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WEIZMANN INSTITUTE OF SCIENCE Introducing New Scientists 2015-2016

Introducing WEIZMANN INSTITUTE OF SCIENCE New Scientists ...€¦ · PROF. URI BADER DEPARTMENT OF MATHEMATICS Finding symmetry amidst disorder In chemistry, for instance, imagine

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Page 1: Introducing WEIZMANN INSTITUTE OF SCIENCE New Scientists ...€¦ · PROF. URI BADER DEPARTMENT OF MATHEMATICS Finding symmetry amidst disorder In chemistry, for instance, imagine

WEIZM

ANN

INSTITUTE O

F SCIENCE

IntroducingNew Scientists2015-2016

Page 2: Introducing WEIZMANN INSTITUTE OF SCIENCE New Scientists ...€¦ · PROF. URI BADER DEPARTMENT OF MATHEMATICS Finding symmetry amidst disorder In chemistry, for instance, imagine

Introducing New Scientists 2015-2016

Table of contents

Page 3: Introducing WEIZMANN INSTITUTE OF SCIENCE New Scientists ...€¦ · PROF. URI BADER DEPARTMENT OF MATHEMATICS Finding symmetry amidst disorder In chemistry, for instance, imagine

5 INTRODUCTION

Recruitingthebest

6 DEPARTMENT OF MATHEMATICS

Prof.UriBader Findingsymmetryamidstdisorder

8 DEPARTMENT OF PARTICLE PHYSICS AND ASTROPHYSICS

Dr.ShikmaBressler Beyondthestandardmodel

10 DEPARTMENT OF MATHEMATICS

Dr.RonenEldan Workinginhighdimensions

12 DEPARTMENT OF MATERIALS AND INTERFACES

Dr.MichalLeskes Theinnerlifeofbatteries

14 DEPARTMENT OF ORGANIC CHEMISTRY Dr.NirLondon Anewkindofdrugdiscovery

16 DEPARTMENT OF PHYSICS OF COMPLEX SYSTEMS

Prof.VictorMalka Beamsofpromise

18 DEPARTMENT OF STRUCTURAL BIOLOGY

Dr.RinaRosenzweig Cellularhousekeeping

20 DEPARTMENT OF COMPUTER SCIENCE AND APPLIED MATHEMATICS

Dr.GuyRothblum Keepingdataprivate

Introducing New Scientists 2015-2016 is published by

the Department of Resource Development

at the Weizmann Institute of Science

P.O. Box 26, Rehovot, Israel 76100

Tel: 972 8 934 4582

e-mail: [email protected]

Design and production: Dina Shoham Design

Photography: Itai Belson and Ohad Herches

of the Weizmann Institute Photo lab;

Niall David Photography; Joshua Touster

Page 4: Introducing WEIZMANN INSTITUTE OF SCIENCE New Scientists ...€¦ · PROF. URI BADER DEPARTMENT OF MATHEMATICS Finding symmetry amidst disorder In chemistry, for instance, imagine

5

The costs run from about $300,000 to

support a theoretical scientist who needs

only computers and help for recruiting

graduate student researchers to several

million dollars for an experimentalist with

a large team and specialized equipment.

The price tag for this year’s new

scientists in terms of their start-up costs

is more than $20 million combined, the

largest sum yet for an incoming group of

new recruits.

We are grateful for the generosity

of our robust community of supporters

around the world who make it possible to

supply our new scientists with everything

they need to start and operate their new

labs—which translates into the freedom to

explore and investigate, and answer key

questions in science that hold meaning

for all of us.

Sincerely,

Prof. Daniel Zajfman

President, Weizmann Institute of Science

INTRODUCTION

Recruiting the bestDear Friends,

The Weizmann Institute of Science

looks for promising researchers who

are rising stars in their fields and who

are pioneering radical new directions

in science. Typically these are

young scientists who are completing

postdoctoral studies abroad and have just

begun their academic careers. Sometimes

we are fortunate to recruit a veteran

scientist who is an established leader in

his or her field. Prof. Victor Malka, who

joins our Department of Particle Physics

and Astrophysics this year is one such

example. Prof. Uri Bader joins us from the

Technion and is another example.

It is the people behind the science who

drive scientific excellence—so when the

Weizmann Institute was ranked 10th in the

world for research quality in the highly

regarded Leiden University ranking earlier

this year, we had our scientists to thank.

Among the many surveys out there, this

survey holds great importance because

it is based on citation data of published

papers, which reflects the quality of the

papers—essentially, their impact. This

rank reflects a significant rise in impact of

Weizmann Institute of Science research.

This year, 13 new recruits are joining

us, including three who begin work

here in 2016. Their quality is absolutely

outstanding, as I trust you will see from

reading their profiles.

To help a scientist establish a new

lab, the Weizmann Institute offers a

commitment of three or more years of

research funding and new equipment.

22 DEPARTMENT OF BIOLOGICAL CHEMISTRY

Dr.RuthScherz-Shouval Discoveringcancer’sdirtytricks

24 DEPARTMENT OF MOLECULAR GENETICS

Dr.SchragaSchwartz MappingRNA

26 DEPARTMENT OF IMMUNOLOGY

Dr.LiranShlush,MD Trackingdownrecurringcancers

28 DEPARTMENT OF IMMUNOLOGY

Dr.ZivShulman Makingstrongerantibodies

30 DEPARTMENT OF NEUROBIOLOGY

Dr.IvoSpiegel Nature-versus-nurture?

32 Newscientistfundsandgifts

Page 5: Introducing WEIZMANN INSTITUTE OF SCIENCE New Scientists ...€¦ · PROF. URI BADER DEPARTMENT OF MATHEMATICS Finding symmetry amidst disorder In chemistry, for instance, imagine

6 7

Uri Bader grew up on Kibbutz Givat

Haim Meuchad and received his BSc

summa cum laude from the Technion-

Israel Institute of Technology in

1999 and his PhD in mathematics

from the Technion in 2004. He was

an instructor at the University of

Chicago from 2004 to 2007 and

joined the Technion’s faculty in 2007.

He joins the Weizmann Institute

in 2015.

He received the Technion

mathematics faculty prize for

excellent PhD theses, the Wolf Prize

for excellent PhD students, the Haim

Hanany Prize, the Elisha Nethaniayhu

Prize, and the Technion Excellency in

Teaching Award.

