Psychopharmacology[Instructor name]

[Class name section number]

Overview

• Introduction• Pharmacokinetics• Drug Administration• Drug Metabolism• Treatment Approaches– Discussion

• Special Populations and Psychopharmacology• Activity

Introduction

Psychoactive DrugsCommunication between neurons

Neurotransmitter ActivityAgonists – increaseAntagonists – decrease

Side Effects

Overview

• Introduction• Pharmacokinetics• Drug Administration• Drug Metabolism• Treatment Approaches– Discussion

• Special Populations and Psychopharmacology• Activity

Pharmacokinetics

Drug effects in the body Absorption Distribution Metabolism Excretion

Overview

• Introduction• Pharmacokinetics• Drug Administration• Drug Metabolism• Treatment Approaches– Discussion

• Special Populations and Psychopharmacology• Activity

Drug Administration

AbsorptionSlowest: OralFastest: Intravenous/Inhalation

Rapid Absorption =high abuse potential

Overview

• Introduction• Pharmacokinetics• Drug Administration• Drug Metabolism• Treatment Approaches– Discussion

• Special Populations and Psychopharmacology• Activity

Drug Metabolism

Liver enzymes

Repeated exposure Tolerance

Enzyme induction

Dangers of grapefruit juice

Overview

• Introduction• Pharmacokinetics• Drug Administration• Drug Metabolism• Treatment Approaches– Discussion

• Special Populations and Psychopharmacology• Activity

Treatment Approaches

Pharmacology + Therapy = Most Effective

Medication can be problematic due to individual variations.

Discussion

What is the best treatment for depression?

Overview

• Introduction• Pharmacokinetics• Drug Administration• Drug Metabolism• Treatment Approaches– Discussion

• Special Populations and Psychopharmacology• Activity

Juveniles and Psychopharmacology

High prevalence Difficult to prescribe and research

Increase in diagnoses

The Elderly and Psychopharmacology

Rapidly aging population

Polypharmacy

Risks

Overview

• Introduction• Pharmacokinetics• Drug Administration• Drug Metabolism• Treatment Approaches– Discussion

• Special Populations and Psychopharmacology• Activity

SSRIs, Suicidality, Violence, and Mania

Why doesn’t everyone just take a “happy pill”?

Serious side-effects

What are other barriers to drug therapies?

Medication AdherenceEasy as can be… right?

Diagnosis: HIV

Treatment: Kool-Aid packets/tic-tac mints

Must adhere to the assigned treatment protocol

What will make treatment easier/harder?

Photo AttributionSlide 1

Photo Credit: Seth Anderson http://www.flickr.com/photos/44124372363@N01/7752724816 https://creativecommons.org/licenses/by-sa/2.0/

Slide 5Photo Credit: anitacanita https://www.flickr.com/photos/86508273@N00/631386556/ https://creativecommons.org/licenses/by-nc-nd/2.0/

Slide 9 Photo Credit: Eme. http://pixabay.com/en/grapefruit-rose-sour-fruit-343615/

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Slide 17Phot Credit: Sharon Drummond http://www.flickr.com/photos/28085418@N07/5159112853 https://creativecommons.org/licenses/by-nc-sa/2.0/

Slide 18 Photo Credit: Auntie P https://www.flickr.com/photos/32625013@N00/3177877243/ https://creativecommons.org/licenses/by-nc-sa/2.0/