Clinical Backbone

4 Nourishing oils

10 Phytonutrientextracts

17 Keratin resembling plantamino acids

Fall ReductionRoot EnergizingBlockage Clearing

Anti Scalp AgeingDandruff Removal

Shaft StrengtheningVolumizingInstant ShineSmootheningFrizz Control

10 Actions against all 5 concerns of hair fall and decreased

hair density / growth on all 3 parts of hair.

The Everything (Hair) Therapy

Concern Active Ingredient Efficacy data Formulation details

Fall Reduction Pisum sativum sprout extract

Increase of growth coefficient (A/T) by 78% in 12 weeks with improvement in hair and scalp quality by more than 80%

Root Deep Hydroil

Ocimum basilicum hairy root culture extract

23% increase in dermal papilla cells after 1 month30.7% decrease in hair fall in 2 months

Root Deep Hydroil

Pterocarpus marsupium bark extract

Reduction of hair fall in male volunteers with androgenic alopecia: Frontal zone – 33% in 4 monthsOccipital zone – 46% in 4 months

Root Deep HydroilRoot Deep Shampoo

Root Energizing Plant extracts with Hexapeptides-11

Around 20% decrease in hair removal due to enlargement of hair bulb after 5 applications

Elementi Puro Root Recharge synergy

Vanillyl Butyl Ether 66.4% increase in scalp microcirculation(10 Minutes after application)Increase in IGF-1 production that will lead to increase in Anagen hair density

Elementi Puro Root Recharge synergy

Blockage Clearing Ocimum basilicum hairy root culture extract

Upto 80% reduction in sebum as compared to 70% with Finasteride after 72 hours

Root Deep Hydroil

Zinc PCA +65% of Anti 5-α reductase activity compared to positive control in 28 days Elementi Puro Root Recharge synergy

Anti Scalp Aging Pterocarpus marsupium bark extract

54% of reduction in glycation after 15 days78% of free radical inhibition in spot laboratory studies (in tubo)

Root Deep HydroilRoot Deep Shampoo

Dandruff Removal Piper nigrum fruit extract and Inga alba bark extract

Effective against dandruff-causing bacterial strain at low MICAround 40% reduction in dandruff after 42 daysAround 50% reduction in sebum 42 days

Root Deep HydroilRoot Deep ShampooRoot Deep Intenso Fluid

Shaft Strengthening

Hydrolyzed Pea Protein +4.0 % increase in tensile strength of Hair after each application+4.3 % increase in Cross section area of Hair after each application+5.71 % increase in Hair moisture after each application

Root Deep ShampooRoot Deep Intenso Fluid

++++Proven Hair Fall reduction

Pisum sativum sprout extract+++ +++

Study design I

• Study period of 12 weeks used twice daily

• 20 volunteers of age 21-37

• 17 females with hair in telogen phase > 15%

• 3 males with hair in telogen phase > 20%

Incorporated inRoot Deep Hydroil

Results+++ Effect on hair fall

Results+++ Reduction of Hair fall

Results+++ Effect on A/T ratio

Results+++ Response from volunteers

+++ +++

Study design II

• Study period of 14 days used twice daily

• 10 volunteers of age 46-60

• 4 females

• 6 males

Pisum sativum sprout extract

Incorporated inRoot Deep Hydroil

Results+++ Effect on the expression of dermal papilla signaling molecules

• Noggin – A protein that shortens the telogen phase• FGF-7 - Fibroblast growth factor – 7 that initiates new anagen phase

Ocimum basilicum hairy root culture extract+++ +++

Biotechnologically derived, holy plant extract with Anti 5-alpha reductase activity. Provides nourishment to starving hair roots & promotes fuller, denser hair.

5α reductase is the key target enzyme in the inhibition of hair loss. Basil root Culture extract inhibit 5α reductase. Testosterone will not convert into dihydrotestosterone (DHT) in absence of 5α reductase. The results showed a clear concentration dependent inhibition of 5α reductase. Consequently, Basil root Culture extract was able to reduce hair loss in people with androgenic alopecia.

Incorporated inRoot Deep Hydroil

Results+++ Increased proliferation of Dermal papilla cells

Ocimum basilicum hairy root culture extract+++ +++

• Study period of 2 months used once daily

• 21 volunteers of age 25-67 with daily hair loss

> 100 strains

• 19 females

• 2 males

Study design

Incorporated inRoot Deep Hydroil

Results+++ +++

Pterocarpus marsupium bark extract+++ +++

• Study period of 6 months used once daily against placebo

• 40 male volunteers of with androgenic alopecia

Study design

Incorporated inRoot Deep HydroilRoot Deep Shampoo

Results+++ +++

++++Proven Root Energizing

Plant extracts with Hexapeptides-11+++ +++

• Plant extracts like sugar cane extract, Lemon fruit extract, Apple fruit extract, green tea leaf extract along with Hexapetides-11 restores hair and scalp vitality at cellular level and energizing hair bulb

Incorporated inElementi Puro Root Recharge Synergy

Plant extracts with Hexapeptides-11+++ +++

• Study period of 5 days used once daily• 15 volunteers of age 30-60 with hair length

of not less than 12 inches

Study design

Results+++ +++

Results+++ +++

Vanillyl Butyl Ether+++ +++

• Enhances microcirculation of blood flow with lesser irritation and warming sensation Incorporated in

Elementi Puro Root Recharge Synergy

Results+++ Increase in Blood flow

Results+++ Effect on the production of IGF-1

++++Proven Blockage Clearing

Ocimum basilicum hairy root culture extract+++ +++

Biotechnologically derived, holy plant extract with Anti 5-alpha reductase activity. Provides nourishment to starving hair roots & promotes fuller, denser hair.

