\

106 1

PROPOSAL

It is proposed to continue research onzproblems

critical to a clarification of the fundamental aspects of the

stimulus-response relationship ia biologicfisysteros. Studies

will be conducted utilising chronic animal pr eparations with

permanent septal electrodes. Investigations will be conducted

utilising chronic electrode preparations coupled with selected

classical-typos o£ conditioning. Studies will be conducted on

the geography of the brain is selected specie s of animalsto

determine the locus in which stimulations will produce specific

reactions.

A careful literature survey, especially of the Russian

literature, of foreign research in this area will be conducted.

106 3

at Jao«»!ry I960

memorandum finance pvtmmVIA ! T^/8ad*M 0m«®r

SUBJECT s MKUDTRAe S«8bproj«c* 106. tavoic*#1

AUotmo** 0->25.100t-4902

I. lavoic® N®. 1 th® ®bor«ittbprojwct U *tUeb«

CERTIFICATIONS

(i) in* hereby certified that this le lavoice #1 applying to

Subproject 104 oI MKULTRA, that performance la aatlafactory,—that eervlcaa are being accompli!bed la accordance

with

mutual agreements, that £ detailed agenda of thepayment* and

.

tecelpti Is^fllid MTSS/CO. that tbOrbiU U jast and correct aad

that payment thereof ha« not yet beea made. 1

Chief, TSS /Chemical Dlvlsloo

(2y It is hereby certified that thisInvoice applies to Subproject 106

under MKULTKA which was duly approved and that the prejget isbeiog carried bat in accordance with the msmoraodora

dated

13 April 1935 from the DC! to the DD/A, r aad the ijcteaeloaof this

authority la aubaequent memoranda. ,

106 SPROPOSED BUDGET '

Salary (Chief Investigator) . $11,500

Technical Services 27000

Materials and Suppliesr 3,000

Travel....... - 2,500

Overhead (107hf«) , 2,014

TOTAL - $217014

I

resident

I have examined

ChieffSD/Biological Branch

Koponae Utlatloruht p* In BK.loalct 1 .SijLtJQaj

!?rittiMnt cf and Expsodtd

Ftbrusry I 57T 1960 t > Febroar? 16 ^. 19^=

Uani-Jesuiti4 ••

Ixptad ltur** ?imili «• t "i — ~~ t

Personnel:Px inc ipi l Invest l £4 tor

Labors tory Tec Ho Ic 1 so

'Jcrcrttsry

Conswae ab l * 5uppl i e •-

f Kpt r t^ACt s 1 Ani

1

•

Sij&oesl Cdg« * /"_\7T“7Peid forl Aniasl*

Laroratory Supplies

$ 9,000.00- 97570

0

1,600.00=-570700

375.00800700

$ 10,500:00

Trave i :Cop ft react Travel 215.00

Moving KxpsnstT Principal_

1n v * a 1 1

t

stor 2.375,00

Cera su i tant 3 : ~^=^_ _^zz=

Overhead Burdtn-

'.:.t s 1 Kitpvndi turte :—

3,345.00

2.590.00

2 , 50*9.00

2.079.00

fvftdt^_Ffbrsj»ri J&aJL&SX t fc?TT„ « , „,7 , x.—

—

/

N

106 f

April 13 , i mi

Q«otl«sMa:

V -k you vary *u«b for ^b* tmwl of yoyr grant in tlvoMovnt of tv.lv. thou..nd dollar. ($12,000.00)

to rua fro. Jan-

uary i, nil for i yariod of iwlva 0?) i

Ucrtvi tb adcloaad it our tactyltulatlon «fth« fvE

^s

racelvad and tba asgaaditWal uodar tba pgarlcm «fML-w®

- * > . . t J "Iwifc Ml 1 1 M 1Vtf> — _ » j.t-^nsircr« aaading you tba ortg

t

eal and eea copy kut wilL o« oappy

to forwardIw^y^opiil if you to daaira.

