB members of National Groups and others from countries with

exchange control restrictions or barriers. 4. The Subcommittee administers the Conference Awards for Scientists for the annual ISCB meetings.

Chair:

1. Julia Singer (AT) julia_singer@ baxter.com

Secretary:

2. Stanislav Katina (GB) stanislavkatina@ hotmail.com

Members:

3. Simon Day (GB) simon.day@ roche.com

4. Gordana Jovic (GB) goj@ ctu.mrc.ac.uk

5. Ewa Kawalec (PL) mxkawale@ cyf-kr.edu.pl

6. Elisabeth Svensson (SE) elisabeth.svensson@ oru.se

7. *Zdenek Valenta (CZ) zdenek.valenta@ fulbrightmail.org


9. John Whitehead (GB) j.whitehead@ lancaster.ac.uk

Statistics in Regulatory Affairs iscb-reg-aff@

googlegroups.com

The subcommittee on Regulatory Affairs will review, comment upon and seek to influence the development of regulatory requirements, guidelines and other

documents concerning the scientific aspects of data generation, collection, management, analysis, and reporting. In general, the subcommittee will seek out

and handle all regulatory issues in the name of the Society with the approval of the President or in his/her absence, the Vice-President.

Chair:

1. Christoph Gerlinger (DE) christoph.gerlinger@ bayer.com

Secretary: TBD

2. Christos Nakas (GR) cnakas@ gmail.com

Members:

3. Harbajan Chadha-Boreham (CH)

Harbajan.Chadha-Boreham@ Actelion.Com

4. *Lutz Edler (DE) edler@ dkfz-heidelberg.de

5. Tim Friede (DE) tim.friede@ med.uni-

goettingen.de

6. Jen-Pei Liu (TW) jpliu@ ntu.edu.tw

7. Martin Schumacher (DE) ms@ imbi.uni-freiburg.de

8. Jørgen Seldrup (FR) Jorgen.seldrup@ quintiles.com

Student Conference Awards iscb-stud-conf-awrd@

googlegroups.com

Student conference awards are available for registered postgraduate students to attend the annual conference and present a paper. The Subcommittee

shall receive submissions, judge them, and administer the awards. The rules and procedures are announced in a timely issue of the Newsletter and on the

ISCB annual conference webpage.

Chair:

1. Ulrich Mansmann (DE) mansmann@ ibe.med.uni-muenchen.de

Secretary:

2. Nadine Grambauer (DE) nadine.grambauer@

imbi.uni-freiburg.de

Members:

3. Carl-Fredrik Burman (SE) carl-fredrik.burman@ astrazeneca.com

4. *Tomasz Burzykowski (BE) tomasz.burzykowski@

uhasselt.be

5. KyungMann Kim (US) kyungmannkim@ wisc.edu

6. Katherine Lee (AUS) katherine.lee@ mcri.edu.au

7. Dimitris Rizopoulos (NL) d.rizopoulos@ erasmusmc.nl

8. Vana Sypsa (GR) vsipsa@ med.uoa.gr

9. Jean-Christophe Thalabard (FR)

jean-christophe.thalabard@ mi.parisdescartes.fr

Vaccines iscb-vaccines@

googlegroups.com

Please see www.iscb-vaccines.info

1. Create a professional platform for statisticians active in the research on vaccines.

2. Discuss new regulatory guidelines and comment upon draft guidelines, in collaboration with the subcommittee on

Statistics in Regulatory Affairs. 3. Keep up-to-date, discuss, apply and encourage relevant statistical and methodological developments.

4. Encourage professional development. 5. Organize symposia in the annual ISCB meetings or in collaboration with ISCB on methodological developments in

vaccines research.

Chair:

1. Jos Nauta (NL) jos.nauta@ abbott.com

Secretary:

2. Jingyee Kou (US) jingyee.kou@ fda.hhs.gov

Members:

