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RESPON REGENERATIF
Dr ASWIYANTI ASRI,M.Si.Med,SpPADr ASWIYANTI ASRI,M.Si.Med,SpPA
S 2 BIOMEDIK
REGENERASI• pertumbuhan sel dan jaringan
untuk menggantikan struktur yang hilang.
• Renewal of a damaged tissue or a lost appendages that is identical to the original one
• Istilah regenerasi biasanya dipakai pada pertumbuhan hepar atau ginjal setelah hepatektomi atau nefrektomi parsial
REGENERASI• Semakin tinggi tingkat
perkembangan spesies maka makin terbatas kemampuannya beregenerasi.
• Stem cells : self renewal and producing clonal progeny
• Embryonic and adult stem cells
Stem cells• The ability to divide without limit and to avoid
senescence and maintain genomic integrity• The ability to intermittenly undergo division or to
remain quiescent• The ability to propagate by self-renewal and
differentiation• The absence of lineage markers• The shared presence of certain growth and
transcription markers common to uncommitted cells
Adult stem cells
Bone marrow-derived
stem cells
Tissue stem cells(some may be Bone-marrow
Derived)
Tissue mesenchymal(mesoderm-derived)
Stem cellsoutside
Bone marrow
# hematopoietic stem cells
# multipotentBone marrow-
derived stem cells
Constantly renewing (labile cells)
Epithelial-like cells : epidermis (unipotent basal keratinocyte stem cells)
Persistent (stable cells)
Epithelial, parenchyma : liver (hepatocyte), kidney (putative kidney renal epithelial progenitor
Tissue Stem Cells
Tissue mesenchymal (mesoderm-derived) Stem cells
•Progenitors of connective tissue cells•Isolated from several tissues
•Muscle cells•Skeletal : satellite cells
•Cardiac : cardiac progenitor cells
Tipe Jaringan
J. Stabil
J. Permanen
J. Labil •Tingkat replikasi rendah•Stimulasi tertentu dapat membelah diri•Fase G0 siklus sel•Sel parenkim hepar
•Sel telah keluar dari siklus sel•Tidak mengalami mitosis•Neuron, sel otot jantung
•sel yang selalu berproliferasi disepanjang hidupnya dan menggantikan sel-sel yang telah rusak.
•epitel berlapis gepeng pada kulit, rongga mulut, vagina dan servik.
Self Renewal
Topic Goes Here
• Subtopic goes here.
Penyembuhan luka dan faktor-faktor pertumbuhan. Sel yang terlibat didalam luka ditampilkan dalam urutan dari kiri ke kanan serta grafik warna memperlihatkan rentang hari dari masing-masing sel didalam luka. (Sumber : Rosenberg dkk, 2006)
STEM CELL
S