Systemic Lupus Erythematosus

Rule IN• Fever• Arthralgia• Hypertension• Edema • Anemia with reticulocytosis• Elevated LDH• Hepatosplenomegaly

Rule OUT• Female predominance 8:1• Absence of cutaneous lesions/

vasculitis• Elevated C3 level• Normal ANA level• Normal urinalysis, BUN and serum

creatinine, serum Na & K findings• Normal to slightly elevated WBC

count

References

• Kliegman R, Stanton B, St. Geme J, Schor N, Behrman R. (2011). Nelson Textbook of Pediatrics 19th Edition. Philadelphia: Saunders Elvesier Inc.

• http://www.merckmanuals.com/professional/musculoskeletal_and_connective_tissue_disorders/autoimmune_rheumatic_disorders/systemic_lupus_erythematosus_sle.html?qt=systemic%20lupus%20erythematosus&alt=sh

Systemic Lupus International Collaborating Clinics (SLICC) Diagnostic Criteria

Classification as SLE by the SLICC criteria requires either of the following:• At least 4 of 17 criteria, including at least 1 of the 11 clinical criteria

and 1 of the 6 immunologic criteria• Biopsy-proven nephritis compatible with SLE plus ANA or anti-dsDNA

antibodies

http://www.merckmanuals.com/professional/musculoskeletal_and_connective_tissue_disorders/autoimmune_rheumatic_disorders/systemic_lupus_erythematosus_sle.html?qt=systemic%20lupus%20erythematosus&alt=sh