SEMINAR REPORT

SYSTEMATIC REVIEWS February 24 – March 2, 2019

Table of Contents

1. Faculty & Group Photo

2. Schedule

3. Faculty Biographies

4. Fellows Contact Information

5. Diaries

a Program of the

33 fellows from 21 different countries and regions

3 faculty members from the Netherlands and the United Kingdom

10 lectures, 10 workshop sessions given by faculty

1 excellent group work presentation

Faculty Photo (L-R) Prof. Maurice P.A. Zeegers, PhD (Course Director) and Anke Wesselius, PhD (Co-Course Director)

not pictured: Jos Kleijnen, MD, PhD

SALZBURG MAASTRICHT UNIVERSITY SYSTEMATIC REVIEWS SEMINAR February 24 – March 2, 2019

Group Photo of Faculty and Fellows

2019 Salzburg Maastricht University Seminar in Systematic Reviews

Sunday 24 February – Saturday 2 March 2019

Sunday

24.02.2019 Monday 25.02.2019

Tuesday 26.02.2019

Wednesday 27.02.2019

Thursday 28.02.2019

Friday 01.03.2019

Saturday 02.03.2019

07:00 – 08:00 BREAKFAST BREAKFAST BREAKFAST BREAKFAST BREAKFAST DEPARTURES

08:00 – 09:00

Introductions

Pre-Seminar Test (Assessing Preliminary

Knowledge)

Workshop Perform Search in

Pubmed Environment Select Relevant Articles and Prepare PRISMA

Flowchart Data Pooling

(Using Stata)

Reporting a Systematic Review (PRISMA)

08:00 – 08:30 Post-Seminar Test

08:30 – 10:00

Introduction to GRADE

09:00 – 10:00 Introduction to

Epidemiology

Workshop Presenting PRISMA

Flowchart

Reflect on Each Other

Introduction to ROBIS

and AMSTAR

10:00 – 10:30 COFFEE BREAK COFFEE BREAK COFFEE BREAK COFFEE BREAK COFFEE BREAK

10:30 – 11:30 Introduction to

Systematic Reviews and Meta-Analyses

Quality Checklists Workshop

Quantitative Data Extraction for Your Own

Meta-Analyses

N= min 5, max 10

Workshop Critical Appraisal of Systematic Review

Presentation (Group 1) Presentation (Group 2)

11:30 – 12:30 Literature Search Quantitative Data

Extraction Presentation (Group 3) Presentation (Group 4)

12:30 – 14:00 LUNCH LUNCH LUNCH LUNCH LUNCH

14:00 – 15:00

Workshop Think of a Subject for Your Own Meta-Analysis (Group

of 4 Students)

Formulate Research Question

Workshop Critical Appraisal

Free Afternoon Workshop

Work on Your Own Meta-Analyses and Prepare ppt for

Post-Seminar Test

Presentation (Group 5) Presentation (Group 6)

15:00 – 16:00 Wrap-up

16:00 – 17:00

Workshop (Grand Hall)

Presenting the Research Question

Reflect on Each Other

17:00 – 18:00

17:00 – 17:15 OMI/AAF

Presentation

Preparing for Next Day

(TBA during Course)

Workshop (Grand Hall) Presenting the Quality

Scores Reflect on Each Other

Preparing for Next Day Read Paper of a

Systematic Review for Critical Appraisal

Prepare for Post-Seminar Test

18:00 – 19:00

Faculty Only

Meeting to Review the Week

FAREWELL RECEPTION

19:00 – 20:00 WELCOME

RECEPTION & DINNER

DINNER DINNER

Faculty Dinner in

Private Home

DINNER DINNER GRADUATION DINNER

Certificates Awarded

20:00 – 21:00

20:30 – 21:30 CHAMBER MUSIC

CONCERT

MAASTRICHT UNIVERSITY SEMINAR

in SALZBURG

"Systematic Reviews"

