Embed Size (px)
Citation preview
Upcoming Deadlines
PIFG Chair (2016-2017): Laura L. Boles Ponto, PhD. Univ. of Iowa Hospitals and Clinics PET Imaging Center, Iowa City, IA [email protected]
ISSUE 4 | VOLUME 5 | August 2016
Quote of the Month – “Social and digital technologies are impacting how we think, how we act, and, perhaps even who we are.” Paul Gordon Brown (speaker and educator, cited in his PhD dissertation) And…..Introduing an NEW Newsletter SECTION!!!! “IMAGING APPLICATIONS” contributed by Hanumantharao (Rao) Madala from Texas Tech University, Amarillo
Editor: Brian R. Moyer BRMoyer & Associates, LLC Amherst, NH [email protected]
PHARMACO-IMAGING FOCUS GROUP
(PIFG)
Co-Editor: Parul Gupta Pfizer Corporation San Diego, CA [email protected] AAPS- PIFG web site: http://www.aaps.org/Pharmaco-imaging/
AAPS-PIFG Linkedin: https://www.linkedin.com/groups/3970151
“Knowledge is limited: Imagination encircles the world” Albert Einstein
Bankson, et al., Cancer Research 2015; 75(22):4708-17
• International Conference on Neuroimaging and Interventional Radiology: Open • International Conference on Bioimaging: Sept 29, 2016 • International Conference and Expo on Radiology and Imaging: Open • International Conference on Medical Imaging & Diagnosis: Open
Featured Image
AAPS- PIFG web site: http://www.aaps.org/Pharmaco-imaging/ AAPS-PIFG Linkedin: https://www.linkedin.com/groups/3970151
Vol 5 Issue 1: Table of Contents:
• Welcome • TOC • PIFG Chair • Meetings of Interest • Selected BLOG from the AAPS
Blog posts • Imaging center highlight • Images for your desktop • From Editor’s Desk • Journal ratings • PIFG member publications • Publications of interest • Books and reviews • Review of a new article • ApplicationsNew • Imaging Solutions (information
resources) • Imaging Tools and IT • In The News
Aug 23th 2 PM (ET) Teleconference Agenda: PIFG Chair Opening Remarks:
Laura Boles Ponto [email protected]
AGENDA for the meeting: 2:00-2:05 Brief introductions and attendance 2:05-2:15 PIFG Chair Laura Boles Ponto 2:15 – 2:20 Discussion on the PIFG Objectives
led by Dr Ponto 2:20-2:40 – Newsletter review process 2:40-2:50 – Volunteers and postings 2:50–3:00 Any Other Business
Adjourn by 3:00 pm
Conf Call every fourth Tuesday of the even months at 2 PM:
Next TCON:
Tues Aug 23rd
@ 2 PM
GET INVOLVED IN THE PIFG!
We NEED volunteers!
• Become PIFG member • Image of the month –highlight your work • Highlight your imaging facility in our Institution
Spotlight in the next Newsletter • Recent citations • Other ideas/ suggestions/ content
Contact us for the telephone number and pass code Send stories, images, references, and your publication citations to the PIFG Newsletter editors
[email protected] or [email protected]
Table of Contents
Editorial Brian R. Moyer, PIFG Newsletter Editor
Editorial: The Role of Imaging in the Zika Crisis The Zika virus has made its way from the tropics of Brazil to the Caribbean, including the US Territory of Puerto Rico, and we are all gearing up for a rather mild and inconsequential viral infection – unless you are pregnant. One in five of people infected with the Zika virus experience some form of fever, lassitude, muscle aches, etc., essentially a minor “flu-like” event. The same is actually true for women who are pregnant but the fetus undergoes a much more direct insult. The placenta appears to be a target tissue for the virus and developing neural tissue is also a primary reservoir. The result of a fetus infection can be serious with a condition called microcephaly, or essentially an absence of brain development. Secondarily and as a consequence of the abnormal tissue development, the cranial brain casing morphometrics forces development of a solid casing around the delayed and minimal brain further preventing normal neural growth and development. What can imaging provide here that can inform the mother and the physician on what is happening to an infected mother? Clearly WHEN the infection happens is important. If the mother is Zika POS before pregnancy begins, the virus has the most opportunity to inflict harm. An infection late in pregnancy may be less consequential to the result of microcephaly ( “minimal brain” ) but it is yet to be determined if such infected and affected babies have cognitive and other neurologic challenges. An early diagnosis of normal cranial development is critical. Do we use CT? No, only in an emergency – and we need multiple readings over time. CT is ionizing radiation which has negatives, especially in developing tissues, and the need for multiple measures over time and spatially as well, which make CT a poor choice. We need to know if the neuro development is arrested, and if bone formation is secondarily arresting further brain development we have two other alternatives: Ultrasound (US) and MRI. US is the preferred method cost-wise and even with less resolution than MRI, it affords quantitative measures.
