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SODIUM CITRATE POWDER Frequently asked questions SODIUM CITRATE POWDER Cranberry Flavour Cystoplus ® Sodium Citrate Powder is indicated for the symptomatic relief of the burning pain and stinging associated with cystitis in adult women. Cystitis is an inflammation of the bladder, which causes painful irritation, stinging and an unpleasant burning sensation when passing urine. References: 1. IMS, CDTI Audit Diagnosis, January-December 2010. 2. Cystoplus ® product label. 3. Spooner JB. Alkalinisation in the management of cystitis. J Int Med Res 1984;12:30-4. When can patients start taking Cystoplus ® ? Cystoplus ® can be started as soon as possible after the onset of cystitis symptoms such as dysuria, frequency and urgency. 2,3 Who can take Cystoplus ® ? Cystoplus ® is indicated for adult women suffering from cystitis symptoms. 2 What are the warnings and contraindications to the use of Cystoplus ® ? Patients should consult a doctor if they have any of the following conditions: heart disease, kidney disease, high blood pressure or diabetes or if they have other underlying or ongoing health concerns. 2 Patients should also inform their doctor if they are taking other medicines, especially ACE inhibitors, diuretics or cyclosporine. 2 Patients must not take more than three sachets in one day. 2 If patients accidentally take more than the recommended dose, they should seek medical advice. 2 Use caution when administering to the elderly. 2 Patients should not use this product if they are taking lithium or hexamine, are on a low-sodium diet, or are sensitive to any of the ingredients. 2 Patients should not use this product if they are pregnant or breast-feeding. 2 Not recommended for use in men and children. 2 What are the possible side effects of Cystoplus ® ? Possible side effects associated with Cystoplus ® include flatulence and frequent urination. If patients experience any unusual side effects while taking this medicine, advise them to discontinue use and consult a physician. 1 2 3 4 Pendopharm, division of Pharmascience Inc., Montreal, Canada H4P 2T4 A1401068E For more information on Cystoplus ® and cystitis or to request a visit by a sales representative, please consult: www.cystoplus.ca OTC relief for your patient for when Stopping is Not an Option. Symptomatic relief of burning pain and stinging associated with cystitis in women

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SODIUM CITRATE POWDER

Frequently asked questions

SODIUM CITRATE POWDER

Cranberry Flavour

Cystoplus® Sodium Citrate Powder is indicated for the symptomatic relief of the burning pain and stinging associated with cystitis in adult women. Cystitis is an in�ammation of the bladder, which causes painful irritation, stinging and an unpleasant burning sensation when passing urine.

References: 1. IMS, CDTI Audit Diagnosis, January-December 2010. 2. Cystoplus® product label. 3. Spooner JB. Alkalinisation in the management of cystitis. J Int Med Res 1984;12:30-4.

When can patients start taking Cystoplus®?Cystoplus® can be started as soon as possible after the onset of cystitis symptoms such as dysuria, frequency and urgency.2,3

Who can take Cystoplus®?Cystoplus® is indicated for adult women suffering from cystitis symptoms.2

What are the warnings and contraindications to the use of Cystoplus®?• Patients should consult a doctor if they have any of the following conditions: heart disease, kidney disease, high blood pressure or diabetes or if they have other underlying or ongoing health concerns.2

• Patients should also inform their doctor if they are taking other medicines, especially ACE inhibitors, diuretics or cyclosporine.2

• Patients must not take more than three sachets in one day.2

• If patients accidentally take more than the recommended dose, they should seek medical advice.2

• Use caution when administering to the elderly.2

• Patients should not use this product if they are taking lithium or hexamine, are on a low-sodium diet, or are sensitive to any of the ingredients.2

• Patients should not use this product if they are pregnant or breast-feeding.2

• Not recommended for use in men and children.2

What are the possible side effects of Cystoplus®?Possible side effects associated with Cystoplus® include �atulence and frequent urination. If patients experience any unusual side effects while taking this medicine, advise them to discontinue use and consult a physician.

1

2

3

4

Pendopharm, division of Pharmascience Inc., Montreal, Canada H4P 2T4 A1401068E

For more information on Cystoplus® and cystitis or to request a visitby a sales representative, please consult: www.cystoplus.ca

OTC relief for your patient for whenStopping isNot an Option.Symptomatic relief of burning pain and stinging associated with cystitis in women

Symptomatic relief in abacteriuric patients withinitial moderate to severe symptoms

100

Frequency

Perc

enta

ge o

f pat

ient

s ex

perie

ncin

g sy

mpt

om re

lief Dysuria

75

50

25

0

p=0.01 4 g sodium citrate 3 times daily for 2 days

Adapted from Spooner

Urgency Hematuria Nocturia Urethral pain Suprapubicpain

74%(n=83/112)

86%(n=75/87)

76%(n=74/97)

86%(n=6/7)

94%(n=48/51)

82%(n=37/45)

84%(n=52/62)

SODIUM CITRATE POWDER

Cranberry Flavour SODIUM CITRATE POWDER

The only non-prescription optionspecifically indicated to relieve the burning pain & stinging symptoms associated with cystitis in women.

• Convenient 2-day dosage: patients only need to dissolve the contents of 1 sachet into a glass of water 3 times daily2

Sodium citrate - Demonstrated to providesignificant cystitis symptom relief 3†

In bacteriuric patients, sodium citrate also demonstratedsigni�cant relief of urgency and frequency symptoms (p=0.01)3†

† Open study involving 205 women presenting with symptoms of cystitis and no clear evidenceof bacterial infection. Symptoms were assessed at study entry and on the third day (severity ofsymptoms evaluated on a four-point scale: absent, mild, moderate, severe).

Raising urine pH reduces the painassociated with cystitis

• Sodium citrate is an alkalizing agent which decreases theacidity of the urine (raises the pH), thereby reducing the burningpain and stinging associated with cystitis2

Fast & EasySymptom Relief

Cystoplus® is the onlynon-prescription option to

relieve symptoms associated with cystitis in women.