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DISCOVERY DELIVERED
Accelerating your drug discoveryOlga Issakova Executive Vice President(408) [email protected]
Accelerating your drug discovery
nanosyn.com
Nanosyn is a biological and chemical services contract research
organization providing high throughput screening, compound
profiling, assay development, protein expression, SAR expansion
and testing, medicinal chemistry, compound libraries, hit-to-lead
optimization, process chemistry, scale-up services and other
innovative solutions to meet your drug discovery needs.
Our comprehensive platform of kinase, protease, phosphatase and epigenetic assays utilizes cutting-edge microfluidics and informatics tools to provide accurate and rapid results for your drug discovery, compound evaluation and prioritization programs.
SCREENING AND PROFILING SERVICESNanosyn’s biochemical assays uti l ize a Caliper
LabChip microfluidic technology—the only
profi l ing technology that affords simultaneous
detection and quantif ication of both substrate
and product of the reaction in the same sample.
The internal normalization of product to substrate
reduces the effects of sampling errors and results
in highly precise measurements. The separation
of product from substrate also minimizes effect
of f luorescent compounds on the assay readout.
The robustness of our assays is documented
by Z’ values higher than 0.75. The intrinsically
low background values also allow for a high
sensitivity of detection with minimal amounts of
substrate, enzyme and compound required. To
ensure the quality we uti l ize only the highest
quality proteins that we source from the most
reliable commercial vendors or produce in house.
MICROFLUIDICS-BASED DETECTION TECHNOLOGY
Olga Issakova Executive Vice President(408) [email protected]
Accelerating your drug discovery
nanosyn.com
In contrast to other high throughput screening
fluorescence- and luminescence-based assays,
including Alpha-Screen, IMAP and Fluor de Lys, the
mobility shift assay tolerates significant levels of
auto- f luorescence associated with many chemical
compounds, allowing unambiguous detection of
positive compounds. An in-house set of compounds
clearly shows that the signature of auto-fluorescent
compounds was unmistakably different from that
of a positive inhibitor/activator trace. In addition,
the simultaneous detection of product and
substrate provides means for internal normalization
of individual enzymatic reactions, resulting in
significantly improved reproducibil i ty.
THE PRINCIPLE OF MICROFLUIDIC DETECTION
Enzymatic reactions are performed in 384-well
microplates and the 12-channel Caliper LabChip
instrument is used as a detection device. The
enzymatic modification of a peptide results in a
change in net charge, enabling electrophoretic
separation of product from substrate. As substrate
and product are separated, two peaks of
f luorescence are observed. Change in the relative
fluorescence intensity of the substrate and product
peaks is the parameter measured, reflecting
enzyme activity. In the presence of an inhibitor, the
ratio between product and substrate is altered: the
signal of the product decreases, while the signal of
the substrate increases.