February 24 – March 2, 2019

FACULTY

Wolfgang Aulitzky, MD is the Medical Director of the American Austrian Foundation. He is Associate Dean for International Medicine and Distance Learning, Adjunct Prof. of Clinical Urology and Adjunct Prof. of Clinical Reproductive Medicine at the Weill Medical College of Cornell University/New York Presbyterian Hospital. In 2016, he was appointed Adjunct Professor of Pediatrics in the Associated Faculty of the Perelman School of Medicine at the Children’s Hospital of Philadelphia. He is also Associate Prof. of Urology at the Medical University of Innsbruck and Visiting Professor at the Medical University of Vienna. Amongst others he is a member of the American, German and Austrian Societies of Urology and was awarded the Zuckerkandlpreis of the Austrian Society of Urology in 1989. In 1995 he received the Silver Medal, in 2007 the Golden Medal for Merits to the Republic of Austria and in 2014 the cross of honor of the Land Salzburg. As Director of the Medical Program of the American Austrian Foundation he has initiated the Open Medical Institute, a scientific and educational collaboration of Weill Cornell and the NewYork Presbyterian Hospital, the Children Hospital of Philadelphia, Duke University, Columbia University, the Cleveland Clinic and leading hospitals in Austria. Dr. Aulitzky earned his medical degree at the University of Innsbruck in 1977, was a research associate at the University of Uppsala, Sweden and the Rockefeller University, New York. He received his training as an urologist at the University of Innsbruck and the General Hospital of Salzburg. He is the author of more than 140 publications on Urology, Andrology and Health Care issues and is co-author of books on basic and clinical urology/andrology.

Wolfgang Aulitzky, MD

Director, Open Medical Institute American Austrian Foundation

Associate Dean and Gerhard Andlinger Professor for International Medicine & Distance Learning Adjunct Professor of Clinical Urology Adjunct Professor of Clinical Reproductive Medicine Weill Medical College of Cornell University

Adjunct Professor of Pediatrics Perelman School of Medicine at the Children’s Hospital of Philadelphia

Associate Professor of Urology Medical University of Innsbruck, Austria

Kärntner Straße 51/II/Top 4 1010 Vienna Austria

Phone: +43-1-533-8658 Fax: +43-1-533-8658-10 Email: w.aulitzky@openmedicalinstitute.org

Prof. Maurice P.A. Zeegers, PhD (Course Director) is the director of the Care and Public Health Research Institute (CAPHRI) at Maastricht University. With over 300 employees and 400 PhD students in the fields of family medicine, epidemiology, methodology and statistics, international health, health promotion, health services research, orthopaedic surgery, rheumatology, geriatrics, emergency medicine, pharmacy, rehabilitation, social medicine and ethics, CAPHRI provides high quality multidisciplinary research and PhD supervision aimed innovating Public Health and Health Care. As the Head of School, Maurice is responsible for helping CAPHRI researchers and to excel, enjoy their work and contribute to society, both internationally and in the region. He maintains a broad network of partners, develops the institutional strategy, policies and supervises the daily management of the Institute, including the financial responsibility, the multidisciplinary cohesion, the scientific quality control and production mechanisms, and the external review cycles. He is full professor of Complex Genetics and Epidemiology and head of the department of Complex Genetics where he and his team perform their scientific studies, within CAPHRI but also within the NUTRIM School of Nutrition and Translational Research in Metabolism. Maurice received formal training across diverse scientific domains ranging from the allied Medical to the Social Science, the Data Science, the Biotechnological Science and Management and Economics. His main research interest is in Epidemiology from which he recombines and integrates other bodies of knowledge. He has published over 250 scientific papers and two books in the fields of Nutritional Epidemiology, Cancer Epidemiology, Genetic Epidemiology, Forensic Epidemiology, Systematic Reviews and the Responsible Conduct of Research. So far, these have been used over 8000 times by other researchers in their publications (H-index: 55). Prof. Maurice P.A. Zeegers, PhD Professor of Complex Genetics and Epidemiology Maastricht University Faculty of Health, Medicine and Life Sciences Universiteitssingel 40 6229 ER Maastricht The Netherlands Phone: +31-43-3882012 Email: m.zeegers@maastrichtuniversity.nl

Anke Wesselius, PhD (Co-Course Director) is working as an assistant professor at the department of Complex Genetics at Maastricht University. Here, she leads the research line “Nutritional and Cancer Epidemiology”, mainly focussing on the relation between diet and bladder cancer. Anke undertook her PhD in Genetic Epidemiology at the Maastricht University, graduating in 2012, with a thesis focusing on purinergic signaling and osteoporosis. Prior to this, Anke completed a MSc in Biomedical Science, with two majors: ‘Epidemiology’ and ‘Pathobiology’ at the Radboud University of Nijmegen. Anke Wesselius, PhD Assistant Professor of Complex Genetics and Epidemiology Maastricht University Faculty of Health, Medicine and Life Sciences Universiteitssingel 40 6229 ER Maastricht The Netherlands Phone: +31-43-3882012 Email: anke.wesselius@maastrichtuniversity.nl

