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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Introduction to Nerves and the Nervous System
Introduction to Nerves and the Nervous System
Chapter 19
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Role of the Nervous SystemRole of the Nervous System
• Controlling the functions of the human body
• Analyzing incoming stimuli
• Integrating internal and external responses
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Make Up of the Nervous SystemMake Up of the Nervous System
• Central Nervous System (CNS)
– Composed of the brain and spinal cord
• Peripheral Nervous System (PNS)
– Sensory receptors bring information into the CNS
– Motor nerves carry information away from the CNS
• Autonomic Nervous System (ANS)
– Uses components of the CNS and PNS to regulate automatic or unconscious responses to stimuli
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Function of the Cells that Make Up the Nervous System
Function of the Cells that Make Up the Nervous System
• Allow movement
• Allow realization of various sensations
• Provide response to internal and external stimuli
• Stimulate learning, thinking, and emotions
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
NeuronNeuron
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Types of Neuron AxonsTypes of Neuron Axons
• Afferent Fibers
– Nerve axons that run from peripheral receptors into the CNS
• Efferent Fibers
– Nerve axons that carry nerve impulses from the CNS to the periphery to stimulate muscles or glands
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Action PotentialAction Potential
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Electrolytes Involved in Nerve Cell ActionElectrolytes Involved in Nerve Cell Action
• Sodium
• Potassium
• Calcium
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Movement of Electrolytes with ActionMovement of Electrolytes with Action
• Rest/Repolarization
– Membrane is impermeable to sodium
– Permeable to potassium
• Action/Depolarization
– Sodium goes into the cell
– Potassium leaves the cell
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Formation of Myelin SheathFormation of Myelin Sheath
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Nerve SynapseNerve Synapse
• Presynaptic Nerve
• Synaptic Cleft
• Postsynaptic Effector Cell
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
QuestionQuestion
What nerve axons carry nerve impulses from the central nervous system to the peripheral nervous system?
A. Somatic axons
B. Efferent fibers
C. Afferent fibers
D. Sensory axons
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
AnswerAnswer
B. Efferent fibers
Rationale: Efferent fibers–Nerve axons that carry nerve impulses from the CNS to the periphery to stimulate muscles or glands
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
NeurotransmittersNeurotransmitters
• Acetylcholine
– Communicates between nerves and muscles
• Norepinephrine and Epinephrine
– Catecholamines released by nerves in the sympathetic branch of the ANS
• Dopamine
– Involved in the coordination of impulses and responses
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Neurotransmitters (cont.)Neurotransmitters (cont.)
• Gamma-aminobutyric Acid (GABA)
– Inhibits nerve activity and is important in preventing over-excitability or stimulation such as seizure activity
• Serotonin
– Important in arousal and sleep and in preventing depression and promoting motivation
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Central Nervous SystemCentral Nervous System
• Made up of brain and spinal cord
• Structures are covered by meninges
• Blood brain barrier
• Blood supply to the brain
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Anatomy of the BrainAnatomy of the Brain
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
HindbrainHindbrain
• Runs from the top of the spinal cord into the midbrain
• Most primitive part of the brain - contains the brainstem
• Controls basic vital functions:
– Breathing
– Blood pressure
– Swallowing
– RAS
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
MidbrainMidbrain
• Contains the thalamus, the hypothalamus, and the limbic system
• The thalamus sends direct information into the cerebrum to transfer sensations
• Hypothalamus acts as major sensor activity in the body
– Temperature regulation
– Water balance
– Appetite
– Endocrine function
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Limbic SystemLimbic System
• Contains high levels of neurotransmitters
– Epinephrine
– Norepinephrine
– Serotonin
• Controls expression of emotions
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
ForebrainForebrain
• Made up of two cerebral hemispheres joined together by the corpus callosum
• Receives and sends nerve impulses, coordinates speech and communication, and facilitates learning
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Spinal CordSpinal Cord
• Made up of 31 pairs of spinal nerves
• Each spinal nerve has two components or roots
– Sensory fiber (dorsal root)
• Brings information into the CNS from the periphery
– Motor fiber (ventral root)
• Causes movement or reaction
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Function of Central Nervous SystemFunction of Central Nervous System
• Sensory Functions
• Motor Functions
• Intellectual and Emotional Functions
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Intellectual and Emotional FunctionIntellectual and Emotional Function
• Two hemispheres of the brain process information differently
• Right Side
– Artistic
• Left Side
– Analytical
• When learning takes place and actual change occurs in a neuron
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Intellectual and Emotional Function (cont.)Intellectual and Emotional Function (cont.)
• Some degree of stress helps facilitate learning
• Increased stress inhibits learning
• The limbic system plays a role in learning
• Emotions associated with memory as well as the present, have an impact on stimulus response
• The placebo effect is a documented effect of the mind on drug therapy: If a person perceives that a drug will be effective, it is much more likely to actually be effective
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
QuestionQuestion
Which of the following documented phenomena may occur as a result of drug therapy?
A. Action potential
B. Placebo effect
C. Expectation effect
D. Learning
Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
AnswerAnswer
B. Placebo effect
Rationale: The placebo effect is a documented effect of the mind on drug therapy: If a person perceives that a drug will be effective, it is much more likely to actually be effective.