The cranial development over weeks 26-40 of gestation is shown below. Note the cranial circumference at 26-30 weeks of gestation is near 240-270 mm and outliers of 3 SD make this 215 – 248 mm. Such a small delta is evident at this mid gestational time. We actually want to know a lot earlier such as at 8 weeks. The issue is clear - in the first and second trimesters the fetal dynamics of the growth rate and the multifactorial changes in the morphometry (brain shape) at head circumferences are steep and noisy making any clear diagnosis very difficult. Clear “out of bounds” measures before 26 weeks are fraught with error which makes accurate diagnosis difficult.
From: http://www.babymed.com/tools/fetus-head-circumference-ultrasound-microcephaly-calculator
It is clear that US is a preferred clinical measure, however, future strategies for medical intervention will require work in animal models together with highly precise measures of the 3-D morphometry and the degree of regional calcification affecting borders and neural pattern development. Imaging systems for the study for these events will have to be more definitive than US provides. MR and CT will have a role to play in defining these measures to add to the modeling of neural damage from Zika. Hopefully, we will have more precise tools (or algorithms) in these pre-clinical models to accurately measure and predict if medical countermeasures to the damaging effects on the brain or other medical interventions can attenuate the viral load or viral targeting to neural tissues. Brian R. Moyer, PIFG Newsletter Editor Additional Refs: Hahn, FJ, et al., CT Measurements of cranial growth: Human subjects, AJNR, Mar/Apr 1984 and in AJR June 1984 http://www.vox.com/2016/1/28/10861094/microcephaly-zika-virus-birth-defect-pregnancy also, from Aunt Minnie web site: http://www.auntminnieeurope.com/index.aspx?sec=sup&sub=mri&pag=dis&ItemID=613314
MRI sheds light on Zika virus, severe joint deformities By Philip Ward, AuntMinnieEurope.com staff writer
August 10, 2016 -- New research from Brazil has provided detailed information about the clinical, imaging, and electromyographic findings in babies with arthrogryposis associated with congenital Zika virus infection. More….