3. Andrew Dunning (US) andrew.dunning@ sanofipasteur.com

4. Ivan Chan (US) ivan_chan@ merck.com

5. Yin Bun Cheung (SG) yinbun.cheung@ scri.edu.sg

6. Allen Izu (US) allen.izu@ novartis.com

7. Catherine Legrand (BE) catherine.legrand@ uclouvain.be

8. Saskia Le Cessie (NL) S.le_Cessie@ lumc.nl

9. Zoe Moodie (US) zoe@ scharp.org

10. Lawrence Moulton (US) lmoulton@ jhsph.edu

11. Jennifer Nelson (US) nelson.jl@ ghc.org

12. Julia Singer (AT) julia_singer@ baxter.com

13. Fabian Tibaldi (BE) fabian.s.tibaldi@ gskbio.com

14. *Koos Zwinderman (NL) a.h.zwinderman@ amc.uva.nl

http://www.iscb-vaccines.info/


ISCB Membership Information

The International Society for Clinical

Biostatistics (ISCB) was founded in 1978 to

stimulate research into the principles and

methodology used in the design and analysis of clinical research and to increase the relevance of

statistical theory to the real world of clinical

medicine.

The ISCB organises an annual scientific meeting

which members and non-members are able to

attend. The main objective of the annual scientific meetings is to create an opportunity for

the exchange of knowledge, experience and ideas

among clinicians, statisticians and members of

other disciplines, such as epidemiologists,

clinical chemists and clinical pharmacologists, working or interested in, the field of clinical

biostatistics.

The scientific meetings cover a broad spectrum

of biostatistical interests and regularly include

sessions on the design and analysis of clinical

trials, epidemiology and statistical methodology, as well as from time to time considering more

specialist issues such as, for example, education

of biometricians and biometrics users,

pharmacokinetics, medical data-bases and

pharmaco-epidemiology.

Meetings in recent years have been held in

Leiden (2004), Szeged (2005), Geneva (2006),

Alexandroupolis (2007), Copenhagen (2008),

Prague (2009) and Montpellier (2010). The next

meeting will be held in Ottawa (2011). A

selection of talks at the meetings, for which papers are submitted for review and which are

eventually accepted, are published in Statistics

in Medicine. The ISCB benefits from a special

journal concession from John Wiley & Sons

Limited, the publishers of Statistics in Medicine, so that members are able to subscribe to the

journal at a preferential rate.

The ISCB also organises courses to cover

particular statistical topics. These are run to

precede or follow on from the annual scientific

meeting and are given by the foremost researchers in the field.

The composition of the Executive Committee (ExCom) for 2011 is as follows:

Officers:

President: Harbajan Chadha-Boreham (CH),

Vice-President: Koos Zwinderman (NL),

Secretary/: David W. Warne (CH),

News Editor Treasurer: KyungMann Kim (US),

Members: Past-President: Norbert Victor (DE),

Webmaster: Ingrid Sofie Harbo (DK),

Members: Michal Abrahamowicz (CA), Lucinda Billingham (GB),

Krisztina Boda (HU),

Tomasz Burzykowski (BE),

Lutz Edler (DE),

Catherine Legrand (BE),

Saskia Le Cessie (NL), Zdenek Valenta (CZ).

The Annual General Meeting of the ISCB is

organised to coincide with the scientific meeting.

Membership of the Society is drawn from around

40 countries worldwide and the number of

members is about 900.

The ISCB also has special Subcommittees dealing with particular aspects of biostatistics.

The Society publishes a Newsletter twice

a year. The ISCB News editor is David W. Warne,

Chemin du Petit-Bel-Air 115, CH-1226 Thônex,

Switzerland. Items for inclusion in the

Newsletter should be sent to him via email to:


Membership of the Society is open to all with an

interest in biostatistics. The current annual (to

31 December 2011) Ordinary membership fee is

€40. The Full-time Student Membership fee is

€20.

Applications for membership should be sent to:

ISCB Permanent Office

Symbion Science Park

Fruebjergvej 3 (Box 67)

DK-2100 Copenhagen Ø

Denmark

Tel: +45 2682 7970

Fax: +45 7022 1571

email: office@ iscb.info

www: www.iscb.info

http://www.iscb.info/


ISCB Membership Subscription

INTERNATIONAL SOCIETY FOR CLINICAL BIOSTATISTICS

2011 Membership Subscription

Surname: First name:

Title (Prof/Dr/etc): Post held:

Institute/Company:

Address:

Post code and country:

Phone No.: E-mail:

Fax No.: Please provide your email address as it will be used to send you the ISCB News in the future, and for voting.

SUBSCRIPTION: Ordinary membership of ISCB (to 31 December 2011): Euros (EUR) 40.00

(please tick one only) Full-time Student Member- of ISCB (to 31 Dec. 2011): Euros (EUR) 20.00

(students should provide a letter from their supervisor or head of department)

Have you previously been a member of ISCB?

