NEOPLASIA

Suimin Qiu, MD, PhD, Norbert Herzog, PhD, Valerie Bauer, MD

Suimin Qiu, MD, PhDAssociate Professor

Division of Surgical PathologyThe University of Texas Medical Branch

PATH 6266: NEOPLASIA

• Neoplasia– The new and abnormal development of cells that may be benign or

malignant• Malignant Tumors

– Carcinoma• Breast Cancer, colon cancer, prostate cancer

– Sarcoma• Liposarcoma• Osteosarcoma• Chondrosarcoma• Leimyosarcoma

– Lymphoma• Diffuse large B cell lymphoma• Hodgkin lymphoma

– Leukemia• Acute lymphoblastic leukemia• CML t(9;22)• AML-M3 t(15;17)

EMT: Epithelial-Mesenchymal Transition or Transformation

E-cadherinRasPI3K/AKTSnal/SnugTGF-Integrin α1β2 WntHedgehog family

Adenoma to Carcinoma Pathway

APCloss

NormalEpithelium

EarlyAdenoma

CancerHyper-

proliferationIntermediate

AdenomaLate

Adenoma

K-rasmutation

Chrom 18loss

p53loss

AdenomaNormal Cancer