Direct readout of enzyme activity by monitoring product and substrate in the same run
Easily identify fluorescent compounds interfering with assays
High precision and reproducibility of the data
Even weak inhibitors can be readily identified
Low level of false positive andfalse negatives
Applicable to a wide range of targets
Activators as well as inhibitors readily identified in a single screen
ADVANTAGES
Enzyme
Labeledsubstrate
384 well plate w/compounds
PS
S
AcK
K
Kinases orPhosphatases
HATs orHDACs
Peptidases
product
substrate
compound
Enzyme
Labeledsubstrate
384 well plate w/compounds
PS
S
PS
PSS
SSS
AcK
K
AcK
AcKK
KKKK
Kinases orPhosphatases
HATs orHDACs
Peptidases
product
substrate
product
substrate
compoundcompound
Olga Issakova Executive Vice President(408) [email protected]
nanosyn.com
Accelerating your drug discovery
ABL1 ABL1 c-abl oncogene 1, non-receptor tyrosine kinaseAKT1 AKT1 v-akt murine thymoma viral oncogene homolog 1AKT2 AKT2 v-akt murine thymoma viral oncogene homolog 2AKT3 AKT3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)ALK ALK anaplastic lymphoma receptor tyrosine kinaseAMP-A1B1G1 PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunitAMP-A2B1G1 PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunitARG ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2ARK5 NUAK1 NUAK family, SNF1-like kinase, 1AURORA-A AURKA aurora kinase AAURORA-B AURKB aurora kinase BAURORA-C AURKC aurora kinase CAXL AXL AXL receptor tyrosine kinaseBLK BLK B lymphoid tyrosine kinaseBMX BMX BMX non-receptor tyrosine kinaseBRAF BRAF v-raf murine sarcoma viral oncogene homolog B1BRK PTK6 PTK6 protein tyrosine kinase 6BRSK1 BRSK1 BR serine/threonine kinase 1BRSK2 BRSK2 BR serine/threonine kinase 2BTK BTK Bruton agammaglobulinemia tyrosine kinaseCAMK1A CAMK1 calcium/calmodulin-dependent protein kinase ICAMK1D CAMK1D calcium/calmodulin-dependent protein kinase IDCAMK2A CAMK2A calcium/calmodulin-dependent protein kinase II alphaCAMK2B CAMK2B calcium/calmodulin-dependent protein kinase II betaCAMK2G CAMK2G calcium/calmodulin-dependent protein kinase II gammaCAMK2D CAMK2D calcium/calmodulin-dependent protein kinase II deltaCAMK4 CAMK4 calcium/calmodulin-dependent protein kinase IVCDK1-CYCLINB CDK1 cyclin-dependent kinase 1 / cyclinBCDK2-CYCLINA CDK2 cyclin-dependent kinase 2 / cyclinACDK2-CYCLINE CDK2 cyclin-dependent kinase 2 / cyclinECDK3-CYCLINE1 CDK3 cyclin-dependent kinase 3 / cyclinE1CDK4-CYCLIND1 CDK4 cyclin-dependent kinase 4 / cyclinD1CDK5-p35 CDK5 cyclin-dependent kinase 5 / p35CDK5-p25 CDK5 cyclin-dependent kinase 5 / p25CDK6-CYCLIND3 CDK6 cyclin-dependent kinase 6 / cyclinD3CDK7/CICLINE H CDK7 cyclin-dependent kinase 7/cyclin HCDK9/CYCLINE T1 CDK9 cyclin-dependent kinase 9 / cyclin T1CHEK1 CHEK1 CHK1 checkpoint human homolog (S. pombe)CHEK2 CHEK2 CHK2 checkpoint human homolog (S. pombe)CK1-ALPHA1 CSNK1A1 casein kinase 1, alpha 1CK1-EPSILON CSNK1E casein kinase 1, epsilonCK1-GAMMA1 CSNK1G1 casein kinase 1, gamma 1CK1-GAMMA2 CSNK1G2 casein kinase 1, gamma 2CK1-GAMMA3 CSNK1G3 casein kinase 1, gamma 3CK2 CSNK2A1 casein kinase 2, alpha 1 polypeptideCLK1 CLK1 CDC-like kinase 1CLK2 CLK2 CDC-like kinase 2CLK3 CLK3 CDC-like kinase 3
Available Kinase AssaysNanosyn Name Symbol Approved Name