Jos Kleijnen, MD, PhD is the director of Kleijnen Systematic Reviews Ltd (KSR). Founded in 2005, KSR is an independent research company that produces systematic reviews, cost effectiveness analyses and health technology assessments of research evidence in health care. KSR works for a variety of commissioners, including the National Institute for Health and Care Excellence, similar institutes in Europe, and for pharmaceutical companies; KSR also publishes KSR Evidence, a database with >93,000 systematic reviews. Following his graduation from medical school at Maastricht University, Jos pursued a career as a clinical epidemiologist and has a wealth of experience in conducting and disseminating systematic reviews and other research. Jos is a member of various steering groups and advisory committees related to systematic reviews and health technology assessments, for example Cochrane Austria and Cochrane Poland. Jos was the founding director of the Dutch Cochrane Centre (1994-1998); professor and director of the Centre for Reviews and Dissemination (CRD) at the University of York, UK (1998-2005); clinical professor at the Joanna Briggs Institute at the University of Adelaide, Australia (2011-2016); and is a member of several Methods Working Groups of the Cochrane Collaboration. Jos also formerly served on the Boards of Cochrane and the Guidelines International Network. Jos teaches courses on systematic reviews and evidence-based medicine in several countries, including Sweden, Poland, Austria, the Netherlands and the UK. He was the external examiner of the MSc course International Health Technology Assessment, Pricing and Reimbursement at the University of Sheffield (2014-2018). He also is professor of Systematic Reviews in Health Care (2011-onwards), at the School for Public Health and Primary Care, Maastricht University, the Netherlands. Jos has published and gets cited extensively, in Web of Science his h-index is 51. Jos runs a LinkedIn group “Systematic Reviews” with >2,600 members. Jos Kleijnen, MD, PhD Kleijnen Systematic Reviews Ltd 6 Escrick Business Park Escrick, York, YO19 6FD United Kingdom Phone: +44-1904-727981 Email: jos@systematic-reviews.com Web: www.systematic-reviews.com

MAASTRICHT UNIVERSITY SEMINAR

in SALZBURG

"Systematic Reviews"

February 24 – March 2, 2019

FELLOWS

a Program of the

Elton Bahtiri

Department of Pharmacology, Faculty of Medicine, University of PrishtinaBulevardi i Deshmoreve, P.N.10000 Prishtina, Kosovo

E-Mail:elton.bahtiri@uni-pr.eduPhone:+37-7-44218692

Leticia Andrea Barajas Nava

Hospital Infantil de Mexico Federico GomezDr. Marquez 16206720 Mexico, Mexico

E-Mail:Leticiaa.barajas@gmail.comPhone:+52-5-552289917 ext.4519

Holger Baumann

Washington University in St. Louis660 S. Euclid Ave. Box 805463110 St. Louis, MO, Netherlands

E-Mail:holger.baumann@mac.comPhone:+13-1-42861225+31-2-07728853+13-1-47575901

Suha Beton

Ankara University Ibni Sina HospitalUlus06000 Ankara, Turkey

E-Mail:shabeton@icloud.comPhone:+90-5-055025197

Elena Bondareva

Pavlov First Saint Petersburg State Medical UniversityL‘va Tolstogo Street 6-8197022 Saint Petersburg, Russian Federation

E-Mail:alonabondareva@gmail.comPhone:+79-2-13089967+78-1-26970306

a Program of the

Jilda Cheishvili

Tbilisi Open University14, Gen.Abashidze street6010 Batumi, Georgia

E-Mail:jilda791@gmail.comPhone:+99-5-599766822+59-9-766822

Husameddin Farouk Siddig Elshiekh

Public Health AdminstrationAirport StreetMedina Munawara, Netherlands

E-Mail:h.elshiekh@maastrichtuniversity.nlPhone:+96-6-542154963+24-9-12341946

Vitaliy Gargin

Kharkiv National Medical UniversityNauki Ave. 461022 Kharkiv, Ukraine

E-Mail:vitgarg@ukr.netPhone:+38-0-990498557+38-0-577077333

Alise Gramatniece

Pauls Stradins Clinical University Hospital13 Pilsonu Street1002 Riga, Latvia

E-Mail:alise.gramatniece@gmail.comPhone:+37-1-28682589

Anas Ismail

Bayero University / Aminu Kano Teaching HospitalZaria Road700001 Kano, Nigeria

E-Mail:ibnmalikanas@yahoo.co.ukPhone:+23-4-8039275786

a Program of the

Tatyana Ivanova-Razumova

National Research Cardiacsurgery Center38 Turan str.010000 Astana, Kazakhstan

E-Mail:tania-ivanova@mail.ruPhone:+87-1-72703095+87-1-72425408+77-0-15334326

Lina Jankauskaite

Lithuanian University of Health SciencesEveniu str. 250166 Kaunas, Lithuania

E-Mail:lina.jankauskaite@fc.lsmuni.ltPhone:+37-0-68626590

Mahtab Karimi

Nime Shaaban HospitalMazandaran ,pasdaran boulevard.nime shaa-ban hospital12345678 Sari, Iran, Islamic Republic of