Meeting Start Dates
End Date
Venue Web Link
5th International Symposium on Focused Ultrasound
28-Aug-16 1-Sep-16 Washington DC
http://www.fusfoundation.org/symposium/
World Molecular Imaging Congress 7-Sep-16 10-Sep-16 New York http://www.wmis.org/meetings/ The Future of Precision Medicine Molecular Imaging for Diagnosis and Surgery/Therapy
18-Sep-16 22-Sep-16 Wyoming http://www.imagingin2020.com/
International Conference on Radiology and Imaging
19-Sep-16 20-Sep-16 Las Vegas http://radiology.conferenceseries.com/
International Conference on Integrated Medical Imaging in Cardiovascular Diseases (IMIC 2016)
10-Oct-16 14-Oct-16 Austria http://www-pub.iaea.org/iaeameetings/50808/International-Conference-on-Integrated-Medical-Imaging-in-Cardiovascular-Diseases-IMIC-2016
Radiology & Imaging Conference (Fall)
19-Oct-16 21-Oct-16 Chicago https://www.hlthcp.com/conferences/rad
International Conference on Medical Imaging and Diagnostics
20-Oct-16 21-Oct-16 Chicago http://clinical-medicalimaging.conferenceseries.com/
Nuclear Science Symposium and Medical Imaging Conference
29-Oct-16 6-Nov-16 Strasbourg, France
http://2016.nss-mic.org/
Theranostics World Congress 7-Nov-16 9-Nov-16 Melbourne http://www.theranostics2016.org/ Society for Neuroscience 12-Nov-16 16-Nov-16 San Diego https://www.sfn.org/annual-
meeting/neuroscience-2016 AAPS Annual Meeting 13-Nov-16 17-Nov-16 Colorado https://www.aaps.org/annualmeeting/ Radiological Society of North America
27-Nov-16 2-Dec-16 Chicago http://www.rsna.org/
EORTC-NCI-AACR Molecular Targets and Cancer Therapeutics Symposium
29-Nov-16 2-Dec-16 Munich http://www.aacr.org/Meetings/Pages/MeetingDetail.aspx?EventItemID=61#.Vwbi1U8rLX4
2016 Meetings of Interest
From the AAPS BLOG Staff: • Greetings from Denver, Colorado: The Mile High City; John Carpenter
“Come to the 2016 AAPS Annual Meeting and Exposition in November and see for yourself why Denver is one of the top travel destinations and fastest growing cities in the U.S. Millennials (and plenty of older folks, too!) are flocking to downtown Denver for work and a whole lot of playing. As you walk through the city, you will quickly experience the vibrant, lively culture and the friendly, welcoming western way of life. Admittedly, these days there are lot more hipsters than cowboys in downtown Denver, but the city’s western heritage and pioneering spirit are evident in both the newest and the oldest parts of the city. And, of great importance to conference attendees, Denver has become a major center for outstanding chef-owned restaurants and other eateries and, of course, is world famous for its numerous craft breweries” https://aapsblog.aaps.org/
• Brian Moyer, the Chairman for the 2016 National Biotech Conf, presented a talk on the Zika Crisis and the US Government and WHO response and has a new Blog Post on the Zika Virus at:
https://aapsblog.aaps.org/2016/05/10/what-does-the-future-hold-for-the-zika-crisis/
AAPS Blog Highlights
Imaging Center Highlight
UT Southwestern Small Animal Imaging Resource (UT-SAIR) seeks to promote and facilitate small animal imaging related to models of human disease. UT-SAIR has three primary functions: Provide state of the art small animal imaging equipment and infrastructure to support research, including consultation services as needed for the planning, performance, and analysis of studies Focus on enabling multimodality imaging methods Develop and implement new methods pushing the frontiers of small animal imaging in terms of spatial and temporal resolution and sensitivity. http://www.utsouthwestern.edu/research/core-facilities/sair/index.html
Images for your Desktop
“Kilauea volcano in Hawaii is ready for its close-up….Cute Modicon! http://www.livescience.com/50717-amazing-images.html
One of our ancestors appears to be flossing her teeth on a warm afternoon in San Diego Zoo: Courtesy-Parul Gupta
Brian Moyer: Just for fun….A special boatload of glass balls at the Chihuly exhibit in Seattle….. Eye Candy!.