He is married to Galit and they

have four children: a girl and three

boys of ages ranging from 4 to 16.

Prof. Uri Bader

randomness. And the building blocks

of Number Theory are the primes

(2,3,5,7,11...) but the list of prime numbers

behave like a random system too.

All mathematical systems involve a

tension between order and disorder.

Algebra is the mathematical theory

which describes so-called “ordered

systems”. And Group Theory describes

symmetric systems. But on the flip side,

Analysis describes so-called “overly

complicated systems”. And Measure

Theory describes disordered systems.

In his research, Prof. Bader studies the

relationship between the two extremes

of disorder and order: symmetric

patterns in disordered systems, which

has relevance to many areas of math and

science from a theoretical standpoint.

Says Prof. Bader, “I always knew I

would be a scientist, and in fact from

an early age I was attracted especially

to math, though as a child I was not

aware that this is an actual option as a

profession! I am very pleased that I have

found my place to do interesting work.”

PROF. URI BADER DEPARTMENT OF MATHEMATICS

Finding symmetry amidst disorder

In chemistry, for instance, imagine gas

in a container. Tracking every atom

of the gas is beyond the power of any

computer, yet it is reasonably easy to

describe the behavior of the system

as whole in statistical terms. Another

example: In geometry, the famous number

pi (=3.1415...) is very explicit: It is the ratio

between the circumference of a circle

and its diameter. Yet the decimal digits

of it behave in a seemingly complete

Some mathematicians get excited by two seemingly contradictory phenomena: the overwhelming complexity of nature on the one hand, and the unexpected amenability of nature to be described in simple laws. For Prof. Uri Bader, this tension between disorder and order is a driving force behind his curiosity about math.

Page 6: Introducing WEIZMANN INSTITUTE OF SCIENCE New Scientists ...€¦ · PROF. URI BADER DEPARTMENT OF MATHEMATICS Finding symmetry amidst disorder In chemistry, for instance, imagine

9

Dr. Shikma Bressler was raised in the

Jezreel Valley. She completed her

BSc summa cum laude in physics and

mathematics at the Technion—Israel

Institute of Technology in 2003,

followed by her MSc there cum laude

in physics in 2006 and PhD in 2011

also at the Technion. In 2012, she

joined the Weizmann Institute of

Science as a postdoctoral fellow.

In 2013 she was appointed a scientist

and formed a particle physics and

detector development team. In 2015

she was promoted to Senior Scientist

in the Department of Particle Physics

and Astrophysics.

Dr. Bressler was honored in 2010

with the Israel Physical Society

(IPS) Ze’ev Fraenkel Prize in Particle

Physics, Nuclear Physics and

Astrophysics. She was awarded

Gutwirth and Polak grants at the

Technion.

Dr. Bressler lives in Moshav Beit

Shearim in the Jezreel Valley and has

two children.

8

Dr. Shikma Bressler

potential of the LHC. Currently,

Dr. Bressler is co-leader of a multinational

team at CERN searching for so-called

lepton flavor violating decays of the

Higgs boson, a quest that challenges

one of the mysterious conservation laws

of nature postulated by the SM. Three

types (flavors) of lepton are known.

The most familiar is the electron, which

is the lightest one, but there are also

the muon and tau leptons. These differ

from the electron only in their mass.

The three lepton flavors carry the same

electric charge and interact with the

other fundamental particles in exactly

the same way. Within the SM, the Higgs

can decay only to a pair of same-flavor

leptons, for instance a tau lepton and an

anti-tau lepton. A decay of the Higgs into

a tau lepton and an anti-muon violates

the lepton flavor number and is forbidden

by the SM. Finding such decays would

revolutionize our understanding of the

fundamental laws of nature.

Dr. Bressler assembled a detector

development team at the Weizmann

Institute which develops novel detection

concepts for large-size radiation-imaging

detectors. Such detectors could improve

the detection techniques currently used

in particle and astroparticle physics

experiments. While this line of work is

motivated by a desire to understand the

fundamental elements of the universe, it

has potential non-scientific applications

in homeland security, medicine,

archaeology, volcanology and more.

DR. SHIKMA BRESSLER DEPARTMENT OF PARTICLE PHYSICS AND ASTROPHYSICS

Beyond the Standard Model

She is an active member of the ATLAS

collaboration at the Large Hadron Collider

(LHC) at CERN that discovered evidence

of the Higgs boson, the final undetected

particle according to the SM. Her current

work involves searching for evidence

of violations of the rules of the SM by

using the data collected by the ATLAS

experiment, and—in parallel—developing

detection techniques and instrumentation

for future experiments.

However, despite its great success

in describing the world of elementary

particles, the SM fails to explain certain

phenomena such as gravity, or the origin

of neutrino mass, or the “dark matter”

needed to describe the rotation of

galaxies. These shortcomings indicate

that the SM is not a complete theory

of nature, suggesting there is more to

discover.

Many models extending the SM have

been developed. The LHC searches for

signatures predicted by these models.

In particular, the ATLAS experiment

was designed to exploit the discovery

Dr. Bressler is pursuing physics beyond the “Standard Model” (SM) that has the potential to shed light on unresolved mysteries of the matter that comprises the universe.

Page 7: Introducing WEIZMANN INSTITUTE OF SCIENCE New Scientists ...€¦ · PROF. URI BADER DEPARTMENT OF MATHEMATICS Finding symmetry amidst disorder In chemistry, for instance, imagine

10 11

Dr. Ronen Eldan served for six years

as an intelligence officer and team

leader of a programming group in the

Israel Defense Forces. He received

his BA degree in mathematics magna

cum laude from the Open University

of Israel in 2004, and an extension to

a second discipline in physics summa

cum laude from Tel Aviv University in

2006. In 2012, he received his PhD in

pure mathematics, also from Tel Aviv

University. He conducted postdoctoral

research at the Weizmann Institute,

and in 2013 was a visiting researcher

at Microsoft Research Theory Group

in Redmond, Washington. He joined

the Weizmann Institute in 2015.

Dr. Eldan received the Israel

Mathematical Union’s Haim Nessyahu

Prize for an outstanding PhD

dissertation, and was named to

the President’s list for outstanding

achievements at the Open University.

At Tel Aviv University he was named

to the Dean’s list of excellence,

recognized as an outstanding PhD

student by the Department of

Mathematics, and given the Rector’s

Outstanding Teachers award, which

recognizes outstanding teaching in

the faculties of management and

engineering. He has also served a

volunteer in a children’s shelter run

by the Municipality of Tel Aviv-Jaffa.