Olga Issakova Executive Vice President(408) [email protected]
nanosyn.com
Accelerating your drug discovery
CLK4 CLK4 CDC-like kinase 4CRAF RAF1 v-raf-1 murine leukemia viral oncogene homolog 1CSK CSK c-src tyrosine kinaseDAPK1 DAPK1 death-associated protein kinase 1DAPK3 DAPK3 death-associated protein kinase 3DCAMKL2 DCLK2 doublecortin-like kinase 2DDR1 DDR1 discoidin domain receptor tyrosine kinase 1DDR2 DDR2 discoidin domain receptor tyrosine kinase 2DYRK1A DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1ADYRK1B DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1BDYRK2 DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2DYRK3 DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3DYRK4 DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4EGFR EGFR epidermal growth factor receptorEPH-A1 EPHA1 EPH receptor A1EPH-A2 EPHA2 EPH receptor A2EPH-A3 EPHA3 EPH receptor A3EPH-A4 EPHA4 EPH receptor A4EPH-A5 EPHA5 EPH receptor A5EPH-A8 EPHA8 EPH receptor A8EPH-B1 EPHB1 EPH receptor B1EPH-B2 EPHB2 EPH receptor B2EPH-B3 EPHB3 EPH receptor B3EPH-B4 EPHB4 EPH receptor B4ERBB2/HER2 ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene
homologERBB4/HER4 ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4FAK PTK2 PTK2 protein tyrosine kinase 2FER FER fer (fps/fes related) tyrosine kinaseFES FES feline sarcoma oncogeneFGFR1 FGFR1 fibroblast growth factor receptor 1FGFR2 FGFR2 fibroblast growth factor receptor 2FGFR3 FGFR3 fibroblast growth factor receptor 3FGFR4 FGFR4 fibroblast growth factor receptor 4FGR FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homologFLT1 FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor
receptor)FLT3 FLT3 fms-related tyrosine kinase 3FLT4 FLT4 fms-related tyrosine kinase 4FMS CSF1R colony stimulating factor 1 receptorFRAP1 MTOR mechanistic target of rapamycin (serine/threonine kinase)FYN FYN FYN oncogene related to SRC, FGR, YESGRK6 GRK6 G protein-coupled receptor kinase 6GRK7 GRK7 G protein-coupled receptor kinase 7GSK3-ALPHA GSK3A glycogen synthase kinase 3 alphaGSK3-BETA GSK3B glycogen synthase kinase 3 betaHASPIN GSG2 germ cell associated 2 (haspin)HCK HCK hemopoietic cell kinaseHIPK1 HIPK1 homeodomain interacting protein kinase 1HIPK2 HIPK2 homeodomain interacting protein kinase 2HIPK3 HIPK3 homeodomain interacting protein kinase 3
Nanosyn Name Symbol Approved Name
Olga Issakova Executive Vice President(408) [email protected]
nanosyn.com
Accelerating your drug discovery
HIPK4 HIPK4 homeodomain interacting protein kinase 4IGF1R IGF1R insulin-like growth factor 1 receptorIKK-ALPHA CHUK conserved helix-loop-helix ubiquitous kinaseIKK-BETA IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betaIKK-EPSILON IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilonINSR INSR insulin receptorIRAK1 IRAK1 interleukin-1 receptor-associated kinase 1IRAK4 IRAK4 interleukin-1 receptor-associated kinase 4IRR INSRR insulin receptor-related receptorITK ITK IL2-inducible T-cell kinaseJAK1 JAK1 Janus kinase 1JAK2 JAK2 Janus kinase 2JAK3 JAK3 Janus kinase 3JNK1 MAPK8 mitogen-activated protein kinase 8JNK2 MAPK9 mitogen-activated protein kinase 9JNK3 MAPK10 mitogen-activated protein kinase 10KDR KDR kinase insert domain receptor (a type III receptor