Animas River. In what was supposed to be a routine inspection, EPA officials released three million gallons of wastewater into one of Colorado’s most scenic rivers. The wastewater---tainted with arsenic, cadmium, lead, and other metals---turned the Animas River sickly orange for days. The toxins still haven’t completely dissipated, and the river’s worst affected tributary is a Superfund Candidate http://www.wired.com/2015/12/the-year-in-science-images/#slide-1
Consider sending your clicks too, we wll happily
showcase here
As your Editor, I had the great privlige of serving the AAPS and the BIOTEC Section as the Chair for the past 2016 NBC in Boston and it was a full glass of opportunity for me as well as for the Biotech community. A summary of the meeting was my task to present as the last talk of the meeting and I have made it available to our membership on our PIFG Discussion Board as well as my business web site at: http://www.brmassocllc-org.com/Summary%20Talk%20for%202016NBC3.pdf Next year I want to encourage the PIFG members to contribute your work to the next NBC. We need programming sourced out of our Focus Group. Also, the Newsletter needs our membership to post a review of something that excited you in the scientific literature. If you have a favorite article on an imaging topic that you need to review and report, please include this Newsletter as another reporting vehicle. We need only a few weeks to tailor your review to the Newsletter format and review the content. Please help us make this Newsletter the envy of the Focus Groups! (BRM)
PHARMACO-IMAGING FOCUS GROUP
(PIFG) “Knowledge is limited: Imagination encircles the world”
Albert Einstein
PART 2: PIFG Newsletter Aug 2016 The issue exceeded 2 MB so we had to split the content
From the Editor’s Desk Brian R. Moyer, PIFG Newsletter Editor
ISSUE 4 | VOLUME 5 | August 2016
PIFG Member Publications
http://www.springer.com/biomed/book/978-1-4614-8246-8
1. Ponto LLB, Menda Y, Magnotta VA, Yamada TH, Denburg NL, Schultz SK. Frontal hypometabolism in elderly breast cancer survivors determined by [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET): a pilot study. Int J Geriatr Psychiatry. 2014 Sep 1. doi: 10.1002/gps.4189. [Epub ahead of print]. PMID: 25176562.
2. Sawatzke AB, Norris AW, Spyropoulos F, Walsh SA, Acevedo MR, Hu S, Yao J, Wang C, Sunderland JJ,Boles Ponto LL. PET/CT imaging reveals unrivaled placental avidity for glucose compared to other tissues. Placenta. 2014 Dec 23. pii: S0143-4004(14)00909-6. doi: 10.1016/j.placenta.2014.12.009. [Epub ahead of print]. PMID: 25555498.
3. Morgan DA, McDaniel LN, Yin T, Khan M, Jiang J, Acevedo MR, Walsh
SA, Boles Ponto LL, Norris AW, Lutter M, Rahmouni K, Cui H. Regulation of Glucose Tolerance and Sympathetic Activity by MC4R Signaling in the Lateral Hypothalamus. Diabetes. 2015 Jan 20. pii: db141257. [Epub ahead of print],PMID: 25605803.
PIFG Members send us your recent publications/ abstracts or other material of interest
http://www.imaging-git.com/applications/bioimage-data-analysis
Pharmacoimaging related journals and organizations
US Molecular Imaging and Nuclear Resource Center on Optical Imaging: http://interactive.snm.org/index.cfm?PageID=11221
PDF: http://www.molecularimagingcenter.org/docs/fact_sheets/Optical_Imaging.pdf
Please report a broken link
to us
Abstract: The most widely used task funtioning magnetic resonance imaging (fMRI) analyses use parametric statistical methods that depend on a variety of assumptions. In this work, we use real resting state data total of 3 million random task group analyses to compute empirical familywise error rates for the fMRI software packages SPM, FSL, and AFNI, as well as a nonparametric permutation method. For a nominal familywise error rate of 5% , the prametric statistical methods are shown to be conservative for voxelwise inference and invalid for clusterwise inference. Our results suggest that the principle cause for the invalid cluster inferences is spatial autocorrelation functions that do not follow the assumed Gaussian shape. By comparison, the nonparametric permutation test is found to produce nominal results for voxelwise as well as clusterwise inference. These findings speak to the need of validating the statistial methods being used in the field of neuroimaging. Key Words: fMRI, neuroimaging, false positives, cluster inferences, voxel inferences, permutation tests Ed