E-Mail:dr.mahtab121@gmail.comPhone:+98-9-113521052+98-1-133219546

Adolfine Kihunrwa

Bugando Medical CentreBugandon/a Mwanza, Tanzania, United Republic of

E-Mail:adolfineh@gmail.comPhone:+25-5-784382616

Besjona Kodra

SUOGJ „Koco Gliozheni“Rr. Andon Z. Cajupi Nd. 16 H. 9 Ap41001 Tirana, Albania

E-Mail:besjonak@hotmail.comPhone:+35-5-696157200+35-5-42246702+39-3-479995183

a Program of the

Aiste Lengvenyte

Vilnius UniversityM. K. Ciurlionio g. 2103101 Vilnius, Lithuania

E-Mail:aistelengvai@gmail.comPhone:+37-0-62679189

Csongor Gyorgy Lengyel

Acratus KftTestver koz 41028 Budapest, Hungary

E-Mail:lengyel.csongor@gmail.comPhone:+36-2-05513586

Abel Makubi

Bugando Medical CentrePO BOX 1370n/a Mwanza, Tanzania, United Republic of

E-Mail:abelmakubi@gmail.comPhone:+25-5-713307170

Astghik Markosyan

Yerevan State Medical UniversityKoryun 20025 Yerevan, Armenia

E-Mail:astgho@yahoo.comPhone:+37-4-10595914+37494555105

Samvel Mkhitaryan

Departement of Health Promotion, CAPHRI Maastricht University, Maastricht, The NetherlandsDebyeplein 1Maastricht, Netherlands

E-Mail:s.mkhitaryan@maastrichtuniversity.nlPhone:

a Program of the

Akbope Myrkassymova

Kazakh National Medical University named after Asfendiyarov, School of Public HealthTole Bi, 94050012 Almaty, Kazakhstan

E-Mail:akbope.myrkassymova@gmail.comPhone:+77-2-73874503+77-7-87764240

Olesea Nicu

State Medical and Pharmaceutical University Nicolae Testemitanu93, BurebistaMD-2060 Chisinau, Republic of Moldova,

E-Mail:olesea.nicu@usmf.mdPhone:+37-3-69948498

Olabayo Reuben Ojeleke

Maastricht UniversityMinderbroedersberg 4-66211LK Maastricht, Netherlands

E-Mail:b.okjeleke@maastrichtuniversity.nlPhone:+45-8-1928478

Tigran Petrosyan

Yerevan State Medical University2 Koryun street0028 Yerevan, Armenia

E-Mail:tigpetrosyan@mail.ruPhone:+37-4-10553310 -137+37-4-10267315+37-4-093734579

Esther Karen Pijl

GGD West-Brabant Doornboslaan 225-227,4816 CZ Bred,a Netherlands

E-Mail:e.pijl@ggdwestbrabant.nlPhone:+06-3-1689162

a Program of the

Veronika Piskovatska

Odessa National Medical UniversityTinysta Street, 865008 Odessa, Ukraine

E-Mail:vprl@mail.ruPhone:+38-0-503922348+38-0-482495441

Esther Steenaart

Maastricht University/CAPHRIP. Debyeplein 16229MD Maastricht, Netherlands

E-Mail:e.steenaart@maastrichtuniversity.nlPhone:+31-4-33885598+31-6-12609983

Igor Stoma

Belarusian State Medical UniversityKropotkina Str. 76220002 Minsk, Belarus

E-Mail:igor.stoma@gmail.comPhone:+37-5-173341462+37-5-296178488

Kyra Theunissen

Maastricht UniversityUniversiteittsingel 506200MD Maastricht, Netherlands

E-Mail:kyra.theunissen@maastrichtuniver-sity.nlPhone:+31-6-43866127

Tuvshinfargal Toivgoo

BattsetsenSkhd31040 Ulaanbaatar, Mongolia

E-Mail:mgltuvshoo@gmail.comPhone:+97-6-88285888+97-6-99007377

a Program of the

Enkh-Oyun Tsogzolbaatar

Mongolian National University of Medical SciencesZorig street14210 Ulaanbaatar, Mongolia