tyrosine kinase)KIT KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homologLATS1 LATS1 large tumor suppressor kinase 1LATS2 LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)LCK LCK lymphocyte-specific protein tyrosine kinaseLOK STK10 serine/threonine kinase 10LRRK2 LRRK2 leucine-rich repeat kinase 2LTK LTK leukocyte receptor tyrosine kinaseLYNA LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog, isoform ALYNB LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog, isoform BMAP4K2 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2MAP4K4 MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4MAP4K5 MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5MAPK1 MAPK1 mitogen-activated protein kinase 1MAPK3 MAPK3 mitogen-activated protein kinase 3MAPKAPK2 MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2MAPKAPK3 MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3MARK1 MARK1 MAP/microtubule affinity-regulating kinase 1MARK3 MARK3 MAP/microtubule affinity-regulating kinase 3MARK4 MARK4 MAP/microtubule affinity-regulating kinase 4MEK1 MAP2K1 mitogen-activated protein kinase kinase 1MEK2 MAP2K2 mitogen-activated protein kinase kinase 2MELK MELK maternal embryonic leucine zipper kinaseMER MERTK c-mer proto-oncogene tyrosine kinaseMET MET met proto-oncogene (hepatocyte growth factor receptor)MINK MINK1 misshapen-like kinase 1MKNK1 MKNK1 MAP kinase interacting serine/threonine kinase 1MRCK-ALPHA CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)MRCK-BETA CDC42BPB CDC42 binding protein kinase beta (DMPK-like)MSK1 RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5MSK2 RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4MSSK1 SRPK3 SRSF protein kinase 3MST1 STK4 serine/threonine kinase 4MST2 STK3 serine/threonine kinase 3MST3 STK24 serine/threonine kinase 24
Nanosyn Name Symbol Approved Name
Olga Issakova Executive Vice President(408) [email protected]
nanosyn.com
Accelerating your drug discovery
MUSK MUSK muscle, skeletal, receptor tyrosine kinaseNDR2 STK38L serine/threonine kinase 38 likeNDRG1 NDRG1 N-myc downstream regulated 1NEK1 NEK1 NIMA (never in mitosis gene a)-related kinase 1NEK2 NEK2 NIMA (never in mitosis gene a)-related kinase 2NEK6 NEK6 NIMA (never in mitosis gene a)-related kinase 6NEK7 NEK7 NIMA (never in mitosis gene a)-related kinase 7NEK9 NEK9 NIMA (never in mitosis gene a)- related kinase 9P38-ALPHA MAPK14 mitogen-activated protein kinase 14P38-BETA MAPK11 mitogen-activated protein kinase 11P38-DELTA MAPK13 mitogen-activated protein kinase 13P38-GAMMA MAPK12 mitogen-activated protein kinase 12P70S6K1 RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1P70S6K2 RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2PAK1 PAK1 p21 protein (Cdc42/Rac)-activated kinase 1PAK2 PAK2 p21 protein (Cdc42/Rac)-activated kinase 2PAK3 PAK3 p21 protein (Cdc42/Rac)-activated kinase 3PAK4 PAK4 p21 protein (Cdc42/Rac)-activated kinase 4PAK5 PAK7 p21 protein (Cdc42/Rac)-activated kinase 7PAK6 PAK6 p21 protein (Cdc42/Rac)-activated kinase 6PAR-1B-ALPHA MARK2 MAP/microtubule affinity-regulating kinase 2PASK PASK PAS domain containing serine/threonine kinasePDGFR-ALPHA PDGFRA platelet-derived growth factor receptor, alpha polypeptidePDGFR-BETA PDGFRB