Opinion: This article should raise a huge “red flag” in our concern that any imaging platform provide what is construed to be a true outcome, i.e. the four quadrant TP, TN, FP, FN is as optimal as can be derived through our attention to imaging instumentation, patient medicine compliance, timing of measures, and analytical assumptions are handled/computed as intended. fMRI procedures described in this article are not the only concern that we should be addressing. Every instrumentation for imaging has computational methods that may also may not be appropriately validated. We can assume that it certainly has shown some level of regulatory oversight and that this may not necessarily be a complete validation package. To focus for now on the fMRI efforts of the authors, they found their results using a powerful approach of normal data and essentially bordering on the role of “Big Data” (data not uniquely derived from their own work nor necessarily controlled with full validation) and this may be a fundamentally new approach for all of our institutions to adopt in the rigor of understanding how the output of our imaging devices plays on clinical decisions. It is, after all, the outcome of a patient decision that is our imaging “product” and not simply an “image”. I certainly recommend reading this paper and read it in the context of not fMRI alone but how would you consider validating the statistical packages that are essentially “run as unknowns” or “used with full assumption of correctness”. In my view, we have potentially touched a third rail in imaging and we need to know if this has a lot of charge in it or not. Editorial Review: Brian R Moyer
Eklund, A, Nichols, TE, Knutsson, H, Cluster failure: Why fMRI inferences for spatial extend have inflated false-positive rates, PNAS, July 12, 2016, vol 113 No. 28 http://www.pnas.org/cgi/doi/10.1073/pnas.1602413113
Review of a Publication of Interest:
New!!! Imaging Applications
Phenoptics™ Quantitative Pathology Research Solution for Cancer Immunology & Immunotherapy Phenoptics™ Quantitative Pathology Research Solution for Cancer Immunology & Immunotherapy, enables to detect, measure, visualize, and compare multiple immune-cell phenotypes simultaneously in FFPE tissue – in the same tumor and its microenvironment. Lung Cancer tissue section, 7-color IHC. Orange: FoxP3, Blue: DAPI, Yellow: CD8, Magenta: CD68, Cyan: PanCK, Green: PDL1, Red: PD1 Source: http://www.perkinelmer.com/cancer-immunology/
Cytation 5 Cell Imaging multi-mode reader
Cytation™ 5 is a configurable system that combines automated digital widefield microscopy with conventional multi-mode microplate reading to provide phenotypic cellular information and well-based quantitative data. This single instrument platform can process workflows that would traditionally require multiple instruments and software interfaces, and is simple to setup and operate. Source: http://www.biotek.com/products/imaging/cytation5_cell_imaging_multi_mode_reader.html?tab=overview
Introducing Hanumantha Rao Madala - Our newest member of our Newsletter Committee. He received his B. Pharmacy degree from Rajiv Gandhi University of Health Sciences, India and M.S in pharmaceutical sciences by studying “Assessment of strength on the in-vitro permeation of Granisetron HCL gels and comparison of microdialysis and conventional sampling techniques” form Long Island University, New York, USA. In 2014 he joined Prof. Kalkunte S. Srivenugopal’s research group as a Graduate student at the Department of Biomedical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo. His research interests include formulation design and development, drug design and studying molecular mechanisms underlying cancer progression. Currently, his research is particularly focused on studying cellular DNA damage responses and how to use this knowledge to develop better therapies for cancer treatment.
Tech-help: Handy Apps, Links and Softwares
Advances for Imaging and Radiation Oncology Download an Imaging Calendar from: http://imaging-radiation-oncology.advanceweb.com/Web-Extras/Online-Extras/2012-Conference-Calendar.aspx A wide variety of photo and imaging apps: http://allmyapps.com/imaging-apps Forum on medical apps: http://www.ipadforums.net/ipad-general-discussions/21269-medical-imaging-apps.html BLOGS: Medical Imaging Blog: McKesson source www.medicalimagingtalk.com Barriers to Informed Consent in Medical Imaging, www.medicalimagingtalk.com/2290/informed-consent-medical-imaging/