E-Mail:enkhoyun_t@yahoo.comPhone:+97-6-99888081+97-6-21253514

Anna Yakimova

Novosibirsk State Medical University, Clinic of Obs./Gyn.Krasniy Prosp.52630091 Novosibirsk, Russian Federation

E-Mail:yakimova@hotmail.comPhone:+73-8-32225221+79-5-29275226

Elvir Zvrko

Clinical Center of MontenegroClinic for ORL and MFSLjubljanska bb, University of Montenegro81000 Podgorica, Montenegro

E-Mail:elvir@zvrko.mePhone:+38-2-69401431

SEMINAR DIARY FROM FELLOW

Esther Steenaart Maastricht University

Maastricht, the Netherlands February 24 – March 2, 2019

February 24, Sunday evening. After a short flight, I arrived in Salzburg in the late afternoon. I took a bus from the Airport to Schloss Arenberg. I unpacked my bags and then went to the welcome reception. We got some Champaign and had the opportunity to meet the other participants and faculty. It turned out that the participants from Maastricht, including me, were the only ones who hadn’t been here before. However, everyone was really nice and took the time to explain things to us. During dinner, we had some more time to talk to others and I was surprised by the diversity of the group in terms of background, country, profession, etc. It was a great opportunity to socialize a little before the actual course started. February 25, Monday. On Monday, we immediately started off with a test to assess our preliminary knowledge. Luckily, this wasn’t an official assessment as it turned out most of us would’ve failed. This did however show us how much we still had to learn and for me that even motivated me more. After, we got an introduction into Epidemiology by Anke. To me, this information wasn’t new, but I think it was nice to freshen up. After the coffee break Prof. Zeegers provided us with some introductory information on Systematic Reviews and talked us through the steps that we will go through this week. During the lunch break we went for a nice walk alongside the water to get some fresh air. After lunch we met with our subgroups for the first time and started formulating the research question that we want to focus on during this week. It was quite challenging to find an interesting topic with six people with different backgrounds, but we managed in the end and I presented the results to the entire group after. As we still had two hours before dinner, we went outside again with a small group and enjoyed the sunset. After dinner, a few of us spent some time together in my room, having a drink and listening to music from our different backgrounds. The first day was quite intense, but very interesting. February 26, Tuesday. On the second day, we first got together with our group members and performed the search based on our research question. After, we had the chance to present our findings again and discuss this with others. We again had two interesting lectures about quality checklists and data extraction and got to apply that to our own topic after lunch. Our group worked really well together. It was quite a struggle, but we managed to get everything finished in time. We again presented the results to the group and found out that everyone experienced difficulties. That is why it was decided to give us an extra hour to work on this assignment the next morning and start the lecture

an hour later. We enjoyed our dinner again and after we went to the city center to grab a drink. We ended up at an Irish pub, were we had a few beers, whiskey and cider. February 27, Wednesday. In the morning, we finished our group work, after which Prof. Zeegers gave an interesting lecture about data pooling. This lecture helped us understanding the next step we had to take and after the lecture we were all excited to work with STATA on our own topic. We finished all our work in time, so everyone had time to enjoy a free afternoon. With a group of 4 participants, we decided to rent a car and drive to Hallstatt. The drive was already amazing, and arriving there even better. We enjoyed the view, had fun in the snow and walked through all the little streets. As it was quite late when we left, we had pizza on the way back. We were really tired when arriving back in Salzburg, but had an amazing day. February 28, Thursday. Today, Prof. Kleijnen showed us how to write a good systematic review and how to assess the risk of bias in a review. He provided us with many examples and stories from his own career. After the coffee break, we had some time to apply the checklists that Prof. Kleijnen showed, to a systematic review of choice. As the weather was really nice today, we decided to go outside and enjoy the sun a little, while doing our assignment. It really showed us that even while a systematic review is perceived as the highest level of evidence, it doesn’t mean it’s always of high quality and the risk of bias is very high. We enjoyed a nice lunch, after which we got together in our subgroups again to finish our meta-analyses and presentation for the next day. Later this afternoon we will probably spend some time preparing for the test and presentation tomorrow. This evening, we have a chamber music night, which I look forward to. Then tomorrow, we will have our final day. This week has been pretty intense. Some parts were really challenging, but in the end I learned a lot about systematic reviews, and about collaborating with people with different backgrounds. Moreover, I met some really friendly, fun and interesting people and got to enjoy the country. I hope I will be back here someday. Esther Steenaart (The Netherlands)