Dr. Ronen Eldan

A system is called high-dimensional if its

behavior is determined by a large number

of variables or parameters. Some examples

of such systems are the stock market,

interacting particles of gas, and the human

brain. In these examples, the “dimension”

corresponds to the number of stocks,

gas particles, or neurons, respectively.

These systems are characterized by an

exponential growth of information and

complexity with respect to the dimension,

a fact that makes exact analysis of most

such problems well beyond the reach of

today’s computers. Dr. Eldan’s research

strives to sharpen the theory behind some

of these high dimensional models.

His notable theoretical results include

finding new connections between well-

known conjectures in high-dimensional

convex geometry, proving new inequalities

regarding high-dimensional normal

distributions, and developing new

algorithmic tools for the analysis of high-

dimensional geometric structures.

Dr. Eldan is especially interested in

exploring new ways to apply tools from

the theory of stochastic calculus to prove

results of a geometric nature. Stochastic

calculus is a branch of mathematics that

is used to model systems which exhibit

the behavior of Brownian motion, such

as the stock market. Dr. Eldan has found

new applications of this theory to several

seemingly unrelated, unexpected areas

of mathematics such as high dimensional

convex geometry.

DR. RONEN ELDAN DEPARTMENT OF MATHEMATICS

Working in high dimensions

Following his service in the IDF, and

during his student and postdoctoral

career, Dr. Eldan worked in the high-

tech and financial sectors using applied

mathematics to create software and

solve “real-life” problems such as trading

algorithms and option pricing for the

stock market, and solving wave equations

for survey modeling for a geophysical

exploration group. In his new position

at the Weizmann Institute, he hopes to

integrate new ideas from mathematical

theories and do basic research that has

the potential to help solve mathematical

challenges in signal processing, computer

vision, machine learning, and other

complex problems.

High dimensional probabilistic or

geometric problems appear in various

branches of mathematics, mathematical

physics, and theoretical computer science.

Dr. Eldan is finding new connections between well-known conjectures in high-dimensional convex geometry, proving new inequalities regarding high-dimensionalnormal distributions, and developing new algorithmic tools for the analysis of geometric structures.

Page 8: Introducing WEIZMANN INSTITUTE OF SCIENCE New Scientists ...€¦ · PROF. URI BADER DEPARTMENT OF MATHEMATICS Finding symmetry amidst disorder In chemistry, for instance, imagine

12 13

Dr. Michal Leskes was born in Safed,

Israel. Following military service in the

Israel Defense Forces, she completed

a BSc in chemistry summa cum laude

at Tel Aviv University in 2004. She

earned her PhD in chemical physics at

the Weizmann Institute of Science in

2010. After working with Prof. Shimon

Vega at the Weizmann Institute to

develop advanced nuclear magnetic

resonance (NMR) methods, Dr. Leskes

applied her training in solid-state

NMR techniques to study lithium-ion

batteries during her postdoctoral

fellowship at the University of

Cambridge in the UK from 2011 to

2015. She joined the Weizmann

Institute in 2015.

Her undergraduate honors include

Tel Aviv University’s Dean and Rector

awards for outstanding students and

a Knesset award for students. Dr.

Leskes received the John F. Kennedy

Prize for achievements in her PhD

studies at the Weizmann Institute, a

Wolf Foundation Fellowship, and the

Award of Excellence by the National

Postdoctoral Award Program for

Advancing Women in Science. She

won a Marie Curie Postdoctoral

Fellowship from the European

Union and was awarded a Yigal Alon

Fellowship.

Dr. Leskes is married.

Dr. Michal Leskes

in on the action. During her PhD studies

at the Weizmann Institute, she worked

with Prof. Shimon Vega to develop

new methods in solid-state nuclear

magnetic resonance (NMR) spectroscopy.

NMR requires the use of very strong

magnetic fields, attained by super-cooled

electromagnets, together with highly

sensitive electronic instruments that use

precisely controlled radio frequencies

to scan and then read and interpret the

nuclear signatures of the sample. Dr.

Leskes has helped find new ways to tune

the pulses of energy used to scan samples

and to boost the sensitivity and resolution

of the instruments used to read and

interpret the results.

Dr. Leskes has new ideas of how

to improve the performance of NMR

to monitor the inner workings and

performance of batteries, zeroing in on

the rapid chemical changes that take

place on the electrode surfaces and

within the electrolytes surrounding the

electrodes. She hopes her results will

enable her to see more details of even

smaller numbers of atoms and molecules,

and to translate this new information into

the development of new, efficient, and

powerful batteries.

DR. MICHAL LESKES DEPARTMENT OF MATERIALS AND INTERFACES

The inner life of batteries

Lithium-ion batteries have the highest

energy densities among the currently

available chemical energy storage

technologies, with ever-improving power

capabilities; they have helped enable

the portable technology revolution,

powering laptops, cell phones, and

portable instruments. However, lithium-

ion batteries are expensive, have safety

issues, and are not appropriate for large-

scale energy storage.

In any kind of battery, all the “action”

takes place at the interface between the

electrodes and the electrolyte, so this

is where Dr. Leskes concentrates her

investigations. But first she needed to

improve the tools that allow her to zoom

Dr. Michal Leskes uses innovations in magnetic resonance technology to investigate the inner workings of batteries and fuel cells, looking for ways to improve their performance and usher in a new generation of energy storage and use.

Page 9: Introducing WEIZMANN INSTITUTE OF SCIENCE New Scientists ...€¦ · PROF. URI BADER DEPARTMENT OF MATHEMATICS Finding symmetry amidst disorder In chemistry, for instance, imagine

14 15

Dr. Nir London served in the

Intelligence Corps in the Israel

Defense Forces. He completed his

BSc magna cum laude in 2006 and

his MSc in 2007, both in computer

sciences and computational

biology at the Hebrew University of

Jerusalem. He completed his PhD

in the Department of Microbiology

and Molecular Genetics at the

Hebrew University Hadassah Medical

School in 2011. He served as a

postdoctoral fellow in the Department

of Pharmaceutical Chemistry at

the University of California, San

Francisco, starting in 2012, and joined

the Weizmann Institute in 2015.