PAYMENT IS MADE BY:

Credit Card Authorisation:

Signature: Date:

Your name on the credit card: Card number to debit (16 digits): Validation code (3 digits)

CVC/CVV:

Expiry date (MM/YY):

Cheque/Money Order:

A cheque made payable in Euros – drawn on a bank in the United Kingdom

A Money Order

Cheque / Money Order No. (if known): Date sent:

Cheques must be made payable to the International Society for Clinical Biostatistics and returned with this form to the

Permanent Office address. Note: Non-Euro cheques, bank cheques not drawn on a U.K. bank, and cheques not made payable to ISCB will be

returned.

Bank Transfer:

Please transfer direct to: Barclays Bank plc PO Box 69 121 Queen Street

Cardiff CF1 1SG UK

Euro Account No. 6687 4511

Bank Sort Code: 20-18-15

IBAN: GB28 BARC 2018 1566 8745 11

SWIFT/BIC: BARCGB22

Please return this form either by e-mail to: [email protected]

or by post to: ISCB Permanent Office Symbion Science Park

Fruebjergvej 3 (Box 67) DK-2100 Copenhagen Ø Denmark

Tel: Fax:

+45 2682 7970 +45 7022 1571


Calendar

21-25 August 2011 Ottawa, Canada

ISCB32 Info: web: www.iscb2011.info, email: ISCB2011@ nrc-cnrc.gc.ca

19-23 August 2012 Bergen, Norway

ISCB33 Info: web: www.iscb2012.info, email: mail @kongress.no

25-29 August 2013 Munich, Germany

ISCB34

ISCB is affiliated to ISI. For the latest conference information, see: isi.cbs.nl/calendar.htm

Jul 24 - 29

2011 International Conference on Statistics and Management Engineering Website:

http://www.iismes.org/indexen.jsp

Jul 25 - 28

6th Annual International Symposium on Economic Theory, Policy and Applications. Website:

www.atiner.gr/economics.htm

Jul 30 -

Aug 4

Joint Statistical Meeting, organized by the American

Statistical Association and to be held at the South Beach Convention Center, Miami Beach, Florida. Website: www.amstat.org/meetings

Aug 1 - 5 Conference in Honour of Søren Asmussen - New Frontiers in Applied Probability. The conference

honours one of the leading researchers in applied probability, Søren Asmussen, on the occasion of his

65th birthday. Location: Sandbjerg Estate, Sønderborg, Denmark. Information: Oddbjørg Wethelund, Thiele Centre, Aarhus University, Denmark. Organizers: Thomas Mikosch (Chair),

Copenhagen, Peter W. Glynn, Stanford, Tomasz Rolski, Wroclaw, Reuven Rubinstein, Haifa. Phone: +45 8942 3515. E-mail: [email protected] Website: www.thiele.au.dk/asmussen

Aug 4 - 6 17th ISSAT International Conference on Reliability & Quality in Design Location: Vancouver, B.C.,

Canada Information: Conference Secretary E-mail: [email protected] Website: www.issatconferences.org

Aug 11 - 13

IASS Satellite Meeting on Small Area Estimation,

Trier, Germany This is a Satellite meeting to the 2011 ISI World Statistics Congress. Website: http://sae2011.surveystatistics.net/

Aug 15 - 18

SARMA/ TIES workshop on visualization of climate data, Reykjavík, Iceland This is a Satellite meeting to

the 2011 ISI World Statistics Congress. Website: http://www.nrcse.washington.edu/NordicNetwork/visual.html

Aug 16 - 18

useR! 2011 Location: University of Warwick,

Coventry, UK A conference centred on the use of R for data analysis and statistical computing. The conference schedule comprises invited lectures and

user-contributed sessions. In addition half-day tutorials presented by R experts will run on Aug 15, 2011, prior to the conference. E-mail: [email protected] Website: www.R-

project.org/useR-2011

Aug 17 - 19

Dynamic Statistical Models in the framework of the Statistics Program of Excellence; Statistical methods for complex and high dimensional models - Bernoulli

Society Satellite meeting to the 2011 ISI World Statistics Congress. Location: University of

Copenhagen, Copenhagen, Denmark Website: http://statistics.ku.dk/isi-satellite/

Aug 18 -

19

IASE 2011 Satellite meeting on Statistics Education and Outreach. Satellite meeting to the 2011 ISI