5α reductase is the key target enzyme in the inhibition of hair loss. Basil root Culture extract inhibit 5α reductase. Testosterone will not convert into dihydrotestosterone (DHT) in absence of 5α reductase. The results showed a clear concentration dependent inhibition of 5α reductase. Consequently, Basil root Culture extract was able to reduce hair loss in people with androgenic alopecia.

Incorporated inRoot Deep Hydroil

Inhibition of 5α reductase

Results+++ +++

Zinc PCA+++ +++

• Zinc salt of pyrrolidone carboxylic acid, a double acting complex that optimally allies the beneficial effects of zinc and L-PCA, physiological components of the organism.

Incorporated inElementi Puro Root Recharge Synergy

Zinc PCA+++ +++

Zinc PCA+++ +++

Inhibition of 5α reductase• Pre-incubation of human Dermal fibroblasts in presence of Zinc PCA / Zinc

chloride and Addition of radioactive (titrated) Testosterone and incubation for 24 hours / preparation of cellHomogenates by sonication and Radioactivity measurement

• Anti 5-alpha reductase activity of Zinc PCA (+65%) much higher than Zinc chloride (+45%)

• Intrinsic activity of Zinc PCA greater than equimolar quantity of Zinc chloride.

Study design

Results+++ +++

Inhibition of 5α reductase

Zinc PCA+++ +++

Seboregulatory activity• Sebometric study on 2 groups of 16 volunteers after 28 daily application on the

half forehead with a cream containing 1% Zinc PCA vs Placebo and non-treated zone

Study design

Results

Zinc PCA+++ +++

Antimicrobial activity• Minimum Inhibitory Concentration of Zinc PCA was identified and optimized for

various bacterial and fungal strains.

Study design

Results

++++Proven Anti scalp Aging

Pterocarpus marsupium bark extract+++ +++

• Anti glycation activity• Against aminoguanidine as positive control

Study design

Incorporated inRoot Deep HydroilRoot Deep Shampoo

Results

Results+++ +++

• Anti free radical activity

Pterocarpus marsupium bark extract+++ +++

• Test on Keratinocytes:• On the model of UVB induced inflammation against positive control of Aspirin• Incubation period of 72 hours

Anti-inflammatory effect:Study design I

Results

Pterocarpus marsupium bark extract+++ +++

• Test on Polymorphonuclear neutrophilic granulocytes (PMN):• On the model of UVB induced inflammation against positive control of Minocyclin• Incubation period of 24 hours

Anti-inflammatory effect:Study design II

Results

++++Proven Dandruff Removal

Piper nigrum fruit extract and Inga alba bark extract+++ +++

• Study period of 6 months used once daily against placebo

• Against Bacterial strains Malassezia globosa and Malassezia furfur, responsible for dandruff, inflammation and irritation

• Incubation period of 48 hours

Anti microbial activity:Study design

Incorporated inRoot Deep HydroilRoot Deep ShampooRoot Deep Intenso Fluid

Results

Piper nigrum fruit extract and Inga alba bark extract+++ +++

• On human keratinocytes on the model of UVB induced inflammation against positive control of Aspirin

• Incubation period of 48 hours

Anti inflammatory activity:Study design

Results

Piper nigrum fruit extract and Inga alba bark extract+++ +++

• To evaluate the scalp conditions (dandruff, sebum) against a shampoo with 1% zinc pyrithione, after 4 weeks of treatment and 2 weeks of remanence period

Improvement of Scalp properties:Study design

Results+++ +++

Reduction in Dandruff:

Results+++ +++

Reduction in Sebum:

Results+++ +++

Response of Volunteers:

++++Proven Shaft strengthening

Hydrolyzed Pea Protein+++ +++

• 17 keratin resembling plant amino acids• Improves hair strength lost by damages• Restores hair moisture and prevents dry hair• Smoothens hair surface

Incorporated inRoot Deep ShampooRoot Deep Intenso Fluid

Results+++ +++

Tensile strength measurement:

Results+++ +++

Cross-section measurement:

Results+++ +++

Hair moisture measurement:

Natural is the most over utilized but perhaps the least specified term in personal care creations. Whenever you make a choice of using natural products, the question is "how much nature does it actually hold"? Subtracting the water part, nature score indicates the exact percentage of natural ingredients in your selected Brillare science product. So the next time when you read our score, count your nature proximity & be assured of our constant endeavor to keep you as close as possible-to nature.

When it comes to cleaning, sensitive skin/hair possesses the common phenomena of over sensitivity towards traditional cleansers.Let's clean it with sulphate free, biodegradable cleansers.It's your body & it's your world. Stand By The Environment.

+++ +++

Personal care cosmetics are formulated with dual purpose of action. One is for the concern specific efficacy and other is for the wellness feel it imparts on human body and soul. Active score is brillare research laboratory's conscious effort to formulate the personal care cosmetics which carries higher percentage of concern specific active ingredients. These active ingredients are carefully combined with organoleptic advancements in cosmetic base. It brings better efficacy, enhanced nourishment and greater cosmetic wellness.

The Difference

+++ +++The Difference

Patented#

Anti hair fall andHair regrowth promoting

Nature quantified formulations

India first – World first

# Patent pending for deep penetrating micro-emulsion techniques of Hydroil & Root Recharge Synergy