His honors include a Rector’s

Scholarship for MSc students

and a Converging Technologies

Fellowship for PhD studies at the

Hebrew University of Jerusalem, the

Chorev Award of the Israel Chemical

Society, the Dimitris N. Chorafas

Foundation Award, an EMBO long-

term postdoctoral fellowship, and a

postdoctoral award from the Program

for Breakthrough Biomedical

Research. Nir has mentored students

and has helped build and teach a new

course in computational structural

biology.

He is married and has two

daughters.

Dr. Nir London

synthesized some of these compounds

and tested them against their target

proteins.

In conventional drug discovery, once

scientists discover a possible “target,”

that is, a protein that controls an

important step in a disease process, they

painstakingly screen huge libraries of

small molecules, testing for candidates

that bind effectively to the target to

either inhibit or stimulate it without

disrupting other systems in the body.

Thus conventional small-molecule

discovery requires screening of tens

or hundreds of thousands of actual

samples. It is an approach that is often

expensive, wasteful, and turns up many

false positives that must be tested and

eliminated. Structure-based virtual

screening using computers has been

around for two decades, but with recent

improvements in technology and methods,

computerized screening is now common

in the pharma and academia.

Dr. London developed new software

and he has identified potential new

candidates for designing drugs to

overcome resistance to cephalosporin

antibiotics and new ways to target an

enzyme that is a potential therapeutic

target for new drugs for autoimmune

diseases such as rheumatoid arthritis. His

discovery of new covalent inhibitors can

generate new chemical compounds for

therapeutic drugs as well as new tools for

better understanding human biology.

DR. NIR LONDON DEPARTMENT OF ORGANIC CHEMISTRY

A new kind of drug discovery

He focused on a class of molecules

overlooked by conventional drug

discovery programs in industry and

academia, molecules that form a covalent

bond—a chemical bond that involves

the sharing of electron pairs between

atoms—with a protein target. These highly

reactive compounds have been avoided

in drug development because they were

considered “promiscuous”—they might

bind to too many targets and generate

too many false positives. However,

covalent compounds bind the protein

far more strongly than regular small

molecules and can lead to a stronger,

more selective, and potent candidate for

a therapeutic drug.

Dr. London developed computational

methods to predict molecular

interactions, first between proteins and,

later between proteins and peptides. He

developed a way to speed up a major step

in the drug discovery pipeline via a new

computational method for discovering

covalent small-molecule inhibitors and

Dr. London has developed new ways to speed up the discovery of a type of specifically targeted new drugs—a quest that could lead to more effective treatments for a wide variety of diseases and disorders.

Page 10: Introducing WEIZMANN INSTITUTE OF SCIENCE New Scientists ...€¦ · PROF. URI BADER DEPARTMENT OF MATHEMATICS Finding symmetry amidst disorder In chemistry, for instance, imagine

16 17

Prof. Victor Malka was born in

Casablanca, Morocco. After studies

in engineering at École Nationale

Supérieure de Chimie de Rennes,

France, in (1982–1984), and an

MSc in physics from the Université

d’Orsay in 1987, he completed his

PhD in atomic and plasma physics at

École Polytechnique in Palaiseau in

1990. He became a CNRS Research

Director and a Professor at École

Polytechnique, and formed his

group specializing in laser-based

particle sources at the Applied

Optics Laboratory (LOA), with École

Nationale Supérieure de Techniques

Avancées (ENSTA), CNRS and

the École Polytechnique. He was

chosen for the IEEE/NPSS Particle

Accelerator Science and Technology

Award and was honored as a Laureate

of the European Research Council

for projects on four occasions. He

was awarded the Grand Prize of the

French Academy of Sciences, and

CNRS scientific excellence awards.

He is married to Agnes Finquel, an

artist, and they have two children,

Maya and Dinah.

Prof. Victor Malka

particle beams had tremendous potential.

In effect, he has miniaturized huge radio-

frequency-based particle accelerators

into elegant, compact, but powerful

and flexible plasma accelerators. Such

interactions can accelerate electrons,

protons, highly charged ions, forming

them into ultra-bright beams that can be

easily controlled. Conventional particle

accelerators require large distances to

accelerate particles.

A range of possible applications exist,

from compact X-ray sources that can

scan a nuclear reactor for cracks, a truck

for hidden explosives, or an airplane

wing for stress fractures. On the medical

side, applications include beams for

proton and hadron therapies for treating

radiotherapy-resistant cancers and deep

tumors. He has shown the potential for

electron beam-based radiotherapy cancer

treatment with clinical trials in prostate

cancer and the potential of X-ray beams

for X-contrast imaging for early stage

cancer detection. And they may be used

as a powerful new investigative tool in

physics and chemistry. Prof. Malka says

that the creativity and innovative spirit

that are hallmarks of Israeli culture

make Israel the best place to realize the

applications for his new laser and plasma

discoveries.

PROF. VICTOR MALKA DEPARTMENT OF PHYSICS OF COMPLEX SYSTEMS

Beams of promise

Prof. Malka is one of the world’s foremost

experts in the field of lasers interacting

with plasmas. He plans to build a pair of

100 terawatt lasers in a laboratory at the

foot of the iconic Koffler Accelerator.

At peak intensity, the two lasers, among

the most powerful in the world, can

concentrate the power of a fraction of

petawatt (one quadrillion (1015) watts)—a

million times higher than the entire power

consumption of the State of Israel, but

only for a tiny fraction of a second on a

very small area.

Prof. Malka achieved one of his

first major breakthroughs in 2002,

accelerating electrons to high energy

by focusing an intense laser beam onto

a gas jet. He quickly realized that this

revolutionary way of producing energetic

Why would a tenured professor heading a world-famous lab in Paris choose to pack up and move from France to Israel? For Prof. Victor Malka, the answer is: to join the Weizmann Institute of Science and realize his dream of living in Israel.

Page 11: Introducing WEIZMANN INSTITUTE OF SCIENCE New Scientists ...€¦ · PROF. URI BADER DEPARTMENT OF MATHEMATICS Finding symmetry amidst disorder In chemistry, for instance, imagine

18 19

Dr. Rina Rosenzweig was born in

Riga, Latvia, moved to Israel with her

parents as a 10-year-old, and grew up

in Haifa. After serving two years in

the Israel Air Force, she enrolled at

the Technion-Institute of Technology

in Haifa, where she spent the next

decade. She completed her BA

cum laude in chemistry. Her PhD in

biochemistry centered on molecular

interactions of the 26S proteasome,

a multi-protein machine that

regulates the life cycle of the vast

majority of cellular proteins.