platelet-derived growth factor receptor, beta polypeptidePDK1 PDK1 pyruvate dehydrogenase kinase, isozyme 1PERK EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3PHK-GAMMA1 PHKG1 phosphorylase kinase, gamma 1 (muscle)PHK-GAMMA2 PHKG2 phosphorylase kinase, gamma 2 (testis)PI3K-ALPHA PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptidePI4K-BETA PI4KB phosphatidylinositol 4-kinase, catalytic, betaPIM1 PIM1 pim-1 oncogenePIM2 PIM2 pim-2 oncogenePIM3 PIM3 pim-3 oncogenePKA PRKACA protein kinase, cAMP-dependent, catalytic, alphaPKACB PRKACB protein kinase, cAMP-dependent, catalytic, betaPKC-ALPHA PRKCA protein kinase C, alphaPKC-BETA1 PRKCB protein kinase C, betaPKC-BETA2 PRKCB2 protein kinase C, betaPKC-ETA PRKCH protein kinase C, etaPKC-EPSILON PRKCE protein kinase C, epsilonPKC-GAMMA PRKCG protein kinase C, gammaPKC-IOTA PRKCI protein kinase C, iotaPKC-THETA PRKCQ protein kinase C, thetaPKC-ZETA PRKCZ protein kinase C, zetaPKN1 PKN1 protein kinase N1PKN2 PKN2 protein kinase N2PLK1 PLK1 polo-like kinase 1PLK2 PLK2 polo-like kinase 2PLK3 PLK3 polo-like kinase 3PLK4 PLK4 polo-like kinase 4PRAK MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
Nanosyn Name Symbol Approved Name
Olga Issakova Executive Vice President(408) [email protected]
nanosyn.com
Accelerating your drug discovery
PRKD1 PRKD1 protein kinase D1PRKD2 PRKD2 protein kinase D2PRKD3 PRKD3 protein kinase D3PRKG1 PRKG1 protein kinase, cGMP-dependent, type IPRKG2 PRKG2 protein kinase, cGMP-dependent, type IIPRKX PRKX protein kinase, X-linkedPTK5 FRK fyn-related kinasePYK2 PTK2B PTK2B protein tyrosine kinase 2 betaRET RET ret proto-oncogeneRIPK2 RIPK2 receptor-interacting serine-threonine kinase 2ROCK1 ROCK1 Rho-associated, coiled-coil containing protein kinase 1ROCK2 ROCK2 Rho-associated, coiled-coil containing protein kinase 2RON MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase)ROS ROS1 c-ros oncogene 1 , receptor tyrosine kinaseRSK1 RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1RSK2 RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3RSK3 RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2RSK4 RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6SGK1 SGK1 serum/glucocorticoid regulated kinase 1SGK2 SGK2 serum/glucocorticoid regulated kinase 2SGK3 SGK3 serum/glucocorticoid regulated kinase family, member 3SIK SIK1 salt-inducible kinase 1SLK SLK STE20-like kinaseSNF1LK2 SIK2 salt-inducible kinase 2SPHK1 SPHK1 sphingosine kinase 1SPHK2 SPHK2 sphingosine kinase 2SRC SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homologSRMS SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sitesSRPK1 SRPK1 SRSF protein kinase 1SRPK2 SRPK2 SRSF protein kinase 2STK16 STK16 serine/threonine kinase 16SYK SYK spleen tyrosine kinaseTAK1/TAB1 MAP3K7 mitogen-activated protein kinase kinase kinase 7 /TAB1TAOK2 TAOK2 TAO kinase 2TAOK3 TAOK3 TAO kinase 3TBK1 TBK1 TANK-binding kinase 1TEC TEC tec protein tyrosine kinaseTIE2 TEK TEK tyrosine kinase, endothelialTNIK TNIK TRAF2 and NCK interacting kinaseTNK2 TNK2 tyrosine kinase, non-receptor, 2TRKA NTRK1 neurotrophic tyrosine kinase, receptor, type 1TRKB NTRK2 neurotrophic tyrosine kinase, receptor, type 2TRKC NTRK3 neurotrophic tyrosine kinase, receptor, type 3TSSK1 TSSK1B testis-specific serine kinase 1BTSSK2 TSSK2 testis-specific serine kinase 2TTK TTK TTK protein kinaseTXK TXK TXK tyrosine kinaseTYK2 TYK2 tyrosine kinase 2TYRO3 TYRO3 TYRO3 protein tyrosine kinaseYES YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1ZAP70 ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