mil-r veuri

,

ctin* Traaturti

MEMORANDUM FOR: THE RECORD

21 May 1962

SUBJECT MKUETRATSubproject No. 1C6

1. It is proposed iocontijBrt^^5©"^_cb^^«rMKHLTIC^

subproject No. 106 on studies^ biological^tems'With, particular

reference to quantifying Jthe relationship^e^

the K^lngical-response to that stimulus.Problems arising from

—the difference in excitability and behavioral

response among members

of an animal populationynU. be mlyjeQy means of animal prepa-

rations particularly suitable for demonstratingspecific functions,

evaluations will beimade of biologicalgeneralizations arisingfrom

the use of one species of animal as anexperimental variable. A

critical review mil be maintained of selectedforeign literature

especially that on the neurophysiologicalmechanism of conditioning

and related behavioral research. :

2. Because of tho very low level ofeffort bn which this program

is to be continued during the next year,reimbursements will be made

directly to Mr, the chiefinvestigator, on the basis of

his invoices for professional servicesrendered atlhe times that these

I

occur. No intervening cutouts will be requiredas werp used in

the previous program;

3. required for this program for oneyear amount to

$3, 000. 00. Charges should be made againstAllotment No. 2125-1390-3902

4. It is notJmticipate

4

O / } -i,, , -< ’K ,r-. ; ". -.r .•;< ,! lfl«:s.-?y,.'s:

\ ', Oatc; ^

i iemorakbum for; the comptroller ’ ; -

'.ATTENTION - ; i Finance Division ; ' ^ „ , - ,,

‘

f < .*' >' - ?

‘

‘ /SUBJECT - J /: 's MKULTRA, Sub?fojav'tl_M^^|*i.

Under the authority graded ia tbs memorandum dated 13 April 19S)

-1 " from t •>i a OCI to the BO/A, atid'lho extension of this authority in cabsequent -

- ; - \ .’

'

-v''

/'

-.

'* ": 't

’•> “

' memoranda, Sub?4isct_Jg$ bests' approved, -’.

,- * . ..

V

» > 1.1^ »• .00 peytblaAram on

• 3. TM» 1* a final invoice. Sowwar, »iac* it Is anticipatethat additional twd* *111 b» obligated fog thle project, tha flSTrtsould not te «lo*$d«

h.ife

Attectoaat» tIaoica 4 C*rWfiea>U©o*

PiatrifcuUonj .CHECKS, v • -•

;

Prig h 2 » AMrttw# - ftgCStvfct.. '.5M%|

^ vviUUNt or si

23- TSD.y >T

•» /•; >

$w am®unto ®fe

CONFIDENTIAL

FUNDS

POST

INO

VOUCHER

T

00 payatl*drum oo

8* I^*« fom3f4 to Cbl*f, fw/wswcaBarateh Offloor >y 9 MM-cfc i£61.

J* 8W» t» * fi»V tatoloo. lowtor, »lnco it l« aatloipoUdthat additional fuaU viU Obligated for this yrojeet, tb« fila#tbculd not to olosod.

9i Osrtif

Distribution!

'#*

,* * l

'

,v.i

n:i*0 ?' 1"E

',0''

.« M»r ;iVrv

.Date:,' v, •

i ,V

,• -

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+.-

:

MEMORANDUM FOR: THE COMPTROLLER , ’ ; jft t i

1V. f * >>;*

ATTENTION#/

; Finance Division*

**

V’

‘ V ^ ^ * ^^

"\ „ ( O / * - > ' , V '*

SUBJECT'* t'MKULTRA, Sobproject^JfjfcJg!

1

,

'

,,ri

'

l \

.

:’ Uader the authority graetocUa tha

Wmorandurn^diteeX 1J April 195 J . .

-from tbaDClfo the iOp/A,,an^ lK^ exto^stono? t’ois authority in subsequent , '

memoraiida,'Sub?Toj«et-_|®|_ -.kas beenapproved, and-. —....

,

~of the ovar-Ali Project MKULTRA Ws h*ve been obligated to cove*; the

-'subproject's expenses Ana $iioutdcpsi center

( Chief

TSD/Research Braach^

approved FOR OBLIGATIONOF FUND'S:

€IM *#«&sl©il 8*vrtw*Date:

Distribution:

Original & Z ~ - Add.vft33 se -

-v .. • 4 --*tD/fA«71 «TSD/RB IX

14 February 1961

MEMORANDUM FOR: THE RECORD

SUBJECT : MKULTRA, Subproject No, 106

1, : It is proposed to continue research under MKULTRA

subproject NoTlOh on etudiea of biological «y»tems with particular

reference to quantifying tbe relationship between a stimulusand

the bioir>gie*l»re spoase to that stimulus. Problem s arising from

the difference ip excitability and behavioral response amongmembers

of an animal population will be analyzed. By means of animal prep-

arations particularly suitable for demonstrating specific functions,

will be made of biological generalizations a rising from

the use of one specie s of animal as an experimental variable. A

critical review will be maintained of selected for eign literature

especially that on the neurophysiological mechanism of conditioning

and related behavioral research. , t

2. Th 11 function

cut oat and cover for this subproject. T he necessary research

will be conducted b who will submit to

sunimary accounting of

funds at the conclusion of the program. Any unused funds remaining

at the conclusion of the program will be returned to the

3 : Fund* required for this programfor one year amount

a four par coat lervtco^ehargeto the

M^^ltittfemakihg the totalamcuut$12, 480, °0y Chargershould

be made against Allotment No. U2S-n90“3902^ ;

4. It is not anticipated thatany permanent equipment will

b. ...d.d for thl. program, fa'k. 1>V« »«"-*ttut docum.tmtlo.

»nd accoubting fortr.vel «*peoi««which »'• r.imbart.M. by

•haitvcoQfornv to the accepted practice

\ \

of that organissatioa.j

5=Xhejr eq^iiTemeot for a semiannual informal accounting

has been waived.

6. All peraouaei^bcQectedmth theplaaning and monitoring

of this program pos a ere Agency Top Secretapproval .

1 7 The project will >>e unclassified after itleave. the

APPROVED FOR OBLI*GATION OF FUNDS:

approved

Attachment;

propos ed BudDistribution;

Original Only

PROPOSED BUDGET

SALARY:

Chief laveltigator. . . • $*0i OOP- 00

TRAVEL. ±»=li°°0, 00

INSURANCErHOSPITAUZATION;SOCIAL SECURITY. »* 3°9 » 00

ADMINISTRATIVE EXPENSES .. . . ... . . , .

.

700700

$12.090.00TOTAL

memorandum FOR;

ATTENTION i FtM>M Divtttoft

SUBJECT : MKULTRA. Subproject104

rn*mm *******;*•«»'aw™******

u April MS^feom the PCI to the PD/A. >*t«d tocover the aubproj*c* «x4*n»ei

TM* ©bUs*tloa of funds should be chargedto Allotment 1125-

li$a»3902 »

TSD/Rossarch Br&nch

approved FOR obligat ionOF FUNDS:

Research Director

Distribution

l - TSD/OCU-^TSD/FASS2 - TSB/RB

•*

tsiS /rft /jhMMSI£

108 26

14 grtmiy Wtl

M£MCR AHDPM FOR: COMPTROLLER

ATTENTION : FImaca DlvUloa

«,miECT s MKULtRA, Subproject 106SUBJECT

Padw tho authority gr*a*«d *» **« mamorapdomdatod

„ af»lt MSS from the PCI 14 the DP/A.aad tha «**»»**» o<

tUt authority la aabae^entmamoraada. Subproject 104 ha.

h««a approved aad $12,480.00o£ the oy«r-aU MKULTBA pro-

ject faada haa beta ohUjaUd to *ov«*the aubprpjcct capeiaear

TM» obllgeUda o* foada «he»ld he charged to /V»otm«at 1US»

1S$0*S902.

T30/Reaaarch Branch

APPROVED FOR OBUGATIONor FUNDS:

~

_:i_

Reaaarch mractor

Dtti ! -

Dlatvlhtttloa:

Oilg. fc l^Addreaeee

l *=TSD/OCl - TSD/FASS

fcn /r'O

!

iu t**v

4

106

29 December iflt

MEMORANDUM FOBS COMPTROLLER

attention

SUBJECTS

V DMMoa

I MKULTRA, Sebpf

CONFIDENTIAL

FUNDS

POSTING

VOUCHER

IT Jwwwy 1940

MEMORANDUM 2"OR: CHIEF, FINANCE DIVISION

VIA i TSS /Badgtt Offlc»r ’

SUBJECT I s MKUiTRA, S*bproJ*ct 106, lavotc* #1AlloUneat 0525-1009-4902

I, larotc* No. 1 cov«rlag th« above eubproject l* ttUchdFeyr' 4 should be made ** follows:

C*«hUr»« £b«ck in the ajaaooat oi.$*41.00 payable

5 E yQ^ ^ 3 ?O t***"! ,

4.,

5.