A fruitful collaboration and a

weeklong visit to the Center for

Nuclear Magnetic Resonance Imaging

in Lyon, France, proved a watershed.

Excited by the possibilities of NMR,

Rina chose to pursue this discipline as

a postdoctoral fellow at the University

of Toronto’s departments of

Molecular Genetics, Biochemistry and

Chemistry. She joins the Weizmann

Institute in 2016.

Her academic and professional

honors include the Joseph Freed

and Benjamin Werber Fellowship, an

Irwin and Joan Jacobs scholarship,

and a fellowship for excellence

from the Department of Biology at

the Technion. Dr. Rosenzweig was

a Revson Fellow of the Weizmann

Institute’s Israel National Postdoctoral

Award for Women in Science. She

won an EMBO long-term fellowship,

a Banting postdoctoral fellowship, and

was a finalist for the Lap-Chee Tsui

(CIHR-IG) Publication Award.

Dr. Rosenzweig is married and has

two sons.

Dr. Rina Rosenzweig

Understanding the molecular

mechanism involved in combating

protein aggregation in vivo is essential

to prevent, slow down, or ultimately,

even reverse the progression of these

diseases.

Chaperone proteins are involved in

the cellular quality control systems that

try to correct protein folding errors

and undo the formation of damaging

protein plaques, such as the amyloid

beta plaques associated with Alzheimer’s

disease. In her postdoctoral work,

Dr. Rosenzweig used nuclear magnetic

resonance to reveal the inner workings

of a chaperone system that engages

in aggregate binding, extraction,

threading, and refolding of proteins.

Cells of bacteria, plants, and fungi have

evolved this machinery to neatly extract

polypeptide chains from large aggregates

and refold them. A scientist highlighting

her study in the journal Science said that

it provides “an important advance in

understanding the remarkable ability of

cells to reverse protein aggregation.”

“While I’m only working on a small

section of a very big puzzle, I’m also part

of a much larger community, all of us

attacking a common problem from many

directions,” she says. “I feel that by each

of us breaking off a piece of the puzzle

and trying to solve it, we’ll eventually be

able to understand the whole.”

DR. RINA ROSENZWEIG DEPARTMENT OF STRUCTURAL BIOLOGY

Cellular housekeeping

Dr. Rosenzweig uses nuclear magnetic resonance (NMR) to understand the cellular mechanisms of diseases associated with protein misfolding and the accumulation of toxic protein aggregates. These include Parkinson’s disease, Huntington’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Prion disease, and Creutzfeldt-Jakob disease.

Page 12: Introducing WEIZMANN INSTITUTE OF SCIENCE New Scientists ...€¦ · PROF. URI BADER DEPARTMENT OF MATHEMATICS Finding symmetry amidst disorder In chemistry, for instance, imagine

20 21

Dr. Guy Rothblum received

his BA magna cum laude in

computer science from the Open

University of Israel in 1999 and

his MSc in computer science

from the Weizmann Institute of

Science in 2005. He received his

PhD in computer science from

the Massachusetts Institute of

Technology (MIT) in 2009, and

went on to complete a postdoctoral

fellowship at Princeton University

in 2011. He was a researcher at

Microsoft Research in Silicon

Valley, California—until 2014, and is

currently a researcher at Samsung

Research America, also in Silicon

Valley. He joins the Weizmann

Institute in 2016.

Dr. Rothblum was awarded a

Computing Innovation Postdoctoral

Fellowship and a Symantec

Graduate Fellowship.

Dr. Guy Rothblum

But with these benefits come risks.

Outsourced data or computations might

be corrupted and fine-grained personal

and sensitive data might fall into the

wrong hands. To avoid falling prey to such

threats, cybersecurity has become a top

priority for businesses, organizations,

and individuals. Dr. Rothblum is an expert

in cryptography—the study of securing

data and computations—and his research

also touches on the study of complexity

theory, machine learning, statistics, and

algorithm design.

His research and approach involve

three key lines of investigation, which

he poses as questions. First, “Can we

verify the correctness of an untrusted

computation without re-executing it?”

This arena is called verifiable computing.

Second, he asks, “Can we data mine

sensitive data while protecting the

privacy of individuals?” The focus here

is so-called privacy-preserving data

analysis. And third, he asks, “Can we

protect computations from attacks that

expose some, or even all, of their internal

components?” That focus, called opaque

computing, offers tools and techniques

for making programs opaque—providing

protection even when an adversary

can observe sensitive activities as they

play out, and has partial access to the

information.

DR. GUY ROTHBLUM DEPARTMENT OF COMPUTER SCIENCE AND APPLIED MATHEMATICS

Keeping data private

Dr. Rothblum learned from some of

the world’s leading computer security

experts during his graduate studies at

the Weizmann Institute and MIT, and is

now charting a career in this increasingly

important field.

In modern computing, sensitive

data and computations are routinely

offloaded to remote providers—and

reside somewhere in a data cloud.

This paradigm comes with tremendous

benefits and empowerment for ordinary

individuals: private banking and monetary

transactions can be performed easily

and swiftly online, medical records can

be stored and accessed, and Internet

algorithms can trace behavioral patterns

and provide a tailored array of services.

Indeed, these developments are

increasingly essential for the modern

global economy.

We are witnessing an explosion in the quantity and sensitivity of personal data and computations that are stored and analyzed online. The need for improved cybersecurity to guarantee the data’s privacy and integrity is greater than ever.

Page 13: Introducing WEIZMANN INSTITUTE OF SCIENCE New Scientists ...€¦ · PROF. URI BADER DEPARTMENT OF MATHEMATICS Finding symmetry amidst disorder In chemistry, for instance, imagine

22 23

Dr. Ruth Scherz-Shouval was born and

raised in Rehovot. She earned a BSc

in the life sciences with honors at the

Hebrew University of Jerusalem in

2002 and a PhD in biological chemistry

at the Weizmann Institute of Science

in 2008 with Prof. Zvulun Elazar. She

conducted postdoctoral research in

Prof. Moshe Oren’s laboratory in the

Department of Molecular Cell Biology

at the Weizmann Institute and at the

Whitehead Institute for Biomedical

Research at the Massachusetts

Institute of Technology. She joined the

Weizmann Institute in 2015.

