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Pathology-LabNeoplasia-127th Oct’09
Ravi A Patel
Memory++ (M++)
Villous adenoma Colon
Lipoma
Verruca vulgaris (warts) - Skin
Leiomyoma Fibro adenoma
Normal ColonTaenia coli
1.Mucosa
2.Submucosa
outerlongitudinal
inner circular
3.Tunica Muscularis Normal Rectum
While Observing the slide of Villous Adenoma
• Epithelial Polyp- (Abnormal growth of tissue from the mucous membrane)
• Generally Sessile- upto 10cm diameter,velvety, cauliflower like projections 1-3 cm above normal mucosa
• The Frondlike(large divided leaf like) villiforms are surrounded by Dyplastic,disorderly arranged columnar epithelium
• Site of Adenoma- Colon, Rectum and Rectosigmoid
Villous Adenoma Epithelial Polyp
Dysplastic Columnar Epithelium
Villous Adenoma
Branching of the glands
Scanty fibrous stroma between the glands
While observing slide of Lipoma
• Tumor• Fibrous capsule• Remnants of the lobules• Mature fat cells • Scanty Stroma
Lipoma
LPO
Mature Fat cells withScanty stroma
RemnantsOf mammaryGlandlobules
Fat cells areWithin a thin fibrous capsule
LPO
HPO
Fibrous capsule
HPO
Scanty stroma and Fat cells
While Observing the Slide of Warts
Central thickened portion----- Represents Epidermal Hyperplasia with Papillomatous formation
•Koilocytes with Halos•Underlying Dermis shows scanty lymphocyte infiltrates•Causative organism-HPV
Verruca Vulgaris Skin (Warts)
Structure at pointer:- Papillomatous formation
LPO
Structure at pointer-Koilocyte with HalosSurrounding the nuclei
HPO
Koilocytes
HPO
Koilocytes
Obvious transition representing the further central thickened portion to follow which signifies the site of Wart
LPO
Another view of centally thickened portion with Papillomatous formation
Scanty Lymphocyte infiltrates in the Dermis
While Observing the slide of Leiomyoma– A.K.A Fibroids
• In HPO- Observe the whorling of the smooth muscles of the myometrium
• Fibrosis of the stroma is found.
• Also Known as Fibroids because they are firm.
• Facts– Leiomyoma is the most common benign tumour in women and they arise from smooth muscle of myometrium. They occur during active reproductive life.In Menopause they may calcify.Estrogen stimulate their Growth.
Leiomyoma
HPO
Whorling of smooth muscles Of myometrium
HPO
Significant FibrosisLPO
While observing the slide of Fibroadenoma
• Proliferating intralobular stroma pushing the epithelium
• There are 2 types of fibroadenoma1. Pericanalicular Fibroadenoma
In this kind of Fibroadenoma the ductal space are round/oval and fairly regualar
2. Intracanalicular Fibroadenoma Over here there is extensive proliferation of
surrounding stroma which compresses the ducts giving them irregular/star shape on cross section.
Poliferating Stroma is pushing The ducts leading to their irregularShape..This signifies of the slide being Intracanalicular fibradenoma
Fibroadenoma
Thanking to the entire Universe