£xpi?a*ion Data?

Project Monitor?

FROM! TSS/CD JJ

Room Bgio • Ext, 8612

106 IlO

February 5, I960

X

Gentlemen; ~t

VUijLpUtud to be able to trsnemlt to you the followingfoods: I

•r*« Chtcls^li*®^df*wo oo thFeb. I960

Treasurer drawn on tor $ 0, dated l Feb. I960

Thsse funds represent a contribution for the use of your

directors In carrying out the very worthwhile researchgoals of

your organisation, r

Tours truly,

End.Checks (2)

106 X%

2f>p«c«mb*v 195$

FOR t COMPTROLLER ,

AffIMflOH I ftlMM DlvUloa i

SUBJECT l WKULTRA, S»$**«J»** W$

Ui4t»;urjjwM^Wttr f***1*4 la U® mansofaadam4if«d

l> Apyll 19S3 item th« PCI to tk« BP/A. »»4t*» *xt®o #lea of

thli Ift «eb8n*eat m**»Of*«

\

D R:A F T29 December 1959

108 xt

MEMORANDUM FOR; THE RECORD

SUBJE

C

T : MKULTR A, Subproj e ct 10

6

1 . The pur

p

o 3 e of MKULTRA subproj e ct 106 i 8 to under-

take studies on biological systems with particular reference to

quantifying the relationship between a stimulus and the biological

response to that stimulus. The lack of a general understanding

and adequate methodology for handling thi

s

;

r elationship in a ^

r ealistic fashion is one of the major roadblocks to rapid technical

progress in the fields of assessment and control of behavior at

the present time. It is planned to utilize an interdisciplinary

approach in this research with emphasis on the side of the physical

science 3 . Several advanced mathematical techniques and physical

models^have been suggested as fruitful research areas not pre s ently

being exploited. Problems arising from the difference in

excitability and behavioral response among members of an animal

population will be analysed. An attempt will be made to elucidate . t

relationships between lower animals and roan by comparing

physiologicalT^bibchemical, and behavioral characteristics. By

means of animal preparation s part icularly suitable for demonstrat- 1

generalizations arising fr^th^se o£ one>ind «f animal as an

experimental variable. A criticaPreview will be made ofselected^

foreign literature especially that on theneurophysiological

mechanism of conditioning and related behavioral r esearch.Par

tintiar reference will be made to the recent shift on the partof

the Russianrf^bmbhe strict 'T^lovian'^iew toa mor^ : realistic

approach to the problem.

2. Thwill function

as f^|pgh^ppfftMiPiP^wrmaking the totalAmount $21, 8SSf 00. Charges should

be made against Allotment No. 0 5 25 -1009 *49 0^- -

4. [t is not anticipated that any permanentequipment will

be needed for this program. It harbeen agre edthat documentation

and ac™»»n*ing for travel expenses which arereimbursable by

2-"-

PROPOSALlUt>

Tt la proposed to mount the initial phase 3 of aprogram

alrae* at-an eventual clarification of the fundamental aspects

of the problem of stimulus - response relationshipin biological

systems. The present theoretical models andconceptsin this

area are- not only inade^te^ut also represent^o^g^to

further progress in the evaluation andcontrol ofMolojical

systems, including man. (See work such asLoe'«re> S,

pg 692 , 1959) The development Ofpractical tools for this vork i

the fora of chronic animal preparationswithpenaanent septal^

electrodes has lately opened the door to effectiveresearch in

this area r~-

~

Initially"the work will consist of a carefulliterature^

especially of the Russian literature, coupledwith various classical

—

types of conditioning experiments uoing the cbr°^e^le^^3^3*0/

tions available from animal guidance programs . :Later,

these experiments will be pooled with those involving3ta"d

^Jd^ei

effects on the sane preparationsto design criticalexperiments -iraei

at providing' new abstract models for thesephenomena.

It is planned that during the first yearone inve stlgatlgfi. can

complete the literature work and with aminimum of help carry

thePinitial animal studies required for the design

of

Avr^r^nenta to be carried out during the second year^ Eiefora of these

experiments cannot presently be visualizedbecause of the inadequacies

—

of pyeaent knowledge.