Diagnostic reading: Mobile MIM Company: MIM Software Inc. Cost: Free (for the app) Version: 3.0.6 Last updated: Sept. 24, 2012 Works on: iPad, iPhone, iPod touch
Productivity: PDF Reader Pro Company: Yuyao Mobile Software Inc. Cost: $5.99 Version: 3.0.1 Last updated: Dec. 18, 2012 Works on: iPhone, iPad and iPod touch
IAnnotate PDF Company: Branchfire Inc. Cost: $9.99 Version: 2.4 Updated: Nov. 30, 2012 Works on: iPad, Android tablet
Calculate Company: QxMD Software Inc. Cost: Free Version: 2.9.3 Last updated: Oct. 15, 2012 Works on: iPhone, iPad, BlackBerry and Android
Viewbox Company: Viewbox Holdings LLC Cost: $2.99 Version: 1.1 Last updated: March 6, 2012 Works on: iPad
MicroMedx Company: Truven Health Analytics Cost: Free Version: 1.44 Last updated: Dec. 17, 2012 Works on: iPhone, iPad, iPod touch and Android MonsterAnatomy Company: Monster Minds Media SAS Cost: 18.99 Version: Varies Last updated: Varies OS: iPhone and iPad
Non-diagnostic viewing: OsiriX HD Company: Pixmeo Sarl Cost: $29.99 Current version: 3.5.2 Last update: Oct. 24, 2012 Works on: iPhone, iPad and iPod touch Reference: Eponyms Company: Pascal Pfiffner Cost: $1.99 (Student version: free) Version: 1.4.2 Late updated: Dec. 18, 2012 Works on: iPhone, iPad and iPod touch Journals and Meetings: RSNA Suite Cost: (generally free, need to subscribe to journals) Version: Varies Last updated: Varies Works on: iPhone, iPad, iPod touch and Android
In the News
“Patient Position During Breast MRI May Influence Success Of Tumor Removal During Lumpectomy - http://www.techtimes.com/articles/166328/20160623/patient-position-during-breast-mri-may-affect-scan-accuracy.htm#sthash.L5TJr7eC.dpuf Magnetic resonance imaging (MRI) of the breast is often performed before patients go through lumpectomy, the surgical removal of cancer or other abnormal tissue from the breast. MRI scans give surgeons an idea of the size, shape and location of the patient's tumor prior to performing the breast-conserving surgery. Findings of a new study, however, have shown that the patient's position during presurgical breast MRI may affect the accuracy of the scan, which could influence the success of tumor removal. In a small study, researchers have found that MRI images taken prior to breast cancer surgery may give inaccurate data if the patient is positioned face down during the scan. Patients who were placed face up during presurgical MRI, on the other hand, appear to have more detailed and accurate information that could result in the effective removal of the tumor. For the study published in the journal Radiology on June 22, radiologists from Brigham and Women's Hospital in Boston involved 12 breast cancer patients who underwent lumpectomy, six of whom had MRI breast scans before and after surgery.
Imaging Information Resources
• http://www.medicalimaging.org/news-and-updates/ • http://www.sciencedaily.com/news/health_medicine/medical_imaging/ • http://www.medimaging.net/ • https://twitter.com/Imaging_News • http://www.molecularimaging.net/ • https://spie.org/x92009.xml • http://www.naturalnews.com/medical_imaging.html • http://www.healthimaginghub.com/ • http://www.merckmedicus.com/medicalnews#?WT.mc_id=MM_SEM_JRN2_US_en_2
Inter-strain DMN Variation in Rat Models Found Using rs-fMRI The default mode network (DMN) is a set of brain regions that are essential to brain function. These areas are referred as the DMN because they are involved in the brain’s default-mode, a “resting state,” where a person may be awake and alert, but not focused on any activity that requires concentration or attention. The DMN is thought to be required for several self-referential functions including imagination, conscious awareness and conceptual processing. Abnormalities of the DMN have been demonstrated in several neuropsychological conditions, one of which is attention deficit hyperactivity disorder (ADHD). DMN research is therefore regarded as potentially valuable for elucidating brain disease mechanisms. A number of researchers have reported using a rat strain called spontaneous hypertensive rat (SHR) as a model for ADHD. The SHR rat displays behaviors characteristic of those seen in ADHD such as poor performance, hyperactivity and impulsivity, when they are subjected to tasks that demand attention. https://www.bruker.com/imaging-blog/inter-strain-dmn-variation-in-rat-models-found-using-rs-fmri/