Nanosyn Name Symbol Approved Name
Olga Issakova Executive Vice President(408) [email protected]
nanosyn.com
Accelerating your drug discovery
HDAC 1 HDAC1 histone deacetylase 1 Deacetylases/SIRTHDAC 2 HDAC2 histone deacetylase 2 Deacetylases/SIRTHDAC 3 HDAC3 histone deacetylase 3 Deacetylases/SIRTHDAC 8 HDAC8 histone deacetylase 8 Deacetylases/SIRTHDAC 4 HDAC4 histone deacetylase 4 Deacetylases/SIRTHDAC 5 HDAC5 histone deacetylase 5 Deacetylases/SIRTHDAC 7 HDAC7 histone deacetylase 7 Deacetylases/SIRTHDAC 9 HDAC9 histone deacetylase 9 Deacetylases/SIRTHDAC 6 HDAC6 histone deacetylase 6 Deacetylases/SIRTHDAC 10 HDAC10 histone deacetylase 10 Deacetylases/SIRTHDAC11 HDAC11 histone deacetylase 11 Deacetylases/SIRTSIRT 1 SIRT1 sirtuin 1 Deacetylases/SIRTSIRT 2 SIRT2 sirtuin 2 Deacetylases/SIRTSIRT 3 SIRT3 sirtuin 3 Deacetylases/SIRT
EP300 EP300 E1A binding protein p300 AcetyltransferasesPCAF AcetyltransferasesGCN5 Acetyltransferases
G9a EHMT2 euchromatic histone-lysine N-methyltransferase 2 MethyltransferasesEZH2 EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit MethyltransferasesSUV39H1 SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) MethyltransferasesSUV39H2 SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) MethyltransferasesSET7/9 SET7/9 SET domain containing (lysine methyltransferase) 7 MethyltransferasesSETD8 SETD8 SET domain containing (lysine methyltransferase) 8 MethyltransferasesMLL SEPT9 septin 9 MethyltransferasesCARM1 CARM1 coactivator-associated arginine methyltransferase 1 MethyltransferasesPRMT1 PRMT1 protein arginine methyltransferase 1 MethyltransferasesPRMT3 PRMT3 protein arginine methyltransferase 3 MethyltransferasesPRMT5 PRMT5 protein arginine methyltransferase 5 Methyltransferases
LSD1 KDM1A lysine (K)-specific demethylase 1A DemethylasesJMJD1A KDM3A lysine (K)-specific demethylase 3A DemethylasesJMJD2A KDM4A lysine (K)-specific demethylase 4A DemethylasesJMJD2B KDM4B lysine (K)-specific demethylase 4B DemethylasesJMJD2C KDM4C lysine (K)-specific demethylase 4C DemethylasesJMJD2D KDM4D lysine (K)-specific demethylase 4D DemethylasesJMJD2E KDM4E lysine (K)-specific demethylase 4E DemethylasesJMJD3 KDM6B lysine (K)-specific demethylase 6B DemethylasesFBXL10 KDM2B lysine (K)-specific demethylase 2B DemethylasesFBXL11 KDM2A lysine (K)-specific demethylase 2A Demethylases
Available Epigentic AssaysNanosyn Name Symbol Approved Name Group
Olga Issakova Executive Vice President(408) [email protected]
nanosyn.com
Accelerating your drug discovery
PDE1A1 PDE1A1 phosphodiesterase 1A, calmodulin-dependent PDE1B PDE1B phosphodiesterase 1B, calmodulin-dependentPDE1C PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDaPDE2A PDE2A phosphodiesterase 2A, cGMP-stimulatedPDE3A PDE3A phosphodiesterase 3A, cGMP-inhibitedPDE3B PDE3B phosphodiesterase 3B, cGMP-inhibitedPDE4A1A PDE4A phosphodiesterase 4A, cAMP-specificPDE4B1 PDE4B phosphodiesterase 4B, cAMP-specificPDE4B2 PDE4C1 PDE4C phosphodiesterase 4C, cAMP-specificPDE4D2 PDE4D3 PDE4D7PDE5A1 PDE5A phosphodiesterase 5A, cGMP-specific