Her honors include an Aharon Katzir

Center travel fellowship, the Feinberg

Graduate School Dean’s Prize for

PhD students, and a Sir Charles Clore

Postdoctoral Fellowship. She received

a Weizmann Institute of Science

Israel National Postdoctoral Award

for Advancing Woman in Science, a

Fulbright Postdoctoral Fellowship, and

a Human Frontiers Scientific Program

Long-Term Fellowship. She was

awarded a Stuart Fellowship for cancer

research, and the AACR Scholar-in-

Training Award supported by Susan G.

Komen.

Outside of the lab, Dr. Scherz-

Shouval, and her husband and three

children enjoy hiking in the great

outdoors.

Dr. Ruth Scherz-Shouval

During her PhD studies at the Weizmann

Institute in Prof. Zvulun Elazar’s lab, she

explored the molecular mechanisms of

autophagy, a basic cellular response to

stress. As a postdoctoral fellow with Prof.

Moshe Oren, she studied the regulation of

autophagy by the “anti-cancer” regulatory

gene p53. She found that, despite its

tumor suppressor role, p53 could be

subverted in cancer cells when nutrients

are limited. While serving as a postdoc at

the Whitehead Institute for Biomedical

Research at MIT, she zeroed in on the

heat shock response that cells activate

when subject to thermal stress such as

inflammation.

In her recent work, Dr. Scherz-Shouval

discovered that heat-shock factor 1 (HSF1),

the master regulator of the evolutionarily

conserved heat-shock response to thermal

stress, plays a vital role in the tumor

microenvironment. She showed how HSF1

helps reprogram fibroblasts, the cells

responsible for making the extracellular

matrix and collagen in a tumor’s nearby

tissues, causing them to support the

tumor’s malignancy. In collaboration with

clinicians at the Brigham and Women’s

Hospital and Beth Israel Hospital in Boston,

and Rabin Medical Center in Israel, clinical

studies confirmed that in early-stage

breast and lung cancer, high stromal HSF1

activation is strongly associated with

poor patient outcome, a finding that has

significant diagnostic and therapeutic

implications.

DR. RUTH SCHERZ-SHOUVAL DEPARTMENT OF BIOLOGICAL CHEMISTRY

Discovering Cancer’s dirty tricks

As the daughter of Weizmann Institute’s

Prof. Avigdor Scherz of the Department

of Plant and Environmental Sciences, and

Dr. Zahava Scherz of the Department of

Science Teaching, Dr. Scherz-Shouval

spent much of her childhood playing

on the grounds of the Institute with

friends who were also children of faculty

members. The experience fostered her

natural curiosity; she would always ask

lots of questions, want to understand

why things were the way they were, and

whether she could find a way to change

them. A close family member’s diagnosis

of breast cancer strengthened Dr. Scherz-

Shouval’s determination to help to find a

cure for cancer.

Dr. Scherz-Shouval is interested in how cancer cells recruit and subvert normal cells to create an environment that promotes tumor progression and metastasis. One of cancer’s dirty tricks is to take advantage of survival mechanisms found in the cells of most species and use these regulatory mechanisms to reprogram healthy cells surrounding a tumor to protect the cancer cells and help them grow.

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24 25

Dr. Schraga (Schragi) Schwartz

completed a BSc in medicine cum

laude at Tel Aviv University (TAU) in

2006 and completed his PhD there in

2010. After a year as a postdoctoral

researcher in Prof. Rotem Sorek’s lab

at the Weizmann Institute, he served

as a postdoctoral fellow at the Broad

Institute of Harvard and MIT until

joining the Weizmann Institute in 2015.

Dr. Schwartz received a TAU

Rector’s Award, a three-year Edmond

J. Safra Scholarship for outstanding

bioinformatics students, and the

Foulkes Foundation Fellowship. He

received the Wolf Prize for outstanding

PhD students, the Israel Society for

Biochemistry & Molecular Biology Prize

for Outstanding Achievements, an

outstanding student award from the

Department of Genetics at TAU, and a

Sheba Hospital Award for outstanding

MD/PhD students. He was also awarded

a Weizmann Institute Dean’s Fellowship

for postdoctoral students. Dr. Schwartz

also won a pair of two-year fellowships:

the EMBO Long-Term Fellowship, and a

Rothschild Fellowship for postdoctoral

students; he was awarded a three-

year Human Frontiers Science Long-

Term Postdoctoral Fellowship and

the RNA Society/Scaringe Young

Scientist Award in recognition of his

postdoctoral achievements in RNA

research.

He has citizenship in Switzerland, the

United States, and Israel.

Dr. Schraga Schwartz

Broad Institute of Harvard and MIT,

Dr. Schwartz developed powerful

new ways to study the roles of RNA

modifications in the biochemistry

of life. He devised experimental and

computational approaches to map diverse

RNA modifications, and is developing

an array of methods using functional

genomics and mass spectrometry to

determine what the various epigenetic

modifications on RNA actually do. For

instance, the innate immune system is

the first line of defense against invading

pathogens, and can recognize and trigger

an immune response in response to viral

RNAs. To ensure that this response is

specific, cells have to distinguish RNA of

viral origin from its cellular counterpart.

Understanding how this recognition

process works can help immunologists

understand the body’s immune response

to viral RNAs, and assist biomedical

researchers seeking to design new RNA-

based therapeutics.

The field of epitranscriptomics is still

relatively new, since techniques that

make it feasible only arose in the last few

years. “It’s fascinating for me to follow

a field from its infancy and to witness

the gradual accumulation of knowledge

over time through the joint work of an

emerging community,” Dr. Schwartz says.

DR. SCHRAGA SCHWARTZ DEPARTMENT OF MOLECULAR GENETICS

Mapping RNA

Ribonucleic acid (RNA) is the crucial

intermediate molecule that allows DNA

to get translated into proteins within

cells. Following their synthesis, DNA,

proteins, and RNA molecules undergo

modifications—called epigenetic changes—

that have the potential to alter their

function or stability.

In his PhD work at the Weizmann

Institute, Dr. Schwartz studied RNA-based

splicing codes, the signals embedded in

strands of DNA that tell RNAs where to

begin cutting-and-pasting snippets of

genetic code to create proteins.