SNMMI 2016: Personalized Kidney Dosimetry Optimizes Radiotherapy Dose in Patients With Neuroendocrine Tumors Researchers at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) presented a molecular imaging technique that allows oncologists to set patients’ radiotherapy doses right at the critical limit of delivering the most powerful dosage to neuroendocrine tumors while protecting vulnerable vital organs. http://www.ascopost.com/News/41675?utm_medium=Email&utm_source=ExactTarget&utm_campaign=&utm_term=55
In the News
SNMMI 2016: PET/CT Imaging of Prostate Cancer With Specific Agent May Be an Accurate Prebiopsy/Preoperative Guide At the 2016 SNMMI Annual Meeting, researchers shared a PET imaging agent that targets prostate-specific membrane antigen, which may be used at the point of initial biopsy and preoperative planning to root out the full extent of prostate cancer. http://www.ascopost.com/News/41676?utm_medium=Email&utm_source=ExactTarget&utm_campaign=&utm_term=5535749
SNMMI 2016: Pretargeted Radioimmunotherapy Eliminates Colorectal Cancer in Preclinical Studies
Presenters at the 2016 SNMMI Annual Meeting unveiled a novel radioimmunotherapy that combines a
cancer-seeking antibody with potent radionuclide agents, resulting in complete remission of colorectal
cancer in mouse models. http://www.ascopost.com/News/41677?utm_medium=Email&utm_source=ExactTarget&utm_campaign=&utm_t
erm=5535749
A New Clue to Causes of Cardiotoxicity in Chemotherapy The antineoplastic agent doxorubicin is highly effective against a number of cancers, including breast and lung cancer as well as many other carcinomas, soft tissue sarcomas and hematological malignancies. Like most chemotherapeutic agents, doxorubicin can have serious adverse effects – most notably, heart muscle damage that can lead to congestive
heart failure – limiting its clinical use. Doxorubicin may affect cardiac muscle cells through oxidative damage, downregulation of contractile proteins, induction
of apoptosis, or most likely, a combination of such factors. Further knowledge of the drug’s interactions with biomolecules in cardiac muscle could help clarify the pathways leading to cardiomyopathy, and potential methods to
prevent it. Amino acids play a key role in cardiac metabolism and protect against several forms of cell damage. To explore
whether they might be involved in doxorubicin toxicity, Heger et al. examined amino acid levels in heart muscle before and after exposure to the drug. The researchers looked for interactions between doxorubicin and biologically important
amino acids using in vitro liquid chromatography and spectrophotometry in chicken myocardium. To confirm the drug’s presence in the heart tissue, the researchers combined fluorescence and X-ray imaging of
chicken hearts, using the Bruker In-Vivo Xtreme multimodal imaging system. Doxorubicin fluorescence (excitation: 480 nm; detection: 600 nm) appeared very clearly, primarily in the apex of the heart and the aortic estuary.
https://www.bruker.com/imaging-blog/a-new-clue-to-causes-of-cardiotoxicity-in-chemotherapy/
WEBINAR:
Emerging Applications in Preclinical microCT Imaging Wednesday, August 24, 2016
8 AM Pacific / 11 AM Eastern / 3 PM GMT | REGISTER Speakers: Christopher Damoci, PhD and Gael Rochefort, PhD
Preclinical microCT imaging systems are utilized across a wide range of applications requiring imaging of small anatomical structures, such as vessels and bones. MicroCT offers superior spatial resolution compared to many other
imaging modalities, and recent research incorporates microCT data with optical and nuclear data to generate multimodality datasets, increasing the understanding of disease and its progression.
https://www.labroots.com/ms/webinar/emerging-applications-preclinical-microct-imaging#thankyou
Save 15% when you register for the complete 2016 Clinical Trials Network Webinar Series.
Webinar Title Speaker Date
PET Imaging of the Brain for Technologists Adam Opanowski & LisaAnn Trembath April 21
Review of Amyloid Imaging and How to Enroll in the IDEAS study LisaAnn Trembath June 23 Using 68Ga-DOTATATE in the Management of Neuroendocrine Tumor Patients Corina Millo August 25 Using Fluciclovine in the Recurrent Prostate Cancer Patient David Schuster October 20 Everything You Need to Know For an IND but are Too Afraid to Ask Kellie Bodeker December 15