Available PDE AssaysNanosyn Name Symbol Approved Name
Olga Issakova Executive Vice President(408) [email protected]
CD45 PTPRC protein tyrosine phosphatase, receptor type, CLAR PTPRF protein tyrosine phosphatase, receptor type, FPTP-Beta PTPRB protein tyrosine phosphatase, receptor type, BPTP-MU PTPRM protein tyrosine phosphatase, receptor type, MPEST PCNP PEST proteolytic signal containing nuclear proteinSHP-1 NR0B2 nuclear receptor subfamily 0, group B, member 2PTP1B PTPN1 protein tyrosine phosphatase, non-receptor type 1TC-PTP PTPN2 protein tyrosine phosphatase, non-receptor type 2PTP-D2 PTGDR2 prostaglandin D2 receptor 2PTEN PTEN phosphatase and tensin homologVHR DUSP3 dual specificity phosphatase 3SHIP2 INPPL1 inositol polyphosphate phosphatase-like 1MEG1MEG2BASLMPTP-APP2AC
nanosyn.com
Available Phosphate AssaysNanosyn Approved Symbol Approved Name
Accelerating your drug discoveryOlga Issakova Executive Vice President(408) [email protected]
Aspartic BACE1 beta-site APP-cleaving enzyme 1Aspartic CTSD CATHEPSIN DCysteine CAPN1 Calpain-1Cysteine CASP1 CASPASE 1Cysteine CASP2 CASPASE 2Cysteine CASP3 CASPASE 3Cysteine CASP5 CASPASE 5Cysteine CASP6 CASPASE 6Cysteine CASP7 CASPASE 7Cysteine CASP8 CASPASE 8Cysteine CASP9 CASPASE 9Cysteine CTSB CATHEPSIN BCysteine CTSK CATHEPSIN KCysteine CTSL CATHEPSIN LCysteine CTSS CATHEPSIN SMetallo ACE angiotensin I converting enzymeMetallo ACE2 "angiotensin I converting enzyme 2"Metallo ADAM10 ADAM metallopeptidase domain 10Metallo DPP3 dipeptidyl-peptidase 3Metallo IDE insulin-degrading enzymeMetallo MMP1 matrix metallopeptidase 1Metallo MMP12 matrix metallopeptidase 12Metallo MMP13 matrix metallopeptidase 13Metallo MMP14 matrix metallopeptidase 14 (membrane-inserted)Metallo MMP2 matrix metallopeptidase 2Metallo MMP3 matrix metallopeptidase 3Metallo MMP7 matrix metallopeptidase 7Metallo MMP8 matrix metallopeptidase 8Metallo MMP9 matrix metallopeptidase 9Metallo MME membrane metallo-endopeptidase (NEPRILYSIN)Metallo ADAM17 ADAM metallopeptidase domain 17 (TACE)Serine DPP4 dipeptidyl-peptidase 4Serine DPP8 dipeptidyl-peptidase 8Serine DPP9 dipeptidyl-peptidase 9Serine FACTOR Xa FACTOR XaSerine FAP fibroblast activation protein, alphaSerine FURIN furin (paired basic amino acid cleaving enzyme)Serine GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)Serine GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)Serine GZMK granzyme K (granzyme 3; tryptase II)Serine Plasma Kallikrein Plasma KallikreinSerine Plasmin PlasminSerine Prolyl Oligopeptidase Prolyl OligopeptidaseSerine THROMBIN THROMBINSerine tPA tPASerine UPA UPASerine HTRA2 HtrA serine peptidase 2Serine ClpP/X caseinolytic mitochondrial matrix peptidase proteolytic subunitThreonine Proteasome Chymo-trypsin like Chymo-trypsin likeThreonine Proteasome trypsin like Proteasome trypsin like
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8Immuno-proteasome trypsin like death-associated protein kinase 1
nanosyn.com
Accelerating your drug discovery
Available Protease AssaysGroup Symbol Approved Name
Olga Issakova Executive Vice President(408) [email protected]