World Statistics Congress. Location: Dublin, Ireland Website: http://isi-web.org/root/wsc2011-call-abstracts-iase

Aug 19 - 21

2011 ISI Young Statisticians Meeting (YSI 2011) -

Satellite meeting to the 2011 ISI World Statistics

Congress. YSI 2011 seeks to promote the active participation of early career statisticians in the epicentre of the ISI World Congress. Poster Funding is in some cases possible Website:

www.isi2011.ie/content/sat-meetings/ysi.html

Aug 21 - Aug 25

The 32nd Annual Conference of the International Society for Clinical Biostatistics will take place

in Ottawa, Ontario, Canada. Information: Tim Ramsay 613-737-8899 x79380 613-739-6266 E-mail: [email protected] Website: www.ohri.ca

Sep 5 - 9 17th European Young Statisticians Meeting, Lisbon,

Portugal. The aim is to provide a scientific forum for the next generation of European researchers in

probability theory and statistics. The meeting will gather about 40 participants coming from about 20 European countries. Participants are less than 30 years old or have 2 to 8 years of research

experience. They are chosen by invitation only in a uniformly distributed way in Europe (2 participants per country). Information: Paulo Canas Rodrigues Phone: +351 936 110 338 E-mail:

[email protected] Website: http://www.fct.unl.pt/17eysm/

Sep 6 - 9 IASC -ERS Summer School 2011: Robust Methods for Advanced Data Structures Location: Leuven

(Belgium) Website: http://wis.kuleuven.be/Events/IASC2011/

Sep 25 - 30

Optimal Design of Experiments - Theory and Application International Conference in Honor of the

late Jagdish Srivastava, Location: Vienna, Austria

Information: Prof. Dieter Rasch ([email protected])

2012: Jul

28 - Aug 2

2012 Joint Statistical Meetings. To be held at the San

Diego Convention Center, San Diego, California. Website: http://www.amstat.org/meetings/jsm.cfm

2012:

Aug 19 – 23

33rd Annual Conference of the International

Society for Clinical Biostatistics Venue: Grieg

Hall, Bergen, Norway The conference will provide a scientific forum for international exchange of theory, methods and applications of biostatistics

in medical research and practice among clinicians, statisticians and members of other disciplines, such as epidemiologists, clinical chemists and clinical pharmacologists, working

or interested in the field of clinical biostatistics. E-mail: [email protected] SPC: [email protected] LOC: [email protected]

2013: Jul 20 - 25

29th European Meeting of Statisticians. To be held in

Budapest, Hungary. Website:

http://www.math.elte.hu/probability/markus/EMS2013.html

2013:

Aug 3 – 8

2013 Joint Statistical Meetings. To be held at the

Montreal Convention Center, Montreal Quebec, Canada. Website: http://www.amstat.org/meetings/jsm.cfm

2013: Aug 25 –

29

ISCB34. Munich, Germany

http://isi.cbs.nl/calendar.htm

http://www.iismes.org/indexen.jsp

http://www.atiner.gr/economics.htm

http://www.amstat.org/meetings


http://www.thiele.au.dk/asmussen


http://www.issatconferences.org/

http://isi.cbs.nl/calendar.htm#ISI2011

http://sae2011.surveystatistics.net/


http://www.nrcse.washington.edu/NordicNetwork/visual.html

http://www.nrcse.washington.edu/NordicNetwork/visual.html



http://www.r-project.org/useR-2011

http://www.r-project.org/useR-2011



http://statistics.ku.dk/isi-satellite/



http://isi-web.org/root/wsc2011-call-abstracts-iase

http://isi-web.org/root/wsc2011-call-abstracts-iase



http://isi-web.org/news/2011March-WSC-YSI-Poster.pdf

http://isi-web.org/news/wsc2011-support-for-young-african-statisticians

http://isi-web.org/news/wsc2011-support-for-young-african-statisticians

http://www.isi2011.ie/content/sat-meetings/ysi.html


http://www.ohri.ca/


http://www.fct.unl.pt/17eysm/

http://wis.kuleuven.be/Events/IASC2011/


http://www.amstat.org/meetings/jsm.cfm






http://www.amstat.org/meetings/jsm.cfm

Documents

International Society for Clinical News Biostatistics - ISCB · International Society for Clinical Biostatistics News Number 51 June 2011 Editor: David W. Warne Executive Committee