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Ann Indian Acad Neurol. 2011 Jan-Mar; 14(1): 1218.

doi: 10.4103/092-232.8043

!M"I#: !M"3098$1%

Menieres disease: Still a mystery diseasewith difficult differential diagnosis

A. &a''iliou!. &. &la'ara*o'1!. Mara+ouda*i'2#. "andiloro'2and ,. !. Ni*olooulo'2

Abstract

ne undred and or-'i ear' aer i' ir' de'criion e dierenial dia+no'i' o

Meniere' di'ea'e reain' 5er callen+in+. ,e ai o e re'en 'ud i' o re5ie6 e

curren *no6led+e on e ad5ana+e' and di'ad5ana+e' o e ne6 dia+no'ic eod' orMeniere' di'ea'e. ,e iorance o accurae dia+no'i' or riar ealcare ''e' i'

al'o di'cu''ed. An een'i5e 'earc o e lieraure 6a' erored in Medline and oer

a5aila7le daa7a'e 'ource'. Inoraion ro elecronic lin*' and relaed 7oo*' 6ere al'o

included. "onrolled clinical 'udie' ro'eci5e coor 'udie' rero'eci5e coor 'udie'

cro''-'ecional 'udie' ca'e reor' 6rien +uideline' ''eaic re5ie6' and 7oo*' 6ere

'eleced. ,e ical clinical riad o 'o' ro e 5e'i7ular and coclear ''e'

(recurren 5eri+o lucuain+ 'en'orineural earin+ lo'' and inniu') i' u'uall e *e or

clinical dia+no'i'. lcerol dedraion e' and elecrococleo+ra are e ain

dia+no'ic e'' in curren racice 6ile 5e'i7ular e5o*ed o+enic oenial' a 7e u'ed

in di'ea'e 'a+in+. Ia+ine ecniue' are no 'eciic enou+ o 'e alone e dia+no'i' o

Meniere' di'ea'e alou+ e a 7e nece''ar o eclude oer aolo+ie'. ecenlde5eloed 3# MI roocol' can delineae e erilaic/endolaic 'ace' o e

inner ear and aid dia+no'i'. Meniere' di'ea'e i' a coninuou' ro7le or e aien' and

aec' eir uali o lie. ,a*in+ ino accoun e reuen naure o e di'ea'e in cerain

counrie' eor' or relia7le dia+no'i' ro reerral and 'ucce''ul ana+een are

undou7edl co'-eeci5e or ealcare ''e'.

Keywords: #ia+no'i' elecrococleo+ra +lcerol e' Meniere' di'ea'e 5eri+o

Introduction

Meniere' di'ea'e i' a di'ea'e o e inner ear caraceried 7 e clinical riad o recurren

5eri+o lucuain+ 'en'orineural earin+ lo'' and inniu'.

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,e ai o e re'en 'ud i' o re5ie6 e curren *no6led+e on e ad5ana+e' and

di'ad5ana+e' o e ne6 dia+no'ic eod' or Meniere' di'ea'e. ,e iorance o

accurae dia+no'i' or riar ealcare ''e' and e ilicaion' o oenial

i'dia+no'e' are al'o di'cu''ed.

Materials and Methods

An een'i5e 'earc o e lieraure 6a' erored in Medline and oer a5aila7le daa7a'e

'ource' u'in+ e *e 6ord' ?Meniere' di'ea'e@ ?5eri+o@ ?inniu'@ ?dia+no'i'@

?elecrococleo+ra@ and ?+lcerol e'@. ,e *e 6ord ?Meniere' di'ea'e@ 6a'

con'idered riar and 6a' eier co7ined o e oer *e 6ord' indi5iduall or u'ed in

+rou' o ree. In addiion reerence li'' ro e rerie5ed aricle' 6ere anuall

'earced. Inoraion ro elecronic lin*' and relaed 7oo*' 6ere al'o included in e

anal'i' o daa.

our conrolled clinical 'udie' 1% ro'eci5e coor 'udie' 10 rero'eci5e coor 'udie'1 cro''-'ecional 'ud 2 ca'e reor' 1 6rien +uideline % ''eaic re5ie6' and 3 7oo*'

e 6i e deined crieria and 6ere included in 'ud 'elecion.

Discussion

Definition, staging and epidemiology of Menieres disease

,e er Meniere' di'ea'e i' 6idel u'ed o de'cri7e e clinical riad o recurren roaor

5eri+o lucuain+ 'en'orineural earin+ lo'' and inniu'. ,i' riad o 'o' 6a' ir'

de'cri7ed 7 !ro'er Meniere in 18%1.

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re'old' a 0.$ 1 2 and 3 *B u'in+ e 6or' audio+ra o a %-on iner5al 7eore

reaen

,e re5alence o Meniere' di'ea'e in Norern Duroean counrie' 'ee' ar*edl

i+: aroiael 430 ca'e' er illion are reored in inland

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iner5al. Bo6e5er ruure' are no 'een in all eoral 7one' 6i Meniere' di'ea'e and e

enire cole o 'o' canno 7e ull elained 6i i' eor.

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di'criinaion 'core' aer +lcerol adini'raion.

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Loun+ et al. reored a anoer eainaion

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en e laenc o 6a5e & in e A i' delaed and ere i' a o''i7ili o a

rerococlear aolo+ (i.e. acou'ic neuroa) and

,o a''e'' e e7ranou' la7rin and enance e le5el o cerain or e

dia+no'i' o Meniere' di'ea'e.eci5e inniu'. No onl

oolo+ic condiion' (i.e. re'7acou'i' noi'e-induced earin+ lo'' Meniere' di'ea'eoo'clero'i' ec.) 7u al'o ea7olic di'order' (o- or erroidi' erliideia

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098516/figure/F0003/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098516/figure/F0003/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098516/figure/F0003/

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inc and 5iain deiciencie') neurolo+ic ro7le' (ead raua 6ila' in>urie' ulile

'clero'i' enin+ii') dru+' (a'irin non'eroidal ani-inlaaor edicaion'

aino+lco'ide' ea5 eal') denal di'order' (eoroandi7ular >oin 'ndroe) and

'colo+ical acor' (dere''ion anie) a 7e re'on'i7le or cau'in+ inniu'