During his postdoctoral research,

first at the Weizmann Institute with

Prof. Rotem Sorek, and then at the

Dr. Schraga Schwartz wants to map, characterize, and understand the 100 or more ways that RNA can modify and change the genetic directions that tell the cell what to do. Until now, scientists have barely touched this additional level of regulation carried out at the level of RNA.

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26 27

Liran Shlush was born in Haifa. He

completed his BSc in medical sciences

with honors in 1996 and his MD in

2001 at the Technion—Israel Institute

of Technology. Dr. Shlush served

as Deputy Director of the Israel

Navy Medical Institute during his

military service from 2002 to 2008.

He completed a PhD in population

genetics in 2012 at the Technion,

and did a three-year residency in

internal medicine at Rambam Medical

Center in Haifa from 2008 to 2011. He

served as postdoctoral fellow from

2012-2014, and a clinical fellow in the

leukemia program beginning in 2014,

both at the Princess Margaret Cancer

Center at the University of Toronto

in Ontario, Canada. He joined the

Weizmann Institute of Science in 2015.

His academic and professional

awards include an American Society

of Hematology Scholar Award, a

five-year postdoctoral fellowship at

the McEwen Centre for Regenerative

Medicine in Toronto, an Excellence

in Teaching Award in 2010 from the

Faculty of Medicine at the Technion,

the Itai Sharon Atidim Award at

the Rambam Health Care Campus

in Haifa, the IDF Excellence Award

for First Response Military Medical

Care, and an Excellence Award in the

Internship program at the Rambam

Health Care Campus.

Dr. Shlush is married and has

three children.

Dr. Liran Shlush, MD

without any prior indication of cancer.

Yet AML, like all cancers, arises from the

multi-step accumulation of mutations. On

average, AML cells already carry about 13

mutations at the time of diagnosis. During

his PhD and medical studies, Dr. Shlush

studied leukemia evolution from diagnosis

to relapse. He compared paired samples

from AML patients at various stages of

the disease and treatment.

Dr. Shlush found that blood samples

from AML patients at diagnosis contained

the ancestral stem and progenitor

cells that carried the initiating genetic

events in AML. He was able to show

that these leukemic stem cells survived

chemotherapy and contributed to

leukemia relapse.

Dr. Shlush’s studies have important

implications for future approaches to

prevent relapse. They suggest that it

should be possible to prevent relapse if

the surviving leukemic can be specifically

targeted. He recently started a clinical

study to track large cohorts of AML

patients by taking samples from

diagnosis, after therapy induction, and

every three months during remission

until relapse.

Dr. Shlush is also planning to study the

early stages of leukemia evolution so that

someday early diagnosis and treatment

might be feasible.

DR. LIRAN SHLUSH, MD DEPARTMENT OF IMMUNOLOGY

Tracking Down recurring cancers

During his postdoctoral work, Dr. Shlush

published a major insight into the biology

of acute myeloid leukemia (AML). By

tracking the “family history” of individual

stem cells from the blood of AML patients,

and using deep sequencing to identify

alterations in genes commonly mutated

in AML, he and his collaborators were

able to identify “pre-leukemic” stem cells.

These mutant stem cells go on to form

cancerous cells. When AML patients are

treated with chemo, the cancerous cells

are killed, but these mutant stem cells

remain. The finding holds significant

promise for treatment, earlier diagnosis,

and new screening for AML, and perhaps

other cancers as well. The editors of

Nature Medicine selected this paper as

one of the most notable advances in

medicine in 2014 with great clinical and

scientific implications.

Most cases of AML are diagnosed

What if doctors were able to identify the body’s cells that become cancerous before they actually become cancerous? This possibility may be in the realm of reality, not prophecy, in the not-too-distant-future.

Page 16: Introducing WEIZMANN INSTITUTE OF SCIENCE New Scientists ...€¦ · PROF. URI BADER DEPARTMENT OF MATHEMATICS Finding symmetry amidst disorder In chemistry, for instance, imagine

28 29

Dr. Ziv Shulman was born and raised

in Rehovot. Following his army service,

Ziv worked as a veterinary assistant

for a biotechnology company in

Rehovot. He earned his BSc in animal

science at the Hebrew University of

Jerusalem, and an MSc (2005) and

PhD in immunology (2010), both with

honors, at the Weizmann Institute

of Science. Dr. Shulman worked as

a postdoctoral research fellow at

the Rockefeller University in New

York from 2011 until he joined the

Weizmann Institute in 2015.

Dr. Shulman’s achievements

were recognized by the Weizmann

Institute’s Feinberg Graduate School

through prizes for outstanding MSc

students and for outstanding PhD

students. He received the Rockefeller

University’s Tri-Institutional Breakout

Award for Junior Investigators for

his postdoctoral studies in 2015

(awarded jointly with Memorial Sloan

Kettering Cancer Center and Weill

Cornell Medical College). He received

a Blavatnik Regional Award for young

scientists; EMBO long-term fellowship;

and a Human Frontiers of Science

Program fellowship.

Ziv is married with two children.

He is an avid runner.

Dr. Ziv Shulman

direct visualization and quantification

of the antibody selection process in

living mice by using two-photon laser

scanning microscopy and high-throughput

computerized analysis.

Dr. Shulman found that T cells engage

B cells in multiple, short-lived contacts

during selection. These interactions

cause T cells to produce signaling

proteins called cytokines, which appear

to select and drive B cells to proliferate

and produce antibodies specific to new

threats. Furthermore, the T cells can

move from niche to niche freely, while

the B cells stay in the same lymph node

site where they mutate their antibody

encoding genes and diversify as they form

new antibodies. Dr. Shulman’s findings

describe the cellular mechanism of the

antibody affinity maturation process and

shed new light on the process of acquired

immunity.

His research aims to discover the

cellular and molecular components that

underline successful vaccinations and

immune responses in order to create

new natural antibodies to be used as

immunotherapy to treat tumors and

other diseases. Since these antibodies

are created by the body’s own immune

system, they do not provoke autoimmune

reactions or other side effects.

DR. ZIV SHULMAN DEPARTMENT OF IMMUNOLOGY

Making stronger antibodies

Dr. Ziv Shulman uses fluorescent live-cell

microscopy to discover the molecular

details of this “dance” and capture real-

time images of the antibody selection and

production process.

