LETCHUMI THANNIMALAYSENIOR RESEARCHERSIRIM BERHAD

GHS Classification Toolkit

GHS Review Conference for Southeast Asia

22nd May 2013

One World Hotel, Kuala Lumpur

Acute Toxicity

Skin corrosion/irritation

Serious eye damage / eye irritation

Skin / Respiratory sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

Specific target organ toxicity (Single exposure)

Specific target organ toxicity (Repeated exposure)

Aspiration hazard

Lung LungHeart

LiverStomach

Kidney KidneyGall bladder

Spleen

Oesophagus

Trachea

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Health Hazards

Classification of detergent for skin irritation/corrosion

Does the mixture as a whole have

data/information to evaluate skin

corrosion/irritation?Yes

Does the mixture contain one or more corrosive ingredients for which additive applies and where the sum of concentrations of ingredients classified as: Skin Category 1 ≥ 5%?

Yes

Category 1

Danger

No

Classification Not Possible

Does the mixture contain one or more corrosive or irritant ingredients for which additive applies and where the sum of concentrations of ingredients classified as:

Skin Category 1 ≥ 1% but < 5%; or

Skin Category 2 ≥10%; or

(10 x Skin Category 1) + Skin Category 2 ≥10%?

Yes

Category 2

Warning

No

Classification Not Possible

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Classification of detergent for eye damage/ irritation

Mixture:

Does the mixture as a whole or its ingredients have eye damage/irritation data?

Yes

Does the mixture contain one or more corrosive or irritant ingredients for which additive applies and where the sum of concentrations of ingredients classified as:

Eye Category 1 ≥ 3% ; or

Skin Category 1 + Eye Category 1: ≥3%?

Category 1

Danger

Yes

No

Classification Not PossibleDoes the mixture contain one or more corrosive or irritant ingredients for which additivity applies, and where the sum of concentrations of ingredients classified as:

(eye or skin Category 1≥ 1% but < 3% or

(eye Category 2/2A ≥ 10% or

((10 x eye Category 1) + eye Category 2A/2B≥ 10%

(Skin Category 1 + eye Category 1≥ 1% but < 3%, or

(10 x (Skin Category 1 + eye Category 1) + eye Category 2A/B ≥ 10%

Yes

Category 2A

Warning

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☺GHS Toolkit was developed to facilitate the classification and labelling of chemical mixtures for 16 physical hazards, 10 health hazards and three environmental hazards.

☺Contains 700 pure chemicals which were classified according to GHS.

☺Able to classify products/mixtures that contain large number of ingredients/chemicals such as detergent.

GHS Toolkit

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☺GHS Toolkit was developed according to Malaysia building block (DOSH-CLASS regulation).

☺The toolkit can predict the classification for the mixtures if the ingredients are available.

GHS TOOLKIT

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GHS Toolkit

Results of Classification for Laundry Detergent

MANUAL CLASSIFICATIONS AND RESULTS FROM THE TOOLKIT FOR HEALTH HAZARD AND ENVIRONMENTAL HAZARD

ADVANTAGES OF TOOLKIT

☺Classification of mixture will be based on the available test data for the raw materials of the mixture using concentration limits or summation method or additivity formula for the ingredients in the mixture.

☺Manual classifications are time consuming with a higher tendency to make mistakes.

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Using local detergent product that contains about 10 ingredients.

Experimental data were conducted (if available) for health and environmental hazards.

Manual classification were also conducted for the detergent product.

The results from the GHS Toolkit were compared with Experimental data and manual classification data.

Validation of the GHS TOOLKIT

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Validation of the GHS Toolkit Using Randomly Selected Mixtures for Health and

Environmental Hazard

1 0 0 ‐ ( ∑ C u n k n o w n i f > 1 0 % )A T E m i x = ∑

C iA T E i

ｎ

(100-50% ) / ATE mix = (2/5.03) +(48/6.6)ATE mix = 50/((2/5.03) +(48/6.6))= 6.5 mg/l classified as Category 3 for acute toxicity inhalation of vapours.(Category 3 is in between 2 mg/l and 10 mg/l as shown in Table 1 in Appendix 4).

Validation for inhalation toxicity

Validation for mutagenicity

If the mixture has more than 1% of mutagenic Category 2 raw materials then the mixture is classified as Category 2. Although the raw material in the mixture, lead chromate, only consists of 2% mutagen, the whole mixture is considered as mutagen.

Validation for Mutagenicity

Validation for Aquatic Toxicity (chronic toxicity)

Validation of the GHS toolkit for aquatic toxicity was conducted using the mixture that contains 4,4’ Methylenedianiline 2% (category 3), disodium tetraborate anhydrous 74.5% (not classified), chloroaniline 0.5% (category 1) and methylstyrene 23% (category 2).

Summation method was used to classify aquatic toxicity (chronic).Step 1 Chronic 1 x M > 25% (M=1 because LC50= 0.46) (category 1 has 0.5% chemicals) 0.5% x 1 not more than 25% so it is not classified as Category 1Step 2 (M x 10x Chronic 1) + Chronic 2 > 25% (1 x 10 x 0.5) + 23% = 28% > 25% (the mixture is classified as Category 2)

Any enquiries please contact

letchumi@sirim.my

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