8/9/2019 Prostate cancer patho (patient based) by francis
oliveros
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RISK FACTORS
Predisposing Factors: Precipitating
Factors:
-Potential Genetic Endowment of HSPG1, HSPG2, HSPGX genes
-Genetic
Mutation
-Advanced age: 85 years old -High intake
of red meat and fats
Normal cell mutates into an abnormal cell due to exposure/
intake of substances Genetic endowment of faulty genes resulting to
developme
Formation originates in the following zones: Peripheral zone,
Central zone, and
Cancerous cells develop small clump formations noted as
microscopic lesion ( Prostatic
Cancerous cells fails to undergo process of apoptosis causing
continuous multiplication in
an unregulated manner, and competes with normal cell utilization
of body nutrients
Formation of Tumor in the prostate region
Presence of active
levels of the
hormone
Binds cancerous
cells androgen
Stimulates growth
and development of
CA cells skip citrate
production necessary for
semen formation enables
Prostate cancer
Cancerous cells proliferates on local nearby structures
(urethra, bladder, seminal vesicles and nearby
Metastasis
Dx Test:
Increase in
Prostatic Specific
Antigen (PSA):
>100.00 ng/dl
8/9/2019 Prostate cancer patho (patient based) by francis
oliveros
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Symmetrically enlarged gland composed by
Narrows the
lumen of the
segment of the
Growth of the so-
called median lobe
of the prostate
extends into the
proximal urethra
Prostate capsule
influence
proliferation to
expand outward
Encroaches upon
the bladder neck
reducing the
ability to funnel
in response to
Lower Urinary Tract Manifestations are
Asymptomatic based on the patients
Assessment
Dx Test:
KUB with Prostate UT
Impression: BilateraCyst; Grade 1 prostatenlargement by
ultra
criteria; Ultrasonogranormal urinary bladd
Progressive Systemic Metastasis
Malignant cells
metastasized
towards the hepatic
Malignancy
occurring the
regions of the
Altered liver
function: decreased
Dramatic decrease
in oncotic pressure
causes the
development of
Pitting Edema
(Grade 4)
Proliferation causes
pressure on the
surrounding normal
tissues of the
Generalized abdominal
pain noted on all
quadrants with Pain scale
of 8/10. (Reflects throughNursing history during
admission to the MSH ER)
DX test reveals: Increased
levels of alkaline
phosphatase: 155.0 u/L
SGPT: 59.0 U/LDx test reveals:
Large Intestinal
ileus Blastic
metastasis
noted
Metastasis to
Asymptomatic
Dx test reveals:
Blastic bone
metastasis as
described,
hyperthropic
degenerativeosteoarthropy
thoracolumbar spine
Metastasis to the
-DOB (+)
-Ineffective gas
exchange
-Pooling of secretio
resulting to Cr
upon auscultation
-increased mucus
production (+) cou
with greenish sput
Dx Test reveals: Chest PA:
Unremarkable cardiopulmona
findings. Blastic metastasis in
thoracic cage as described.