Forming efficient antibodies against

specific pathogens involves a biological

process called “affinity maturation” in

which random mutations are introduced

into B cell antibody genes. During his

postdoctoral studies, Dr. Shulman

studied how T and B cells interact with

one another during a critical period

following infection in order to prepare

the best antibodies and establish

long-lasting protection. In order to

understand the cellular dynamics of

this process, he developed a system for

Creating antibodies to fight infection involves an intricate cellular and molecular dance. This dance takes place in the body’s lymph nodes between antibody-producing B cells and T helper cells: T cells select B cells to produce antibodies in large quantities.

Page 17: Introducing WEIZMANN INSTITUTE OF SCIENCE New Scientists ...€¦ · PROF. URI BADER DEPARTMENT OF MATHEMATICS Finding symmetry amidst disorder In chemistry, for instance, imagine

30 31

Dr. Ivo Spiegel received his BSc

in biology with honors from Tel

Aviv University, his MSc from the

Weizmann Institute of Science

in 2001, and his PhD from the

Weizmann Institute in 2007 in

the Department of Molecular Cell

Biology. He completed a postdoctoral

fellowship in the Department of

Neurobiology at Harvard Medical

School.

His awards and honors

include the Weizmann Institute’s

Feinberg Graduate School prize

for excellence, its Dean’s award,

and its John F. Kennedy Prize. He

received a certificate of excellence

from the Israeli Society for

Biochemistry and Molecular Biology

during his PhD studies, a Long-

Term Fellowship from the Human

Frontiers Science Program, and a

Marie Curie International Outgoing

Fellowship from the European

Research Council, an EMBO long-

term fellowship. He also received a

fellowship for advanced researchers

from the Swiss National Science

Foundation and a Louis Perry

Jones Postdoctoral Fellowship from

Harvard Medical School.

Dr. Ivo Spiegel

signal to the next neuron is determined

by the amount of excitation and inhibition

that it receives. The tight control over this

balance between the amounts of excitation

and inhibition (“E/I Balance”) in the face of

changing sensory experiences is critically

important for normal brain function. It is

achieved by regulating the sites through

which neurons connect to each other to

transmit information, the synapses. Indeed,

genetic mutations that affect synapses

and lead to changes in E/I balance were

recently linked to psychiatric disorders

such as autism and schizophrenia.

During his postdoctoral training at

Harvard Medical School, Dr. Spiegel

explored the molecular components

underlying this delicate balancing

mechanism and its effect on brain

function and health. He found that each

type of neuron responds to sensory

stimulation by activating a transcriptional

program that modifies its synapses in a

manner that matches the function of this

specific neuron. The cell-type-specific

transcriptional networks that underlie

these synaptic adaptations include genes

that regulate the expression of other

genes as well as genes that act directly at

synapses. Dr. Spiegel plans to investigate

the inner mechanics of such cell-type-

specific transcriptional networks, and to

test how these gene programs regulate

E/I-balance and the function of cortical

circuits during experience-dependent

behavioral paradigms, and how these

experience-dependent mechanisms are

affected by our internal, emotional states.

DR. IVO SPIEGEL DEPARTMENT OF NEUROBIOLOGY

Nature-versus- nurture?

The function of our nervous system

requires a finely tuned interplay between

molecular, cellular, and systemic

mechanisms, which are not hard-wired

but respond to and are modulated by

how we sense and interact with our

environment. In fact, even within a

single neuron in our brains a multitude

of molecular mechanisms are regulated

by sensory experience and the resulting

neurophysiologic (i.e. electric) activity.

The cortex, a brain area responsible for

sensory processing and memory storage,

is home to a diverse population of neurons,

each with its own distinct function in

the circuit. Excitatatory neurons receive

electric input and generate a stimulating

(i.e. excitatory) output for connected

neurons. Inhibitory neurons do the exact

opposite: They transmit to their connected

neurons a signal that is inhibitory as it

opposes the currents coming from the

excitatory neurons. Thus, whether a given

neuron will or will not send an electric

To what extent does experience and environment dictate brain function, and to what extent do our genes do so? It is a question many have been asking for decades, but science is inching closer to an answer. Dr. Ivo Spiegel’s research aims to tackle this quandary head-on.

Page 18: Introducing WEIZMANN INSTITUTE OF SCIENCE New Scientists ...€¦ · PROF. URI BADER DEPARTMENT OF MATHEMATICS Finding symmetry amidst disorder In chemistry, for instance, imagine

32 33

The Delta Career Development Chair in •

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The Aryeh and Ido Dissentshik Career •

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Scientists in Memory of Cantor John Y. Jade

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of Cancer Research in Perpetuity

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New scientist funds and giftsTheWeizmannInstituteofSciencehasreceivedsubstantialgiftsforthebenefitofnewscientistsfromthefollowingindividuals,familiesandfunds,andwishestoexpressitsappreciationtothem:

EndowmentsandCenters

Ordered alphabetically

The Abramson Family Center for Young •

Scientists

Ruth and Herman Albert Scholars Program •

for New Scientists

The Asher and Jeannette Alhadeff Research •

Award

A.M.N. Fund for the Promotion of Science, •

Culture and Arts in Israel

Candice Appleton Family Trust•

Estate of David Arthur Barton•

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Bierzwinsky

Frances Brody Young Scientists Fund•

Raymond Burton Endowment for Prizes•

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J. Joseph and Betty Auerbach Cohen New •

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Research

Cymerman-Jakubskind Prize•

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Dan Kane•

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The Koret Foundation•

Leff Family•

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Estate of Paul Ourieff•

Estate of Victor Pastor •

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Lois Rosen•

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34 35

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T• he Norman E. Alexander Family Foundation

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Spencer Charitable Fund•

Alan Fischer•

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United Mashadi Jewish Community of •

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Abbott•

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36

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Blythe Brenden-Mann New Scientist Fund•

Ruth Scherz-Shouval

Estate of Annice Anzelewitz•

The Gurwin Family Fund for Scientific Research•

Ms. Hilda Namm•

David M. Polen Charitable Trust•

Dr. Zwi & Amelia Steiger Cancer Research Fund•

Shraga Schwartz

The Abramson Family Center for Young Scientists•

Liran Shlush

The Morris & Ruth Wagner and Marek Sutkiewicz •

Laboratory for Cancer Research

Ziv Shulman

The Sir Charles Clore Research Prize •

Kahn Foundation•

Rising Tide Foundation•

Comisaroff Family Trust•

Irma & Jacques Ber-Lehmsdorf Foundati• on

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IntroducingNew Scientists2015-2016